Early warning signs of oral cancer

Author: MetroCreative Connection Source: www.washtimesherald.com Oral cancer is a significant threat across the globe. Data from the World Health Organization indicates that more than 450,000 new cases of oral cancer are diagnosed each year. The Oral Cancer Foundation notes that oral cancers are part of a group of cancers referred to as head and neck cancers. All cancers in that group are potentially dangerous, but oral cancers account for roughly 85 percent of all head and neck cancer diagnoses, which underscores the importance of routine oral health checkups. The Moffitt Cancer Center® in Florida notes that many dentists perform oral cancer screenings during routine checkups, which dispels the notion that checkups are unnecessary for individuals who practice proper dental hygiene every day. The American Dental Association notes there is not a one-size-fits-all regimen for dental health. However, at least two visits to a dentist per year can ensure teeth stay clean and afford dentists opportunities to screen for oral cancers and detect other issues, including gingivitis. In addition to scheduling routine checkups, individuals can learn to spot the common symptoms of oral cancer. The Moffitt Cancer Center urges individuals to seek medical attention if any of these signs persist for more than two weeks: A sore, irritation or thickness in the mouth or throat • A white or red patch on the inside of the mouth • A feeling that something is caught in the throat • Hoarseness or other vocal changes • Persistent coughing • Difficulty chewing, swallowing or [...]

2022-04-05T07:38:47-07:00April, 2022|Oral Cancer News|

Your Healthy Family: Vaping puts teens at higher risk of oral cancer

Author: Lisa Greenburg Source: www.fox4now.com Many people think vaping isn't as bad for you as smoking, but health experts say that's a myth. A dentist says vaping has the same oral effects as tobacco, and puts teens at high risk of oral cancer. A team of researchers from the University of California found teens who vape had five times the cancer-causing chemicals in their bodies than teens who did not, especially from the fruit-flavored vaping cartridges. Dr. Fred Guerra of Guerra Dental said vaping negatively impacts your mouth in the same ways as tobacco. "It can be precancerous. It can lead to gum disease. It gives people bad breath. It gives people dry mouth, and dry mouth increases cavities, so while people may think it's safer for the rest of the body, it's not necessarily," Dr. Guerra said. He said all dentists need to be on the front lines of oral cancer and talk to teens and young adults about the dangers of vaping. "Dentists are in such a unique position to counsel our patients on never starting. Or if they have, to do it in a manner that's not threatening and not demeaning. To try to show them that they have control over the effects of some of these devices, so that they can make a rational decision to say 'OK, I need to quit. How can I quit?” Dr. Guerra said. Even if the vaping products have no nicotine, Dr. Guerra said it's still bad for your mouth. [...]

2022-03-05T11:56:48-07:00March, 2022|Oral Cancer News|

Cancer Symptoms: Bad Breath May Be A Sign Of Mouth Cancer

Author: Monica Lozano Source: www.vervetimes.com The Mouth Cancer Foundation says that the majority of deaths from mouth cancer occur because of late detection, “due to a low public awareness of the signs, symptoms, and risks”. It explains that self-checks for mouth cancer take just two minutes and “could save your life, or someone you know”. Around 8,300 people are diagnosed with mouth cancer each year in the UK, which is about one in every 50 cancers diagnosed, according to the NHS. Mouth cancer is the general term given to the variety of malignant tumours that develop in the mouth, according to The Mouth Cancer Foundation. The charity recommends that everyone over the age of 16 has a professional examination for early signs of mouth cancer, once a year, at their dentist. Cancer Research UK says that if you go to see your GP, they will ask you about your symptoms and they might examine you. They may arrange tests or a referral to a specialist. The organisation notes there are many conditions that cause mouth cancer symptoms, most of which are much more common than mouth and oropharyngeal cancer. Nonetheless, it is important to get these symptoms checked by a doctor. One of the signs is bad breath. It explains: “Most people have bad breath at some point in their life and it is not cancer. But if you have cancer, bad breath might be worse and happen more often.” The Oral Health Foundation says: “Bad breath is a very [...]

2022-03-01T08:17:18-07:00March, 2022|Oral Cancer News|

Breath analysis for effective detection of cancer

Source: washingtonnewsday.com Author: Jonathan Edwards By analyzing a breath sample, it seems possible to successfully identify different types of cancer, according to the results of the new study involving researchers from Flinders University. The study was published in the English language journal British Journal of Cancer. Researchers have now made significant progress in developing a breath analysis to detect cancer. The new method has made it possible to effectively identify cancer of the head and neck. Six percent of all cancers worldwide are head and neck cancers, which kill more than 300,000 people every year. Tobacco, alcohol and poor oral hygiene are known major risk factors for this form of cancer. The increase in head and neck cancer is associated with human papilloma virus (HPV) and also affects younger population groups, the research team continued. Current therapies are effective in treating early-stage disease, but such diseases are often detected in the late stages and are often associated with a poorer prognosis and high morbidity. It is therefore important to identify dangerous diseases such as head and neck cancer as quickly as possible. Cancers of the neck and head are widespread The global effort to use a person’s breath analysis for fast, inexpensive and accurate testing for cancer and other early-stage diseases could take a big step forward with the new method. For the study, breath samples were taken from 181 people suspected of having early head and neck squamous cell carcinoma. By examining exhalation profiles, the newly developed method made [...]

John Prine, Who Chronicled the Human Condition in Song, Dies at 73

Source: The New York Times Date: April 7th, 2020 Author: William Grimes   John Prine, the raspy-voiced country-folk singer whose ingenious lyrics to songs by turns poignant, angry and comic made him a favorite of Bob Dylan, Kris Kristofferson and others, died on Tuesday in Nashville. He was 73. The cause was complications of the coronavirus, his family said. Mr. Prine underwent cancer surgery in 1998 to remove a tumor in his neck identified as squamous cell cancer, which had damaged his vocal cords. In 2013, he had part of one lung removed to treat lung cancer. He had been hospitalized since late last month. Mr. Prine was a relative unknown in 1970 when Mr. Kristofferson heard him play one night at a small Chicago club called the Fifth Peg, dragged there by the singer-songwriter Steve Goodman. Mr. Kristofferson was performing in Chicago at the time at the Quiet Knight. At the Fifth Peg, Mr. Prine treated him to a brief after-hours performance of material that, Mr. Kristofferson later wrote, “was unlike anything I’d heard before.” A few weeks later, when Mr. Prine was in New York, Mr. Kristofferson invited him onstage at the Bitter End in Greenwich Village, where he was appearing with Carly Simon, and introduced him to the audience. “No way somebody this young can be writing so heavy,” he said. “John Prine is so good, we may have to break his thumbs.” The record executive Jerry Wexler, who was in the audience, signed Mr. Prine to [...]

2020-04-08T11:13:26-07:00April, 2020|Oral Cancer News|

How Marijuana Accelerates Growth of HPV-related Head and Neck Cancer Identified

University of California San Diego School of Medicine researchers have identified the molecular mechanism activated by the presence of tetrahydrocannabinol (THC) — the ingredient that causes people to feel the euphoria or “high” associated with cannabis — in the bloodstream that accelerates cancer growth in patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma. “HPV-related head and neck cancer is one of the fastest growing cancers in the United States. While at the same time, exposure to marijuana is accelerating. This is a huge public health problem,” said Joseph A. Califano III, MD, senior author and professor and vice chief of the Division of Otolaryngology in the Department of Surgery at UC San Diego School of Medicine. Head and neck squamous cell carcinoma is the sixth most common cancer worldwide. These cancers begin in the cells that line the mucous membranes inside the mouth, nose and throat. Approximately 30 percent of cases of this disease are related to HPV infection, and it is these cases, in particular that are on the rise. Califano suggested increased marijuana use may be a driving factor. Previous studies have linked daily marijuana exposure to an increased prevalence of HPV-related throat cancer. However, a mechanism linking cannabis exposure to increased growth of the cancer was unknown. Reporting in the January 13, 2020 online edition of Clinical Cancer Research, a journal of the American Association for Cancer Research, researchers outline how the presence of THC in the bloodstream activates the p38 MAPK pathway, which [...]

2020-01-16T15:44:42-07:00January, 2020|Oral Cancer News|

How the ADA Oral Cancer Policy Amendment Will Affect Your Practice

Source: Dentistry Today Date: November 29th, 2019 Author: Jo-Anne Jones The ADA recently announced an expansion to its policy on oral cancer detection recommending that dentists and dental hygienists perform routine examinations for oral cancer includingoropharyngeal cancer for all patients. Passed by the ADA House of Delegates in September, this change was brought about to align with concerns from the Centers for Disease Control and Prevention (CDC) over the escalating numbers of diagnosed cases of oropharyngeal cancer linked to the human papillomavirus (HPV). While HPV-related oropharyngeal cancer has risen by 225% over the past two decades, oral cancer linked to the historical etiologic pathways of tobacco and alcohol use has declined by 50%. The ADA’s policy also aligns with support for the HPV vaccine, as 70% of oropharyngeal cancers in the United States are related to HPV, according to the CDC. Dentists and dental hygienists play a critical role in opportunistic screening on all adult patients despite whether they possess the historical risk factors of using tobacco products or alcohol. There is a distinct knowledge gap in today’s population to fully understand that a non-smoker and non-drinker may in fact be at risk for oral and oropharyngeal cancer due to HPV. It is our responsibility to educate our dental patients about all of the risk factors that exist for both oral and oropharyngeal cancer. Now more than ever, it is critically important to extend our screening practices, both visual and tactile, to every adult in the practice on an annual basis. [...]

2019-12-03T17:49:17-07:00December, 2019|OCF In The News, Oral Cancer News|

Oral HPV DNA Persistence After Head and Neck Cancer Treatment Linked to Disease Progression

Source: genomeweb Date: May 2, 2019 Author: Staff Reporter NEW YORK (GenomeWeb) – Persistent traces of human papilloma virus DNA after treatment for HPV-positive head and neck cancer is linked to an increased recurrence risk, a new study has found. Head and neck cancers affect some 53,000 people in the US each year, according to the National Cancer Institute, and HPV has been implicated in many of those cases. In general, patients with HPV-positive tumors have higher survival rates than those with HPV-negative tumors. A team of MD Anderson Cancer Center-led researchers collected oral rinse samples from nearly 400 patients with head and neck squamous cell carcinomas at diagnosis and as their treatments progressed. As they reported today in JAMA Oncology, the researchers found that viral load in patients' oral samples broadly decreased as they underwent therapy. But some patients' viral loads persisted despite treatment, which was linked to an increased risk of cancer recurrence and death, the researchers reported. "Our data suggest that a subset of patients with HPV-positive HNSCC at high risk for locoregional recurrence can be identified by detection of persistent, oral HPV after treatment," MD Anderson's Maura Gillison and her colleagues write in their paper. The researchers enrolled 396 patients with oral cavity, oropharyngeal, or unknown primary HNSCC in their study. They tested the patients' tumors for the presence of 13 high-risk HPV types using an mRNA expression test and found 202 patients had HPV-positive tumors. At the same time, the researchers collected oral rinse samples from patients [...]

2019-05-06T10:20:43-07:00May, 2019|Oral Cancer News|

CDC: Top HPV-Associated Cancer Is Now Oropharyngeal

Date: 08/23/18 Source: medscape.com Author: Nick Mulcahy Oropharyngeal squamous cell carcinoma (SCC) is now the most common HPV-associated cancer in the United States, according to a new report from the Centers for Disease Control and Prevention (CDC) that covers the years 1999 to 2015. During that period, cervical cancer dropped from being the top HPV-associated cancer and oropharyngeal SCC took its place. The transition happened because cervical carcinoma incidence rates decreased 1.6% per year, and oropharyngeal SCC incidence rates increased 2.7% per year among men and 0.8% per year among women. In 2015, there were a total of 11,788 cervical cancers compared with 18,917 oropharyngeal SCCs. The decline in cervical cancer is a "continued trend since the 1950s as a result of cancer screening," write the report authors, led by Elizabeth Van Dyne, MD, MPH, an epidemic intelligence service officer at the CDC. The uptick in oropharyngeal SCC could be due in part to "changing sexual behaviors," including unprotected oral sex, especially among white men, who report having the highest number of sexual partners and performing oral sex at a younger age compared with other racial/ethnic groups, the authors say. Oropharyngeal SCCs include those at the base of tongue, pharyngeal tonsils, anterior and posterior tonsillar pillars, glos­sotonsillar sulci, anterior surface of soft palate and uvula, and lateral and posterior pharyngeal walls. The new report was published August 24 in the Morbidity and Mortality Weekly Report. The study authors defined HPV-associated cancer as "an invasive malignancy in which HPV DNA was frequently [...]

2019-01-02T13:54:33-07:00January, 2019|Oral Cancer News|

Study: Immunotherapy better than chemotherapy for subtype of head and neck cancer

Date: November 30th, 2018 Source: Scienmag A randomized clinical trial involving 97 medical centers in 20 countries, including Moores Cancer Center at UC San Diego Health, found that treating patients who have chemotherapy-resistant head and neck cancer with the immunotherapy drug pembrolizumab is more effective and less toxic than standard chemotherapy, reports an international team of researchers in the November 30 online issue of The Lancet. Previous research had shown that pembrolizumab (Keytruda) was safe and effective for treating patients with recurrent or metastatic head and neck squamous cell carcinoma whose disease had progressed while on or after receiving standard chemotherapy. Data from this clinical trial called KEYNOTE-040, a phase III study sponsored by Merck & Co., the manufacturer of the drug, takes the research a step further by comparing the immunotherapy drug head-to-head to three go-to chemotherapy drugs currently used as standard treatment: methotrexate, docetaxel and cetuximab. "We compared pembrolizumab against standard of care to see if it fulfilled the promise of early data for patients who are unlikely to do well on standard therapy," said Ezra Cohen, MD, professor of medicine at University of California San Diego School of Medicine and corresponding author on the study. "In this trial, patients who received pembrolizumab alone had a higher response rate compared to those receiving standard chemotherapy while those responses lasted, on average, one-and-a-half years. Furthermore, the median survival at one year was markedly better. I feel it is safe to say that these types of therapies should be the [...]

2018-12-03T11:14:28-07:00December, 2018|Oral Cancer News|
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