larynx – Page 2 – Oral Cancer News

Larynx preservation studies should consider treatment impact

Source: www.internalmedicinenews.com Author: Sara Freeman, Internal Medicine News Digital Network Almost one-quarter of patients who had been given induction chemotherapy before radiotherapy for head and neck cancer experienced long-term swallowing difficulties, with another 15% experiencing voice disabilities that correlated with the mobility of the vocal cords. Long-term data from the GORTEC (Groupe Oncologie Radiothérapie Tête et Cou) 2000-01 larynx preservation trial also show that approximately two-thirds of long-term head and neck cancer survivors experienced severe problems with sticky saliva and dry mouth, which were in turn linked to nutritional problems. These findings, reported May 9 at the European Society for Therapeutic Radiation Oncology (ESTRO) Anniversary Conference, further confirm that studies looking at the effects of chemoradiotherapy on the larynx in head and neck cancer need to consider prospective assessment of laryngeal function, rather than just looking at anatomical preservation, according to a French radiation oncologist. Dr. Gilles Calais of the Centre Hôpitalier Régional et Universitaire de Tours (France) presented data from a prospective analysis of 61 patients who had participated in the original 213-patient GORTEC 2000-01 trial. He also presented updated results from the trial using a recently developed composite end point. "Larynx preservation can be achieved for most of our [head and neck] patients by using three different strategies: induction chemotherapy, concomitant [chemoradiotherapy], or alternating chemoradiotherapy," Dr. Calais observed. Indeed, larynx preservation is a possibility in approximately 80% of patients, he said. However, anatomical preservation does not mean that laryngeal function is maintained, especially with respect to the ability [...]

Oral Cancer Foundation News Team - A2011-05-21T14:31:34-07:00May, 2011|Oral Cancer News|

Mayo Clinic finds robotic surgery effective for removing hard-to-reach throat cancer

Source: www.eurekalert.org Author: press release Robotic surgery has become a mainstream tool for removing an ever-increasing variety of head and neck tumors. Now, a team of head and neck surgeons from Mayo Clinic has found robotic surgery can treat cancer in the narrow, hard-to-reach area beyond the tongue at the top of the voice box. Some patients were able to avoid further treatment with chemotherapy or radiation, and most could resume normal eating and speaking. "We've known it's useful for tongue base and tonsil cancers, but we wanted to assess its effectiveness in the larynx," says Kerry Olsen, M.D., Mayo Clinic otolaryngologist and senior author of the study that was presented April 29 at the Combined Otolaryngological Spring Meetings in Chicago. The investigation of transoral robotic surgery (TORS) followed nine patients for up to three years following removal of supraglottic squamous cell carcinoma, which affects the area of the larynx above the vocal cords. Most of the patients had advanced-stage disease. The results showed TORS effectively removed cancer, with "clean," disease-free margins, and was easier to perform than the approach of transoral laser microsurgery via a laryngoscope. The patients also underwent the surgical removal of their adjacent neck nodes at the same operation. "We were pleased with the cancer outcomes," Dr. Olsen says. "We also found patients had minimal trouble after surgery, in most cases resuming normal eating, swallowing and speaking." With TORS, the robotic arms that enter the mouth include a thin camera, an arm with a cautery or [...]

Oral Cancer Foundation News Team - A2011-04-30T16:14:07-07:00April, 2011|Oral Cancer News|

Modest Drinking can Heighten your Risk for Cancer

Source: MedScape.org April 14, 2011 — "A considerable proportion of the most common and most lethal cancers is attributable to former and current alcohol consumption," concludes a large European study published online April 8 in BMJ. The researchers attribute about 10% of all cancers in men and about 3% of all cancers in women to previous and current alcohol consumption. The estimates come from an analysis of data from the huge ongoing European Prospective Investigation Into Cancer (EPIC) and from representative data on alcohol consumption compiled by the World Health Organization (WHO). The risk increases even with drinking moderate amounts. "This research supports existing evidence that alcohol causes cancer and that the risk increases even with drinking moderate amounts," coauthor Naomi Allen, DPhil, an epidemiologist at Oxford University, United Kingdom, said in a statement. The original data in the EPIC study were collected from 1992 to 2000, so "the results from this study reflect the impact of people's drinking habits about 10 years ago," Dr. Allen noted. "People are drinking even more now than they were then, and this could lead to more people developing cancer because of alcohol in the future," she added. Data From 8 Countries The EPIC study, which is still ongoing, is one of the largest studies of diet and cancer ever conducted. It involved more than half a million people in Europe. For this analysis of alcohol and cancer, the researchers used EPIC data from 363,988 participants from 8 European countries — France, Italy, Spain, [...]

Oral Cancer Foundation News Team - A2011-04-26T10:06:35-07:00April, 2011|Oral Cancer News|

Alcohol’s hidden effects revealed in new National Health Service campaign

Source: www.medicalnewstoday.com Author: staff A new 6 million pound NHS campaign to reveal alcohol's hidden effects warns people of the unseen damage caused by regularly drinking more than the advised limits and highlights drinkers' affected organs while they sup their drink in the pub or at home. The campaign was launched recently by Public Health Minister, Gillian Merron. It forms part of a government-wide strategy to tackle the harmful effects of alcohol and is backed by major health charities. Merron said in a press statement that: "Many of us enjoy a drink - drinking sensibly isn't a problem." But, she warned that: "If you're regularly drinking more than the NHS recommended limits, you're more likely to get cancer, have a stroke or have a heart attack." The Department of Health developed the campaign with Cancer Research UK, the British Heart Foundation and the Stroke Association. Part of it entails showing a series of strong messages on TV, in the press and outdoor posters, showing how much harm drinking more than the NHS advised daily limit can do to your body. In the TV campaign, one advert of three men drinking in a pub, shows one of them with a semi-transparent body, and as he sups his beer, different organs are highlighted to show which parts the narrator, who is explaining the risks of drinking alcohol, is talking about (for example, when high blood pressure is mentioned, the heart becomes more visible). The NHS advises that women should drink no more [...]

Oral Cancer Foundation News Team - A2010-03-01T18:58:24-07:00March, 2010|Oral Cancer News|

Q&A: treating larynx cancer with chemotherapy alone

Source: www2.mdanderson.org/cancerwise Author: Cancerwise Blogger In certain cases, cancer of the larynx (voicebox) can be treated successfully with chemotherapy alone, according to a recent study at M. D. Anderson. Chris Holsinger, M.D., assistant professor in the Department of Head and Neck Surgery, was co-author of the study, which is the first of its kind in the United States. He answers questions about this groundbreaking research that may provide hope for some patients. How has the treatment for larynx cancer evolved over the past few decades? Thirty years ago, the only option for cancer of the larynx, also called laryngeal cancer was surgical removal of part of the larynx. In the 1970s, treatment moved away from surgery and more toward radiation. Then we began to combine radiation and chemotherapy. What are some of the disadvantages of treating cancer of the larynx with radiation? Radiation can have side effects, especially long-term toxicity. In many patients, the cancer returns. Sometimes, radiation therapy saves the larynx and trachea (windpipe), but they do not work as well. This requires some patients to have a tracheotomy (a surgical procedure that makes an incision in the trachea to open a direct airway) or gastrostomy (surgical opening into the stomach). If patients who have radiation need surgery later, they often have more surgical complications and lower survival rates. What inspired you to look at treating larynx cancer with chemotherapy? While the treatment of larynx cancer was evolving in the United States, another story was unfolding in Paris. Two [...]

Oral Cancer Foundation News Team - A2009-12-02T21:12:25-07:00December, 2009|Oral Cancer News|

Patterns of alcohol and tobacco use affect head and neck cancer risk

Source: www.rtmagazine.com Author: staff Assuming that total exposure is the same, it is worse to smoke lightly for many years than to smoke heavily for a few years when it comes to the risk of head and neck cancer, new research shows. With alcohol use, however, the opposite is true. The results, which were published in the October 15th issue of the American Journal of Epidemiology, also confirmed previous research showing that smoking was more strongly associated with laryngeal cancer and that alcohol consumption was more strongly associated with pharyngeal and oral cavity cancers. "Cigarette smoking and alcohol consumption are known risk factors for head and neck cancers, including cancers of the larynx, oral cavity, and pharynx," co-researcher Dr. Jay H. Lubin, of the National Cancer Institute, Rockville, Maryland, told Reuters Health. "This paper presented a detailed quantitative evaluation of their effects, using data which were pooled from 15 case-control studies." The researchers modeled the excess odds ratio (EOR) to assess risk by total exposure (pack-years and drink-years), as well as the modification of risk by exposure rate (cigarettes/day and drinks/day). The smoking analysis included 1761 laryngeal, 2453 pharyngeal, and 1990 oral cavity cancer cases. For controls, 7963 were included for laryngeal and 10,114 for pharyngeal and for oral cavity cancer cases. The alcohol analysis included 2551 laryngeal, 3693 pharyngeal, and 3116 oral cavity cancer cases. For controls, 12,179 were included for laryngeal cancer and 15,589 for pharyngeal and oral cavity cancer cases. While smoking increased the risk of all [...]

Oral Cancer Foundation News Team - A2009-11-07T11:01:10-07:00November, 2009|Oral Cancer News|