Oral Cancer Foundation breaks records in April’s Awareness and Screening Month

Source: MSNBC News Author: staff Oral cancer is an insidious disease that too often is not discovered until very late in its development, as it might not produce symptoms the average person may notice. By then treatments are less effective, and because of late discovery in far too many patients, it has a five year survival rate of only about 57%, much lower than cancers we commonly hear about. Oral cancer has existed outside the awareness of much of the public, yet it will take one life, every hour of every day in the U.S. This year the combination of unprecedented efforts by the relatively small, non-profit Oral Cancer Foundation, a coalition of strategic partners they formed, and a dose of celebrity power, created what might be called a perfect storm; and one that potentially will change public awareness of one of the few cancers that is actually increasing in incidence in the U.S. For thirteen years in a row, April has been oral cancer awareness month nationally. More than 85% of all head and neck cancers are oral and oropharyngeal disease. Historically, a loose coalition of stakeholders in the disease has mustered about 200 screening events in April in facilities ranging from large institutions to individual dental offices around the country. Those participants opened their doors for at least a half-day to opportunistically screen members of the public in their communities for free, to find early stage disease, and to raise public awareness. This year the Oral Cancer Foundation, [...]

Good speaking, swallowing after chemoradiotherapy for head/neck cancer

Source: www.medscape.com Author: Fran Lowry Most patients with locoregionally advanced head and neck cancer who were successfully treated with intensive chemoradiotherapy had no residual deficits in speaking or swallowing after their treatment, according to the results of a study done by University of Chicago researchers. The study appears in the December issue of the Archives of Otolaryngology–Head & Neck Surgery. Of 163 patients with head and neck cancer who were assigned a speaking score an average of 35 months after completing treatment, 84.7% were found to have no lasting difficulties and were given a score of 1 on a scale of 1 to 4, with 1 being the best and 4 being the worst function. In addition, among 166 patients who were assigned a swallowing score an average of 35 months after treatment, 63.3% were found to have no lasting difficulties swallowing and were given a score of 1. "We weren't surprised by our findings," senior author Joseph K. Salama, MD, told Medscape Medical News. "However, it was nice to quantify formally our clinical impressions—that most patients in the long run do well." Dr. Salama was with the University of Chicago, Illinois, at the time the study was conducted and is now at Duke University Medical Center in Durham, North Carolina. Expert Disagrees However, Robert L. Ferris, MD, PhD, professor and vice chair of the Department of Otolaryngology at the University of Pittsburgh Medical Center in Pennsylvania, disagreed with the view that so many patients with head and neck cancer [...]

2010-12-27T21:20:46-07:00December, 2010|Oral Cancer News|

Quality of life of patients with tongue cancer 1 year after surgery

Source: www.joms.org Authors: Zhao-hui Yang et al. Purpose: To study the changes and factors affecting the quality of life (QOL) of patients with tongue cancer 1 year after primary surgery. Patients and Methods: A total of 289 consecutive patients with tongue cancer who had undergone primary surgery from 2003 to 2008 at our hospital were recruited. Patient QOL was evaluated using the University of Washington Quality of Life Questionnaire, version 4. Statistical analysis was conducted using a paired-samples t test and multiple stepwise linear regression with Statistical Package for Social Sciences, version 11.5 (SPSS, Chicago, IL). Results: At 1 year after surgery, the appearance, activity, speech, swallowing, shoulder function, salivary, and taste domain scores were significantly lower than the preoperative scores (P

FDA clears transoral robotic surgery – developed at Penn –for tumors of mouth, throat and voice box

Source: www.healthcanal.com Author: staff A minimally invasive surgical approach developed by head and neck surgeons at the University of Pennsylvania School of Medicine has been cleared by the U.S. Food and Drug Administration (FDA). The da Vinci Surgical System (Intuitive Surgical, Inc., Sunnyvale, California) has been cleared for TransOral Otolaryngology surgical procedures to treat benign tumors and selected malignant tumors in adults. Drs. Gregory S. Weinstein and Bert W. O’Malley, Jr. of the University of Pennsylvania School of Medicine’s Department of Otorhinolaryngology: Head and Neck Surgery founded the world’s first TransOral Robotic Surgery (TORS) programat Penn Medicine in 2004, where they developed and researched the TORS approach for a variety of robotic surgical neck approaches for both malignant and benign tumors of the mouth, voice box, tonsil, tongue and other parts of the throat. Since 2005, approximately 350 Penn patients have participated in the world’s first prospective clinical trials of TORS. These research trials compromise the largest and most comprehensive studies of the technology on record. “TORS has dramatically improved the way we treat head and neck cancer patients, completely removing tumors while preserving speech, swallowing, and other key quality of life issues,” said Bert O’Malley, Jr., MD, professor and chairman of Penn Medicine’s Department of Otorhinolaryngology:Head and Neck Surgery. “It is very exciting that a concept conceived at PENN, evaluated in pre-clinical experimental models at Penn, tested in clinical trials at Penn, and then taught to key surgeons and institutions both within the U.S. and internationally has been officially [...]

2009-12-19T23:10:00-07:00December, 2009|Oral Cancer News|

Laser microsurgery for tongue cancer

Source: www.ajho.com Author: staff A retrospective chart review undertaken at a Rush University Medical Center in Chicago, Illinois, indicates that transoral laser surgery to treat cancer of the tongue is as effective as open surgery. The less invasive procedure may also improve patients' quality of life. The study reviewed data from 71 patients who underwent transoral laser microsurgery for squamous cell carcinoma of the base of the tongue. At 24 months, overall survival was 90% and disease-specific survival was 94%. Of the 46 patients for whom quality-of-life information was obtained, the majority reported mild or no pain, minimally impaired to normal swallowing, and normal speech. Surgical approaches through the neck once provided the only safe access to the base of the tongue, although the voice box, trachea, esophagus, lymph nodes, muscles, and large nerves make surgical resection in this area difficult. Significant complications often included impairment of speech and of swallowing. Transoral laser microsurgery, using an endoscope with a lighted camera, a microscopic lens, and a CO-2 laser, enables surgeons to treat cancers that were not treatable previously. Dr Guy Petruzzelli, study author and chief of the Section of Head, Neck and Skull Base Surgery at Rush University Medical Center, noted, “Due to the precision of this surgery, most patients require less adjuvant chemotherapy, and in some cases patients will not need chemotherapy. And the functional outcomes are superior. Patients are able to speak and swallow much sooner and better than with an open technique.” Of patients responding, 91% reported [...]

Aspiration, weight loss, and quality of life in head and neck cancer survivors

Source: Arch Otolaryngol Head Neck Surg. 2004;130:1100-1103 Authors: Bruce H. Campbell, MD et al. Objective: To determine associations between objective assessments (swallowing function and weight change) and subjective quality-of-life (QOL) measures. Design: Observational case series using clinical testing and questionnaires. Setting: University hospital-based tertiary clinical practice. Patients: Convenience sample of 5-year survivors of head and neck cancer (62 nonlaryngectomy survivors were studied). Interventions: Objective testing included examination, weight history, videofluoroscopic swallow studies (VFSS), and oropharyngeal swallowing efficiency (OPSE). Subjective testing included QOL questionnaires (University of Washington Quality-of-Life [UWQOL] Scale, Performance Status Scale for Head and Neck Cancer Patients [PSS-HN], Functional Assessment of Cancer Treatment–General [FACT-G] Scales, and Functional Assessment of Cancer Therapy–Head and Neck [FACT-H&N] Scale). Main Outcome Measures: Aspiration (identified by VFSS), weight change, and QOL measures. Results: Aspiration was associated with the decreased QOL scores in chewing, swallowing, normalcy of diet, and additional concerns of the FACT-H&N Scale. No association was found between aspiration and willingness to eat in public, subjective understandability, or any of the FACT-G scales. Of the nonlaryngectomy survivors, 27 (44%) demonstrated some degree of aspiration during VFSS. Associations were found between aspiration, primary tumor T stage, weight change, and OPSE. Aspirators lost a mean of 10.0 kg from precancer treatment weight, while nonaspirators gained a mean of 2.3 kg (P

Speech and swallowing impairment after treatment for oral and oropharyngeal cancer

Source: Arch Otolaryngol Head Neck Surg. 2008;134(12):1299-1304 Authors: Maria-Mercedes Suarez-Cunqueiro, DDS, PhD et al. Objectives: To assess the prevalence of speech and swallowing impairment after radical surgery for oral and oropharyngeal cancer from the patient's viewpoint and to examine the association of these functional alterations with selected clinical characteristics regarding patients, tumors, and oncologic treatment. Design: Cross-sectional, multicenter study using a self-administered questionnaire. Setting: Forty-three hospitals in Germany, Switzerland, and Austria. Patients: A total of 3894 questionnaires about rehabilitation problems after treatment for oral and oropharyngeal squamous cell carcinoma were sent to patients. Of these, 1652 were filled out and returned, and 1334 (80.8%) met the inclusion criteria. Main Outcome Measures: Morbidity associated with treatment of oral and oropharyngeal cancer. Results: Speech problems were reported by 851 patients (63.8%), and swallowing problems were reported by 1006 patients (75.4%). The variables that presented a significant association with speech and swallowing impairment were sex, tumor location, pTNM stages, stage of tumor, treatment modality, and reconstruction type. Conclusions: This survey, based on patient perception, suggests that those who undergo radiotherapy associated with the surgical removal of a tumor, have late-stage tumors (III-IV), or have tumors located in the floor of the mouth should be informed of the greater risk of persistent severe speech and swallowing problems. Authors: Maria-Mercedes Suarez-Cunqueiro, DDS, PhD; Alexander Schramm, DDS, MD, PhD; Ralf Schoen, DDS, MD, PhD; Juan Seoane-Lestón, DDS, MD, PhD; Xosé-Luis Otero-Cepeda, PhD; Kai-Hendrik Bormann, DDS; Horst Kokemueller, MD, DDS; Marc Metzger, MD, DDS; Pedro Diz-Dios, DDS, [...]

2008-12-16T12:59:18-07:00December, 2008|Oral Cancer News|

Reconstructive surgery aids swallowing after tongue cancer resection

Source: www.medicexchange.com Author: David Douglas Almost all patients with base of tongue cancers treated with primary surgery and reconstructed with a modified radial forearm free flap consistently achieve efficient and safe swallowing postoperatively, Canadian researchers report in the August issue of the Archives of Otolaryngology, Head and Neck Surgery. As senior investigator Dr. Hadi Seikaly told Reuters Health, "This procedure effectively restores swallowing, speech and quality of life for patients requiring major resections of the tongue." Dr. Seikaly of Walter C. MacKenzie Health Sciences Centre, Edmonton, Alberta and colleagues note that there is a lack of information on the functional outcome of such procedures. To investigate further, the team prospectively followed patients who were treated with primary surgical resection and reconstruction with the beavertail modification of radial forearm free flap followed by radiotherapy. After a follow-up of at least one year, 19 of the 20 patients with complete data who were included in the final analysis were able to swallow safely. Nevertheless, mobility of the base of the tongue was reduced compared to presurgical findings according to videofluoroscopic swallowing study data, but no significant difference was found in pharyngeal wall mobility, and the bulk of the base of the tongue was preserved. The procedure, the researchers conclude, maintains adequate base of the tongue and posterior pharyngeal wall apposition allowing "structures such as the pharyngeal, oral, and suprahyoid musculature to contract and generate the necessary force to propel the food bolus through the oropharynx, resulting in a safe swallow." Original source: [...]

2008-09-13T10:07:29-07:00September, 2008|Oral Cancer News|
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