Sexually transmitted virus leads to rise in oral cancer

Source: The Boston Channel Author: Staff Boston cancer specialists are trying to learn what’s behind an “epidemic” spike in oral cancer cases that they say is caused by the human papillomavirus, commonly known as HPV. “What you're seeing here is a five-fold increase in the numbers that we would expect,” said Dr. Marshall R. Posner, of the Dana Farber Cancer Institute. “So that, to me, is an epidemic.” NewsCenter 5’s Heather Unruh reported Thursday that most adults have been exposed to HPV. Doctors say it can be sexually transmitted, even through deep kissing. What doctors don’t know yet is why in some people, such a common virus develops into cancer. “Most people who get infected with HPV naturally clear the virus,” said DFCI’s Dr. Karen Anderson. Anderson and her team of researchers are trying to isolate who’s at risk for oral cancer from HPV, and why. “Because then,” Anderson said, “we can focus on more aggressive screening approaches for people who are at higher risk and start to look at more therapeutic interventions earlier on.” Posner said that at least 20,000 cases of oropharyngeal cancer are diagnosed in the United States each year. Most patients are young. Three in four occur in men. Tony is one face among the statistics. Five days a week he psyches himself up for radiation to treat the cancer that grew at the base of his tongue, where it meets his throat. “What I say,” he said, “is, ‘It is not of me, or a [...]

2010-05-14T14:37:01-07:00May, 2010|Oral Cancer News|

Long Island friends honor their dads fight against cancer with inaugural walk on Father’s Day

Source: Long Island Exchange Author: Staff (Hicksville, N.Y.) Serena Ahne and Lisa Leone, of Long Island, are friends whose fathers are both cancer survivors; Fred Ahne, who was diagnosed with testicular cancer in 2008 and Fred Leone, who was diagnosed with oral cancer in 2003. Both girls looked for a way to educate others about the diseases from which their fathers suffered and the answer is the first annual Fred K’s Cancer Event, being held on June 20th in Cantiague Park in Hicksville, NY.  Serena and Lisa, otherwise known as the Traveling Baseball Babes, due to their avid love of New York sports, will be joined by their fathers, family members, friends and supporters, on Father’s Day, as they walk in honor of their dads and all those who have fought oral and testicular cancer. All funds raised from this inaugural event will go to the Oral Cancer Foundation and the Sean Kimerling Testicular Cancer Foundation, to help educate others about the importance of prevention and early detection through self-examinations and check-ups. The walk, which will include the two miles of the Cantiague Park’s Fitness Trail in Hicksville, NY, will take place on June 20th from 9:00 AM to 11:00 AM, with registration beginning at 8:00 AM. Participants are encouraged to fundraise before the day of the event, by gathering others to sponsor them in the walk, to help Lisa and Serena reach their fundraising goal of $2,000. Approximately 35,000 people in the U.S. will be newly diagnosed with oral [...]

2010-05-14T14:36:22-07:00May, 2010|OCF In The News, Oral Cancer News|

Smokeless tobacco can take you out of the game

Source: www.healthcanal.com Author: staff Another baseball season is under way and fans are heading to the ballpark to watch their favorite players hit home runs, steal bases, and argue over what's fair and foul. Marshall Posner, MD, says that the first step in reducing oral cancer risk is to avoid tobacco use altogether. Unfortunately, they will also see something else that many consider to be "foul" — players chewing tobacco. Dana-Farber Cancer Institute and the Massachusetts Dental Society (MDS) are partnering to spread the word that chewing tobacco, otherwise known as spit, dip, chew, or smokeless tobacco, is not a safe alternative to smoking. In fact, it's very addictive and a serious health risk. According to a Massachusetts survey released earlier this spring, teens may be turning away from cigarettes to other forms of tobacco, including smokeless tobacco. The report was funded by the United States Centers for Disease Control and conducted by state education and health departments. The survey asked middle- and high-school students about their tobacco habits and found that for the first time, students are using smokeless tobacco and cigars more than cigarettes. Of those high-schoolers who were surveyed, 16 percent admitted to smoking cigarettes in the past 30 days, while 17.6 percent admitted to using other tobacco products, such as smokeless tobacco. "Chewing tobacco is the most dangerous form of tobacco because it comes in contact directly with the oral mucosa," states David P. Lustbader, DMD, an MDS Trustee and an oral and maxillofacial surgeon at [...]

HPV types 16/18 adjuvant vaccine shows long-term efficacy

Source: DocGuide.com Author: Jenny Powers NICE, France -- May 11, 2010 -- The human papillomavirus (HPV) vaccine (types 16 and 18) AS04-adjuvanted vaccine shows a sustained immune response, as demonstrated by high levels of neutralising antibodies, up to 8.4 years after first vaccination, researchers said here at the 28th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID) on May 6. Cecelia Maria Roteli-Martins, MD, Hospital Leonor Mendes de Barros-Secretaria d Saude de São Paulo, in São Paulo, Brazil, headed an international team that evaluated the efficacy and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine by measuring neutralising antibody levels in a follow-up analysis yearly for up to 8.4 years post vaccination Healthy women aged 15 to 25 years who were DNA-negative for oncogenic HPV types, 16 and 18 with normal cytology at baseline received the vaccine (n = 560) or placebo (n = 553). A total of  223 women who were vaccinated with the active vaccine returned for extension studies, as well as 213 of the women who were given placebo. In these women, HPV-16 and 18 antibodies were measured annually. Cervical samples were taken every 6 months and gynaecological and cytopathological examinations were performed every 12 months. All (100%) of the women in the trial have remained seropositive for HPV-16 and -18 antibodies. After 2 years of follow-up, 5 incident infections and 1 infection of low grade squamous intra-epithelial lesion or higher (LSIL) associated with HPV 16 and 18 occurred in the placebo group. The vaccine efficacy [...]

2010-05-13T07:58:42-07:00May, 2010|Oral Cancer News|

FDA’s risk aversion is endangering children

Source: Forbes.com Author: Henry Miller The agency has sown confusion by asking physicians to stop administering a vaccine that even they admit is safe. By applying its now-customary excessive precaution, the FDA has painted itself into a most interesting corner. The result will likely be confusion among pediatricians and the public and parents reluctant to permit their children to get an important vaccination. And that in turn will cause unnecessary cases of rotavirus infection, debilitating diarrhea and, in a few children, death. The FDA last March asked pediatricians to stop administering GlaxoSmithKline's ( GSK - news - people ) Rotarix, a vaccine that prevents rotavirus infection, a diarrheal illness that commonly affects infants and children and that can cause severe dehydration. Their rationale was self-contradictory and unpersuasive. On one hand, the FDA seemed still to be confident about the vaccine, explaining that, "Extensive studies, including placebo-controlled, randomized clinical studies involving tens of thousands of vaccine recipients, support the safety and effectiveness of the vaccine." And the positive experience of countless infants and children vaccinated since the licensing of the vaccine two years ago further confirms its safety. So why do regulators want a "pause" in administration? Because using a new ultra-sensitive assay, small amounts of DNA from a pig virus were detected in the vaccine preparation. That might sound like a good reason for concern--except that the FDA itself confirms "that the material has been present since the early stages of product development, including during clinical studies." In other words, all of the studies that confirmed the [...]

2010-05-13T07:58:04-07:00May, 2010|Oral Cancer News|

Plastic surgery gives ‘ green’ doctor his tongue & voice back

Source: www.thefreelibrary.com Author: staff His lifelong mission has been to save trees. He used to spend a lot of time delivering lectures, shouting slogans and transplanting trees. But three months ago, all this came to an abrupt end as Dr Nitin Pandey was diagnosed with tongue cancer of the second stage. A paediatrician by profession, he could hardly speak and doctors at the Capital's Max hospital had no option except chopping off half his tongue carrying the deadly cancer cells But thanks to reconstructive plastic surgery, Pandey has now got not only a new tongue but also his voice back. Today he is back doing what he loves best -- creating awareness about our vegetation at his hometown in Dehradun. But all this would have been impossible had not the doctors at the hospital made a timely intervention. "Generally people chewing tobacco and tobacco products suffer from tongue cancer. But Pandey was unfortunate that he caught the disease without using tobacco. We had to perform a surgery to remove his left half of the tongue," said Dr Vedant Kabra, consultant surgical oncologist at the hospital. After half his tongue was removed, Pandey could neither speak nor drink or eat. Hence, a reconstruction became necessary. Doctors carried out a complex 10- hour surgery to help Pandey speak again. "We took tissue from his forearm and reconstructed his tongue. The arm has two arteries and it can do with one only. So we took an artery from the forearm along with a [...]

Robotic surgery for oral cancer

Source: speech-language-pathology-audiology.advanceweb.com Author: Advance, Vol 20, Issue 2 A minimally invasive surgical approach to treat benign tumors and select malignant tumors in adults has been cleared by the U.S. Food and Drug Administration (FDA). The da Vinci Surgical System, developed by head and neck surgeons at the University of Pennsylvania School of Medicine, in Philadelphia, has been cleared for transoral otolaryngologic surgical procedures. Gregory Weinstein, MD, FACS, and Bert O'Malley, Jr., MD, founded the first TransOral Robotic Surgery (TORS) program in the world at Penn Medicine in 2004. They developed and researched the TORS approach for a variety of robotic surgical neck approaches for both malignant and benign tumors of the mouth, larynx, tonsil, tongue, and other parts of the throat. Since 2005, approximately 350 patients at Penn have participated in the first prospective clinical trials of TORS. The trials compromise the largest and most comprehensive studies of the technology on record. "TORS has dramatically improved the way we treat head and neck cancer patients, completely removing tumors while preserving speech, swallowing, and other key quality-of-life issues," said Dr. O'Malley, chair of the Department of Otorhinolaryngology-Head and Neck Surgery at Penn Medicine. "It is very exciting that a concept conceived and tested at PENN and taught to surgeons and institutions within the U.S. and internationally has been officially recognized by our federal governing agencies and peers around the world as a new and improved therapy for select neck cancers and all benign tumors." As many as 45,000 Americans and approximately [...]

Fluorescent probe for oral cancer

Source: www.physorg.com Author: UC Davis Approximately 43,000 people in the U.S. are diagnosed with tumors of the mouth, pharynx and larynx each year. The main risk factor is smoking, but a recent rise in cases has been linked to human papillomavirus. Most cases are not diagnosed until the cancer has reached an advanced stage. "There's a lot out there about breast, prostate and brain cancer, but people are not so aware about oral cancer and its devastating consequences," said Laura Marcu, a professor of biomedical engineering at UC Davis. "People don't think to look for it, and there isn't any routine screening." Marcu's laboratory collaborated with Dr. Gregory Farwell's group in the Department of Otolaryngology at the UC Davis Cancer Center to develop the fiber-optic probe. The probe stimulates molecules in the patient's tissues with a laser. Some of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called "time-resolved fluorescence spectroscopy" (TR-LIFS), which provides information about the types of molecules present. During surgery, blood can distort the intensity of the fluorescence signal but not its duration. By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue. Based on encouraging results in animal tests, Marcu and Farwell's team recruited nine human volunteers from among patients who arrived at the UC Davis Medical Center for surgical therapy of the mouth, throat and larynx. They compared readings from [...]

Prosthetics advancements giving some patients a new look on life

Source: www.wmbfnews.com Author: staff Doctors call it a cancer you cannot hide -- head and neck cancer. South Carolina has one of the highest rates in the country, claiming ears, eyes, noses, and other parts of the face. What is cut away for the patient's life to be saved, often has horrific consequences, but a team at the Medical University of South Carolina is using science, art and medicine to help patients literally put a new face on their disease. Gary Reeves is a patient who has found new confidence with his prosthetic ear. The Conway minister shows no embarrassment when he pulls off his silicone prosthetic ear. It's part of his daily routine. His prosthesis was custom made for him at MUSC. Reeves was born without a right ear, although most often, ear patients come to the MUSC clinic following cancer. "It's silicone," said Reeves. His prosthesis was custom made for him at MUSC. He is willing to tell his story, to help the many people who suffer injuries to the face, or cancer. "I think head and neck cancer is the most devastating form of cancer," says Dr. Betsy K. Davis, "because it's the one form you cannot hide from society." Davis is the director of the Maxillofacial Prosthodontic Clinic at the Medical University of South Carolina. In fact, cancer brought Dawn Wright to the clinic. The woman from Pawley's Island lost her right eye to ocular melanoma in February of 2009. That meant she had to wear [...]

Cancer risk reduction study reports green tea extracts may protect against oral cancer

Source: baileyshealthstore.wordpress.com Author: staff Over 50 per cent of participants in the University of Texas M. D. Anderson Cancer Center study experienced a clinical response to the green tea extracts, according to findings published in Cancer Prevention Research. “While still very early, and not definitive proof that green tea is an effective preventive agent, these results certainly encourage more study for patients at highest risk for oral cancer,” explained the research team. “The extract’s lack of toxicity is very crucial in prevention trials. It’s very important to remember that these are otherwise healthy individuals and we need to ensure that agents studied produce no harm,” they added. Green tea contains between 30 and 40 per cent of water-extractable polyphenols, while black tea (green tea that has been oxidized by fermentation) contains between 3 and 10 per cent. Oolong tea is semi-fermented tea and is somewhere between green and black tea. The four primary polyphenols found in fresh tealeaves are epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), and epicatechin (EC). The study followed 41 people with oral leukoplakia, a condition is a sign of oral cancer risk. The participants were assigned to receive either placebo or green tea extract at one of three doses, including 500 milligrams or 1,000 mg three times a day. The researchers collected oral tissue biopsies, which they say was “essential in that it allowed us to learn that not only did the green tea extract appear to have benefit for some patients, but we pointed [...]

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