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Nicotine vaccine shows effectiveness in early tests

Source: CNN Author: Val Willingham (CNN) -- A vaccine that could help people stop smoking is showing promise in early clinical trials, researchers announced this week at a national meeting of addiction specialists. The vaccine is designed to stimulate the immune system to generate antibodies that would latch on to nicotine in a smoker's body and prevent it from ever entering the brain. The vaccine maker, Nabi Biopharmaceuticals, reported that those who responded best to NicVAX in earlier testing had been able to quit smoking for three times longer than those in the placebo group, with data from 19 to 26 weeks, and then for 12 months. These are considered statistically significant results and superior to the testing results of Zyban and Chantix, prescription medications already approved to help smokers over the age of 18 quit, Nabi officials told the National Institute on Drug Abuse conference in Albuquerque, New Mexico. In addition, those whose bodies responded most effectively to NicVAX cut the number of cigarettes smoked, from a baseline of 20 cigarettes per day to 10 cigarettes per day. Those who took the vaccine experienced few side effects, said Dr. Raafat Fahim, president and CEO of Nabi Biopharmaceuticals. In 2009, Zyban and Chantix were ordered by the Food and Drug Administration to carry "black box" warnings of the risk of depression and suicidal thoughts. Nabi began the first phase III trials for NicVAX last November, enrolling 1,000 people. In March, a second phase III trial began with another 1,000 participants. [...]

Charlotte Parker2010-04-23T07:03:24-07:00April, 2010|Oral Cancer News|

Epidemiology and cost analysis for patients with oral cancer in a university hospital in China

Source: 7thspace.com Author: Sheng et al. Although several studies have reported the direct cost of oral cancer (OC), little research has invested the factors that could influence the costs of OC patient. This study analyzes the epidemiological characteristics and the direct cost of OC. More specifically, the study examines the relationship between patients' medical costs and influencing factors of epidemiology. Methods: All patients encountered from January 2007 to December 2007 at the School of Stomatology of the Fourth Military Medical University (FMMU) in China with diagnosis of oral cancer have been selected. Medical hospitalization days (MHD) and cost per patient (CPP) of the samples have been calculated for different patient groups, and the results have been compared using statistical methods. Results: A total of 456 oral cancer patients have been selected in this study. The epidemical characteristics are as follows: female/male 176/280; squamous cell carcinoma (SCC) /adenocarcinoma /sarcoma /lymphoma /other types 246/127/40/27/16; stage I/ II/ III/ IV 90/148/103/115; smoker/non-smoker 136/320; rural/urban patients 82/374. Of all the patients, 82.24% were over 40 years of age. Rural patients were significantly younger than urban patients. SCC was the majority histology in older patients, while sarcoma was more common in younger patients. 372 of the patients received treatment and 84 gave up any treatment after diagnosis. Treatment cost accounted for majority of the payment. The CPP and MHD of patients in late clinical stage were higher than that of patient in early stage. Conclusion: Gender, smoking habit and age older than 40 years are [...]

Oral Cancer Foundation News Team - A2010-04-20T08:16:15-07:00April, 2010|Oral Cancer News|

Fruit and vegetables only modestly linked to reduced cancer risk, large study questions conventional wisdom

Source: www.medicalnewstoday.com Author: Catharine Paddock, PhD A large study of over 400,000 people living in ten western European countries found only a modest link between high intake of fruit and vegetables and reduction in overall cancer risk: thus failing to confirm the widely held belief enshrined in the World Health Organization's recommendation that people should eat five servings of fruit and vegetables a day to prevent cancer and other diseases. Dr Paolo Boffetta, of the Mount Sinai School of Medicine in New York, and colleagues, wrote about their findings in a study published in the 6 April online issue of the Journal of the National Cancer Institute. In 1990 the World Health Organization recommended people eat five helpings of fruit and vegetables a day to reduce their risk of cancer, cardiovascular and other diseases. But since then, many studies have either produced inconsistent results or failed to find a significant link between fruit and vegetable intake and cancer risk, wrote the authors. For their prospective study, Boffetta and colleagues analyzed data from the European Prospective Investigation into Cancer and Nutrition (EPIC), which recruited 142,605 men and 335,873 women in Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden and the United Kingdom, between 1992 and 2000. The data were mostly self-reported by the participants and detailed their dietary and lifestyle habits. The participants were followed for a median of 8.7 years, during which time deaths and incidents of cancer diagnoses were noted. The researchers then analysed the data using [...]

Oral Cancer Foundation News Team - A2010-04-19T22:20:54-07:00April, 2010|Oral Cancer News|

Another call to extend HPV vaccine to boys. Is anyone listening?

Source: www.abc.net.au Author: Lindy Kerin Australian researchers say the human papillomavirus (HPV), which can cause cervical cancer in women, is now a leading cause of oral cancer in men in the Western world. The news has reignited debate over whether the HPV vaccine, which is free for young women, should also be offered to men. A University of Sydney study shows that 60 per cent of throat and tonsil cancers are caused by the virus. "We've tested just over 300 cancers of the oropharynx, and the oropharynx includes the tonsil and the base of tongue and part of the pharangyl wall," said Barbara Rose, an Associate Professor in research at the University of Sydney. "We've tested those for the human papillomavirus type-16 and type-18, which are the major cause of cervical cancer in women. "And we found a sizeable proportion are associated with those types. In fact, probably in excess of 50 per cent now." Those figures from 2001 to 2005 increased to almost 60 per cent in 2006 and 2007. Associate Professor Rose says head and neck cancers have traditionally been associated with older men and related to alcohol and smoking. She says these findings show that has now changed and most are due to the increasing practise of oral sex. "We now know that there's another subset, which is quite distinct biologically, which tends to affect younger people who don't smoke and don't drink, caused by human papillomavirus probably by sexual transmission," she said. "And the types of [...]

Oral Cancer Foundation News Team - A2010-04-19T22:26:55-07:00April, 2010|Oral Cancer News|

Oral sex can add to risk of HPV positive cancers

Source: www.time.com Author: Coco Masters Oral sex can get most men's attention. The topic becomes considerably more relevant, however, when coupled with a new study linking the human papillomavirus (HPV) to an increased risk of a kind of oral cancer more often seen in men. The study, which appears in this week's New England Journal of Medicine (NEJM), shows that men and women who reported having six or more oral-sex partners during their lifetime had a nearly ninefold increased risk of developing cancer of the tonsils or at the base of the tongue. Of the 300 study participants, those infected with HPV were also 32 times more likely to develop this type of oral cancer than those who did not have the virus. These findings dwarf the increased risk of developing this so-called oropharyngeal cancer associated with the two major risk factors: smoking (3 times greater) or drinking (2.5 times greater). HPV infection drives cancerous growth, as it is widely understood to do in the cervix. But unlike cervical cancer, this type of oral cancer is more prevalent in men. HPV is ubiquitous. Of the 120 strains isolated from humans — about 40 of which are in the mouth and genital tracts — Merck's recently FDA-approved vaccine, Gardasil, protects against four: HPV-6 and HPV-11, which cause warts; and HPV-16 and HPV-18, which cause about 70% of cervical cancers. Similarly, according to the study, HPV-16 was present in 72 of the 100 cancer patients enrolled in the study. Between 12,000 and [...]

Oral Cancer Foundation News Team - A2010-04-19T22:32:29-07:00March, 2010|Oral Cancer News|

Analysis of primary risk factors for oral cancer from select US states with increasing rates

Source: Tobacco Induced Diseases 2010, 8:5 Authors: Anthony BunnellNathan et al. Objectives: To examine the primary risk factor for oral cancer in the US, smoking and tobacco use, among the specific US states that experienced short-term increases in oral cancer incidence and mortality. Methods: Population-based data on oral cancer morbidity and mortality in the US were obtained from the National Cancer Institute's (NCI) Surveillance, Epidemiology, and End Results (SEER) database for analysis of recent trends. Data were also obtained from the Centers for Disease Control and Prevention (CDC) Behavioral Risk Factor Surveillance System (BRFSS) to measure current and former trends of tobacco usage. To comprehensive measures of previous state tobacco use and tobacco-related policies, the Initial Outcomes Index (IOI, 1992-1993) and the Strength of Tobacco Control index (SoTC, 1999-2000) were also used for evaluation and comparison. Results: Analysis of the NCI-SEER data confirmed a previous report of geographic increases in oral cancer and demonstrated these were state-specific, were not regional, and were unrelated to previously observed increases among females and minorities. Analysis of the CDC-BRFSS data revealed these states had relatively higher percentages of smokers currently, as well as historically. In addition, analysis of the IOI and SoTC indexes suggest that many factors, including cigarette pricing, taxes and home or workplace bans, may have had significant influence on smoking prevalence in these areas. Trend analysis of these data uncovered a recent and significant reversal in smoking rates that suggest oral cancer incidence and mortality may also begin to decline in [...]

Oral Cancer Foundation News Team - A2010-02-23T21:13:40-07:00February, 2010|Oral Cancer News|

SIBLING proteins may predict oral cancer

Source: www.scienceblog.com Author: staff The presence of certain proteins in premalignant oral lesions may predict oral cancer development, Medical College of Georgia researchers said. SIBLINGs, or Small Integrin-Binding Ligand N-linked Glycoproteins, are a family of five proteins that help mineralize bone but can also spread cancer. SIBLINGs have been found in cancers including breast, lung, colon and prostate. "Several years ago we discovered that three SIBLINGs -- osteopontin, bone sialoprotein and dentin sialophosphoprotein -- were expressed at significantly high levels in oral cancers," said Dr. Kalu Ogbureke, an oral and maxillofacial pathologist in the MCG School of Dentistry. "Following that discovery, we began to research the potential role of SIBLINGs in oral lesions before they become invasive cancers." The study, published online this week in the journal Cancer, examined 60 archived surgical biopsies of precancerous lesions sent to MCG for diagnosis and the patients' subsequent health information. Eighty-seven percent of the biopsies were positive for at least one SIBLING protein -- which the researchers discovered can be good or bad, depending on the protein. For instance, they found that the protein, dentin sialophosphoprotein, increases oral cancer risk fourfold, while bone sialoprotein significantly decreases the risk. "The proteins could be used as biomarkers to predict [the potential of a lesion to become cancerous]," said Dr. Ogbureke, the study's lead author. "That is very significant, because we would then be in a position to modify treatment for the individual patient's need in the near future." Precancerous oral lesions, which can develop in [...]

Oral Cancer Foundation News Team - A2010-02-23T12:59:57-07:00February, 2010|Oral Cancer News|

Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils in Taiwan

Source: 7thspace.com Author: staff Purpose: To explore if exposures to specific heavy metals in the environment is a new risk factor of oral cancer, one of the fastest growing malignancies in Taiwan, in addition to the two established risk factors, cigarette smoking and betel quid chewing. Methods: This is an observational study utilized the age-standardized incidence rates of oral cancer in the 316 townships and precincts of Taiwan, local prevalence rates of cigarette smoking and betel quid chewing, demographic factors, socio-economic conditions, and concentrations in farm soils of the eight kinds of heavy metal. Spatial regression and GIS (Geographic Information System) were used. The registration contained 22,083 patients, who were diagnosed with oral cancer between 1982 and 2002. The concentrations of metal in the soils were retrieved from a nation-wide survey in the 1980s. Results: The incidence rate of oral cancer is geographically related to the concentrations of arsenic and nickel in the patients'residential areas, with the prevalence of cigarette smoking and betel quid chewing as controlled variables. Conclusions: Beside the two established risk factors, cigarette smoking and betel quid chewing, arsenic and nickel in farm soils may be new risk factors for oral cancer. These two kinds of metal may involve in the development of oral cancer. Further studies are required to understand the pathways via which metal in the farm soils exerts its effects on human health. Notes: 1. Authors: Che-Chun SuYo-Yu LinTsun-Kuo ChangChi-Ting ChiangJian-An ChungYun-Ying HsuIe-Bin Lian 2. Source: BMC Public Health 2010, 10:67

Oral Cancer Foundation News Team - A2010-02-13T10:17:43-07:00February, 2010|Oral Cancer News|

Saskatchewan students choose anti-tobacco ad for national non-smoking week

Source: www.canadaviews.ca Author: Government of Saskatchewan Saskatchewan’s Health Minister is pleased to announce the winning anti-tobacco advertisement selected by Saskatchewan students participating in the View and Vote program. Students in Grades 6 to 12 were given the opportunity to view and vote on some of the best international, American and Canadian anti-tobacco television ads. Two hundred and fifty seven schools in Saskatchewan participated in this year’s View and Vote program, which generated 14,000 student ballots. Nearly 3,200 students rated the Australian ad “Mouth Cancer” as most effective. This ad will be aired on Saskatchewan television stations starting January 17 during the National Non-Smoking Week. “Encouraging our youth to be tobacco-free is an important step toward healthy, productive lives,” Health Minister Don McMorris said. “This project is an innovative way of reaching large numbers of young people and educating them about the addictive nature of tobacco and the effects of smoking. Studies show that if young people remain tobacco-free until they become adults, they are less likely to start using tobacco in the future.” Students played an active role in the project. The ads were used as a tool to generate classroom discussions about the effects of tobacco use. Students then voted on the ad that they felt would keep them from starting to use tobacco or, if they already use tobacco, the ad that made them think about quitting. View and Vote is one component of the provincial tobacco reduction strategy focusing on youth, which has three main goals: prevention [...]

Oral Cancer Foundation News Team - A2010-01-15T19:52:47-07:00January, 2010|Oral Cancer News|

Tongue reconstruction

Source: www.wsoctv.com/health Author: staff Tongue cancer accounts for about 25 percent of all oral cancers. According to the National Cancer Institute, about 10,530 cases of tongue cancer will be diagnosed in the U.S. this year. Although the cancer can occur at any age, it’s most commonly diagnosed in older people, with a median age at diagnosis of 61. Men are affected about twice as often as women. Two important risk factors for tongue cancer are smoking and drinking. For people who smoke and drink, the risk may be up to 100 times that of those who neither smoke nor drink. Another risk factor for tongue cancer is HPV (human papillomavirus) infection. Douglas Chepeha, M.D., Microvascular Reconstructive Surgeon with the University of Michigan, says doctors are also seeing cases of tongue cancer in young and older women who neither smoke nor drink. The reasons for these cases are not clear. Overall five-year survival rates for tongue cancer are about 59.5 percent. However, the cancer has the potential to spread fairly quickly. If the cancer is detected when the condition is still localized, 5-year survival rates are over 77 percent. Once the cancer spreads regionally, survival rates drop to about 55 percent. Thus, early diagnosis is important. Patients who develop a sore on the tongue that doesn’t heal or bleeds easily should see a physician for evaluation. Treating Tongue Cancer: Reconstruction After Surgery Tongue cancer typically occurs on one side of the tongue. The main treatment is surgery, which can require removal [...]

Oral Cancer Foundation News Team - A2009-12-19T23:14:42-07:00December, 2009|Oral Cancer News|