Hollywood star’s diagnosis highlights high risk of mouth cancer

Source: www.dentalhealth.org.uk Author: press release THE British Dental Health Foundation, which runs UK Mouth Cancer Action Month each November, is calling for more attention to be paid to mouth cancers reminding people that there is a death from mouth cancer on average every five hours in the UK. Oral health experts and the Foundation are advising the public to regularly check their mouths after news broke this week of actor Michael Douglas being diagnosed with oral cancer. The Academy Award winner has recently been diagnosed with a tumour in his throat, and now faces an eight–week cause of chemotherapy and radiotherapy. This high profile case has brought oral cancers into the lime light, and oral health experts are keen to make the public more aware of the key risk factors and early warning signs. Douglas quit smoking in 2006, after a long ‘half a packet a day’ habit. Yet, the possibility of developing oral cancer remains higher for ex–smokers than non–smokers for 20 years after quitting. Tobacco is considered to be the main cause of mouth cancer, with three in four cases being linked to smoking. Drinking in excess is also a known factor, with those who both smoke and drink to excess being up 30 times more likely to be at risk. The Chief Executive of the British Dental Health Foundation, Dr Nigel Carter said: “It is crucial the public know about the risk factors and early symptoms as early detection can save lives. Survival rates can increase from [...]

HPV-positive oropharnygeal cancer has better prognosis than tobacco-induced cancer

Source: www.enttoday.org Author: Alice Goodma Mounting evidence suggests that human papillomavirus (HPV)-positive oropharyngeal cancer has an improved prognosis compared with HPV-negative disease. The most recent supportive evidence comes from an analysis of a Phase III trial presented at the 2009 annual meeting of the American Society of Clinical Oncology. Our study showed that HPV status is as strong a predictor of outcome as cancer stage for patients with oropharyngeal cancers, even after considering other factors such as age and smoking history, said lead author Maura Gillison, MD, PhD, Professor of Hematology and Oncology, Epidemiology, and Otolaryngology at Ohio State University in Columbus. Dr. Gillison said that tumor HPV status should now be part of the routine workup of patients with oropharyngeal cancers. Oropharyngeal cancers are mainly attributable to chronic tobacco use and smoking, or to HPV infection. Retrospective analyses, meta-analysis, and small trials have suggested that HPV-positive oropharyngeal cancer is a distinct entity, and the present Phase III study provides the most compelling evidence, she said, because it is the largest study to date. It is not clear why HPV-associated oropharyngeal cancer has a better prognosis. In the trial, HPV-positive patients were younger, mostly Caucasian, and had improved performance status and smaller tumors. Dr. Gillison said that these factors could have a positive influence on survival. Survival Benefit The retrospective correlative analysis of Radiation Therapy Oncology Group (RTOG) 0129, presented by Dr. Gillison, focused on outcome according to HPV status. The randomized study included 206 patients with cancers positive for [...]

Finally, a positive message for smokers sick of revulsion

Source: The Sydney Morning Harald Author: Ennis Cehic Ads worse than zombie movies just make you want to turn the TV off. QUIT Victoria has told us about the detrimental effects of smoking for years, and advertisers have focused on communicating to the public the risks. As such, we have seen ads that are so scary, so full of brutal detail, that you cannot stomach watching and want to turn off the television. When the packaging got worse, smokers started begging retailers to give them the pack with the ''statistics'' - the others were just too horrible to look at. From cut-up brains on a silver platter to X-rays of badly damaged lungs, to the camera view of the smoke literally going down one's throat, the point was hammered home - smoking is very, very bad. But recently, a new kind of anti-smoking ad is appearing on TV. It has no physical lungs in a surgeon's hands, no brains cut up on the screen, no little kids crying at the airport and definitely no cancerous mouths staring at you. No, this is a fast-paced ad about a man who has been attempting to quit for a while and it portrays the difficult stages he goes through. He quits, then he starts again, he quits and then he starts again, and at the end of the ad, he hasn't had a cigarette for more than three years. I watched the ad and felt something tingle in my stomach. I smiled and wanted [...]

2010-08-11T11:13:05-07:00August, 2010|Oral Cancer News|

Fluorescent probe for oral cancer

Source: www.physorg.com Author: staff/ UC Davis Approximately 43,000 people in the U.S. are diagnosed with tumors of the mouth, pharynx and larynx each year. The main risk factor is smoking, but a recent rise in cases has been linked to human papillomavirus. Most cases are not diagnosed until the cancer has reached an advanced stage. "There's a lot out there about breast, prostate and brain cancer, but people are not so aware about oral cancer and its devastating consequences," said Laura Marcu, a professor of biomedical engineering at UC Davis. "People don't think to look for it, and there isn't any routine screening." Marcu's laboratory collaborated with Dr. Gregory Farwell's group in the Department of Otolaryngology at the UC Davis Cancer Center to develop the fiber-optic probe. The probe stimulates molecules in the patient's tissues with a laser. Some of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called "time-resolved fluorescence spectroscopy" (TR-LIFS), which provides information about the types of molecules present. During surgery, blood can distort the intensity of the fluorescence signal but not its duration. By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue. Based on encouraging results in animal tests, Marcu and Farwell's team recruited nine human volunteers from among patients who arrived at the UC Davis Medical Center for surgical therapy of the mouth, throat and larynx. They compared readings [...]

New types of smokeless tobacco present growing risks for youth: products mistaken for candy

Source: thenationshealth.aphapublications.org Author: Kim Krisberg The decline in the U.S. smoking rate is arguably one of the biggest achievements in the nation’s public health history. But as public health makes inroads, the tobacco industry is pushing back, offering new ways to deliver nicotine and hook lifelong customers. As nonsmoking ordinances sweep across the country, tobacco manufacturers are marketing new smokeless and spitless tobacco products, often selling them as complementary products to cigarettes — pushing the message that such “novel” tobacco products can deliver a nicotine fix whether smoking is allowed or not. Going by brand names such as Orbs, Snus and Taboka, the products are smokeless and spitless, often dissolving in a user’s mouth. For example, Marlboro Snus comes in a teabag-like pouch that a user puts between the cheek and gum and then discards after about 30 minutes. Camel Orbs look similar to small pieces of candy — almost like a Tic Tac — come in flavors such as “fresh” and “mellow,” and dissolve in a user’s mouth. Camel Sticks and Camel Strips also dissolve in a user’s mouth. A recent Camel Snus ad reads “Boldly Go Everywhere” and “Break Free.” While such products have yet to catch on in a significant way in the United States, public health advocates warn not to underestimate the influence of tobacco marketing, especially in regard to young people. They also warn that tobacco companies seem to be portraying the novel products as a “healthier” alternative to cigarettes or as a quitting aid. [...]

Head and neck cancer among lifelong never-smokers and ever-smokers: matched-pair analysis of outcomes after radiation therapy

Source: HighWire Medline Author: Am J Clin Oncol From the Departments of *Radiation Oncology and daggerOtolaryngology-Head and Neck Surgery, University of California Davis School of Medicine, Sacramento, CA. PURPOSE:: An increasing proportion of patients with head and neck cancer have no history of smoking. The purpose of this analysis was to compare the clinical outcomes between patients without a history of smoking (never-smokers) and those with a previous history of smoking (ever-smokers) treated by radiation therapy. METHODS AND MATERIALS:: Seventy patients with newly diagnosed squamous cell carcinoma of the oropharynx or oral cavity without a previous history of smoking were matched to a control ever-smoker with a positive tobacco history (>10 pack-years) based on age, gender, ethnicity, Karnofsky Performance Status, primary tumor site, disease stage, primary treatment, radiation dose, and start date. Outcome was compared using Kaplan-Meier analysis. Normal tissue effects were graded according to the Radiation Therapy Oncology Group/European Organization for the Treatment of Cancer radiation toxicity criteria. RESULTS:: With a median follow-up of 33 months, lifelong never-smokers had an increased 3-year overall survival (86% vs. 69%), disease-free survival (82% vs. 65%), and local-regional control (85% vs. 70%) compared with the ever-smoker control population (P < 0.05, for all). These differences remained statistically significant when patients treated by postoperative or definitive radiation therapy were analyzed separately. The incidence of grade 3+ complications was also significantly lower among never-smokers compared with ever-smokers (10% vs. 29%, P = 0.01). CONCLUSIONS:: Prognosis differed significantly between never-smokers and ever-smokers with head and neck [...]

2010-07-20T14:11:01-07:00July, 2010|Oral Cancer News|

Congress approves bill curbing internet tobacco sales in victory for kids and taxpayers

Source: Campaign for Tobacco-Free Kids Author: Matthew L. Myers Voting 387 to 25, the U.S. House of Representatives today gave final congressional approval to the Prevent All Cigarette Trafficking (PACT) Act, legislation to curtail the growing sales of tax-evading, low-cost cigarettes and other tobacco products over the Internet and through the mail.  Passage of this legislation is a milestone in the fight to keep kids from smoking and prevent tax evasion that costs state and federal taxpayers billions each year. We applaud Rep. Anthony Weiner (D-NY), the chief House sponsor, and Sen. Herb Kohl (D-WI), the Senate sponsor, for their leadership and persistence in pursuing this legislation and winning its approval. The Senate unanimously approved the bill onMarch 11.  We look forward to President Obama continuing his strong leadership on tobacco control by signing the PACT Act into law. Internet sales of tobacco products are a serious and growing problem that keeps prices down and smoking levels up.  Such sales make it easier and cheaper for kids to buy cigarettes, facilitate tax evasion and cost federal and state governments billions in revenue.  Many vendors that sell cigarettes and smokeless tobacco products over the Internet or through other mail-order sales do not pay applicable tobacco taxes and do not have sufficient safeguards to prevent sales to children, such as effective policies to verify a purchaser's age. The PACT Act will: Require Internet sellers to pay all federal, state, local or Tribal tobacco taxes and affix tax stamps before delivery to any customer; Mandate that the [...]

2010-07-14T20:16:19-07:00July, 2010|Oral Cancer News|

Man wins £18k on tv game show after tongue cancer op

Source: www.thisisderbyshire.co.uk Author: staff For a man who had to learn how to talk again, there can be few greater tests than speaking on a TV game show beamed across the nation. But Maurice Paulson passed with flying colours – and won £18,000 and praise from Noel Edmonds in the process. The 81-year-old appeared on Channel 4's hit show Deal or No Deal having been taught how to speak again following an operation on his cancer-ridden tongue. Maurice said the show was great fun and that his appearance was a reward for the hard work Derby's doctors and nurses had put in to help him recover. Although he speaks with a rasp, every word is intelligible as long as he speaks slowly and enunciates. He said: "Noel said I was very brave for coming on. I didn't think so at the time – if people don't understand me now there's nothing I can do about it. The crowd were brilliant though. I won £18,000 and they all came down from their seats and hugged and congratulated me." Maurice, of Stenson Fields, was stunned when he was diagnosed with tongue cancer in 2004. He said: "I had gone for a check-up because my neck kept swelling up and then going back to normal again. It's not the sort of thing you imagine would be cancer. "They asked me if I drank or smoked. But I gave up smoking decades before and, despite being a landlord for three pubs in my time, [...]

Could HPV be transmitted orally?

Source: Bright Hub Author: Kira Jaines Can a kiss transmit HPV? Or oral sex? Studies conducted by researchers at Johns Hopkins University found that not only can human papilloma virus be transmitted orally, it can also increase the risk of oropharyngeal cancer. Can HPV Be Transmitted Orally? In a word, yes. Once thought to be uncommon, the oral transmission of human papilloma virus (HPV) through oral sex and even French kissing has been documented and linked to an increasing rate of oropharyngeal cancer. The oropharynx consists of the base the tongue, the tonsils, the back of the mouth and the walls of the throat. Results of a study by Johns Hopkins researchers published in the New England Journal of Medicine in 2007 linked HPV exposure and infection to an increased risk of cancer of the mouth and throat. HPV infection has rapidly caught up with tobacco and alcohol as a risk factor for oral cancer, and has, in fact, become one of the leading causes of oral cancer in men, independently of smoking and drinking. About HPV Over 120 different HPV viruses have been identified, according to the Oral Cancer Foundation. Different types of HPV infect different parts of the body. Some cause warts on the skin. Some cause warts on the genitals. Some are harmless. Some cause cancer. The HPV virus is easily passed via skin-to-skin contact or sexual contact. HPV viruses cause no early identifiable symptoms and most are fought off by the body’s immune system. In fact, sexually-active adults have a [...]

2010-07-11T16:10:45-07:00July, 2010|OCF In The News, Oral Cancer News|

Is drinking coffee as good as it is made out to be?

Source: healthcare.tmcnet.com Author: Mini Swam Studies about the drinking habits of coffee and tea drinkers have always managed to excite attention, and with more and more studies being conducted, newer information has surfaced. Nine existing studies were looked at and analyzed. Researchers determined how much of coffee was consumed by more than 5,000 cancer patients and 9,000 healthy people. In the latest study conducted, researchers have found that the incidence of head and neck cancers appeared to decrease when four or more cups of coffee were drunk every day. The risk in such cases decreased by 39 percent in respect of oral cavity and pharynx cancers. However, it did not appear to have any effect on laryngeal cancer. By and large, the results seemed really positive, but Mia Hashibe, lead researcher and an assistant professor in the department of family and preventive medicine at the University of Utah, cautioned against drinking lots of coffee. Looking at the results from a logical point of view, Hashibe pointed out that the main risk factors for oral cancers were smoking and drinking alcohol, and the best way to prevent such cancers would be to stay away from smoking and drinking alcohol. Further Hashibe indicated that it would be highly misleading to suggest that drinking lots of coffee without taking into account the real risk factors could prevent people from getting those cancers. Different people metabolize caffeine or coffee in different ways, and it was important to realize this fact before indulging in lots [...]

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