Johnson & Johnson Sued for $70 Million Over Oral Cancer Test Detection

Source: Dr.Bicuspid.com July 8, 2011 -- Oral Cancer Prevention International (OCPI), makers of the Oral CDx brush test for oral cancer detection, is suing Johnson & Johnson (J&J) over a terminated distribution contract with OraPharma. OraPharma was previously a subsidiary of J&J until it was acquired last December by Water Street Healthcare Partners, a private equity firm in Chicago. J&J, which among other things sells Listerine mouthwash, was worried that a 2008 study linking alcohol-containing mouthwashes with oral cancer would negatively affect sales of Listerine and allegedly induced OraPharma to breach the sales agreement, according to OCPI. The lawsuit, filed July 6 in U.S. District Court, District of New Jersey, claims that J&J "maliciously and fraudulently" interfered with a contract between OCPI and OraPharma that gave OraPharma exclusive rights to sell the test to U.S. dentists. J&J's interference caused OraPharma "to suppress sales of and withhold from the public a proven lifesaving oral cancer prevention product in order to protect sales of its mouthwash, Listerine, which has been linked to oral cancer," according to the complaint. After OCPI signed the contract in February 2010, J&J did not want to "lend credence to the link between Listerine and oral cancer" by selling both its mouthwash and OralCDx, the complaint states. As of press time, J&J did not return calls for comment by DrBicuspid.com. Sales of Listerine bring in more than $1 billion per year, the suit claims. OralCDx is a "quick, painless, and inexpensive test that can prevent oral cancer by [...]

Global Rise in Cancer Cost $300 Billion in 2010, Harvard Economist Says During Press Briefing Hosted by the American Cancer Society and the United Nations

23 June 2011 United Nations — Newly diagnosed cancer cases cost the global economy $300 billion in 2010, as illnesses once believed to be largely confined to wealthier countries took hold in developing nations, a Harvard University economist said during a press briefing hosted by the American Cancer Society Global Health Programs and the United Nations Department of Public Information. Tobacco use, alcohol intake, obesity and decreased physical activity have grown in poorer countries, causing the rise of cancer and diabetes, said David E. Bloom, professor of economics and demography at Harvard’s School of Public Health in Boston. Bloom and other researchers held a briefing today in advance of the United Nations High Level Meeting on noncommunicable diseases. The Sept. 19-20 meeting will be the first gathering of the UN Assembly dealing with cancer, cardiovascular illness, chronic lung conditions and diabetes. These diseases cause 60 percent of deaths worldwide, killing 36.1 million people annually, according to an April report by the World Health Organization. “Noncommunicable diseases will evolve into a staggering economic burden in the coming years,” Bloom said. “It’s a huge impediment to the mitigation of poverty.” Bloom said treating newly diagnosed cancer cases cost $300 billion globally in 2010, and obstructive pulmonary disease -- often correlated with smoking tobacco -- costs $4 billion a year. Not Confined to Health “Economic policy makers like ministers of finance and ministers of planning see noncommunicable diseases as an issue confined to the health sector,” a misperception that needs to be addressed, [...]

UCSF Professor of Oral Medicine speaks about Oral Cancer

Source: Dr.Bicuspid.com May 17, 2011 -- DrBicuspid.com is pleased to present a new feature series, Leaders in Dentistry, a series of interviews with researchers, practitioners, and opinion leaders who are influencing the practice of dentistry. For the first installment, we spoke with Sol Silverman Jr., DDS, a professor of oral medicine in the University of California, San Francisco (UCSF) School of Dentistry and head of one of the oral medicine clinics at UCSF. In addition to seeing patients in the clinic, his research is focused on the diagnosis and treatment of precancerous lesions, as well as effective anti-inflammatory agents for autoimmune diseases that do not have adverse side effects. An advocate for the prevention and early detection of oral cancer and an expert in the treatment of oral cancers, Dr. Silverman has helped develop training programs for dentists to better detect oral cancer and education programs on smoking cessation to reduce the risk of oral cancer. Sol Silverman, DDS, University of California, San Francisco School of Dentistry. Image courtesy of the University of California, San Francisco. DrBicuspid: What is the greatest challenge we face today regarding oral cancer? Dr. Silverman: Professional and public education. The No. 1 thing for professionals is to perform examinations and pursue any deviations from normal signs and/or symptoms and to take part in their patients' lives. If they have a patient who smokes, they should try to get them to stop smoking or tell them not to start. On the other hand, it's public education. [...]

Alcohol may lower oral cancer risk in older women

Source: www.drbicuspid.com Author: staff Contrary to previous research, postmenopausal women are not more vulnerable than men to alcohol-induced carcinogenesis in the oral cavity, according to a new study in Oral Oncology (May 5, 2011). While it has been well documented that alcohol consumption is a strong risk factor for oral cancer, "an ambiguous biphasic impact of moderate and excessive alcohol intake on the risk of upper aerodigestive tract cancers" also has been published, according to researchers from Semmelweis University in Budapest. To clarify the dose-related risk of alcohol consumption for oral cancer in men and women, they studied 608 nonsmoker patients (466 males and 142 females) with squamous cell oral carcinomas and 406 nonsmoker tumor-free controls (264 males and 142 females). The researchers recorded the drinking habits of both groups, dividing them into abstinent, moderate, and excessive consumers of alcohol. Blood glucose levels in male and female cases and the menopausal state of the women also were registered. The researchers found that while excessive alcohol consumption was a strong risk factor for both sexes, moderate alcohol intake proved to be an oral cancer risk for men but it decreased the risk for women. However, elevated blood glucose levels proved to be a risk factor for the predominantly postmenopausal women but did not affect the oral cancer risk among the men. These findings suggest that increased insulin sensitivity and higher estrogen levels are advantageous systemic effects of moderate alcohol intake and might reduce the risk for oral carcinoma in postmenopausal women, [...]

HPV Becomes a Major Topic for Researchers as a Source of Oral Cancers

By Andy Blatchford, The Canadian Press MONTREAL — Amid Michael Douglas's personal and philanthropic battle with throat cancer, the Oscar-winning actor is shedding light on a viral form of the disease lurking in a growing number of mouths. Oral cancer has long been linked to tobacco and alcohol use, but an expanding body of research suggests human papillomavirus, or HPV, is an increasing cause of the deadly disease. The culprit behind the sexually transmitted virus' emergence in mouth and throat cancers? Experts say a major factor is the prevalence of oral sex. More and more researchers have cast their microscopes on the mysteries of HPV-caused oral cancers, including McGill University, which received a big fundraising boost last week with the help of Douglas. The grateful actor, diagnosed with throat cancer last year in a Montreal hospital, volunteered to headline a charity event for the McGill Head and Neck Cancer Fund. The 66-year-old, who calls himself a "poster boy" for head-and-neck cancer, has blamed alcohol as a likely source of his illness, not HPV. Still, a portion of the $2 million amassed at the event will support HPV-caused oral cancer research. The doctor who first detected the walnut-sized tumour in Douglas's throat said the fund has supported HPV projects in the past and more are in the works. "This is an area of increasing incidence," Dr. Saul Frenkiel said of HPV-caused oral cancer at the university-affiliated hospital where he treated Douglas. Although relatively rare, the Canadian Cancer Society estimates oral cancers, [...]

Spouses of Head/Neck Cancer Patients More Inclined to PTSD

Source: MedScape Today Partners of patients with newly diagnosed head and neck cancer are significantly more likely to meet research criteria for post-traumatic stress disorder (PTSD) than patients themselves, according to a study presented here at the Society of Behavioral Medicine 32nd Annual Meeting and Scientific Sessions. Donna Posluszny, PhD, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, and colleagues from there and from the University of Texas, Arlington, Texas, found that 8 of 20 partners of patients with head and neck cancer (20%) had a mean score on the PTSD Checklist (also known as the PCL) of 50 or higher, compared with only 2 of 40 patients (5%). Patients who score at least 50 on the PCL meet the criteria for PTSD. "This is not a formal diagnosis of PTSD but for research purposes, a score of 50 or higher is meaningful," Dr. Posluszny told delegates. "And we were very surprised to find that partners of patients with newly diagnosed head and neck cancer experience greater amounts of traumatic stress than patients themselves do." For the study, investigators recruited 40 dyads (2 individuals regarded as a pair) where the partner was considered to be a "romantic" partner. Some 78% of the patients were male, while most partners were female; all but a small minority were married. Almost all were white, and, as a cohort, they were somewhat better educated and made more money than the majority of patients with head and neck cancer. Sixty-five percent of them also had [...]

Oral Cancer…what does sex have to do with it?

Source: DentistryIQ.com The answer is … plenty! This issue will focus on oral cancer awareness. While there are many topics we can delve into regarding this dreadful disease, we will focus on a few topics. We will share two personal and very poignant stories. Kim Anzalotti, Bill Wislon, and Eva Grayzel impart information that will move you and make you think about your daily in-office procedures. JoAnn Gurenlian, RDH, PhD, will share insights on the human papillomavirus, or HPV, a sexually transmitted virus, and its relationship to oral cancer. And last, but certainly not least, Jamie O'Day, Treatment Facilities Coordinator, The Oral Cancer Foundation Inc., The Bruce Paltrow Oral Cancer Fund, will share her insight on oral cancer screening and the need for a thorough examination. One personal story is shared by Eva Grazel, an international motivational speaker, author, performer, and cancer survivor. I had the pleasure of meeting Eva a number of years ago. In 1998 at age 33, Eva, a non-smoker, saw a number of dentists and physicians for over two years for an “ulcer” on her tongue that became larger and more painful, without any resolution. She was finally diagnosed with advanced oral cancer, Stage IV squamous cell carcinoma, on the lateral border of her tongue. After the many missed opportunities for diagnosis, Eva was given a 15% chance of survival. While her late stage diagnosis is not uncommon, her recovery was unique, as she beat the odds. After diagnosis, Eva underwent a partial tongue reconstruction, a [...]

Modest Drinking can Heighten your Risk for Cancer

Source: MedScape.org   April 14, 2011 — "A considerable proportion of the most common and most lethal cancers is attributable to former and current alcohol consumption," concludes a large European study published online April 8 in BMJ. The researchers attribute about 10% of all cancers in men and about 3% of all cancers in women to previous and current alcohol consumption. The estimates come from an analysis of data from the huge ongoing European Prospective Investigation Into Cancer (EPIC) and from representative data on alcohol consumption compiled by the World Health Organization (WHO). The risk increases even with drinking moderate amounts. "This research supports existing evidence that alcohol causes cancer and that the risk increases even with drinking moderate amounts," coauthor Naomi Allen, DPhil, an epidemiologist at Oxford University, United Kingdom, said in a statement. The original data in the EPIC study were collected from 1992 to 2000, so "the results from this study reflect the impact of people's drinking habits about 10 years ago," Dr. Allen noted. "People are drinking even more now than they were then, and this could lead to more people developing cancer because of alcohol in the future," she added. Data From 8 Countries The EPIC study, which is still ongoing, is one of the largest studies of diet and cancer ever conducted. It involved more than half a million people in Europe. For this analysis of alcohol and cancer, the researchers used EPIC data from 363,988 participants from 8 European countries — France, Italy, Spain, [...]

American Dental Association encourages public to get screened for oral cancer

Source: www.prnewswire.com Author: press release The American Dental Association (ADA) and the Oral Cancer Foundation (OCF) encourage people  to take part in Oral Cancer Awareness Month in April by visiting a dentist for a free oral cancer screening.  So far, more than 1,250 sites across the nation have registered their screening events with the OCF. "Although many dentists perform oral cancer screenings as a routine part of dental examinations, the ADA encourages dentists to go out into their communities during the week of April 11-15 to provide free oral cancer screenings to people who might not regularly visit a dentist," said ADA Spokesperson Sol Silverman, D.D.S., a professor of oral medicine at the University of California, San Francisco. "Early detection is critical in increasing survival rates for patients who have developed an oral cancer; and recognizing and managing precancerous lesions is extremely important in prevention," he said. Mr. Brian Hill, OCF executive director and an oral cancer survivor, also stressed the importance of early detection and the important role that dentists play.  "Early detection is important because it reduces treatment-related morbidity and improves survival rates," he said. In 2010, the National Cancer Institute estimated that approximately 36,540 people were diagnosed with oral cancer and approximately 7,880 people died of oral cancer. The National Institute of Dental and Craniofacial Research (NIDCR) estimates that the five-year survival rate for people diagnosed early, when the disease has not spread beyond the original location, is approximately 83 percent compared to a 20 percent survival [...]

Alcohol linked to 10% of cancer cases, study finds

Source: www.irishtimes.com Author: Dr. Muiris Houston Reducing alcohol intake would reduce the number of cancer cases in the Republic, the Irish Cancer Society has said. It was responding to the results of a major European study, published online by the British Medical Journal, which found that up to one in 10 cancers in men and one in 33 in women could be caused by drinking. Researchers concluded that drinking above recommended alcohol limits was likely to be responsible for the majority of cancer cases linked to alcohol, although for some people even a small consumption may increase the risk. They analysed data from eight European countries, involving more than 360,000 men and women who were aged between 35 and 70 at the beginning of the study. The research is part of the European Prospective Investigation of Cancer, one of the largest ever studies into the links between diet and cancer. Some 17 per cent of bowel cancers in men were linked to drinking, as were 4 per cent of cases in women. And 5 per cent of cases of breast cancer in women were also linked to drinking, the study showed. Overall, more than 18 per cent of cancers in men were down to drinking more than 24g of alcohol a day. In women, 4 per cent of cancers were due to drinking more than 12g of alcohol daily. Naomi Allen, from Oxford University, one of the researchers, said: “This research supports existing evidence that alcohol causes cancer and that [...]

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