surgery

Skin from her arm gives woman a new tongue

Source: www.wptv.com Author: Amanda Kahan Getting her kids out the door, in the car, and to school is a daily mission for mom Lisa Bourdon-Krause. It's also one she doesn't take for granted. A few years ago, Lisa was diagnosed with tongue cancer. Doctors said surgery would mean removing half of Lisa's tongue. One of her doctors told her she might not ever talk again. At the time, Lisa's son was just two. She didn't know if he'd hear his mom's voice again, so she recorded herself. Thanks to surgeon, Douglas Chepeha, Lisa never had to give her son those recordings. In a 10-hour surgery, surgeons cut out the cancerous part of Lisa's tongue. Then, doctor Douglas Chepeha took skin from her own forearm and attached it to her tongue -- using a pattern as a guide. The result: A tongue that looked and felt much like the real thing. Lisa was able to talk a few days after her surgery. After a couple of weeks, she could eat. It was a relief -- but not the biggest one for Lisa. A mom who's grateful for every moment -- and every word she can speak. Background: According to the Mayo Clinic, tongue cancer is a serious type of head and neck cancer. It usually appears as squamous cells (a lump, white spot or ulcer) on the outer layer of the tongue. When it's caught early, tongue cancer is highly curable. When the cancer forms in the front two-thirds of the [...]

Oral Cancer Foundation News Team - A2011-04-03T10:07:02-07:00April, 2011|Oral Cancer News|

Predicting the Prognosis of Oral Squamous Cell Carcinoma After First Recurrence

Source: Archives of Otolaryngology- Head and Neck Surgery Objectives To describe the clinicopathologic features of oral squamous cell carcinoma in patients who develop locoregional recurrence of disease, to identify factors that predict prognosis in the subset of patients treated with salvage surgery, and to determine the adjusted effect of time to recurrence. Design Cohort study. Setting A head and neck cancer institute in Sydney, New South Wales, Australia. Patients A total of 77 patients who underwent salvage surgery for oral squamous cell carcinoma that had been treated initially by surgery, radiotherapy, or surgery with postoperative radiotherapy. Main Outcome Measures Univariable and multivariable analysis of clinical and pathologic risk factors. Results Median time to recurrence from initial treatment was 7.5 months (range, 0.9-143.9 mo), with 86% of recurrences occurring within the first 24 months. Surgical salvage was attempted in 77 patients who had experienced recurrence at the primary site (n = 39), ipsilateral neck (n = 27), and contralateral neck (n = 11). Time to recurrence, initial treatment modality, and site of failure were independent prognostic variables. Conclusions The relationship of these prognostic variables displays a dynamic interaction. Initial combined-modality treatment and shorter time to recurrence were associated with worse outcome, while the effect of site of recurrence (local vs regional) was dependent on an interaction with the time to recurrence. The result of this interaction was that local recurrence was worse for those who experienced it early (eg, <6 mo after the initial treatment) and nodal recurrence was worse for those who experienced it late (eg, [...]

Oral Cancer Foundation News Team - A2010-12-22T11:11:20-07:00December, 2010|Oral Cancer News|

Michael Douglas Fights Oral Cancer

Source: The Science of Dentistry Actor Michael Douglas‘ recent revelation that he has stage IV oral cancer has highlighted the growing incidence of oral cancer, and experts say dentists can help stem the alarming increase of the disease by checking for it during routine examinations.The actor’s cancer includes a walnut-sized tumor at the base of his tongue, and he will require radiation therapy, chemotherapy, and surgery. Douglas says his doctors told him he has an 80% survival rate if it hasn’t spread to his lymph nodes. While tobacco was the prime cause of oral cancer in the past, recent studies have attributed the steady increase of the disease to the human papillomavirus (HPV). HPV are common viruses that cause warts. There are approximately 130 versions of HPV but only nine cause cancers, and the HPV16 version causes almost half of the oral cancers in the U.S., said Brian Hill, executive director of the Oral Cancer Foundation. “Tobacco is no longer the only bad guy,” he told DrBicuspid.com. “HPV16 is increasing in incidence as the causative etiology, and if it continues on this trend line, it will replace tobacco as the primary cause of oral cancers.” Dentists can play a key role in catching the disease in its early stages if they check for it during examinations. Most Americans have never even heard of oral cancer, but it’s not as rare or uncommon as people would like to think it is. This is why an opportunistic screening by the dental community [...]

Oral Cancer Foundation News Team - A2010-12-13T15:13:27-07:00December, 2010|OCF In The News, Oral Cancer News|

Implant survival rate after oral cancer therapy: A review.

Source: HighWire, Stanford University The overall impression regarding the success of dental implants (DI) in patients having undergone oral cancer therapy remains unclear. The aim of the present review study was to assess the implant survival rate after oral cancer therapy. Databases were explored from 1986 up to and including September 2010 using the following keywords in various combinations: "cancer", "chemotherapy", "dental implant", "oral", "osseointegration", "radiotherapy", "surgery" and "treatment". The eligibility criteria were: (1) original research articles; (2) clinical studies; (3) reference list of pertinent original and review studies; (4) intervention: patients having undergone radio- and chemotherapy following oral cancer surgery; and (5) articles published only in English. Twenty-one clinical studies were included. Results from 16 studies reported that DI can osseointegrate and remain functionally stable in patients having undergone radiotherapy following oral cancer surgery; whereas three studies showed irradiation to have negative effects on the survival of DI. Two studies reported that DI can osseointegrate and remain functionally stable in patients having undergone chemotherapy. It is concluded that DI can osseointegrate and remain functionally stable in patients having undergone oral cancer treatment.

Oral Cancer Foundation News Team - A2010-11-17T17:40:03-07:00November, 2010|Oral Cancer News|

Large Thyroid Nodules Linked to High Malignancy Risk

Elsevier Global Medical News Author - MG Sullivan PARIS (EGMN) - Patients with a non-decisive fine-needle aspiration for large non-diagnostic thyroid nodules or lesions of undetermined significance should be considered for surgery because more than half of these large nodules can be malignant. In a review of 156 patients with non-decisive fine-needle aspirations (FNAs), nodule size was a major determinant in surgical referral, Dr. Susana Mascarell said at the International Thyroid Congress. "Nodules of this size were associated with a malignancy rate of up to 60%," said Dr. Mascarell of the John H. Stroger Jr. Hospital of Cook County, Chicago. FNA is considered the main diagnostic tool in deciding which patient to refer to surgery. "However," Dr. Mascarell said, "the FNA results may not be helpful when the cytology specimen is non-diagnostic or qualifies as a follicular lesion of undetermined significance - both classifications that are part of the new six-level FNA classification system suggested by the National Cancer Institute." When an FNA comes back as non-decisive on such specimens, the clinician must choose between surgery and clinical follow-up as the next step. Unfortunately, said Dr. Mascarell, there are no hard-and-fast rules about which management path to choose. Molecular markers are becoming more important in the decision, but can't be relied upon in every patient, she said. "When these markers are present in high concentrations, they are up to 99% accurate in identifying malignant nodules and so are a very helpful tool. But only 40% of nodules are positive for [...]

Charlotte Parker2010-10-26T13:38:00-07:00October, 2010|Oral Cancer News|

Get moving: cancer survivors urged to exercise

Source: apnews.myway.com Author: Lauran Neergaard New guidelines are urging survivors to exercise more, even - hard as it may sound - those who haven't yet finished their treatment. There's growing evidence that physical activity improves quality of life and eases some cancer-related fatigue. More, it can help fend off a serious decline in physical function that can last long after therapy is finished. Consider: In one year, women who needed chemotherapy for their breast cancer can see a swapping of muscle for fat that's equivalent to 10 years of normal aging, says Dr. Wendy Demark-Wahnefried of the University of Alabama at Birmingham. In other words, a 45-year-old may find herself with the fatter, weaker body type of a 55-year-old. Scientists have long advised that being overweight and sedentary increases the risk for various cancers. Among the nation's nearly 12 million cancer survivors, there are hints - although not yet proof - that people who are more active may lower risk of a recurrence. And like everyone who ages, the longer cancer survivors live, the higher their risk for heart disease that exercise definitely fights. The American College of Sports Medicine convened a panel of cancer and exercise specialists to evaluate the evidence. Guidelines issued this month advise cancer survivors to aim for the same amount of exercise as recommended for the average person: about 2 1/2 hours a week. Patients still in treatment may not feel up to that much, the guidelines acknowledge, but should avoid inactivity on their good [...]

Oral Cancer Foundation News Team - A2010-06-28T20:08:45-07:00June, 2010|Oral Cancer News|

Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy

Source: 7thspace.com Authors: Su Jung Shim et al. Background: The aim of this study was to assess the results of curative surgery with and without radiotherapy in patients with T1-2N0-1 oral tongue squamous cell carcinoma (OSCC) and to evaluate survival and prognostic factors. Methods: Retrospective analysis of 86 patients with T1-2N0-1 OSCC who received surgery between January 2000 and December 2006. Fourteen patients (16.3%) received postoperative radiotherapy (PORT). Patient characteristics, tumor characteristics, treatment modality, failure patterns, and survival rates were analyzed. Results: The median follow-up was 45 months. The five-year overall survival (OS) and disease-free survival (DFS) rates were 80.8% and 80.2%, respectively. Higher tumor grade and invasion depth [greater than or equal to] 0.5 cm were the significant prognostic factors affecting five-year OS and DFS (OS rate; 65% vs. 91%, p = 0.001 for grade; 66% vs. 92%, p = 0.01 for invasion depth: DFS rate; 69% vs. 88%, p = 0.005 for grade; 66% vs. 92%, p = 0.013 for invasion depth). In the risk group, there was no local failure in patients with postoperative radiotherapy. Conclusions: In T1-2N0-1 OSCC, factors that affected prognosis after primary surgery were higher tumor grade and deep invasion depth over 0.5 cm. Postoperative radiotherapy should be considered in early oral tongue cancer patients with these high-risk pathologic features. Authors: Su Jung Shim, Jihye Cha, Woong Sub Koom, Gwi Eon Kim, Chang Geol Lee, Eun Chang Choi, Ki Chang Keum Source: Radiation Oncology 2010, 5:43

Oral Cancer Foundation News Team - A2010-05-27T07:56:08-07:00May, 2010|Oral Cancer News|

UC Davis probes into oral cancer

Source: theaggie.org Author: Eric C. Lipsky UC Davis is searching for new and more effective methods to deal with oral cancer. Researchers have begun using a fluorescent oral probe to aid in the detection of malignant tissues. The probe allows doctors to differentiate between healthy and malignant tissue, along with having the capacity of working as a screening device. Although still a prototype, the fluorescent probe is showing that it can be helpful to doctors both prior to and during surgery. "The big picture is to improve the ability to diagnose tumors at an earlier stage," said Dr. Gregory Farwell, a head and neck surgeon at the UC Davis Medical Center. Farwell said that people's ability to survive oral cancer is significantly increased if the cancer is detected at an early stage. He said that oral cancer is primarily caused by smoking, drinking and human papillomavirus (HPV). Farwell said oral cancer through HPV usually takes 10 to 20 years to develop. 43,000 Americans are diagnosed with oral cancer each year. While the cancer is not the most prevalent in the United States, Farwell said it is a major problem worldwide, especially in countries like India and China. He said this probe could be of great utility for efficiently diagnosing different stages of cancer. "It is a very effective way to discriminate between normal tissue and tumor tissue," Farwell said. "We're showing better results in distinguishing differences in tissue. It can even help discriminate between pre-cancer and advanced cancer." The probe, [...]

Oral Cancer Foundation News Team - A2010-05-20T12:26:51-07:00May, 2010|Oral Cancer News|

Robotic tongue cancer surgery-Mayo Clinic

Fighting cancer is not easy. Chemotherapy, radiation and surgery can be very hard on your body. Take head and neck cancers, for example. These tumors are often hard to reach. Doctors have to cut through bones such as your jaw to reach them. Now, doctors at Mayo Clinic are using robots to access these cancers through your mouth, leaving face bones intact.

Oral Cancer Foundation News Team - A2010-04-26T19:14:12-07:00April, 2010|Oral Cancer News|

West Michigan woman serves as test subject for voice recreation

Source: www.wwmt.com Author: staff For Steve and Annet Shannon it's a chance to maintain normalcy, and regain a voice that could be lost. Five years ago Annet Shannon was diagnosed with a rare form of tongue cancer, and doctors removed 30% of the back of her tongue followed by a series of radiation treatments, which Steve Shannon says were working, "Everything was going well with no evidence of recurrence until this last December where she found a lump on her neck. To make a long story short she will be having surgery May 4, 2010. There is a possibility she could be losing her tongue and voice box and her ability to speak." For the Shannons it's a grim reality that Annet's surgery could take her voice, but the couple had at least heard of famed film critic Roger Ebert, who lost his jaw to cancer surgery, but was given a new custom text to voice device where he was able to communicate using his own voice. To Steve Shannon, that seemed like just the thing for them, "My wife was very interested in this technology and she was searching to learn more. By fate we met Professor John Eulenberg, director of MSU's Artificial Language Lab. The Artificial Language Lab has begun a project as one of five sites to help people to create their own personal text-to-speech software systems." The Shannons learned that the underlying technology was created by Tim Bunnell and his team at the University of Delaware [...]

Oral Cancer Foundation News Team - A2010-04-23T08:45:18-07:00April, 2010|Oral Cancer News|