HPV – Page 32 – Oral Cancer News

Oropharyngeal cancer patients with HPV have a more robust response to radiation therapy

Source: Eurekalert.org (SACRAMENTO, Calif.) — UC Davis cancer researchers have discovered significant differences in radiation-therapy response among patients with oropharyngeal cancer depending on whether they carry the human papillomavirus (HPV), a common sexually transmitted virus. The findings, published online today in The Laryngoscope Journal, could lead to more individualized radiation treatment regimens, which for many patients with HPV could be shorter and potentially less toxic. HPV-related cancers of the oropharynx (the region of the throat between the soft palate and the epiglottis, including the tonsils, base of tongue and uvula) have steadily increased in recent years, according to the National Cancer Institute, especially among men. At the same time, the incidence of oropharyngeal cancers related to other causes, such as smoking or alcohol consumption, is declining. HPV is the most common sexually transmitted infection in the United States; it can spread through direct skin-to-skin contact during vaginal, anal and oral sex. The UC Davis study, conducted by Allen Chen, associate professor in the UC Davis Department of Radiation Oncology, examined patterns of tumor reduction during radiation treatment in two otherwise similar groups of patients with oropharyngeal cancer: those who tested positive for HPV and those who tested negative for the virus. None of the HPV patients in the study was a smoker, a leading risk factor for the disease. Chen used CT scans acquired during image-guided radiation therapy (IGRT) and endoscopy (a tube with a small camera) to capture 3D images of the patients' tumors and monitor their treatment progress. [...]

Charlotte Parker2012-09-27T10:38:35-07:00September, 2012|Oral Cancer News|

High HPV Immunization Rates Achieved With PATH Initiative

Source: Medscape.com August 30, 2012 (Montreal, Quebec) — Exceptionally high immunization rates against human papillomavirus (HPV) have been achieved in target-aged girls in India, Peru, Uganda, and Vietnam as a result of a PATH initiative, researchers told delegates here at the Union for International Cancer Control World Cancer Congress 2012. Vivien Tsu, PhD, MPH, director of the HPV vaccines project at PATH, reported that a minimum of 80% — and in some countries well over 90% — of school-aged girls received at least 1 dose of the HPV vaccine in the 4 countries to which the initiative has been directed over the past several years. "The reason the program was successful in these countries, and likely many others, is that there is visible government endorsement and involvement in the program," Dr. Tsu explained. "For the most part, people trust that the government is trying to help them, so if the government is saying 'this is worth doing,' the community participates." As Dr. Tsu noted, cervical cancer — at least 70% of which is caused by HPV types 16 and 18 — is a major health issue for women in low- and middle-income countries, with a projected incidence in 2030 of more than 750,000 women. In North America and Europe, cytology has been extremely effective in detecting cervical cancer and, more important, precursor lesions. However, in low- and middle-income countries, "cytology has failed to have much of an impact," Dr. Tsu explained, because these countries lack the necessary resources to offer widespread [...]

Charlotte Parker2012-08-31T11:09:43-07:00August, 2012|Oral Cancer News|

HPV vaccine not just for girls

Source: www.statesmanjournal.com Author: staff It’s been hard enough to persuade parents to get their preteen girls vaccinated against the virus that causes cervical cancer. Now, health-care providers have an even harder sell: reaching the parents of boys. The vaccine that protects against human papillomavirus, or HPV, has been approved for use in boys since it hit the market in 2006. And while boys don’t share the cervical cancer risk, the vaccination can help stop the virus’ spread, as well as protect boys from other cancers. But as of last fall, just more than 1 percent of all eligible boys had received the vaccine. Since then, the Centers for Disease Control and Prevention has more strongly recommended that boys get it. And the American Academy of Pediatrics threw its support behind the series of three shots for 11- and 12-year-old boys. But experts don’t expect to see a significant increase in the number of boys who have received the vaccine when the CDC releases new vaccination statistics late this summer. Why are so many parents reluctant to have their children vaccinated? Because HPV is transmitted through intimate skin-to-skin contact, parents may fear that vaccinating their children sends the message that premarital sex is OK. Nationwide, 49 percent of girls ages 13 to 17 have received at least one shot, and about 32 percent of girls have received the three doses required for complete protection, according to a CDC report. For girls, doctors cite statistics about how the vaccine protects against the [...]

Oral Cancer Foundation News Team - A2012-08-28T09:31:15-07:00August, 2012|Oral Cancer News|

Fewer teens having oral sex

Source: CNN.com Fewer teens aged 15 to 17 are having oral sex now than in 2002, according to a new report from the U.S. Centers for Disease Control, but the number remains high. The report, based on data from The National Survey of Family Growth, found that more than a third of teens had engaged in oral sex by the time they turned 17. That number climbed to almost 50% by age 19, and more than 80% for 24-year-olds. The study - based on computer surveys given to over 6,000 teens - also looked at the timing of first oral sex in relation to the timing of first vaginal intercourse. It found that the prevalence of having oral sex before vaginal intercourse was about the same as those having vaginal intercourse before oral sex. "This new CDC analysis debunks many myths about when young people are initiating oral sex," wrote Leslie Kantor, vice president for education at Planned Parenthood, a family planning advocacy group. "Although there has never been data to support it, there has been the perception that many teens engage in oral sex as a 'risk-free' alternative to intercourse. But the CDC analysis shows that sexually active young people are likely to engage in both activities," she wrote. How Americans view teen sex But oral sex, like vaginal intercourse, is not risk-free. According to the CDC's website, "numerous studies have demonstrated that oral sex can result in the transmission of HIV and other sexually transmitted disease," not the least of which [...]

Charlotte Parker2012-08-20T10:51:44-07:00August, 2012|Oral Cancer News|

Oral cancer deaths declining among well-educated

Source: www.reuters.com Author: Genevra Pittman Deaths from mouth and throat cancer have dropped since the early 1990s, according to a new study -- but only among people with at least a high school education. Researchers said that may be due to higher rates of smoking and other oral cancer risks among less educated, poorer Americans, and because they're also less likely to have access to timely health care. Similar trends have been shown in rates of death from lung and breast cancers, for example, they added. "We have a lot more to do in terms of (the fact that) socioeconomic status probably is a really significant factor in mortality from oral and oropharyngeal cancers," said Dr. Joseph Califano, who studies those cancers at the Johns Hopkins University School of Medicine in Baltimore but wasn't involved in the new research. "Clearly access to health care to detect cancer in early stages is very important." The study, led by Dr. Amy Chen at the Emory University School of Medicine in Atlanta, included mouth and throat cancer data from 1993 through 2007 in 26 states. Among adults age 25 to 64, there were about 19,300 deaths during that period. Cancer deaths declined during the 1990s and 2000s by two to five percent every year, on average, researchers found. By the end of the study period, the cancers killed three out of every 100,000 white men, six out of every 100,000 black men, and one each of every 100,000 white and black women annually. [...]

Oral Cancer Foundation News Team - A2012-08-06T13:59:07-07:00August, 2012|Oral Cancer News|

Oropharyngeal cancer survival better in those with HPV

Source: www.dailyrx.com Author: Laurie Stoneham The human papillomavirus (HPV) causes a number of malignancies, including head and neck and cervical cancers. Oddly enough, being infected with the virus may help those living with oral cancer. Researchers believe that having HPV improves the lifespan of African Americans who have throat cancer, compared to African Americans who do not have the virus. These are the unexpected findings of a group of researchers, led by Maria J. Worsham, PhD, director of research in the Department of Otolaryngology-Head & Neck Surgery at Henry Ford Health System in Detroit. "This study adds to the mounting evidence of HPV as a racially-linked sexual behavior lifestyle risk factor impacting survival outcomes for both African American and Caucasian patients with oropharyngeal cancer," Dr. Worsham said. Oropharyngeal cancer affects part of the throat, including the base of the tongue, tonsils, soft palate (back of the mouth) and the walls of the throat (pharynx). Risk factors for this oral cancer include smoking, drinking alcohol and HPV infection. To look at how HPV status impacted the outlook of throat cancer patients, researchers worked with 118 patients - 67 of whom did not have the virus and 51 individuals who did. A total of 42 individuals in the study were African American. Here's what researchers learned: African Americans were less likely than Caucasians to have the virus (HPV-positive) as are people over the age of 50 HPV-negative patients who didn't have the virus were nearly 3 times (2.9) more likely to die as [...]

Oral Cancer Foundation News Team - A2012-07-25T09:51:54-07:00July, 2012|Oral Cancer News|

Gardasil vaccine to be free for boys for protection against human papilloma virus

Source: Herald Sun IN a world first, Australian schoolboys will receive the Gardasil vaccine free from next year. Federal Health Minister Tanya Plibersek's announcement yesterday comes five years after it was first funded for girls. She said about 870,000 boys would receive Gardasil over the next four years under the national immunisation program, costing about $21 million. The vaccine, which protects against four strains of the human papilloma virus, will be funded for 12 and 13-year-old boys, but Year 9 students will also be included in a two-year catch-up program. HPV causes cervical cancer in women, as well as a range of other cancers affecting both sexes, including tumours of the head and neck. Ms Plibersek made the announcement at Brisbane's Diamantina Institute, where the vaccine was developed. She said the decision continued Australia's reputation as being a world pioneer in immunisation. "We were one of the first countries to introduce polio and measles vaccinations," the Minister said. "We're the first country to provide free HPV vaccinations for girls, and from next year we will be the first country to provide free HPV vaccinations for boys." Scientist Ian Frazer, who developed Gardasil, hailed the "important public health measure". "The papillomavirus is responsible for some of the cancers inside the mouth and throat along with cancers of the genital tract," Prof Frazer said from overseas. "This is a very safe and effective vaccine." Cancer Council Australia CEO Ian Olver said funding Gardasil for girls was already having positive impacts, decreasing the [...]

Charlotte Parker2012-07-12T08:55:51-07:00July, 2012|Oral Cancer News|

Viral Marketing: What’s Stopping Men From Getting the HPV Vaccine

Source: GOOD Mobile By: Jake Blumgart on July 6, 2012 at 3:00AM PDT In early 2011, my doctor informed me that a vaccine to protect against the human papillomavirus—HPV—was now available for men. I was relieved, then frustrated—my doctor didn’t actually offer the principal vaccine, Gardasil, to her male patients. After a couple days of hunting around town, I finally found the vaccine at the Mazzoni Center, a LGBT health clinic in downtown Philly. I received all three shots, and joined the less than 1 percent of American men who are vaccinated against the most dangerous strains of the virus. While I was exceedingly grateful to the Mazzoni Center inoculating me, I knew of only one other male friend who’d received his shots. So since I got my shots, I’ve made a point of discussing my experience with any friend, acquaintance, or bemused bystander who will listen. And I’ve learned two things about young, straight men and HPV: We all know it exists, and not much else. When I posted about my vaccinations on Facebook and Twitter, the response was largely positive—but the dozen or so likes and comments mainly came from my female friends. When I brought up the issue with a few straight guys, they seemed confused about my decision to air the information in public. Embarrassed, I let the conversation drop. But a couple weeks later, I received a Facebook message from an acquaintance in another city, freaking out about his own HPV scare, and asking me whether [...]

Charlotte Parker2012-07-09T09:04:05-07:00July, 2012|OCF In The News, Oral Cancer News|

Facing the facts: HPV-associated head and neck cancers get a second look

Source: www.curetoday.com Author: Charlotte Huff Kevin Pruyne knew he didn’t fit the stereotype of a hard drinker or heavy smoker who one day develops an oral cancer. The 52-year-old mechanic had been working a three-week stint in a remote section of northern Alaska, repairing trucks on an oil field, when he noticed a hard lump beneath his jaw while shaving. For nearly three months, as Pruyne was prescribed antibiotics for a possible infection and then later shuttled between physician specialists, he kept hearing the same thing: the lump could not be cancer. Pruyne only occasionally consumed alcohol and had never smoked. His wife, Kathy, began researching her husband’s symptoms, which included repetitive throat clearing, a nagging sensation that something was lodged in his throat and ringing in his ears. And the lump, which looked like the top half of an egg, felt solid to the touch. This wasn’t some inflamed lymph node from a lingering head cold, Kathy Pruyne says. “He had every symptom [of cancer], but nobody would listen to me.” Pruyne received a diagnosis of stage 4 oral cancer, which started with a tumor at the base of his tongue. He had already begun chemotherapy when he learned that researchers had discovered an association between the human papillomavirus (HPV) and increasing rates of oropharyngeal cancers. He asked that his tissue be tested; the results came back positive. Pruyne says he wanted to know whether his cancer was caused by HPV because “the prognosis is considerably better with HPV-positive cancer.” [...]

Oral Cancer Foundation News Team - A2012-07-03T17:34:09-07:00July, 2012|Oral Cancer News|

Study links gum disease, HPV-status of head and neck cancer

Source: www.buffalo.edu/ubreporter Author: Sara R. Saldi Human Papilloma Virus (HPV), once almost exclusively associated with cancer of the cervix, is now linked to head and neck cancer. Furthermore, according to a new UB study just published in the Archives of Otolaryngology—Head & Neck Surgery, a JAMA publication, gum disease is associated with increased odds of tumors being HPV-positive. Primary investigator Mine Tezal, assistant professor of oral biology in the School of Dental Medicine, and a team of scientists from UB evaluated data from 124 patients diagnosed with primary head and neck squamous cell carcinoma (HNSCC) between 1999 and 2007. “The aim of the study was to test the presence of periodontitis, a persistent inflammatory process and HPV-status of HNSCC,” Tezal says. Of the 124 tumor samples Tezal and her team studied, 50 were positive for HPV-16 DNA and that subjects with HPV-positive tumors had a significantly higher severity of periodontitis when compared to subjects with HPV-negative tumors. According to the National Cancer Institute, there has been a steady increase in the prevalence of oropharyngeal cancers in the U.S. since 1973. This is despite the significant decline in tobacco use since 1965, a year after the U.S. Surgeon General issued the landmark Report on Smoking and Health. Tezal notes that this increase has mainly been attributed to oral HPV infection. Understanding the natural history of the oral HPV infection and targeting factors associated not only with its acquisition but also with its persistence, says Tezal, will lead to more effective strategies, [...]

Oral Cancer Foundation News Team - A2012-06-22T21:24:45-07:00June, 2012|Oral Cancer News|