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So far OCF News Team - B has created 19 blog entries.

DNA biomarker test helps predict recurrence of HPV-driven oropharyngeal cancer after treatment

Author: Emily Henderson, B.Sc. Source: www.news-medical.net A large, multi-institutional study demonstrates that a blood test to detect circulating tumor DNA can accurately predict recurrence of HPV-driven oropharyngeal cancer following treatment. Results also indicate that the biomarker test may detect recurrent disease earlier than imaging or other standard methods of post-treatment surveillance, allowing physicians to personalize treatment more quickly for patients whose cancer returns. Findings from the study will be presented today at the 2022 Multidisciplinary Head and Neck Cancers Symposium. Roughly 15-25% of patients with HPV-driven oropharyngeal cancer experience recurrence after treatment, often presenting as distant disease that has spread past the throat and neck. Currently, recurrence is detected primarily through imaging and physical exams, but there is wide variability in the use and frequency of these surveillance methods. In the study, researchers retrospectively examined data from 1,076 patients who had one or more tests to detect circulating tumor tissue modified viral (TTMV)-HPV DNA as part of their post-treatment surveillance. All patients were examined more than three months after completing standard treatment with surgery, radiation therapy and/or chemotherapy. Of the 80 patients (7% of the total sample) who tested positive for the biomarker in surveillance, 95% were confirmed through imaging, biopsy and/or endoscopy as having recurrent HPV-positive disease. The presence of TTMV-HPV DNA was the first indicator of recurrence for 72% of the patients whose cancer returned, and roughly half of the recurrences (48%) were found in patients tested more than 12 months after completing therapy. "Most patients had no [...]

2022-03-03T12:18:52-07:00March, 2022|Oral Cancer News|

Tumor tissue modified viral-HPV DNA test predicts HPV-driven oropharynx cancer recurrence

Author: Ryan Lawrence Source: www.healio.com A blood test to detect circulating tumor DNA accurately predicted recurrence of HPV-driven oropharyngeal cancer after treatment, according to research presented at Multidisciplinary Head and Neck Cancers Symposium. In addition, findings from the retrospective clinical case series suggested the biomarker test may detect disease recurrence earlier than imaging or other surveillance methods, allowing clinicians to personalize treatment faster for patients whose cancer returns. "We believe that tumor tissue modified viral [TTMV]-HPV DNA testing should be incorporated into surveillance guidelines for monitoring patients treated for HPV-driven oropharyngeal cancer," Glenn J. Hanna, MD, director of the Center for Salivary and Rare Head and Neck Cancers at Dana-Farber Cancer Institute and assistant professor of medicine at Harvard Medical School, told Healio. Background Hanna and colleagues pursued the research because, despite favorable outcomes, up to 20% of patients with HPV-driven oropharyngeal squamous cell carcinoma (OPSCC) experience recurrence within 5 years of curative-intent therapy, roughly half of whom present with distant disease. Meanwhile, current practices for surveillance after treatment rely on physical exams and imaging. “Because we now have ultrasensitive blood-based assays to detect HPV DNA in circulation, it made sense to evaluate the impact of testing throughout surveillance. This serves as a liquid biopsy of sorts to detect tumor tissue modified viral-HPV DNA,” Hanna said. “We hoped this would be more sensitive in detecting recurrence as compared with physical exam and/or imaging in follow-up. Detecting recurrence sooner could lead to early intervention for patients and improved outcomes.” Methodology The analysis included 1,076 consecutive patients [...]

2022-03-03T11:54:07-07:00March, 2022|Oral Cancer News|

Cancer Symptoms: Bad Breath May Be A Sign Of Mouth Cancer

Author: Monica Lozano Source: www.vervetimes.com The Mouth Cancer Foundation says that the majority of deaths from mouth cancer occur because of late detection, “due to a low public awareness of the signs, symptoms, and risks”. It explains that self-checks for mouth cancer take just two minutes and “could save your life, or someone you know”. Around 8,300 people are diagnosed with mouth cancer each year in the UK, which is about one in every 50 cancers diagnosed, according to the NHS. Mouth cancer is the general term given to the variety of malignant tumours that develop in the mouth, according to The Mouth Cancer Foundation. The charity recommends that everyone over the age of 16 has a professional examination for early signs of mouth cancer, once a year, at their dentist. Cancer Research UK says that if you go to see your GP, they will ask you about your symptoms and they might examine you. They may arrange tests or a referral to a specialist. The organisation notes there are many conditions that cause mouth cancer symptoms, most of which are much more common than mouth and oropharyngeal cancer. Nonetheless, it is important to get these symptoms checked by a doctor. One of the signs is bad breath. It explains: “Most people have bad breath at some point in their life and it is not cancer. But if you have cancer, bad breath might be worse and happen more often.” The Oral Health Foundation says: “Bad breath is a very [...]

2022-03-01T08:17:18-07:00March, 2022|Oral Cancer News|

Tobacco and Your Oral Health

Author: Tricare Communications Source: newsroom.tricare.mil FALLS CHURCH, Va.  –  There’s a great deal of scientific information that proves using tobacco products is seriously harmful to your health. Nicotine products can increase your risks for cancer of the throat, lungs, and stomach. Also, tobacco products can negatively impact your oral health in several ways. “Tobacco use can lead to gum disease,” said Doug Elsesser, program analyst with the Defense Health Agency’s TRICARE Dental Program. “Smoking or chewing tobacco makes it tougher for your body to fight infection, including in the gums.” The more you use tobacco in any form, the greater the risk of gum disease, according to the Centers for Disease Control and Prevention. And gum disease may require you to get deeper, more invasive teeth cleanings, or even surgery. The bacteria from gum disease can also worsen existing chronic medical conditions such as diabetes, heart disease, and rheumatoid arthritis. Besides gum disease, smoking and smokeless tobacco can have several other negative effects on your oral health. According to the American Dental Association, tobacco use can also lead to: Tooth staining Loss of tooth enamel Gum tissue loss Tooth loss Oral lesions Oral cancer Knowing these facts, you may want to quit tobacco. Or you may want to help a friend or family member quit. Keep in mind, quitting tobacco can be hard, and it may take several attempts. You may also need some support and resources to help you stay quit and get your health back on track. For information on TRICARE’s tobacco [...]

2022-02-28T10:22:29-07:00February, 2022|Oral Cancer News|

What to know about palatine tonsils

Author: Medically reviewed by Nicole Leigh Aaronson, MD, MBA, CPE, FACS, FAAP — Written by Cara Williams on February 20, 2022 Source: www.medicalnewstoday.com   The palatine tonsils sit in the back of the throat and are made up of lymphatic tissue. Along with the pharyngeal, tubal, and the lingual tonsils, they act as a defence against possible infections. The palatine tonsils are oval-shaped lymphatic tissue located at both sides of the back of the throat. People can see their palatine tonsils by opening their mouths and looking in the mirror. When a person refers to tonsils, they usually refer to the palatine tonsils. While they protect the body, complications such as infection and swelling can cause health problems. Overview The palatine tonsils serve as a component of Waldeyer’s ring. It also consists of the pharyngeal (adenoids), tubal tonsil, and lingual tonsil. The role of the palatine tonsils is to act as the firstTrusted Source defense against pathogens and help stimulate an immune response to fight off infection. Small crypts cover the surface of the palatine tonsils. These crypts give them a large surface area to catch incoming pathogens that may cause infection. The tonsil tissue also aidsTrusted Source in developing B cells and T cells, white blood cells that help fight off infection. Complications associated with palatine tonsils The palatine tonsils play an important role in trapping bacteria and viruses as they enter the body. However, this can make them prone to infection. Doctors refer to an infection in the tonsils as tonsillitis which is fairly common. This infection accounts for 1.3%Trusted Source of outpatient [...]

2022-02-24T13:41:44-07:00February, 2022|Oral Cancer News|

MSSU student detects oral cancer

Source: www.fourstateshomepage.com Author: Mike Olmstead JOPLIN, Mo. — A routine cleaning last fall at Missouri Southern’s Dental Hygiene Clinic led to quite the discovery by a dental hygiene student. Senior Emily Valence was actually examining her future father-in-law, when she noticed a whitish area under his tongue. Mike Eddings, who lives in Ozark, has never smoked or chewed tobacco — so what was found came as a shock. He eventually saw a specialist who determined it was a pre-malignant cancerous lesion. “Very relieving. When they find something like pre-cancerous like that, it is best to get it removed as fast as possible, because normally oral cancer is a very fast-spreading cancer, so who knows how long, you know, it could’ve been until it was spreading to farther stages?” said Valence. “That is just an example of the program working and the education working and them actually absorbing it. And these are our hygienists of the future. They are who is going to be taking care of us 10, 20, 30 years from now,” said Dr. Dennis Abbott, MSSU Adjunct Clinical Supervising Dentist. Valence will graduate in May. Her future father-in-law is doing just fine.    

2022-02-23T13:25:46-07:00February, 2022|Oral Cancer News|

Woman, 20, Diagnosed With Cancer After STD Fears Stopped Her Seeking Help

Author: BY AATIF SULLEYMAN Date: 2/15/2022 Source: www.newsweek.com Ayoung woman who was diagnosed with cancer said she delayed seeing a doctor for months because she was "embarrassed" that she might have had a sexually transmitted disease (STD). Olivia Wallace, from Sunderland in northeastern England, had been experiencing issues with her tongue for seven months before her father eventually took her to see a doctor. She was diagnosed with stage 4 tongue cancer, which had spread to her lymph nodes. Some 8,001 people aged between 20 and 24 years old were diagnosed with cancer in the U.S. in 2018 (the most recent year for which data exists), according to the U.S. Centers for Disease Control and Prevention. She had first noticed a lump on her tongue in 2015, but initially thought that it was a recurring ulcer. However, when the lump continued to expand and became increasingly sensitive to the touch, to the extent that Wallace would be in pain whenever she tried to eat anything, she became convinced that she had contracted an STD, which is also known as a sexually transmitted infection (STI). "Luckily for me, my dad had taken me to the doctors and he was in the waiting room as I thought it was an STI and I was embarrassed," Wallace told Chronicle Live. "There is a stigma attached to young women and STIs, so that deterred me from getting checked out even though it was frightening me." Now aged 26, Wallace is cancer free. However, she fears that would [...]

2022-02-16T07:55:49-07:00February, 2022|OCF In The News, Oral Cancer News|

Reduced Radiation Dose After Surgery May Improve Survival Rates in HPV-Related Throat Cancer

Author: Darlene Dobkowski, MA Source: www.curetoday.com A recent study demonstrated that a lower dose of radiation after surgery for HPV-related throat cancer may provide a greater benefit than a higher dose of radiation with chemotherapy. Transoral robotic surgery followed by low-dose radiation may reduce treatment intensity and improve long-term quality of life compared to usual care, which consists of high-dose radiation and chemotherapy, in patients with HPV-associated throat cancer, recent study findings demonstrate. Positive results from the E3311 study led by the ECOG-ACRIN Cancer Research Group may have been related to the ability of researchers to categorize patients by risk before undergoing surgery. “The study was very helpful in that it gave us a big national sample of people getting transoral surgery,” said Dr. Barbara Burtness, a professor of medicine at Yale School of Medicine, lead of the Head/Neck Cancer Research Program at Yale and a co-leader of the Developmental Therapeutics Program at the Yale Cancer Center, in an interview with CURE®. “It helped us to understand if our rules for deciding who was low risk, intermediate risk and high risk reflected the real natural biology of the cancer. I think that they gave us the first signs that with pathologic staging in HPV-associated cancer, you can actually reduce the intensity of the postoperative treatment. So we actually reported extremely remarkable results.” Increased Incidence of HPV-Associated Throat Cancer Over the past few decades, there has been an increase in throat cancer associated with HPV, which is usually transmitted through sexual [...]

2022-01-21T09:37:46-07:00January, 2022|Oral Cancer News|

Squamous cell carcinoma: A pathology case report follow-up

Author: Stacey L. Gividen, DDS Source: www.dentistryiq.com Remember that case about the pathology on the right posterior lateral border of the tongue that had some “meat” to it? The lesion was small, caused no discomfort, and would have gone on to be something much worse had it not been caught early. What was the definitive? Well, as suspected, it was cancer—squamous cell carcinoma (SCC) to be exact. Refreshers regarding pathology are always good for us, so take a quick second and read up on this type of cancer that is more common than you think. Chances are, you’ve diagnosed this before; if you haven’t, keep looking because at some point in your career, you will. Stats/General Information 1 What is SCC? It’s an end-stage alteration in stratified squamous epithelium, beginning as an epithelial dysplasia until the dysplastic epithelial cells breach the basement membrane and invade the connective tissue. Another common name is epidermoid carcinoma. SCC represents 3% of all cancer in males, 2% in females. The survival rate is 50% SCC is the most common malignant neoplasm of the oral cavity, representing approximately 90% of all oral cancers. Etiologic factors: Tobacco habit, Alcohol consumption Viruses Actinic radiation Immunosuppression Nutritional deficiencies Preexisting diseases Chronic irritation. Treatment 1 Clinical staging of the head and neck using the TNM system (T = primary tumor; N = regional lymph node; M = distant metastasis). There is a specific system for the oral cavity. Treatment is by surgical excision, radiation therapy, and if extensive enough, [...]

2022-01-16T11:12:45-07:00January, 2022|Oral Cancer News|
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