Monthly Archives: May 2010

Human papillomavirus knowledge and vaccine acceptability among a national sample of heterosexual men

Source: BMJ.com
Authors:
Paul L Reiter, Noel T Brewer, & Jennifer S Smith

  • Accepted 26 October 2009
  • Published Online First 30 November 2009

Abstract

Objectives If approved for use in young males in the United States, prophylactic human papillomavirus (HPV) vaccine may reduce the incidence of HPV-related disease in vaccinated males and their sexual partners. We aimed to characterise heterosexual men’s willingness to get HPV vaccine and identify correlates of vaccine acceptability.

Methods Participants were from a national sample of heterosexual men (n=297) aged 18–59 y from the United States who were interviewed in January 2009. We analysed data using multivariate logistic regression.

Results Most men had not heard of HPV prior to the study or had low HPV knowledge (81%; 239/296). Most men had heard of HPV vaccine prior to the study (63%; 186/296) and 37% (109/296) were willing to get HPV vaccine. Men were more willing to get vaccinated if they reported higher perceived likelihood of getting HPV-related disease (OR 1.80, 95% CI 1.02 to 3.17), perceived HPV vaccine effectiveness (OR 1.86, 95% CI 1.22 to 2.83) or anticipated regret if they did not get vaccinated and an HPV infection later developed (OR 2.01, 95% CI 1.40 to 2.89). Acceptability was also higher among men who thought (OR 9.02, 95% CI 3.45 to 23.60) or who were unsure (OR 2.67, 95% CI 1.30 to 5.47) if their doctor would recommend they get HPV vaccine if licenced for males.

Conclusions Men had low HPV knowledge and were moderately willing to get HPV vaccine. These findings underscore the need for HPV educational efforts for men and provide insight into some of the factors that may affect the HPV vaccination decision making process among men.

May, 2010|Oral Cancer News|

Boot scootin’ for oral cancer screening…again!

Source: The Oral Cancer Foundation
Author: John Pohl

Nashville Hygienists Walk to Promote Oral Cancer Detection

For the second straight year, the Nashville Area Dental Hygienists’ Society (NADHS) has organized a successful walk to raise both oral cancer awareness and funding for the Oral Cancer Foundation.  Despite grey skies and cold temperatures, the $7,700 raised by “Boot Scootin’ for Oral Cancer Screening II” represented more than a 20% increase over the inaugural event’s results.

The walk took place took place the morning of Saturday, March 13 at Nashville’s Centennial Park.  Outgoing NADHS president Nicki Raines, who had convinced the organization to embrace the cause of oral cancer detection when she began her two-year presidential term, and her 6-person committee worked countless hours to ensure that the event would top last year’s efforts.  Before the walk, participants were treated to three inspiring speakers.  Two are oral cancer survivors:  Kathi Gill, a Georgia resident who attended but did not speak at the 2009 walk, and ShayLynn Grant, a 24-year-old from Kentucky.  The third speaker was Cydney Miller, Mrs. Tennessee International, who is a staunch advocate of early cancer detection.

As with last year’s event, Nashville area merchants outdid themselves with their display of southern hospitality.  Auction and raffle items donated include bags of groceries from Whole Foods and Trader Joe’s, gift cards from Wal-Mart, fine wines from anonymous donors, and autographed memorabilia by such Nashville area superstars as George Strait, Tim McGraw, Faith Hill, and Brooks and Dunn (whose “Boot Scoot Boogie” mega-hit song inspired the event’s theme).  The 100-plus attendees were also treated to coffee donated by Starbucks, water donated by Kroger’s, and donuts donated by Krispy Kreme.

One significant upgrade from the inaugural event was the availability of free oral cancer screenings for all attendees.

The event committee was able to generate local awareness of the walk through posters displayed at area Starbucks and Panera Bread stores and news releases sent to all local media.  In fact, a local TV station aired an interview with ShayLynn Grant both the night before and the morning of the walk.

According to Nicki Raines, “I can’t say enough about the dedication of my committee members, the generosity of the merchants who supported the walk, or the compassion of our walkers and their supporters.”   She was also very grateful for the counsel and materials provided by two key representatives of the Oral Cancer Foundation:  founder and executive director Brian Hill, and event coordinator Susan Lauria.  In fact, Nicki has been so inspired by their support that she has recently agreed to serve part-time as the foundation’s Southeast Dental Hygiene Liaison while continuing her hygienist duties.

Shortly after her Nashville walk, Nicki was already acting in her new capacity by driving to Chattanooga to lend her support to that city’s first-ever oral cancer walk.  But even though she now has 11 states to coordinate, she isn’t forgetting her Nashville roots:  she’s already making plans for “Boot Scootin’ for Oral Cancer Screening III.”

The little town that could!

Source: The Oral Cancer Foundation
Author: John Pohl

Rossville, Indiana Delivers Big Results With Oral Cancer Walk


Don’t tell Kelly Hodson and Shana Frey that a town with a population of 1,513 is too small for an oral cancer walk.  The Oral Cancer Foundation certainly won’t.

Kelly is a certified dental assistant and Shana a registered dental hygienist for Rossville Family Dentistry, the best—and only—dental practice in Rossville, Indiana.  The practice is owned by a mother-and-daughter team:  mom Dr. Alice Sue Green has been practicing for almost 40 years, while daughter Dr. Jennifer Green-Springer has been at it for 11 years.  The practice’s all-femaie staff understandably has a soft spot for women’s health issues.

About a year ago, after participating in breast cancer walks in Indianapolis and Lafayette, Kelly and Shana decided to organize their own cancer walk.  Given that they work as dental professionals, it seemed natural to them that oral cancer would be the cause they would target.  So Kelly started surfing online and quickly discovered the Oral Cancer Foundation.  Soon thereafter, she was in touch with Susan Lauria, the Foundation’s New Jersey-based Event Coordinator.

As Kelly put it, “I had lots of questions, and Susan had all the answers.” To promote the event, Susan advised Kelly and Shana to send letters and posters to dental practices in Lafayette and other nearby towns, and to contact newspapers and radio stations in those areas as well.  They also relied heavily on word-of-mouth support.  And support is exactly what they got:  two practices in Lafayette volunteered to help sponsor the event, as did the dental lab that Rossville Family Dentistry uses.

The walk was held on April 17, a cool but sunny Saturday.  Amazingly, a grand total of 117 people attended, including the 12 women from Rossville Family Dentistry and teams from four dental practices in nearby towns.  Prior to the 3-mile walk, attendees listened to two speakers:  Dr. Brett Henrikson, a Lafayette oral surgeon who discussed important facts and advice regarding oral cancer, and John Groves, who spoke about his experience as a neck cancer survivor.  Walkers were also treated to water, coffee, fruit, granola bars and cinnamon rolls donated by local merchants.

The event generated revenue of over $3,400, a truly remarkable feat considering the size of Rossville, Indiana.  Cleary, the size of a town’s population is less important than the size of its heart.

No choo choo needed–Chattanooga walks for oral cancer

Source: The Oral Cancer Foundation
Author: John Pohl

Chattanooga Walk  Promotes Early Detection of Oral Cancer!


Chattanooga, Tennessee derives its name from a Cherokee word that means “big catch” and refers to the great fishing that can be found on the Tennessee River.  And “big catch” is exactly what the cause of oral cancer detection has landed in the way of Jeanna Richelson, a very determined Chattanooga-based engineer and oral cancer survivor who is very clearly on a mission.

On Saturday, April 10, Jeanna organized the First Annual Chattanooga Oral Cancer Awareness Walk, which raised over $18,000 for the Oral Cancer Foundation.  According to Foundation founder and executive director Brian Hill, “I don’t believe there has ever been an oral cancer walk that was this successful in its first year.  This was an absolutely amazing effort by Jeanna.”

Less than one year ago, it dawned on Jeanna that while other types of cancer had support groups, there was no support group for oral cancer in the Chattanooga area.  Not one to sit around and wait for things to happen, Jeanna let local hospitals and media know that she was starting such a group.  Only one other person attended the group’s first meeting in 2009.  Fortunately, word soon started to spread, and today the group numbers 20 members.  One of these members is Kathi Gill, who lives just across the Tennessee-Georgia border and who had attended an oral cancer walk in Nashville in 2009.  Last fall, Kathi suggested that the group organize a walk in Chattanooga.  April 10 was selected as the date, and the team, with Jeanna leading the way, got to work.

One of Jeanna’s first moves was to contact the Oral Cancer Foundation’s New Jersey-based Event Coordinator, Susan Lauria.  Susan, who had organized walks in New Jersey for two years before agreeing to become the Foundation’s liaison with walk organizers across the country, was a tremendous resource.  “Susan not only answered every question I had,” said Jeanna, “she made me aware of so many important steps that I otherwise would never have even considered.”  Thanks to Susan’s counsel, the planning and dedication of Jeanna and her team, and the generosity of the Chattanooga community, the event came off without a hitch.

Prior to the 2.5 mile walk, the more-than-300 participants listened to inspirational talks by five oral cancer survivors:  Jeanna; Amber Olinger; William Pressley; ABC Channel 9 TV personality Marcia Kling; and Charlie Poor, who drove from Atlanta to attend the event.  The event’s emcee was Cydney Miller, Mrs. Tennessee International, who is a staunch advocate of early cancer detection.  In fact, Cydney had read about the walk on Jeanna’s CaringBridge website and contacted her to ask how she could help out.

Participants were treated to a deli lunch donated by Jason’s Deli and soft drinks donated by the local Coca Cola and Pepsi bottlers.  To make sure that everyone was comfortable while they ate, Kathi Gill and her husband brought chairs and tables they had borrowed from their church.

Following the walk, a raffle and silent auction took place, featuring such items as a dinner and wine for eight donated by Bonefish Grill, and several items donated by the Tennessee Titans NFL football team.

While Chattanooga’s Memorial Hospital and BMW of Chattanooga made very generous donations of $1,000 each, the largest donation was made by a former customer of Jeanna’s employer, Siskin Steel.  This gentleman drove from his home in Alabama to attend the event as a further demonstration of his support for Jeanna.  Also lending support to Jeanna was hygienist Nicki Raines, who had organized two oral cancer walks in Nashville and who recently was named the Oral Cancer Foundation’s Southeast Dental Hygiene Liaison.

One week after the march, a related event was held at Memorial Hospital when Dr. Peter Hunt, an ENT specialist, conducted free oral cancer screenings on 54 people.  Dr. Hunt was assisted by several hygiene students from Chattanooga State Community College.

According to Jeanna, “Our walk was a wonderful opportunity for oral cancer survivors to meet, share stories and, most of all, learn that they’re not alone.”  If anyone has a compelling story, it is Jeanna.  A lifelong non-smoker, she was diagnosed with cancer in a lymph node on the right side of her neck in 2001.  She underwent surgery to remove both the lymph node and her tonsils, hoping that her cancer was behind her.  She married Robert Richelson in 2002, but six months after her wedding, she was diagnosed with cancer at the base of her tongue.  Determined to get the best care possible for his wife, Robert quit his job and took his new bride to the world-renowned M. D. Anderson Cancer Center in Houston, Texas for several months of treatment including six weeks of radiation therapy.  The couple then returned to Chattanooga, where Jeanna received chemotherapy treatment for the remainder of the year.  She was cancer-free for two years, but in early 2005 the cancer returned, this time in her thyroid.  Jeanna and Robert headed back to M. D. Anderson for more radiation therapy.  By the time the therapy was completed, Jeanna had been subjected to over 90 radiation treatments.  Fortunately, they seem to have done the trick, as Jeanna has been cancer-free for four years.

In addition to an extremely supportive and caring husband, Jeanna has been blessed to have a very compassionate employer.  “Both times I had to take a leave of absence to get treatment, Siskin Steel could not have been more understanding,” said Jeanna.  “And each time my treatment was completed, I was welcomed back to my old position as if nothing had happened.”

Jeanna Richelson is fortunate to have a great husband and a great employer in her corner.  And the cause of oral cancer awareness is fortunate to have Jeanna Richelson on its team.

Oral cancer failed to silence Sen. Diane Allen

Source: The Philadelphia Inquirer
Author: Cynthia Burton

As Diane Allen lay on a gurney at the Hospital of the University of Pennsylvania, she knew she had to learn to let go.

She had found the right doctor, the right hospital. She told relatives and close friends she was about to undergo surgery for an aggressive form of oral cancer. Part of her tongue and part of the floor of her mouth were to be removed in that November surgery. Her doctors had told her she probably would never speak normally again.

So, the woman who had made a living talking – as a television news reporter and anchor in Philadelphia and Chicago and most recently as a Republican New Jersey state senator – probably would lose one of her greatest assets.

But that’s not what made her tear up the most as she recently recalled her feelings over the last few months. The hardest part was the thought of never again being able to read to her three grandchildren.

She tried to take control of that, too. She recorded CDs for them, reading Goodnight Moon and “A Visit From St. Nicholas.”

Everything she could control was under control. And then, as she lay on the gurney, she gave up control. She felt a sense of calm.

Allen, a Quaker, said, “I learned submission for the first time in my life, to rest in the Lord.”

She woke up able to speak, not well, but people could understand her.

After months of speech therapy, she got her TH’s, her S’s and her Z’s down. She still mispronounces sometimes, she said, when she’s tired.

“I get a little sloppy,” she joked in an interview Friday, one day after her first public event since the autumn.

She was diagnosed in October and had her first operation in early November; she had a second surgery in March.

Allen, 62, of Edgewater Park, kept in touch with her Senate office via phone and e-mail. Her staff, which she calls “the best legislative staff in New Jersey,” kept up with constituent service. Allen sometimes got involved when it was necessary for her to talk to state officials.

But mostly she was home recuperating because her immune system wasn’t back up to speed.

Allen was unaware of oral cancer, or even that her grandfather died of it before she was born.

Months before her diagnosis, Allen felt pain in her tongue and dismissed it as something that would go away – and went on with her work.

Elected to the Assembly in 1995 and the Senate in 1997, Allen is known for keeping long hours and building coalitions in Trenton. She introduces more bills than many of her colleagues, especially bills on matters of education and children’s health. And her name routinely comes up when Republicans are considering candidates for a statewide race. Last year, she came up as a potential running mate for Gov. Christie.

He never talked to her about the job, and that may have been for the best.

“If Chris Christie had asked me to be lieutenant governor, I probably would have waited” to get to a doctor, she joked. “So, not running for lieutenant governor probably saved my life.”

Another important factor was confiding in a friend about the pain. The friend insisted she see a doctor. Allen got the biopsy and then the awful news that the cancer had settled in her tongue.

According to the National Institutes of Health, factors leading to oral cancer include chronic irritation from rough teeth, fillings, or dentures, and poor dental hygiene. Ways to prevent it are to avoid tobacco and alcohol abuse, as well as to practice good oral hygiene.

But Allen takes good care of her teeth, smoked for only a few years in college, and hasn’t lighted up in 40 years. Though she enjoys an occasional drink, she is not a drinker.

“I really feel like people don’t know about this cancer,” she said.

Allen advised people to ask their dentists to check for it if they don’t automatically include a cancer check in their regular examinations.

She is now thinking about getting involved in a foundation that raises money for treating oral cancer, which means she’s back at work doing what she has been doing for years: trying to bring attention to problems.

Her first public event was a meeting last week of the Women’s Legislative Caucus at Rutgers University. She was moved by the standing ovation she got when she entered.

And then they got down to business. Allen said they would soon hold hearings aimed at getting women better access to doctors, particularly obstetricians and gynecologists, whose numbers are dwindling in the state.

She plans to be back in the Statehouse for committee meetings and sessions as legislators wrangle over Gov. Christie’s budget proposal.

Allen is already looking for alternative funding sources for libraries, which face deep cuts and which may have to curtail hours and services. She set up a meeting with state Education Commissioner Bret Schundler and hopes to have meetings with Gov. Christie, the state treasurer, and officials in the state Department of Health.

And she is running for reelection in 2012. She says she is not very good at politics because she stands her ground, but says she is pretty good “at solving problems and speaking up.”

Contact staff writer Cynthia Burton at 856-779-3858 or cburton@phillynews.com.

May, 2010|Oral Cancer News|

Integration of epidermal growth factor receptor inhibitors with preoperative chemoradiation

Source: Clincancerres
Author: Annelies Debucquoy1, Jean-Pascal Machiels2, William H. McBride3, and Karin Haustermans1

  1. Corresponding Author:
    Annelies Debucquoy, Laboratory of Experimental Radiotherapy, Department of Radiation Oncology, CDG Building, Box 815, UH Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium. Phone: 32-16-346900; Fax: 32-16-346905; E-mail:annelies.debucquoy@med.kuleuven.be.

Abstract

In many different cancer cell types, the epidermal growth factor receptor (EGFR) pathway becomes hyperactivated because of overproduction of the ligand, overproduction of the receptor, or constitutive activation of the receptor. The overproduction of EGFR and its ligands correlates with poor prognosis in several solid tumors such as lung, colon, and ovary. These observations led to the development of EGFR inhibitors for anticancer treatment. In the last few years, promising results have been obtained in several tumor types, with EGFR inhibitors given as monotherapy or in combined treatments. In particular, cetuximab in combination with curative-intent radiotherapy in head and neck cancer increases median survival over radiation alone. Similarly, the same approach might benefit patients with locally advanced rectal cancer. Unfortunately, the first clinical studies combining chemoradiation with cetuximab in rectal cancer gave disappointing results. Translational research suggested that the low response rate observed might have been due to the strong antiproliferative effect of cetuximab that may have compromised the activity of chemotherapeutics that target proliferating cells. This result indicates the need for more translational research to unravel how the molecular mechanisms might be manipulated to optimize the combined treatment regimen and to identify biomarkers that can select those patients who will derive most benefit. Clin Cancer Res; 16(10); OF1–6. ©2010 AACR.

Footnotes

    • Received September 15, 2009.
    • Revision received February 24, 2010.
    • Accepted March 3, 2010.
May, 2010|Oral Cancer News|