prevention – Page 3 – Oral Cancer News

Effects of antioxidant supplements on cancer prevention: meta-analysis of randomized controlled trials

Source: Ann. Onc., July 21, 2009 Author: S-K Myung et al. Background: This meta-analysis aimed to investigate the effect of antioxidant supplements on the primary and secondary prevention of cancer as reported by randomized controlled trials. Methods: We searched Medline (PubMed), Excerpta Medica database, and the Cochrane Review in October 2007. Results: Among 3327 articles searched, 31 articles on 22 randomized controlled trials, which included 161 045 total subjects, 88 610 in antioxidant supplement groups and 72 435 in placebo or no-intervention groups, were included in the final analyses. In a fixed-effects meta-analysis of all 22 trials, antioxidant supplements were found to have no preventive effect on cancer [relative risk (RR) 0.99; 95% confidence interval (CI) 0.96-1.03). Similar findings were observed in 12 studies on primary prevention trials (RR 1.00; 95% CI 0.97-1.04) and in nine studies on secondary prevention trials (RR 0.97; 95% CI 0.83-1.13). Further, subgroup analyses revealed no preventive effect on cancer according to type of antioxidant, type of cancer, or the methodological quality of the studies. On the other hand, the use of antioxidant supplements significantly increased the risk of bladder cancer (RR 1.52; 95% CI 1.06-2.17) in a subgroup meta-analysis of four trials. Conclusions: The meta-analysis of randomized controlled trials indicated that there is no clinical evidence to support an overall primary and secondary preventive effect of antioxidant supplements on cancer. The effects of antioxidant supplements on human health, particularly in relation to cancer, should not be overemphasized because the use of those might be [...]

Oral Cancer Foundation News Team - A2009-07-24T04:48:57-07:00July, 2009|Oral Cancer News|

Chinese e-cigs gain ground amid safety concerns

Source: apnews.myway.com Author: Audra Ang With its slim white body and glowing amber tip, it can easily pass as a regular cigarette. It even emits what look like curlicues of white smoke. The Ruyan V8, which produces a nicotine-infused mist absorbed directly into the lungs, is just one of a rapidly growing array of electronic cigarettes attracting attention in China, the U.S. and elsewhere - and the scrutiny of world health officials. Marketed as a healthier alternative to smoking and a potential way to kick the habit, the smokeless smokes have been distributed in swag bags at the British film awards and hawked at an international trade show. Because no burning is involved, makers say there's no hazardous cocktail of cancer-causing chemicals and gases like those produced by a regular cigarette. There's no secondhand smoke, so they can be used in places where cigarettes are banned, the makers say. Health authorities are questioning those claims. The World Health Organization issued a statement in September warning there was no evidence to back up contentions that e-cigarettes are a safe substitute for smoking or a way to help smokers quit. It also said companies should stop marketing them that way, especially since the product may undermine smoking prevention efforts because they look like the real thing and may lure nonsmokers, including children. "There is not sufficient evidence that (they) are safe products for human consumption," Timothy O'Leary, a communications officer at the WHO's Tobacco Free Initiative in Geneva, said this week. The [...]

Oral Cancer Foundation News Team - A2009-02-28T06:32:42-07:00February, 2009|Oral Cancer News|

Diagnostic aids in the screening of oral cancer

Source: 7thspace.com Author: Stefano Fedele The World Health Organization has clearly indentified prevention and early detection as major objectives in the control of the oral cancer burden worldwide. At the present time, screening of oral cancer and its pre-invasive intra-epithelial stages, as well as its early detection, is still largely based on visual examination of the mouth. There is strong available evidence to suggest that visual inspection of the oral mucosa is effective in reducing mortality from oral cancer in individuals exposed to risk factors. Simple visual examination, however, is well known to be limited by subjective interpretation and by the potential, albeit rare, occurrence of dysplasia and early OSCC within areas of normal-looking oral mucosa. As a consequence, adjunctive techniques have been suggested to increase our ability to differentiate between benign abnormalities and dysplastic/malignant changes as well as to identify areas of dysplasia/early OSCC that are not visible to naked eye. These include the use of toluidine blue, brush biopsy, chemiluminescence and tissue autofluorescence. The present paper reviews the evidence supporting the efficacy of the aforementioned techniques in improving the identification of dysplastic/malignant changes of the oral mucosa. We conclude that available studies have shown promising results, but strong evidence to support the use of oral cancer diagnostic aids is still lacking. Further research with clear objectives, well-defined population cohorts, and sound methodology is strongly required. Source: Head &Neck Oncology 2009, 1:5

Oral Cancer Foundation News Team - A2009-01-30T13:29:53-07:00January, 2009|Oral Cancer News|

Cranberry and grape seed extracts inhibit the proliferative phenotype of oral squamous cell carcinomas

Source: Evid. Based Complement. Altern. Med., July 23, 2008 Authors: Kourt Chatelain et al. Proanthocyanidins, compounds highly concentrated in dietary fruits, such as cranberries and grapes, demonstrate significant cancer prevention potential against many types of cancer. The objective of this study was to evaluate cranberry and grape seed extracts to quantitate and compare their anti-proliferative effects on the most common type of oral cancer, oral squamous cell carcinoma. Using two well-characterized oral squamous cell carcinoma cell lines, CAL27 and SCC25, assays were performed to evaluate the effects of cranberry and grape seed extract on phenotypic behaviors of these oral cancers. The proliferation of both oral cancer cell lines was significantly inhibited by the administration of cranberry and grape seed extracts, in a dose-dependent manner. In addition, key regulators of apoptosis, caspase-2 and caspase-8, were concomitantly up-regulated by these treatments. However, cranberry and grape seed extracts elicited differential effects on cell adhesion, cell morphology, and cell cycle regulatory pathways. This study represents one of the first comparative investigations of cranberry and grape seed extracts and their anti-proliferative effects on oral cancers. Previous findings using purified proanthocyanidin from grape seed extract demonstrated more prominent growth inhibition, as well as apoptosis-inducing, properties on CAL27 cells. These observations provide evidence that cranberry and grape seed extracts not only inhibit oral cancer proliferation but also that the mechanism of this inhibition may function by triggering key apoptotic regulators in these cell lines. This information will be of benefit to researchers interested in elucidating which dietary [...]

Oral Cancer Foundation News Team - A2008-11-03T09:42:11-07:00November, 2008|Oral Cancer News|

Foreign docs bring home message on cancer

Source: timesofindia.indiatimes.com Author: staff A group of seven leading specialists who have been globe-trotting with a special message -- to spread the word on preventing head and neck cancer -- stopped by in Mumbai on Monday. The busy doctors, well-known names in the medical world, planned the stopover in the city in October as it coincides with the month in which the Centre's ban on smoking in public places comes into force. "If we can prevent people from tobacco use, it will be a bigger advance in the field of head and neck cancer than molecular biology,'' said Dr Jatin Shah of the International Federation of Head and Neck Oncologic Societies (IFHNOS) who is spearheading the world tour. The doctors who have taken five weeks off from work, have already visited seven cities including London, Barcelona, Rome and Moscow and will spend three days in Mumbai during which they will interact with cancer specialists, doctors and medical students. The focus was on exchanging latest treatment modalities and research in the field of head and neck cancer. "There has been significant medical and technological advances in the field. If we could successfully treat two in every four patients of head and neck cancer in the seventies, we can cure three out of four today,'' said Dr Shah. Earlier the diagnosis, better is the chance of treatment, pointed out Dr A K D'cruz of Tata Memorial Hospital. "People should look out for warning signs and consult a doctor within four weeks if [...]

Oral Cancer Foundation News Team - A2008-10-21T10:01:17-07:00October, 2008|Oral Cancer News|

The neglected epidemic and the Surgeon General’s report: a call to action for better oral health

Source: www.redorbit.com Author: Myron Allukian The first US surgeon general's report on oral health will be released soon. Oral diseases have been called a "neglected epidemic," 1-4 because, although they affect virtually the entire population, they have not been made a priority in our country. The surgeon general's report can help educate and sensitize policymakers and health leaders about the importance of oral health and the need to make oral health an integral component of all health programs. In the words of former Surgeon General C. Everett Koop, "You're not healthy without good oral health." We must seize this unprecedented opportunity to ensure that the mouth becomes reconnected to the rest of the body in health policies and programs. It makes no sense that children, diabetic persons, or senior citizens with an abscess on their leg can receive care through their health insurance or a health program, but if the abscess is in their mouth, they may not be covered. For vulnerable populations and the "have-nots," the barriers to dental care are even greater. Although we have made much progress in improving oral health since the 1970s as a result of fluoridation, fluorides, new technology, changing attitudes, and increased use of services, oral diseases are still a neglected epidemic. The facts speak for themselves. Seventy-eight percent of 17-year-olds have had tooth decay, with an average of 7 affected tooth surfaces (C. M. Vargas, unpublished estimates, Third National Health and Nutrition Examination Survey, 2000), and 98% of 40- to 44-year-olds have [...]

Oral Cancer Foundation News Team - A2008-09-02T08:12:45-07:00September, 2008|Oral Cancer News|