Trying to improve oral cancer treatment

Source: abclocal.go.com Author: staff It's a journey that can begin in the mirror or at the dentist's office. A small lesion in the mouth or throat can turn out to be oral cancer. Notoriously known to be unpredictable, these cancers are hard to treat, but some young doctors at the New York University's School of Dentistry are working to change that. Oral cancers take one American life every hour and it's because the unpredictability is a challenge. One person's cancer might be slow growing and another's wildly aggressive. It is impossible to tell which it is. The NYU researchers are trying to decipher their instruction codes, their genomics. If doctors know which way the cancer is going, it can be stopped. Halima Mohammed always carries water she constantly needs to drink. She is also a big consumer of fruits and vegetables. The reason: for nine years she has been fighting an oral cancer. "I can't have solid food so I get my nutrition from juices and most of these foods, especially the cabbage and the broccoli, are cancer fighting foods," she said. The cancer has had a huge impact on her life. She's already lost part of her tongue. "It is from my research one of the most painful type of cancers that you can have and I'm not diminishing cancer and the types of cancer, there is a constant pain, constant pain," said Mohammed. "It makes masticating difficult, swallowing difficult. You cannot have your favorite food anymore." But, Mohammed [...]

2011-09-23T16:16:45-07:00September, 2011|Oral Cancer News|
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Cancer clip on tobacco pouch

Source: www.telegraphindia.com Author: staff Packets of chewing tobacco sold across India after December 1, 2011 will have to show graphic images portraying the disfiguring effects of oral cancer, but cigarette and bidi packets may show milder pictures, the Union health ministry said today. The health ministry has notified two new sets of pictorial warnings — harsher images for packets of chewing tobacco — that will replace the existing pictures, scorpions on chewed tobacco products, and diseased lungs on cigarette and bidi packets. Cancer and public health specialists have welcomed the new images, but pointed out that the choice of images given to manufacturers of smoking tobacco will allow them to use a milder warning of a man with diseased lungs rather than of mouth cancer. “I’m not happy at all at the choice of pictures for smoking tobacco products,” said Pankaj Chaturvedi, an associate professor of head and neck cancer surgery at the Tata Memorial Hospital, Mumbai. “Pictorial warnings need to have a strong deterrence effect that impacts people — the pictures for chewing tobacco are likely to have such an effect, but the pictures for smoking tobacco don’t,” he said. “The new four pictures for chewing tobacco are very similar and graphically depict the consequences of mouth cancer,” said Monika Arora, the head of health promotion and tobacco control at the Public Health Foundation of India, New Delhi. But three of the four images for smoking tobacco packets show a male with lungs in different stages of disease, while [...]

2011-05-29T05:51:08-07:00May, 2011|Oral Cancer News|
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Study findings may change surgical practice

Source: www.digitaljournal.com Author: press release Currently, about 30 per cent of patients who receive oral surgery have their cancer recur. But a new, Canada-wide surgical trial using a new approach to remove tumours and pre-cancerous cells from the mouths of those diagnosed with early-stage oral cancer offers new hope for patients. The Terry Fox Research Institute (TFRI) announces the launch of a $4.7 million Pan-Canadian Phase III clinical trial aimed at improving outcomes for patients undergoing surgery for oral squamous cell cancers. The Canadian Optically Guided Approach for Oral Lesions Surgical Trial (The COOLS Study) has the potential to revolutionize clinical practice here and around the world for this kind of cancer. "Our investment in this promising study is our response to a serious clinical concern expressed by head and neck surgeons across Canada and it has the potential to change surgical practices for cancer of the mouth nationally and internationally," said Dr. Victor Ling, TFRI President and Scientific Director. Using a new surgical approach guided by an existing hand-held light tool, the surgeons, pathologists, and scientists involved in this nine-centre study will determine whether recurrence is reduced when they shift the surgical field for the removal of tumours or pre-cancerous cells in the mouth. The surgeons will use fluorescence visualization (FV) or "blue light" provided by the optical aid rather than traditional white light to determine the tissue to be removed. Under the blue light, normal tissue generates a fluorescence which is absent in tumour or pre-cancerous tissue. The [...]

2011-05-27T05:26:01-07:00May, 2011|Oral Cancer News|
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Oral cancer: How discovery devices assist screenings

Source: www.dentistryiq.com Author: Nick Efthimiadis, Vice President, Sales & Marketing, LED Dental Inc. As the intense media attention surrounding Michael Douglas’s illness clearly demonstrated, oral cancer is increasingly in the news these days. With the unfortunate growth in the number of relatively young people contracting the disease due to exposure to the sexually-transmitted human papilla virus — specifically, the HPV-16 strain — oral cancer will only become a bigger concern for both patients and dental practices over time. In fact, the Oral Cancer Foundation recently announced that HPV-16 has now replaced tobacco as the leading cause of this disease. Sadly, one North American dies every hour of every day from oral cancer, and many of those who survive the disease are forced to deal with lengthy, painful treatment and permanent disfigurement. The main problem is that oral cancer is typically discovered in late stages, when the five-year survival rate is only around 30%. The good news: when discovered early, the survival rate leaps to 80%-to-90%. The key to early discovery is the dental practice. Ideally, each and every practice should be conducting a two-step oral cancer screening on all adult patients as part of their annual or semi-annual hygiene checkup. The first step consists of a conventional “white light” exam comprising visual inspection and palpation. The second step consists of examination with an adjunctive screening device. Fortunately, the two steps should take no more than five minutes combined. For the past several years, the adjunctive device that has [...]

2011-04-10T17:42:46-07:00April, 2011|Oral Cancer News|
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Dentists don’t need tools to screen for oral cancer

Source: auburnpub.com Author: Dr. Michael Keating A comment from a patient the other day inspired this month’s topic. I had gone down to the room of one of the hygienists on my team to examine a patient at their six-month preventive therapy visit. I sat down and began examining the skin of the face and neck when the patient asked me what exactly I was looking for. It made me think. Maybe our patients don’t know what we are looking for as we dentists examine them. The exam is much more than coming in, picking up a mirror and explorer and checking just the teeth. Each dentist has their own method and technique of performing the exam. Rest assured, this important step is not missed. So what is it I am looking for? This particular patient that prompted me to discuss oral cancer asked me the question as I was looking along their hairline and lifting back their bangs so I could examine the scalp and forehead. If you were to look at the Skin Cancer Foundation website (www.skincancer.org) you would find that basal cell carcinoma is found mainly on the face, scalp, ears, neck, shoulders and back. Let’s see, four out of six of those are right front and center to me when I go to look at a patient at their recall exam. Sure makes sense for me to check! So for this patient I told them I was looking for any signs of skin cancer, and if [...]

2010-09-30T14:04:25-07:00September, 2010|Oral Cancer News|
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Dental researchers discover human beta defensins-3 ignite in oral cancer growth

Source: www.innovations-report.com Author: Kimyette Finley Detecting oral cancer in its earliest stages can save the lives of the nearly 40,500 people diagnosed annually. But early detection has been difficult. Case Western Reserve University School of Dental Medicine researchers discovered a biomarker, called human beta defensin-3 (hBD-3), which may serve as an early warning. The defensin is present in all oral cancers and associated with the early stages of oral cancer. “Using the biomarker to detect oral cancer holds potential for saving lives when the cancer is most curable. Annually some 10,000 people die from this cancer,” said Ge Jin, assistant professor of biological sciences at the dental school. He led the study, “An Antimicrobial Peptide Regulates Tumor-Associated Macrophage Trafficking via the Chemokine Receptor CCR2, a Model for Tumorigenesis.” The Public Library of Science published the research in PLoS ONE. Oral cancer first appears as white or red lesions in the mouth, the same as noncancerous lesions. Often, the lesions are not biopsied, and cancer is not discovered until it becomes apparent in its later stages, when it has metastasized to other organs. Such a late-stage diagnosis is generally fatal and can result in costly surgeries and treatments or disfigurement that may include removing parts of the tongue, jaw and cheek. All this can be avoided with early removal of the lesion. The hBD-3 biomarker is one of many innate immune peptides found in the epithelial lining of the mouth. In a normal, healthy oral cavity, hBD-1, -2 and -3 ward [...]

2010-07-20T14:18:41-07:00July, 2010|Oral Cancer News|
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Screen play: Take steps to prevent oral cancer

Source: www.pnwlocalnews.com Author: Dr. Stuart Rich, DDS. April is National Oral Cancer Awareness Month. More than 35,000 cases of oral cancer are diagnosed in the United States annually, and more than 45 percent of those will not be alive in five years. To put it another way, oral cancer kills one person every hour, 24 hours per day, seven days per week in the U.S. You can you avoid becoming a statistic for this deadly disease by abstaining from tobacco and alcohol use, since 75 percent of all oral cancers are diagnosed in people who use tobacco products. Those who use tobacco and alcohol have an even higher risk. However, there has been a 60-percent increase over the past decade in the number of oral cancer diagnoses in people under the age of 30 with none of the classic risk factors listed, due to a connection with the HPV virus. Everyone must be screened. While the rates of colon, cervical and prostate cancer have seen major declines in recent years due to early detection through professional screening, the oral cancer survival rate has not increased significantly in the last 50 years. However, if oral cancer is detected and treated in its early stages, the five-year survival rate climbs to 80-90 percent. Areas of highest risk for oral cancer are the side of the tongue, floor of the mouth and back of the throat, so regular dental visits must include a comprehensive examination of the soft tissues at least annually. All [...]

2010-04-20T06:58:24-07:00April, 2010|OCF In The News, Oral Cancer News|
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Chip checks for oral cancer. Is this the beginning of an accurate lost cost alternative?

Source: Rice University Author: Mike Williams Rice's nano-bio-chip effective in pilot study to detect premalignancies The gentle touch of a lesion on the tongue or cheek with a brush can help detect oral cancer with success rates comparable to more invasive techniques, according to preliminary studies by researchers at Rice University, the University of Texas Health Science Centers at Houston and San Antonio and the University of Texas M.D. Anderson Cancer Center. The test that uses Rice's diagnostic nano-bio-chip was found to be 97 percent "sensitive" and 93 percent specific in detecting which patients had malignant or premalignant lesions, results that compared well with traditional tests. The study appeared online in the journal Cancer Prevention Research. "One of the key discoveries in this paper is to show that the miniaturized, noninvasive approach produces about the same result as the pathologists do," said John McDevitt, the Brown-Wiess Professor of Chemistry and Bioengineering at Rice. His lab developed the novel nano-bio-chip technology at the university's BioScience Research Collaborative. Oral cancer afflicts more than 300,000 people a year, including 35,000 in the United States alone. The five-year survival rate is 60 percent, but if cancer is detected early, that rate rises to 90 percent. McDevitt and his team are working to create an inexpensive chip that can differentiate premalignancies from the 95 percent of lesions that will not become cancerous. The minimally invasive technique would deliver results in 15 minutes instead of several days, as lab-based diagnostics do now; and instead of an invasive, [...]

2010-04-19T22:25:12-07:00April, 2010|Oral Cancer News|
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Hills attorney boasts ‘largest jury verdict’

Source: www.hometownlife.com Author: Stacy Jenkins It may be the largest jury verdict award for a dental malpractice lawsuit, but Michigan's tort laws prevent the $15 million award from becoming a reality. Farmington Hills attorney Robert Gittleman said he is “thrilled” by the $15 million verdict reached Aug. 27 by an Oakland County Circuit Court jury because “it sends a strong message.” But the tort laws, he says, are “ludicrous and unfair.” Under Michigan's tort laws, his client will receive $500,000 instead of the $15 million the jury thought she deserves. “It's not tort reform, it's tort deform,” he said. “It's an oppressive law that messes up the jury (process) because the jury speaks, then the judge has to (rule) something else.” Gittleman represented Herta Hopton, 61, of Novi, in the jury trial in Circuit Court Judge Steven Andrews' courtroom in August. Hopton, who was referred to board-certified oral surgeon Warren Vallerand, in Novi, had pain in her lower right jaw in 2005. She visited her general dentist at that time, and again in February 2006 when three lower teeth became loose in the area of the jaw pain. She was referred to a periodontist, who recommended the teeth be pulled and a bridge be inserted. A white lesion in her mouth at that time was considered to be “aspirin burn,” according to court documents. The lesion cleared up, but another surfaced in May 2006. Hopton was then referred to oral surgeon Vallerand for lesion evaluation and a possible biopsy. “His [...]

2009-09-14T06:58:22-07:00September, 2009|Oral Cancer News|
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Follow doctor’s advice, have lesion removed

Source: www.cantonrep.com Author: Peter Gott, M.D. Patients' question: In 1999, my dentist saw a discoloration on the floor of my mouth. He told me to see a doctor about it. The doctor talked me into having the spot surgically removed. A while back, I remember reading in your column that, 95 percent of the time, discolorations in the mouth are nothing to worry about. Recently, I had a procedure done to see if I had oral cancer. That procedure revealed another abnormal area. I assume it is the same thing as what I had removed before but the doctors now want me to have the spot surgically removed with a laser. I am hesitant and would like your advice. I have enclosed copies of both pathology reports, the first from 1999 and the second from a biopsy taken during the screening. Dr. Gott's response: In your first pathology report, the lesion was examined under a microscope. Abnormal changes were noted. These changes were labeled as mild to moderate squamous epithelial dysplasia. Primarily, this means that the flat, platelike cells in the interior covering of your mouth were altered in size, shape and organization. It was not stated that this was cancerous, but in my opinion, these changes were probably precancerous. Thus, having the lesion removed was a smart choice. Now, to the pathology report of your new lesion. According to the report, it very clearly showed that you have oral squamous cell carcinoma in-situ. This means that you have a [...]

2009-07-03T18:00:37-07:00July, 2009|Oral Cancer News|
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