June 2012 – Page 2 – Oral Cancer News

Tobacco Smoking and Increased Risk of Death and Progression for Patients With p16-Positive and p16-Negative Oropharyngeal Cancer

Source: Journal of Clinical Oncology Purpose Tobacco smoking is associated with oropharynx cancer survival, but to what extent cancer progression or death increases with increasing tobacco exposure is unknown. Patients and Methods Patients with oropharynx cancer enrolled onto a phase III trial of radiotherapy from 1991 to 1997 (Radiation Therapy Oncology Group [RTOG] 9003) or of chemoradiotherapy from 2002 to 2005 (RTOG 0129) were evaluated for tumor human papillomavirus status by a surrogate, p16 immunohistochemistry, and for tobacco exposure by a standardized questionnaire. Associations between tobacco exposure and overall survival (OS) and progression-free survival (PFS) were estimated by Cox proportional hazards models. Results Prevalence of p16-positive cancer was 39.5% among patients in RTOG 9003 and 68.0% in RTOG 0129. Median pack-years of tobacco smoking were lower among p16-positive than p16-negative patients in both trials (RTOG 9003: 29 v 45.9 pack-years; P = .02; RTOG 0129: 10 v 40 pack-years; P < .001). After adjustment for p16 and other factors, risk of progression (PFS) or death (OS) increased by 1% per pack-year (for both, hazard ratio [HR], 1.01; 95% CI, 1.00 to 1.01; P = .002) or 2% per year of smoking (for both, HR, 1.02; 95% CI, 1.01 to 1.03; P < .001) in both trials. In RTOG 9003, risk of death doubled (HR, 2.19; 95% CI, 1.46 to 3.28) among those who smoked during radiotherapy after accounting for pack-years and other factors, and risk of second primary tumors increased by 1.5% per pack-year (HR, 1.015; 95% CI, 1.005 to [...]

Charlotte Parker2012-06-11T10:02:05-07:00June, 2012|Oral Cancer News|

Cannabis chewing gum targets oral side effects

Source: Author: staff The company Medical Marijuana has acquired a 50% stake in CanChew, a cannabinoid (CBD)-based chewing gum developed as a pharmaceutical delivery mechanism to relieve pain, xerostomia, and other side effects of disease and disease treatment. The acquisition gives Medical Marijuana worldwide exclusive rights to develop, manufacture, market, and distribute both tetrahydrocannabinol (THC) and non-THC hemp-derived cannabinoid-infused chewing gum to medical marijuana consumers, according to the company. The U.S. Food and Drug Administration currently considers non-THC based hemp products to be "food-based" and therefore legal without a medical marijuana license. Cannabinoids have had positive effects in clinical trials on neuralgic pain, multiple sclerosis, and spinal cord injuries, nausea and vomiting from chemotherapy and radiation treatment, as well as palliative treatment of various cancers and HIV/AIDS, the company stated. According to Sanammad, the company that developed CanChew, the gum can: Alleviate acute and chronic pain Diminish nausea and vomiting, as well as cachexia, which is a syndrome common in cancer patients on chemotherapy that causes appetite loss and loss of weight and muscle-mass Enhance appetite Improve muscle relaxation, coordination, and mobility Diminish xerostomia Promote fresh breath and maintain oral hygiene "Functional chewing gum is well-established as an effective way to deliver pharmaceutical active ingredients," said Michael Llamas, president of Medical Marijuana. "A great example is Nicorette. Within 10 minutes of chewing Nicorette gum, the consumer's symptoms of nicotine withdrawal begin to ease. Our formulations also have an exceedingly safer side-effect profile compared to the currently available analgesics such as [...]

Oral Cancer Foundation News Team - A2012-06-08T08:02:29-07:00June, 2012|Oral Cancer News|

Head and neck cancer presentation highlights

Source: www.dailyrx.com Author: Travis Giddings The field of head and neck cancer from ASCO 2012 A recent presentation at the American Society of Clinical Oncology expanded on several molecular breakthroughs concerning head and neck cancers, and a team of doctors gave an overview of recent conclusions from their respective fields. The newly identified molecular pathway for cancers of the head and neck that involves the epidermal growth factor receptor (EGFR) led to developments of highly effective drugs specific for the cancerous cells, EGFR inhibitors. Soon afterwards, scientists discovered the increasingly important role that the human papillomavirus (HPV) played in the development of cancers in the head and neck. Following the explosion of research in the field of molecular pathways involved in head and neck cancers, doctors quickly found that the cancer was a lot more complicated than previous believed. Additional research continues as scientists try to make sense of the data. Approaching the treatment of head and neck cancer from their perspectives from surgery, radiology, and oncology, doctors on the panel discussed the difficulties the field currently faced. The director of Johns Hopkins' Head and Neck Cancer Research department, oncologist David Sidransky, MD, opened the meeting. “The genetic and epigenetic alterations in human tumors are becoming increasingly important for devising and implementing personalized oncology approaches,” said Dr. Sidransky. “Unlike in some other cancers, in head and neck cancer the common mutations that have been identified have not been very helpful for treatment.” The chair of the conference was held by [...]

Oral Cancer Foundation News Team - A2012-06-08T07:56:18-07:00June, 2012|Oral Cancer News|

Dental oncology: Meeting a growing need

Source: Dr.Biscuspid.com The good news is more cancer patients are surviving than ever before. The bad news is it creates new challenges for the medical community to provide adequate and appropriate aftercare and treat the many short- and long-term side effects of cancer treatment. For example, chemotherapy and radiation often cause oral problems such as mucositis, xerostomia, oral and systemic infections, and accelerated caries development. But many dentists refuse to treat cancer patients with these conditions due to the increased risk of osteonecrosis from radiation treatment or bisphosphonate use. Enter Ryan Lee, DDS, MPH, MHA, who is finishing a postgraduate clinical fellowship in dental oncology at Memorial Sloan-Kettering Cancer Center in New York City. He hopes to help solve the shortage of dentists with the training to treat the growing number of cancer patients who need specialized oral care. Ryan Lee, DDS, is one of a handful of dentists specializing in dental oncology. Dr. Lee is one of two fellows in Sloan-Kettering's dental oncology fellowship program, which has been offering the specialty training for at least a decade. "All along I've liked working on medically complex cases with dental needs, so cancer fit into that niche very well," he told DrBicuspid.com. "I've come to realize how much of a growing need it is and how little is available to meet that need," he explained. Currently, only two cancer hospitals offer fellowship training programs for dental oncology: the Memorial Sloan-Kettering Cancer Center and the University of Texas MD Anderson Cancer Center. [...]

Charlotte Parker2012-06-07T10:09:20-07:00June, 2012|Oral Cancer News|

Cancer immunotherapy firm raises $1.5M, eyes strategic partners

Source: medcitynews.com A company developing products to restore the immune system of cancer patients has raised $1.5 million and is now looking for strategic partners. IRX Therapeutics’ lead product, IRX-2, aims to correct dendritic cell and T-cell defects in cancer patients in order to overcome cancer-induced immune suppression and restore antitumor response, according to the company’s website. The cell-based drug has completed a phase 2a trial in which it was well tolerated by patients with head and neck cancer, and showed a good safety profile, which suggests it could be combined with a number of cancer treatment regimens to improve their effectiveness. “This last $1.5 million round will primarily fund the company’s efforts to align with strategic partners for the development of IRX-2,” chief financial officer Jeffrey Hwang said in an email. At least 40 additional unique cancer immunotherapies are currently being tested, according to a report from MD Becker Partners LLC, including ones developed by Bavarian Nordic, GlaxoSmithKline, Bristol-Myers Squibb, Oncothyreo/Merck and Transgene/Novartis. IRX has raised more than $80 million so far and has received Fast Track Designation from the U.S. Food and Drug Administration

Oral Cancer Foundation News Team - A2012-06-06T14:46:40-07:00June, 2012|Oral Cancer News|

The FDA’s power over cigars

Source: www.latimes.com/health Author: editorial The 2009 federal law that required the U.S. Food and Drug Administrationto begin regulating cigarettes also gave it the option of regulating cigars. Now two bills, one in each chamber of Congress, would remove the agency's authority over "traditional" cigars — the regular size that you're used to, not the ones the size of cigarettes. It's true that cigarettes are the far bigger health scourge in the United States, accounting for nearly one in five deaths each year, according to the U.S. Centers for Disease Control and Prevention. Traditionally, cigars have not been popular among young people, which is significant because preventing smoking among youth is one of the key reasons for regulating tobacco. But there's nothing good to be said about the health effects of cigar smoking levitra de 20 mg xifaxan médicament. Even though cigar lovers don't typically inhale the smoke, their lung cancer rates are higher than those of nonsmoking Americans — though lower than those of cigarette smokers. According to the National Cancer Institute, cigars have higher levels of tar, toxins and carcinogens than cigarettes and cause cancers of the mouth, lips, throat and esophagus. They also produce more secondhand smoke. The rate of cigar smoking have been increasing for the last two decades, and cigars can now be found in fruit and candy flavors, including chocolate — the same kind of flavor tweaking that got many teenagers hooked on cigarettes. That was why the Family Smoking Prevention and Tobacco [...]

Oral Cancer Foundation News Team - A2012-06-07T18:59:24-07:00June, 2012|Oral Cancer News|

Throat cancer survivors sing to give thanks, encourage others

Source: www.wfaa.com Author: Jim Douglas Five cancer survivors stepped up to the microphones Tuesday at Baylor All Saints Medical Center in Fort Worth. About 300 people waited to hear the North Texas Laryngectomy Choir. Video available here. It takes courage for anyone to sing in front of a crowd. Imagine doing it without vocal cords. Howard Defibaugh found his courage by first singing to his wife, Diana. He sang her the song she sang to him to soothe his recovery from throat surgery a couple of years ago: You are my sunshine, my only sunshine. You make me happy when skies are gray. It came out low and raspy... almost mechanical. Doctors removed Defibaugh's larynx to save his life. Same with John Robinson. They now have plastic implants. Both hold their hands over the valves in their necks as they talk... and sing. "I don't know how I'm going to do with a big crowd today," Robinson said with a smile. Defibaugh gave him a reassuring pat on the back. This is how the North Texas Laryngectomy Choir started: As a support group. They joke they couldn't carry a tune in bucket (even when they had their real voices). But this concert is about what they carry in their hearts. The five singers stepped to the mics, and sang, "What a Wonderful World." The occasion was the first annual banquet for cancer survivors and caregivers at Baylor All Saints. The crowd gave them a standing ovation.

Oral Cancer Foundation News Team - A2012-06-06T14:37:24-07:00June, 2012|Oral Cancer News|

Tobacco use and baseball

Source: www.quitsmokingforyou.com Like cigarettes, smokeless tobacco (snuff and chewing tobacco), cause mouth cancer, gum disease, and heart disease. Yet many think that chewing tobacco is safe or less so than smoking. This is not true! In 1986, the Surgeon normal closed that the use of smokeless tobacco “is not a safe substitute for smoking cigarettes. It can cause cancer and a whole of noncancerous conditions and can lead to nicotine addiction and dependence.” Since 1991, the National Cancer institute (Nci) has officially recommended that the group avoid and desist the use of all tobacco products, including smokeless tobacco. Nci also recognizes that nitrosamines, found in tobacco products, are not safe at any level. Chewing tobacco and baseball have a long tight affiliation, rooted in the cultural confidence among players and fans that baseball players chew tobacco and it is just part of the grand old game. This mystique is slowing changing with campaigns by ballplayers who have had or have seen friends with mouth cancer caused by chewing tobacco use. Jeff Bagwell Jeff Bagwell, retired first baseman with the Houston Astros and Joe Garagiola, a previous baseball player and commentator, campaign against tobacco use among children and addicted adults. In 1993, when Bagwell was 25-years-old, his dentist discovered leukoplakia, a whitish pre-cancerous sore in his mouth where he continually located chewing tobacco. About 5% of leukoplakias institute into cancer. Fortunately this did not happen to Jeff Bagwell due to the early detection by his dentist. Rick Bender, The Man Without [...]

Oral Cancer Foundation News Team - A2012-06-04T20:47:24-07:00June, 2012|Oral Cancer News|

If You Fail to Look

Source: The American Academy of Oral Systemic Health Newsletter Author: Cris Duval Detecting oral cancer in its earliest stages saves lives, eases suffering, reduces morbidity, and ameliorates post-surgery recovery. Remember when you took driver’s education in high school? I do! When I grew up, driver’s education students in Washington State were required to watch “shock” highway-safety films. These videos, depicting the aftermath of drivers’ actions, showed actual accident scenes, complete with audio recordings of victims’ screams and color close-ups of mangled bodies. My bet is that, if you have ever watched one of these videos, you have never forgotten it. For me, when I saw these videos, I thought about my family and my friends. I know that I have a family that loves and cares about me, and thus, I owe it to them to avoid doing something stupid behind-the-wheel. I never want one of my loved ones to have to go through the pain of seeing me hurt. This means to me that my driver’s license is more than just a “key” to get behind the wheel. Rather, as a website for traffic safety in Texas states, a driver’s license signifies that the driver possesses the “essential knowledge, skills, and experience to perform reduced risk practices in [a] total traffic environment.” In other words, the driver is accountable to himself and other drivers. My response to these driver’s education videos is akin to my reaction to videos that I watched at the Pacific Northwest Head, Neck & Thyroid Cancer [...]

Charlotte Parker2012-06-01T09:35:08-07:00June, 2012|Oral Cancer News|