tobacco – Page 15 – Oral Cancer News

Prognostic Significance of HPV Status in Oropharyngeal Cancer

OncologySTAT Editorial Team Dr. Maura Gillison is Professor of Medicine, Epidemiology, and Otolaryngology at Ohio State University in Columbus. OncologySTAT: The results of the Radiation Therapy Oncology Group (RTOG) 0129 trial showed that the human papillomavirus (HPV) is an independent prognostic factor in oropharyngeal cancer. Could you tell us about the rationale for this study? Dr. Gillison: Over the last 10 years, our research has shown that cancers of the oropharynx are actually 2 completely different diseases that can look quite similar. One subset is caused HPV infection, and the other is more closely associated with long-term use of alcohol and tobacco. Initial studies suggested that the presence of HPV in a patient’s tumor had prognostic significance, but study limitations made that conclusion dubious. We set out to determine whether or not HPV was indeed an independent prognostic factor in head and neck cancer. To show whether there was a direct relationship between HPV infection and head and neck cancer, we needed to prospectively study a uniformly treated and uniformly staged patient population. Thus, we used the study population from the trial conducted by the RTOG. We divided the patients into 2 groups—those whose tumors were caused by HPV and those whose tumors were not—and we compared survival outcomes for the 2 groups. The results showed that HPV status was the single most important predictor of patient outcome, even more so than disease stage and other well-known prognostic factors such as performance status and presence of anemia. In fact, after [...]

Charlotte Parker2012-04-18T10:16:03-07:00April, 2012|Oral Cancer News|

Oral cancer and cultural factors in Asia

Source: findarticles.com Authors: Sherry L Priebe, Jolanta Aleksejuniene, Shafik Dharamsi, Christopher Zed Abstract: Oral cancer is on the rise worldwide, with over 200,000 cases diagnosed yearly. The predisposing social and cultural habits related to this disease acquired in resource-poor countries in Southeast Asia remain prevalent among its users following migration to other and better resourced countries. As a result, countries that once rarely experienced high levels of oral cancer will likely see an increased incidence of this disease. Therefore, oral health professionals need to be aware of the cultural risk factors and the resulting oral health effects in order to respond effectively to the increasing incidence of oral cancer. The objective of this overview is to inform what is known about populations from resource poor countries in Asia in regards to oral cancer and its related cultural factors. Introduction: The social and cultural habits that may predispose people to oral cancer are common in resource-poor countries in Southeast Asia, and remain prevalent among its users following migration to other and better resourced countries. As a result, countries that once rarely experienced high levels of oral cancer will likely see a considerable increase of this disease. It has been suggested that following migration from these countries to North America, the habit has remained prevalent among this ethnic group. (1) Increasing the level of awareness among oral health professionals about oral cancer and its related cultural risk factors, as well as developing better early diagnosis are of key importance in addressing morbidity [...]

Oral Cancer Foundation News Team - A2012-04-17T05:33:42-07:00April, 2012|Oral Cancer News|

Exposure to Nicotine and Carcinogens among South Western Alaskan Native Cigarette Smokers and Smokeless Tobacco User

Source: AACR Journals Background Prevalence of tobacco use, both cigarette smoking and smokeless, including iqmik (homemade smokeless tobacco prepared with dried tobacco leaves mixed with alkaline ash), and tobacco-related cancer is high in Alaska Native people (AN). To investigate possible mechanisms of increased cancer risk we studied levels of nicotine and tobacco-specific nitrosamines (TSNA) in tobacco products and biomarkers of tobacco toxicant exposure in South Western AN people. Methods Participants included 163 cigarette smokers (CS), 76 commercial smokeless tobacco (ST), 20 iqmik, 31 dual CS and ST (DT) and 110 non-tobacco (NT) users. Tobacco use history, samples of tobacco products used and blood and urine samples were collected. Results Nicotine concentrations were highest in cigarette tobacco and TSNAs highest in commercial ST products. AN participants smoked on average 7.8 cigarettes per day (CPD). Nicotine exposure, assessed by several biomarker measures, was highest in iqmik users, and similar in ST and CS. TSNA exposure was highest in ST users, and polycyclic aromatic hydrocarbon exposure highest in CS. Conclusions Despite smoking fewer CPD, AN CS had similar daily intake of nicotine compared to the general US population. Nicotine exposure was greatest from iqmik, likely related to high pH due to preparation with ash suggesting high addiction potential compared to other ST products. TSNA exposure was much higher with ST compared to other product use, possibly contributing to high rates of oral cancer. Impact Our data help understanding high addiction risk of iqmik use and cancer-causing potential of various forms of tobacco use [...]

Charlotte Parker2012-04-09T09:31:27-07:00April, 2012|Oral Cancer News|

Declines in Smoking and Lung Cancer Mortality in the U.S.: 1975–2000

Source: Oxford Journals Although changing smoking behaviors have had a major impact on lung cancer mortality in the U.S., the numbers of lung cancer deaths averted are only a small fraction of deaths that could have been avoided had all smoking ceased following the 1964 Surgeon General’s Report. Further efforts to control tobacco use are needed to decrease the impact of the disease, according to a study published March 14 in the Journal of the National Cancer Institute. The restrictions on smoking in public places, escalations in cigarette taxes, reduced access to cigarettes, and an increased public awareness on the health issues related to smoking have all helped steadily decrease the number of smokers in the U.S. since the mid 1950’s; however, little measurable information exists in regards to the amount lung cancer deaths have diminished in association with the decline in smoking. In order to determine the effect that reduced tobacco smoking has had on lung cancer mortality in the U.S., Suresh H. Moolgavkar, M.D., Ph.D., of the Program in Biostatistics and Biomathematics at the Fred Hutchinson Cancer Research Center in Seattle, Washington and colleagues built independent models based on cohort, case-control, or registry data and adjusted to overall mortality to estimate the number of lung cancer deaths prevented between 1975–2000. The data were distinguished by sex and birth decade (1890–1970), and the prevalence of smoking and lung cancer deaths were considered based on actual tobacco control (ATC), historical changes in smoking rates, no tobacco control (NTC), predicted smoking [...]

Charlotte Parker2012-04-04T09:10:41-07:00April, 2012|Oral Cancer News|

The 795 Thousand and Ending a Century of Tobacco

Source: Oxford Journals Tonight, a grandfather will read his grandson a soothing bedtime story. Yesterday, a mother saw her son perform a brilliant violin solo. Tomorrow, a grandfather will see his granddaughter complete the first unassisted triple play in their community's t-ball league history. What do these vignettes have in common? They represent just three of the 795 851 people––the 795 thousand––whose premature deaths from lung cancer were averted in the United States through aggressive tobacco control policies and interventions between 1975 and 2000, as determined by a series of consortium-based sophisticated modeling techniques and reported by Moolgavkar et al. (1) in this issue of the Journal. Sometimes, we become inured to the sheer number of deaths caused by tobacco—for example, a predicted 1 billion tobacco-caused deaths this century, 100 million people killed by tobacco in the 20th century, 6 million deaths per year globally, 443 000 deaths per year in the United States, etc. But, despite these enormous, and even numbing, numbers, we need to remember that every one of these 1 billion, 100 million, 6 million, or 443 000, was a father, mother, brother, sister, son, or daughter who, if tobacco had not intervened, would have enjoyed, and shared, a longer, healthier, and more fulfilling life. How did this happen? How did we allow tobacco, over the past 100 years, to kill and cause disease with such abandon? And, more important, how have we begun to turn the tide against the tobacco tsunami and how can we continue to learn from [...]

Charlotte Parker2012-04-04T08:27:45-07:00April, 2012|Oral Cancer News|

Researchers identify a gene that predicts recurrence in squamous cell carcinoma of the head and neck

Source: http://www.eurekalert.org/ Author: press release Squamous cell carcinoma of the head and neck—which typically arises from thin, flat cells that line moist surfaces inside the mouth, nose and throat—is the sixth most common type of cancer worldwide, and it has a relatively low five-year survival rate and a high recurrence rate. Recently, the disease has become even more prevalent among adults 40 years of age or younger. These statistics underscore the need for a greater understanding of the molecular underpinnings of this form of cancer. Toward this goal, Fox Chase Cancer Center researchers have identified a gene that predicts disease recurrence in individuals with squamous cell carcinoma of the head and neck. The new findings, which will be presented at the AACR Annual Meeting 2012 on Monday, April 2, show that patients with one common variant of a gene which encodes the cytochrome P450 (CYP1B1) protein are likely to have a longer time-to-recurrence than those with the more typical form of the gene. "This is the first study to look at the association between CYP1B1 variants and time-to-recurrence in head and neck cancer, and the findings could lead to personalized treatment strategies for patients with this type of cancer," says Fox Chase study author Ekaterina Shatalova, Ph.D., research associate in the lab of Margie L. Clapper, Ph.D., also senior investigator on the study. Shatalova, Clapper and their colleagues focused on CYP1B1 because this enzyme is known to produce carcinogens by metabolizing tobacco smoke and alcohol—substances that increase the risk of [...]

Oral Cancer Foundation News Team - A2012-04-03T09:09:51-07:00April, 2012|Oral Cancer News|

Cancer-causing chemical found in smokeless tobacco

Source: www.foxnews.com Author: staff A chemical in smokeless tobacco products has been found to cause cancer, according to a new study in animals. The chemical was a strong inducer of oral tumors, the study showed. While use of smokeless tobacco products has been strongly linked to the development of cancer, no specific chemical in the products had been identified as a strong oral-cancer causing agent until now, the researchers say. The chemical, called (S)-N'-nitrosonornicotine, or (S)-NNN, "is the only chemical in smokeless tobacco known to cause oral cancer," study researcher Silvia Balbo, a cancer researcher at the University of Minnesota, said in a statement. The finding may explain how smokeless tobacco products cause cancer, Balbo said. Balbo said the findings are an affirmation that tobacco products should be avoided. Smokeless tabacco products are already required to carry warning labels saying the products can cause mouth cancer or are not a safe alternative to cigarettes, the Food and Drug Administration says. The most common type of smokeless tobacco product is moist snuff placed in the mouth. Previous studies have suggested that a group of chemicals called nitrosamines, of which (S)-NNN is a member, cause various types of cancer in animals, but no study has looked at the carcinogenicity of (S)-NNNspecifically, the researchers say. Balbo and colleagues administered (S)-NNN to 24 rats. The rats were given (S)-NNN or tap water. The total dose was approximately equivalent to the amount of (S)-NNN to which a smokeless tobacco user would be exposed from [...]

Oral Cancer Foundation News Team - A2012-04-03T08:59:01-07:00April, 2012|Oral Cancer News|

April: Oral Cancer Awareness Month

Source: Aspen Dental April is Oral Cancer Awareness Month. According to Brian Hill, founder and executive director of the Oral Cancer Foundation, as many as 40,000 people in the United States will be told they have oral or pharyngeal cancer in 2012. Some of them may be sitting in your dental chair today. With one person dying of oral cancer every hour of every day, and more than 50% of those diagnosed not living more than 5 years, this is a reminder to screen every patient yourself, and encourage your dental hygiene staff to do the same. The Statistics About 100 people are diagnosed with oral cancer every day in the United States. Few people are aware that the death rate for oral cancer is higher than for many other types of cancers, which is because oral cancer often is not discovered until it has reached later stages. This is particularly true for human papilloma virus number 16 (HPV16)-related oral cancer, which occurs most frequently in the posterior areas of the mouth—at the base of the tongue, around the tonsils, and in the oropharynx—where it’s harder to spot without a very thorough exam. To further complicate things, HPV16-related cancer does not always present the tell-tale physical characteristics, including lesions, that are easily distinguished from healthy oral tissues. This is not good news, because HPV16 has reached epidemic levels in the United States: of the 37,000 incidences of oral cancer, about 20,000 (up to 60%) can be linked to HPV, according [...]

Charlotte Parker2012-04-02T09:47:20-07:00April, 2012|OCF In The News, Oral Cancer News|

Mouthing off against oral cancer

Source: www.marketwatch.com Author: staff April Is Oral Cancer Awareness Month According to the Centers for Disease Control and Prevention (CDC), more than 30,000 new cases of oral cancer are diagnosed each year, and more than 8,000 deaths occur annually. The five-year survival rate for oral cancers is roughly 50 percent. In observance of Oral Cancer Awareness Month, the Academy of General Dentistry (AGD) recommends that patients receive a dental exam from a general dentist every six months. Dental exams not only help to decrease a patient's risk of oral diseases, such as cavities and periodontal (gum) disease, but they also may help to diagnose other, sometimes life-threatening, medical conditions, such as oral cancer. "The next time you visit your dentist, ask about an oral cancer screening," says AGD spokesperson Seung-Hee Rhee, DDS, FAGD. "Your dentist will feel for lumps or irregular tissue changes in your neck, head, cheeks, and oral cavity and thoroughly examine the soft tissues in your mouth, specifically looking for any sores or discolored tissues. Although you may have already been receiving this screening from your dentist, it's a good idea to confirm that this screening is a part, and will remain a part, of your regular exam." Although oral cancer is sometimes difficult to self-diagnose, warning signs may include bleeding sores; sores that do not heal; lumps; thick, hard spots; soreness or feeling that something is caught in the throat; difficulty chewing or swallowing; ear pain; difficulty moving the jaw or tongue; hoarseness; and numbness of [...]

Oral Cancer Foundation News Team - A2012-03-30T05:19:13-07:00March, 2012|Oral Cancer News|

HPV-related head and neck cancer on the rise among middle-aged white men

Source: www.news-medical.net Author: staff Research led by Lauren Cole, a public health graduate student, and Dr. Edward Peters, Associate Professor of Public Health and Director of the Epidemiology Program at LSU Health Sciences Center New Orleans, reports that the incidence of head and neck cancer has risen at sites associated with Human Papilloma Virus (HPV) infection, with the greatest increase among middle-aged white men. At the same time, younger, Non-Hispanic blacks experienced a substantial decrease in these cancers. They also found that the disease process for tumors associated with HPV is different from those caused by exposure to tobacco and alcohol, with implications for treatment. The findings are published this month in the PLoS ONE journal. Tobacco and alcohol are the most common risk factors for cancers of the head and neck, but HPV infection is emerging as an important risk factor as well. The objectives of this study were to assess the recent incidence of head and neck cancer in the United States and to investigate the trends of these cancers associated with HPV infection. Using incidence data for 1995-2005 from 40 US population-based cancer registries, the researchers described the epidemiology of head and neck cancer (HNC) in the US and examined the variation in cancer rates by age, sex, race/ethnicity, stage and cancer location. As some HNC sites are strongly associated with a tendency for HPV infection, they also examined if rates varied by those sites associated with HPV. "During 1995-2005, we observed a significant overall increase in [...]

Oral Cancer Foundation News Team - A2012-03-30T05:12:03-07:00March, 2012|Oral Cancer News|