Exploring the link between HPV infection and head and neck cancers

Source: www.targetedonc.com Author: Jordyn Sava In an interview with Targeted Oncology for Head and Neck Cancer Awareness Month, Noel Laudi, MD, MRCP, discussed the link between human papillomavirus infection and head and neck cancers. There is a complex relationship that exists between human papillomavirus (HPV) and head and neck cancers. According to Noel Laudi, MD, MRCP, “no one is immune to HPV-related head and neck cancers, with certain demographics at higher risk.” Common areas of occurrence for HPV-related head and neck cancer are in the mouth, including tonsils, soft palate, oropharynx, and base of tongue. HPV can cause cancer by staying in the system for 1 to 3 years and affecting lymphatic tissue in fertile areas of the mouth. HPV-related head and neck cancers often present late due to silent growth. Those at a higher risk of developing HPV-related head and neck cancer include those with more sexual partners and those exposed to oral sex. Additionally, smoking increases the risk of cancer for those with HPV, creating a double risk with the virus and smoke. Laudi, of Allina Health Cancer Institute, emphasized that the HPV vaccine is effective in preventing these cancers, with the ideal age for vaccination being around 11 to 13 years old. However, there is an unmet need for better screening methods and higher vaccination rates of children to prevent HPV-related cancers. “I think the vaccine has been a huge move in the right direction. The treatment is very tough, and if we can prevent the cancer [...]

Yes, really – the HPV vaccine is essential for men, too

Source: uk.news.yahoo.com Author: Rhod Gilbert Welsh comedian Rhod Gilbert was diagnosed with stage four cancer last year. The cancer was in his head and neck and was caused by a virus known as HPV. HPV virus is often associated with cervical cancer and with good reason. The virus is responsible for over 15% of cases of cervical cancer. However, as Gilbert’s diagnosis proves, HPV can affect anybody. In his documentary, Rhod Gilbert: A Pain In The Neck For SU2C, the comic spoke about why he’d decided to invite a film crew to watch him experience treatment for his condition and HPV, it seems, was a huge part of the reason. Gilbert said: “I knew I wouldn’t be well enough to go on stage or TV, but I thought I might be well enough to lie in bed and talk to a documentary team about how ill I was. I thought, ‘It will give me something to do’. “Also, by that point, I’d found out my cancer had been caused by the HPV virus, something we vaccinate kids for. At every turn, I thought, ‘I can do something here, which might actually change things.’” Who the HPV vaccine is for According to the NHS, the HPV vaccine reduces your chances of getting the virus which is spread through skin contact – usually during sex, but not always. The vaccine protects against an increased risk of cervical, mouth, anal, and penile cancer. HPV can also cause genital warts. The vaccine is recommended [...]

2023-11-01T14:40:50-07:00November, 2023|Oral Cancer News|

Doctors couldn’t operate on my tumour, but this robot did — and it may have saved my life

Source: www.cbc.ca Author: Glenn Deir This is a First Person column by author Glenn Deir, who lives in St. John's, Newfoundland. Glenn Deir has special thanks for the robot who operated on his tonsil cancer. Long before I had cancer, and long before I lived in Japan, the rock band Styx released a synthesizer-drenched song with the hook "Domo arigato, Mr. Roboto." Forty years later I, too, found myself thanking a robot. Its name is da Vinci. Da Vinci resembles a giant spider with four arms, and my journey to lying beneath those arms began with a niggling problem: I was having discomfort swallowing. Even sipping water sometimes stung. A flexible scope up my nose and down my throat revealed an apparent ulcer on my tonsil, the right tonsil, my one remaining tonsil. But given my history, my doctor couldn't ignore it. Ah, my history. Sixteen years ago, I contracted cancer in the left tonsil thanks to the human papillomavirus. That's the same virus that causes cervical cancer. Most folks shed the HPV virus with no harm done, but I had crappy luck. The subsequent radiation had me retching into a toilet for weeks. I turned into an advocate for the HPV vaccine. The da Vinci robot operates on Glenn Deir. (Glenn Deir) "Sex gave me cancer," I used to say. "You don't want your little boy to grow up and go through what I went through." What I wanted to ask Dr. Boyd Lee was, "So, what's [...]

Interdisciplinary group focuses on developing personalized oral cancer vaccine

Source: web.musc.edu Author: Leslie Cantu Jason Newman, M.D., Angela Yoon, D.D.S., and Shikhar Mehrotra, Ph.D., are working together on a project to develop a personalized vaccine to prevent oral cancer from returning. Photo by Clif Rhodes Interdisciplinary innovation is a hallmark of MUSC Hollings Cancer Center, and it doesn’t get much more interdisciplinary than this – three people, one each with an M.D., a D.D.S., and a Ph.D., working together to develop a new type of personalized vaccine to prevent oral cancer recurrence. “The amazing thing to me is that Jason Newman and I started on the same day at MUSC, which was March 1 of last year. He came from UPenn. I came from Columbia, and Shikhar has been at MUSC forever. It's just three different people who never knew each other before that time, and then we somehow got together and the synergy was there,” said Angela Yoon, D.D.S. Yoon, a professor in the James B. Edwards College of Dental Medicine who focuses on cancer biomarkers and immunomodulatory therapy, is leading the effort in collaboration with the two professors from the College of Medicine: Jason Newman, M.D., Head and Neck Cancer Division director, and Shikhar Mehrotra, Ph.D., scientific director of the Center for Cellular Therapy. They’re getting their project started using funding provided by Hollings. Periodically, Hollings awards funds to MUSC departments as a way to reinvest in faculty members who are conducting cancer research. Participating in clinical trials and on scientific committees and writing new [...]

Cancer research specialist believes uptake in HPV vaccine should be higher

Source: www.mayonews.ie Author: Anton McNulty Parents are potentially harming their children's health by not signing them up to receive the HPV vaccine, which protects against cancer in both males and females. That is the opinion of Martin Clynes, Emeritus Professor of Biotechnology in Dublin City University, who has spent his life researching cancer cells and how they develop in the body. The HPV vaccine is currently available free of charge to all second level students to protect against cervical cancer in women as well as other cancers. The free school-based vaccination programme started in 2010 but uptake of the vaccine slowed around 2016 when some parents established lobby groups because of concerns raised about the vaccine's safety. The current uptake is at 76 percent for the first dose and 65 percent for the second dose. Last year the scheme was extended to women under 25 years of age following a campaign from Bernie and Larry Brennan, parents of the late Laura Brennan who campaigned for higher uptake of the HPV vaccine before her death from cervical cancer in 2019, aged 26. Despite the European Medicines Agency (EMA) dismissing any long-term effects caused by the vaccine, Prof Clynes believes that the uptake is not as good as it should be. Speaking to The Mayo News ahead of a talk he gave on cancer as part of the Féile Chill Damhnait festival on Achill last Wednesday evening, Prof Clynes said parents should get their children to take the vaccine. Scare stories “I [...]

HPV vaccine: Some studies say one and done might be better

Source: www.cnn.com Author: Jen Christensen, CNN This week, at the World Health Organization’s 76th World Health Assembly, health leaders from nearly 100 countries will join with thousands of others who have signed off on a global initiative to eliminate cervical cancer. Globally, cervical cancer is the fourth most common type of cancer in women, according to WHO, but many cases are completely preventable with the human papillomavirus vaccine. HPV is a group of more than 200 related viruses. Many don’t cause any symptoms at all. Some strains cause warts, and some cause cancer. The HPV vaccine protects against the strains that cause most HPV-related cancers. “Vaccines are bringing the dream of eliminating cervical cancer within reach,” WHO Director-General Tedros Adhanom Ghebreyesus said in his remarks to the World Health Assembly on Monday. The vaccine is recommended for children because it works best before someone has been exposed to the virus. HPV is often spread through sexual contact, and the US Centers for Disease Control and Prevention says that almost every sexually active person who is not vaccinated will get HPV at some point. The vaccine’s introduction to the US in 2006, along with more regular screening, has led to a notable drop in cervical cancer cases and deaths in the US, according to the American Society of Clinical Oncology. Cervical cancer rates among the first American generation to get vaccinated have dropped significantly. Among women ages 20 to 24, cervical cancer incidence rates declined 65% from 2012 through 2019, according [...]

California bill would mandate HPV vaccine for incoming college students

Source: www.cancerhealth.com Author: Rachel Scheier and KFF Health News When she was a college freshman, Joslyn Chaiprasert-Paguio was told by a doctor she had a common sexually transmitted infection called the human papillomavirus but not to worry. Four years later, a few days before her wedding, she was diagnosed with cervical cancer, which caused complications when she became pregnant. She had a hysterectomy eight years later, after the disease returned in 2021. The 38-year-old medical journal editor of Menifee in Riverside County, California, hadn’t been immunized as a teenager because there wasn’t yet a vaccine for HPV, which causes nearly all cervical cancers and a handful of other potentially lethal forms of the disease in men and women. Now, her 10-year-old daughter, Samantha, is scheduled to get her first shot this month. “This is the only vaccine that prevents cancer,” Chaiprasert-Paguio said. [Editor’s note: The hepatitis B vaccine prevents liver cancer.] A bill pending in the California legislature would require schools to notify parents that their kids are expected to be vaccinated for HPV before entering eighth grade, as part of a push to get more children inoculated against the cancer-causing strains of the virus, theoretically before they become sexually active. AB 659 stops short of mandating the vaccine for middle schoolers, as the bill originally proposed. Lawmakers stripped out that provision without any debate, reflecting the contentious nature of school vaccine mandates even in a state with some of the nation’s strictest immunization laws. “Now is a tough time [...]

Personalised cancer vaccine trials produce ‘really hopeful’ results

Source: news.sky.com Author: Thomas Moore, Science correspondent @SkyNewsThomas A personalised cancer vaccine made from individual patients' own DNA has produced "really hopeful" early results. The ground-breaking jab, created using technology perfected in the COVID pandemic, is being given to patients after they complete conventional treatment for head and neck cancers. Patients have a high chance of the cancer returning. Preliminary data from a clinical trial being run at The Clatterbridge Cancer Centre show that none of the first eight patients given the jab have relapsed, even after several months. But the cancer has returned in two of eight patients who weren't immunised. The numbers are far too small to draw firm statistical conclusions. But Professor Christian Ottensmeier, a consultant medical oncologist and director of clinical research at the centre, told Sky News he was "cautiously optimistic". "I am really hopeful, yes," he said. "I am quite excited about it. All the data are pointing in the right direction." A small clinical trial of the vaccine on patients with ovarian cancer in France and the US is also showing promising results How does the vaccine work? The jab, codenamed TG4050, is made by a French company called Transgene using similar technology that produced AstraZeneca's COVID vaccine. DNA from an individual patient's tumour is cut and pasted into a harmless virus. When the genetically modified virus is injected into the body, it trains the immune system to be on watch for cancer cells, hopefully destroying them at an early stage before there [...]

WVU Medicine Head and Neck Cancer Team works to increase tonsil cancer awareness

Source: wvumedicine.org Author: staff, WVU Medicine News Head and neck surgical oncologists at WVU Medicine, the WVU Cancer Institute, and across the country are seeing increased incidences of tonsil cancer. “The majority of tonsil cancers, nearly 70 percent, are caused by human papilloma virus (HPV),” Meghan Turner, M.D., head and neck surgeon in the WVU Medicine Department of Otolaryngology, said. “In the last 10 years, tonsil cancer caused by HPV has become more common than cervical cancer caused by the same virus.” In most cases of HPV infection, the body fights off the virus like it would the common cold. In other cases, the virus remains in the body, increasing the risk of both tonsil and cervical cancer. Unlike cervical cancer, there is no regular screening for tonsil cancer. Most commonly, tonsil cancer is first diagnosed as a nontender mass in the neck. “Another common presentation for tonsil cancer is actually recurrent or persistent tonsil pain in spite of treatment for a throat infection,” Dr. Turner said. “This happens between the ages of 50 and 60. It may seem like recurrent strep throat, but it is uncommon for people in that age range to develop recurrent strep throat. If you’re having pain that isn’t resolved after a course of antibiotics, you should ask your doctor if it could possibly be something like tonsil cancer.” It is also regularly discovered during routine dental visits, appearing as asymmetrical tonsils. Those who have had their tonsils removed by tonsillectomy are not immune to [...]

2022-02-05T10:20:45-07:00February, 2022|Oral Cancer News|

The ‘big three’ causes of mouth cancer

Source: www.hippocraticpost.com Author: staff By knowing the causes of mouth cancer, we can take positive steps to reduce our own level of risk, says a leading health charity. The Oral Health Foundation is raising awareness about the causes of mouth cancer, following new research that shows far too many people remain unaware of the main risk factors. The number of people diagnosed with mouth cancer in the UK has doubled in the last 20 years, with tobacco, drinking alcohol to excess and the human papillomavirus, being the considered the most common causes. However, new data shows that awareness into the three big risk factors is as low as 15%. With more than half of all mouth cancer cases linked to lifestyle factors, the charity along with Denplan, part of Simplyhealth, are using November’s Mouth Cancer Action Month to shed light on the biggest risks factors associated with the disease. Tobacco Smoking tobacco increases your risk of developing mouth cancer by up to ten times. This includes smoking cigarettes, pipes or cigars. Around two-in-three mouth cancers are linked to smoking. Dr Nigel Carter, Chief Executive of the Oral Health Foundation says: “Despite the number of smokers continuing to fall, it remains the leading cause of mouth cancer. Our focus must be on providing smokers with the support and information they need in order to kick tobacco for good. It’s never too late to quit and by making this positive step, the health of your mouth and body will see both instant [...]

2021-12-22T13:06:29-07:00December, 2021|Oral Cancer News|
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