HPV – Page 55 – Oral Cancer News

Males can get HPV vaccine Gardasil thanks, in part, to Gulfport cancer survivor

Source: St. Petersburg Times Author: John Barry David Hastings' crusade to inoculate boys against a cancer-causing virus that afflicts women — but threatened him, too — has scored a victory. But it's not quite the one he has been fighting for in the past three years. A panel of the Centers for Disease Control and Prevention last week allowed a vaccine to be given to boys and young men that is already used to protect girls and young women from human papillomavirus, HPV, which causes cervical cancer. The panel's vote followed the Food and Drug Administration's recent okay of the vaccine for boys as a protection against genital warts. The vaccine, Gardasil, was approved only for females, ages 9 to 26, in 2006. But research has since linked HPV to many oral cancers in men. Hastings, who owns the Habana Cafe in Gulfport with his wife, Josefa, testified before the CDC's Advisory Committee on Immunization Practices. He told them how HPV was found in a deadly carcinoma in his throat in 2006. It took seven weeks of simultaneous chemotherapy and radiation at the H. Lee Moffitt Cancer Center in Tampa to arrest the cancer. Ever since, he has spread the message that HPV is a threat to men. He urged the CDC panel to recommend routine vaccinations for boys, as it already does for girls. Hastings and other proponents argued that only 17 percent of girls are completing the series of three doses needed for protection. "We rely on females [...]

Charlotte Parker2009-10-30T10:58:18-07:00October, 2009|Oral Cancer News|

Pinter opens up about private battle with cancer

Source: Fairfield Citizen Author: Morgan Thomas In the 31 years that Redding actress Colleen Zenk Pinter has played Barbara Ryan on As the World Turns, her character has been in a coma following an automobile accident, survived a gunshot wound, been burned to a crisp in an explosion and imprisoned for a crime she did not commit -- the stuff of soap writers' fecund imaginations. But when Barbara was "diagnosed" with oral cancer in 2008, the script was ripped from the real life drama of the actress who plays her and fact-checked with the Oral Cancer Foundation, for which Pinter is now the spokesperson. Warning the public about this little-known cancer and about a simple 3--5 minute screening your dentist can do has become a mission for Pinter. "The screening is painless," she said in an interview with the Westport News. "And you don't have to take your clothes off!" Oral cancer kills more people each year than cervical, skin or prostate cancer, yet when found early, there is an 80 to 90 percent survival rate. She took her private health battle public first on the CBS Early Show, filmed a PSA for the Oral Cancer Foundation, a birthday commercial for the American Cancer Society and has spoken before such groups as the 2009 graduating class. University's School of Dentistry. Pinter first noticed that her speech was slurring in December 2005 but her dentist assured the then 52-year-old actress that it was just her teeth shifting. Then in July 2006, [...]

Charlotte Parker2009-10-30T10:13:47-07:00October, 2009|OCF In The News, Oral Cancer News|

FDA approves two HPV vaccines: Cervarix for girls, Gardasil for boys

Sources: www.cancer.gov/ncicancerbulletin Author: news bulletin The FDA has approved a second vaccine to prevent cervical cancer and cervical precancers, the vaccine’s manufacturer, GlaxoSmithKline, announced last week. The approval is based on data from a large clinical trial showing that the vaccine, Cervarix, prevented precancerous lesions in 93 percent of those who received the full vaccine sequence of three injections over 6 months. Cervarix is a bivalent vaccine, meaning it is specifically designed to protect against two human papillomavirus (HPV) types, HPV 16 and 18, which together are responsible for three-quarters of cervical cancers in North America. Clinical trial data also indicate that Cervarix offers more modest protection against precancerous lesions associated with HPV 31, GSK explained in a statement, as well as other tumor-causing (or oncogenic) HPV types. The company expects the vaccine to be available in the United States by the end of the year. The FDA last week also approved the HPV vaccine Gardasil for the prevention of genital warts in boys. Gardasil is already approved and is being actively used in girls and young women for the prevention of cervical cancer. Gardasil is a quadrivalent vaccine that is designed to specifically protect against infections with four HPV types: 16, 18, 6, and 11. HPV types 6 and 11, which are not considered to be oncogenic, cause genital warts. The agency’s approval of Gardasil for boys aged 9 to 26 is based on data from a randomized clinical trial of more than 4,000 males aged 16 to 26, [...]

Oral Cancer Foundation News Team - A2009-10-21T04:44:55-07:00October, 2009|Oral Cancer News|

Wart virus makes for less deadly cancer

Source: www.montrealgazette.com Author: Maggie Fox A wart virus best known for causing cervical cancer may make for a less-deadly kind of head and neck cancer, researchers reported on Thursday. People whose head and neck tumours carried the human papillomavirus virus, or HPV, were 59 percent less likely to die than people whose tumours were not caused by the virus, the researchers said. "A patient who has this actually has a better prognosis than patients with HPV-negative tumours," Dr. Richard Schilsky, president of the American Society of Clinical Oncology and a cancer specialist at the University of Chicago, said in an interview. He said it may be clear now that there are two kinds of head and neck cancers -- those caused by HPV and those linked to other causes, such as smoking and drinking. Not only can patients be treated differently, perhaps waiting longer for toxic chemotherapy if they have an HPV-positive tumour, but there may be ways to prevent these tumours, Schilsky said. Two vaccines -- Cervarix, made by GlaxoSmithKline, and Gardasil, made by Merck & Co Inc -- prevent HPV-16 infection. "There is every reason to think that vaccination with the HPV vaccine will prevent these," Schilsky said. Dr. Maura Gillison and colleagues at Johns Hopkins University in Baltimore studied 317 head and neck cancer patients whose tumours could be tested for HPV. The phase III study confirms earlier work Gillison's lab did linking HPV and these tumours. They said 87 percent of patients with tumours that tested [...]

Oral Cancer Foundation News Team - A2009-10-16T15:43:55-07:00October, 2009|Oral Cancer News|

Girls aware of HPV vaccine’s benefits

Source: www.sciencedaily.com Author: Dr. Stacy Tessler Lindau, Dr. G. Caleb Alexander Contrary to concerns that the human papillomavirus vaccine might promote promiscuity, a national survey of girls and young women found that the majority of respondents did not believe the HPV vaccine protected them against other sexually transmitted infections. The study, conducted by University of Illinois at Chicago and University of Chicago researchers, appears online and in the November issue of the Journal of Adolescent Health. The findings are reassuring in that girls and young women did not think that the vaccine provided benefits beyond protecting them from HPV, said Dr. Rachel Caskey, assistant professor of pediatrics and general internal medicine at UIC and lead author of the study. "We also found that they did not think that they could stop cervical cancer screening, or pap smears, which is critical." Researchers used a national sample, representative of the U.S. population, to conduct an online survey of more than 1,000 females ages 13 to 26. The data provide some of the first nationally representative estimates of both adolescents' and young women's adoption of the HPV vaccine, barriers to vaccination, and sources of information about HPV and the HPV vaccine, according to the researchers. Knowledge about the HPV virus itself ran the gamut, said Caskey. Some people knew absolutely nothing and a few people were moderately informed. Knowledge about the HPV vaccine, however, was better. "Messages about the vaccine are getting across, though they are not including messages about the virus itself," [...]

Oral Cancer Foundation News Team - A2009-10-16T15:34:41-07:00October, 2009|Oral Cancer News|

Nobel scientist urges wider vaccination against HPV infection

Source: www.european-hospital.com Author: staff A global vaccination programme against human papilloma virus (HPV), to include boys as well as girls, could lead to eradication of the virus and virtual disappearance of cervical cancer, predicted Nobel Prize winner, Professor Harald zur Hausen, after delivering the key-note lecture at the 16th International Meeting of the European Society of Gynaecological Oncology (ESGO) in Belgrade, Serbia, this week. Professor zur Hausen, who was awarded the Nobel Prize in Physiology or Medicine in 2008 for his discovery of HPV as the cause of cervical cancer, explained that although HPV prevention will impact mainly on women’s health, it also has important implications for men’s health: “If we wish to achieve eradication within a reasonable period of time, we will need to vaccinate both sexes, and research has shown that boys respond to vaccination in the same way as girls. The main risk of developing cancer after HPV infection is with women and, because of the cost of vaccines, it has been decided to start with girls. But other cancers associated with HPV infection, such as anal and oral cancer, are more common in men, and genital warts occur in both sexes. So there is good reason to vaccinate boys before the onset of sexual activity as well,” said Professor zur Hausen. He suggested that future reductions in production costs and development of cheaper vaccines will make wider vaccination a realistic option, and added that a major reduction in HPV 16 and 18 – the viruses which [...]

Oral Cancer Foundation News Team - A2009-10-15T13:31:36-07:00October, 2009|Oral Cancer News|

At our throats

Source: www.forbes.com Author: Matthew Herper Oncologist Maura Gillison was looking for patients with tonsil cancer for a clinical study several years ago. The first enlisted was a malpractice lawyer, followed by a doctor, then a scientist. She joked to a colleague that all she needed was a rear admiral. In walked a member of the military brass. All were in their 30s, 40s and 50s. People in their prime didn't used to get throat tumors. Head-and-neck cancer, as doctors call it, was a disease of older problem drinkers who also chain-smoked (more men than women). Years of exposure to scotch and Lucky Strikes would damage the DNA of cells lining the throat, leading to cancer. But Gillison, 44, a professor at Ohio State University, was among the first researchers to make a startling realization: The old cigarettes-and-alcohol form of the disease was being eclipsed by a new form, caused by the same human papilloma virus (HPV) that causes cervical cancer. The tumors grow in the tonsils or in the tissue that remains after tonsillectomy. The only good news is that the prognosis for these patients is better than for the old disease. Gillison and researchers at the National Cancer Institute estimate that 4,000 people, 75% of them men, develop this new form of throat cancer annually. That's only a tenth of head-and-neck cases, but it's half as many people as get cervical cancer in the U.S. More worrisome, Gillison's work shows HPV tonsil cancer is increasing at a rate of [...]

Oral Cancer Foundation News Team - A2009-10-15T13:20:48-07:00October, 2009|Oral Cancer News|

Study questions whether or not HPV vaccination of boys is cost effective

Source: professional.cancerconsultants.com Author: staff Researchers from Harvard have reported that including boys in a human papillomavirus (HPV) vaccination program may not be cost effective. The details of this study were published online in the British Medical Journal on October 8, 2009.[1] Human papillomaviruses are probably the sole cause of cancers of the cervix and have been associated with cancers of the vulva, vagina, penis, and rectum. Epidemiologic and molecular biology studies have also suggested that HPV infection may be associated with cancers of the head and neck. Gardasil® (Quadrivalent Human Papillomavirus [Types 6, 11, 16, 18] Recombinant Vaccine) is already approved by the U.S. Food and Drug Administration for the prevention of cervical, vulvar, and vaginal cancers caused by HPV types 16 and 18; genital warts caused by HPV types 6 and 11; and precancerous or dysplastic lesions caused by HPV types 6, 11, 16, and 18 in girls and young women nine through 26 years of age. Cervarix®, a human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine made by GlaxoSmithKline, will probably be approved by the U.S. FDA this year. Male HPV can lead to genital warts, penile cancer, perianal cancer, anal cancer, and head and neck cancer. In addition, it contributes to HPV infection in women and subsequent cervical disease, including cervical cancer. Although males can spread the virus, and many other countries have approved the HPV vaccine for use in males, it has not been approved for males in the United States. However, researchers from the H. Lee Moffitt Cancer [...]

Oral Cancer Foundation News Team - A2009-10-13T21:19:32-07:00October, 2009|Oral Cancer News|

Routine Oesophageal Screening Recommended for Patients Previously Treated for Head and Neck Cancer: Presented at AAO-HNSF

Source: Docguide.com By Kristina Rebelo SAN DIEGO -- October 12, 2009 -- Patients who have been treated for head and neck cancer (HNCA) should be screened for oesophageal pathologies about 3 months out whether they are symptomatic or not, according a poster presentation here October 4 at the American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting 2009. Oesophageal pathology is extremely common in patients who have been treated for HNCA, according to the researchers. "When we talk about HNCA, the 5-year survival rate for this cancer is 50%," Peter C. Belafsky, MD, Head and Neck Oncological Surgery, University of California at Davis, and the Voice and Swallowing Center, Davis, California, told DocGuide. "We took a look at the oesophagus in patients after treatment for head and neck cancer and we did oesophagoscopy and biopsy, as indicated, on all of them. We successfully performed the oesophagoscopy on all 100 patients without complication and we had only 13% of the entire cohort who had a normal examination." The study included 100 patients who had chemoradiation and underwent follow-up oesophagoscopy. Patient demographics, symptom surveys, treatments received, reflux medications prescribed and oesophageal findings were prospectively determined. Findings on oesophagoscopy included stricture (22%), candidiasis (9%), peptic oesophagitis (67%), Barrett's (8%), and new primary tumours -- 1 hypopharynx, 2 oesophageal, and 1 stomach (4%); 13% had a normal oesophagoscopy. The mean age of the cohort was 64 years and 74% were male. The mean time between the cessation of treatment and endoscopy was 40 [...]

Charlotte Parker2009-10-13T10:26:11-07:00October, 2009|Oral Cancer News|

Routine oesophageal screening recommended for patients previously treated for head and neck cancer

Source: www.docguide.com Author: Kristina Rebelo Patients who have been treated for head and neck cancer (HNCA) should be screened for oesophageal pathologies about 3 months out whether they are symptomatic or not, according a poster presentation here October 4 at the American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting 2009. Oesophageal pathology is extremely common in patients who have been treated for HNCA, according to the researchers. "When we talk about HNCA, the 5-year survival rate for this cancer is 50%," Peter C. Belafsky, MD, Head and Neck Oncological Surgery, University of California at Davis, and the Voice and Swallowing Center, Davis, California, told DocGuide. "We took a look at the oesophagus in patients after treatment for head and neck cancer and we did oesophagoscopy and biopsy, as indicated, on all of them. We successfully performed the oesophagoscopy on all 100 patients without complication and we had only 13% of the entire cohort who had a normal examination." The study included 100 patients who had chemoradiation and underwent follow-up oesophagoscopy. Patient demographics, symptom surveys, treatments received, reflux medications prescribed and oesophageal findings were prospectively determined. Findings on oesophagoscopy included stricture (22%), candidiasis (9%), peptic oesophagitis (67%), Barrett's (8%), and new primary tumours -- 1 hypopharynx, 2 oesophageal, and 1 stomach (4%); 13% had a normal oesophagoscopy. The mean age of the cohort was 64 years and 74% were male. The mean time between the cessation of treatment and endoscopy was 40 months and 77% of the HNCA [...]

Oral Cancer Foundation News Team - A2009-10-12T12:05:11-07:00October, 2009|Oral Cancer News|