Tag Archive | "epidermal growth factor receptor"
Epidermal Growth Factor Receptor and the Changing Face of Oropharyngeal Cancer
Source: Journal of Clinical Oncology To the Editor: In their article, Chaturvedi et al1 document the rise in human papillomavirus (HPV) –associated cancers as a proportion of squamous cell carcinomas of the oropharynx over the last 25 years. The contemporary figures are mirrored by two recent British studies2,3 demonstrating that the majority of oropharyngeal cancers [...]
Continue reading...Erlotinib dose doubled for smokers with head/neck cancer
Saturday, January 28, 2012
Source: www.oncologyreport.com Author: Miriam E. Tucker Giving smokers a higher, short-course dose of erlotinib before definitive surgery for squamous cell carcinoma of the head and neck resulted in favorable responses for the first patients evaluated in a small pilot study. Investigators gave 300 mg of erlotinib (Tarceva) to smokers daily and 150 mg daily to [...]
Continue reading...Roche scientist provides a look at drugmaker’s early pipeline
Monday, January 2, 2012
Source: www.nj.com/ Author: Susan Todd/The Star-Ledger Jean-Jacques Garaud, who heads Roche’s pharmaceutical research and early development efforts in Switzerland, visited the drugmaker’s Nutley campus in mid-December and spent some time speaking with The Star-Ledger about the company’s efforts in the laboratory. The talk with Garaud provided a rare glimpse of the giant Swiss drugmaker’s early-stage [...]
Continue reading...‘Synthetic lethality’ strategy improves molecularly targeted cancer therapy
Tuesday, September 21, 2010
Source: www.physorg.com Author: Fox Chase Cancer Center Molecularly targeted therapies can reduce tumors rapidly. However, not all tumors respond to the drugs, and even those that do often develop resistance over time. Looking for a way to combat the problem of resistance, researchers at Fox Chase Cancer Center hypothesized that hitting already weakened cancer cells [...]
Continue reading...ASCO: Antibody improves head and neck cancer results
Sunday, June 6, 2010
Source: www.medpagetoday.com Author: Michael Smith, North American Correspondent, MedPage Today A novel antibody improved outcomes for patients with advanced and inoperable squamous cell carcinoma of the head and neck, researchers reported. Combined with radiation or chemoradiation, the substance — a fully humanized monoclonal antibody dubbed nimotuzumab — significantly outperformed either modality alone in an open-label [...]
Continue reading...Boehringer Ingelheim will announce preliminary data in the area of head and neck cancer
Sunday, May 23, 2010
Source: pr-usa.net Author: press release Boehringer Ingelheim will announce preliminary data in the areas of head and neck cancer and non-small cell lung cancer (NSCLC) for one of the company’s investigational compounds, BIBW 2992. These data will be presented at the 2010 Annual Meeting of the American Society of Clinical Oncology (ASCO) annual meeting in [...]
Continue reading...Integration of epidermal growth factor receptor inhibitors with preoperative chemoradiation
Monday, May 3, 2010
Source: Clincancerres Author: Annelies Debucquoy1, Jean-Pascal Machiels2, William H. McBride3, and Karin Haustermans1 Corresponding Author: Annelies Debucquoy, Laboratory of Experimental Radiotherapy, Department of Radiation Oncology, CDG Building, Box 815, UH Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. Phone: 32-16-346900; Fax: 32-16-346905; E-mail:annelies.debucquoy@med.kuleuven.be. Abstract In many different cancer cell types, the epidermal growth factor receptor (EGFR) pathway becomes hyperactivated because [...]
Continue reading...Genmab to review clinical plans for head and neck cancer candidate after mixed results from phase III trial
Sunday, April 18, 2010
Source: www.genengnews.com Author: staff Genmab is reporting that Phase III results of its antibody for head and neck cancer, zalutumumab, showed that the treatment did not increase overall survival enough for it to be statistically significant but did significantly boost progression-free survival. The company says that it is evaluating its development program in this indication [...]
Continue reading...Nano-bio-chip sensor platform for examination of oral exfoliative cytology
Sunday, April 4, 2010
Source: Cancer Prevention Research 3(4); 518-28, March 23, 2010 Authors: SE Weigum et al. Oral cancer is a deadly and disfiguring disease that could greatly benefit from new diagnostic approaches enabling early detection. In this pilot study, we describe a nano-bio-chip (NBC) sensor technique for analysis of oral cancer biomarkers in exfoliative cytology specimens, targeting [...]
Continue reading...Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer
Monday, March 22, 2010
Source: 7thspace.com/headlines Author: staff Many cancerous cells accumulate beta-catenin in the nucleus. We examined the role of epidermal growth factor receptor (EGFR) signaling in the accumulation of beta-catenin in the nuclei of oral cancer cells. Results: We used two strains of cultured oral cancer cells, one with reduced EGFR expression (OECM1 cells) and one with [...]
Continue reading...- Accuracy of Dentists in the Clinical Diagnosis of Oral Lesions
- New Evaluation for HPV16 Related Cancers Using "Pap-Test Equivalent"
- New Study Indicates Tobacco Industry Was Aware of Their Own Products Dangers
- Increase in oral cancers linked to HPV
- Systems Strategies To Support Cancer Screening in U.S. Primary Care Practice
- Study Finds- Fewer Dying from Throat & Mouth Cancer in the U.S.
- UI professors: HPV editorial misses the mark
- Girls-Only Vaccine Could Be Best Weapon Against HPV
- Many Head and Neck Cancer Survivors Face Eating Problems
- The Gardasil Problem: How The U.S. Lost Faith In A Promising Vaccine
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- Keith Hern – Battling throat cancer, chemotherapy, radiotherapy and NLP
- Vitamin B veggies cut risk of mouth cancer
- Oral sex may cause more oral cancer than smoking in men, researchers say
- Big Tobacco Spending More Than a Super PAC to Defeat Cancer Research
- Actor’s Diagnosis Puts Spotlight on Oral Cancer
- Actor Michael Douglas Partners With Oral Cancer Foundation For Early Detection PSA Campaign
- 2009 Federal Tobacco Tax Increase Cut Number of Youth Smokers by At Least 220,000 in First Two Months Alone, New Study Shows
- Radiotherapy May Be Enough for HPV-Positive Throat Cancer
- Stem cell sparing radiotherapy for head and neck cancer may avoid salivary gland damage
- 1 of 6 cancer deaths worldwide caused by preventable infections
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Friday, March 9, 2012
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