melanoma – Page 2 – Oral Cancer News

Mice with toys and friends have better anti-cancer responses

Source: Medscape Blogs Author: Alok Khorana, MD As clinicians, we know that patients with excellent support systems will (in general) do better than patients without. I had personally always thought of this as being secondary to better reporting and oversight - for instance, a patient with a spouse is more likely to be brought in with a fever whereas a patient living by him/herself is more likely to try and ride it out, leading to more dangerous complications. In a fascinating animal model study published in Cell, researchers led by Cao et al at identify even more of a therapeutic benefit for having such an "enriched environment". The authors show this by placing mice with different types of cancers (melanoma, colon cancer) in two different types of environments: one, the usual laboratory housing (5 mice per cage) and the other "enriched" with "groups (18-20 mice per cage) in large cages of 1.5 m x 1.5 m x 1.0 m supplemented with running wheels, tunnels, igloos, huts, retreats, wood toys, a maze, and nesting material". The results all clearly favored having an enriched environment: "In the mice housed in enriched environment for 3 weeks prior to tumor implantation, the mean volume of the tumor was 43% smaller than those in the control housing (p < 0.05). For the 6 week groups, the tumor mass in EE mice was reduced by 77.2% p < 0.001). Notably, all mice in the control groups developed solid tumors, whereas 5% of mice with 3 weeks [...]

Charlotte Parker2010-07-25T20:12:24-07:00July, 2010|Oral Cancer News|

Scientists decode entire genetic code of cancer

Source: www.popsci.com Author: Jeremy Hsu And cigarette smokers get a free mutation in every pack In a major step toward understanding cancer, one of the biggest problems bedeviling modern medicine, scientists have now cracked the genetic code for two of the most common cancers. This marks just the beginning of an international effort to catalog all the genes that go wrong among the many types of human cancer, the BBC reports. Cracking the Cancer Code A cluster of breast cancer cells, with blue ones marking actively growing cells and yellow marking dying cells. Could scientists crack their code next? Too much time spent under the sun apparently leads to most of the 30,000 mutations contained within the DNA code for melanoma, or skin cancer. Outside experts told the BBC that no previous study has managed to link specific mutations to their causes. Wellcome Trust scientists also found more than 23,000 errors in the lung cancer DNA code, with most caused by cigarette smoke exposure. A typical smoker might get one new mutation, possibly harmless but also possibly a cancer trigger, for every 15 cigarettes that they smoke. The new cancer maps could lead to better blood tests for diagnosing the respective cancers, as well as better targeted drugs. Blood tests might even reveal the DNA patterns that suggest cancer lies on the horizon. The International Cancer Genome Consortium still expects to spend hundreds of thousands of dollars in cracking the code of the many human cancers. The U.S. has the [...]

Oral Cancer Foundation News Team - A2009-12-17T19:52:17-07:00December, 2009|Oral Cancer News|

The Vitamin D difference

Source: www.curetoday.com Author: Diana Steele Plain old vitamin D might finally be ready for its day in the sun. New research is shedding light on the leading role that this vitamin may play in preventing cancer and in keeping tumors in check. Vitamin D isn’t technically a vitamin, since it’s produced in the body as a result of exposure to sunlight (“vitamins” are essential to life but by definition can be obtained only outside the body, through diet or supplements). It’s only when we don’t get enough sun that our bodies don’t make enough vitamin D and we need to get it from other sources. But while one of those sources, milk, is fortified with enough vitamin D to prevent the bone disease rickets in children, dietary sources—even a multivitamin—don’t provide nearly enough D to help prevent cancer, many scientists now say. New findings are showing that vitamin D acts as a sentinel to help regulate cell growth and prevent a cell from becoming malignant, says Boston University Medical Center researcher Michael Holick, PhD, MD. “And that’s why we think that you need an adequate vitamin D level throughout your entire life, and that [anytime] you become vitamin D-deficient, you put yourself at increased risk of potentially developing a malignancy later in life, because you’ve lost the policing ability of vitamin D to help keep cell growth in check.” The prescription? Sensible sun exposure for your skin type, plus vitamin D supplements. The payback? Greatly reduced risk of colon, breast, [...]

Oral Cancer Foundation News Team - A2009-10-16T09:37:19-07:00October, 2009|Oral Cancer News|