Throat cancer from HPV proves treatable
Source: Sciencenews.org Author: Nathan Seppa Cancer of the throat that stems from a human papillomavirus infection responds to treatment better than throat cancer that’s triggered by other causes, researchers report online July 29 in Cancer Prevention Research. The scientists also find that blacks are less likely than whites to have throat cancer that’s attributable to HPV, which may explain why the cancer also proved more deadly in blacks in this study. Throat cancer, formally known as oropharyngeal cancer, includes malignancies at the base of the tongue, on the tonsils, in the back of the mouth or on the walls of the throat. The cancer has been linked to smoking and alcohol use, but it can also arise from HPV infections acquired via oral sex (SN: 5/12/07, p. 291). In the new study, researchers analyzed two sets of people with throat cancer. One group included 196 whites and 28 blacks participating in an ongoing international medical trial. While 66 of the white patients had HPV-positive cancer, only one of the blacks did. All received chemotherapy and radiation. Looking at survival among these patients over more than five years, the researchers found that HPV-negative throat cancer patients had a median survival of only 20 months. Race didn’t change this data significantly. In contrast, patients with HPV-positive throat cancer lived substantially longer. Their median survival time could not be accurately discerned because many patients were still alive when the study data were analyzed, says study coauthor Kevin Cullen, a medical oncologist at the University [...]