alcohol – Page 10 – Oral Cancer News

Regular dental checkups key to early detection of oral cancer

Source: www.dentistryiq.com Author: Mark Newman, News Staff Julie DiNardo knew something wasn't right. The long-time Mountain registered dental hygienist was chatting with Pino, her husband of 23 years, at the breakfast table back in April 2011 when she became concerned about a lack of symmetry on Pino's face. "He looked a little off on one side of his throat," said Julie, who has been screening people for oral cancer for more than a quarter-century. As she has been trained to do, Julie began to feel her husband's neck, her fingers pushing down gently, but firmly in a number of places. Little did she know, her many years of encouraging the public to get annual oral check-ups was about to hit home. Under Pino's right ear, along the jaw line, Julie discovered something she described as feeling like a fish. Her heart skipped a beat. "When you've felt thousands of necks and you've felt thousands of normals, when an abnormal comes up, you know it," Julie said. While dozens of worrisome thoughts raced through her mind at the time, the mother of four told her husband to get the lump checked out at their family doctor right away. The family doctor couldn't find anything and sent Pino home with antibiotics in case there was some inflammation. Julie said she insisted her husband see a specialist and Pino was examined by an ear, nose and throat doctor who was also unable to find anything. The specialist did send Pino for an ultrasound [...]

Oral Cancer Foundation News Team - A2013-03-12T06:55:37-07:00March, 2013|Oral Cancer News|

Alcohol consumption ups oral cancer risk in men

Source: www.drbicuspid.com/ Author: Donna Domino, Features Editor Alcohol consumption causes approximately 20,000 cancer deaths in the U.S. annually, especially oral cavity cancer in men and breast cancer in women, according to a new study in the American Journal of Public Health (February 14, 2013). It is the first comprehensive analysis of alcohol-attributable cancer deaths in the U.S. in more than 30 years, the study authors noted. Notably, even moderate drinkers who consume 1.5 drinks daily or fewer accounted for 30% of alcohol-caused cancer deaths, according to researchers from the Boston University School of Medicine and the School of Public Health. Cancers of the mouth, throat, and esophagus were common causes of alcohol-related cancer deaths among men, resulting in a total of about 6,000 annual deaths, they noted. Breast cancer was the most common cause of alcohol-caused cancer deaths in women, resulting in about 6,000 deaths annually, or about 15% of all breast cancer mortality. In addition, alcohol was cited as a prominent cause in the premature loss of life, resulting in the loss of about 18 years among people who died of cancers attributed to alcohol, the study found. Previous research consistently shows that alcohol increases the risk for cancers of the oral cavity and pharynx, larynx, esophagus, and liver. And recent studies show that alcohol also increases the risk of cancers of the colon, rectum, and women's breasts. While estimates have shown that alcohol accounts for about 4% of all cancer-related deaths worldwide, there is a lack of attention [...]

Oral Cancer Foundation News Team - A2013-03-01T15:32:12-07:00March, 2013|Oral Cancer News|

Even moderate drinking may substantially raise risk of dying from cancer

Source: www.nydailynews.com Author: Tracy Miller, New York Daily News Alcohol causes about 19,500 cancer deaths each year — and even as little as 1.5 drinks per day can make you part of that statistic, according to a sobering new study. The research, published in the American Journal of Public Health, is the first in several decades to examine deaths from a variety of cancers that can be attributed to alcohol consumption, said lead study author David E. Nelson of the National Cancer Institute. "One of the reasons we did the study was to update data that hadn't been looked at for 30 years," Nelson told the Daily News. "In that time, other diseases, and other cancers, have been linked to alcohol." The researchers looked at mortality data from two national surveys conducted in 2009, and using a mathematical formula, determined which of the cancer deaths were alcohol related. About 3.2 to 3.7% of all cancer deaths in 2009 were attributed to alcohol, with oral cancers, pharynx, larynx and esophageal cancers the top killers in men, and breast cancer the most deadly in women. About 15% of all breast cancer deaths were attributable to alcohol consumption, the study found. Furthermore, while the risk of death was greatest among people who had three or more drinks per day, about 30% of deaths occurred among people who consumed 20 ounces, the equivalent of 1.5 drinks, per day. "There's no question that people who drink more frequently are at greater risk," Nelson said. "What [...]

Oral Cancer Foundation News Team - A2013-02-20T07:48:50-07:00February, 2013|Oral Cancer News|

New research reveals genetic mutations of HNC

Source: www.drbicuspid.com Author: DrBicuspid Staff New findings regarding the genetic mutations that cause head and neck cancer (HNC) may lead to new therapies, according to collaborative research presented in November at the 2012 Chemotherapy Foundation Symposium in New York City. Aaron Tward, MD, PhD, and colleagues analyzed tumor samples provided by the University of Pittsburgh from 92 patients with head and neck squamous cell carcinoma (HNSCC), according to an article on onclive.com. Patient samples were chosen to reflect the normal distribution of patients with these cancers -- that is, mostly men and smokers, noted Dr. Tward. Of these patients, 89% reported a history of tobacco use and 79% alcohol use; 14% of all tumors and 53% of oropharyngeal tumors were found to be positive for human papillomavirus (HPV). Tumor sites also were selected to be roughly representative of the general HNSCC patient population -- that is, most were oral cavity cancers, followed by a substantial proportion of oropharynx cancer samples and a few from patients with hypopharyngeal or laryngeal tumors. Investigators used hybrid capture sequencing to compare tumor tissue and nontumor tissue from the same patient. They also compared the total number of mutations in the HNSCC samples with samples from previous tumor studies. The analysis yielded a large number of mutations. For example, 5,000 genes had at least one mutation, and 1,300 had at least two, the researchers reported. Dr. Tward emphasized, however, that most of these are not implicated either in promoting or maintaining the cancer. He said [...]

Oral Cancer Foundation News Team - A2012-12-31T12:21:03-07:00December, 2012|Oral Cancer News|

Searching for new pathways and treatments for head and neck squamous cell carcinoma

Source: www.onclive.com Author: Lauren M. Green Scientists now know a lot more about the genetic landscape of head and neck cancer and hope that eventually this knowledge will lead the way to new therapies, according to Aaron D. Tward, MD, PhD, of the Broad Institute of MIT and Harvard in Cambridge, Massachusetts. Tward described findings of recent collaborative research on the topic at the 2012 Chemotherapy Foundation Symposium. For this research, Tward, also with the Department of Otology and Laryngology at Harvard Medical School and a clinical fellow in those specialties at the Massachusetts Eye & Ear Infirmary in Boston, and colleagues analyzed tumor samples provided by the University of Pittsburgh from 92 patients with head and neck squamous cell carcinoma (HNSCC). The samples were chosen to be reflective of the normal distribution of patients with these cancers, that is, “mostly men and mostly smokers,” noted Tward. Of these patients, 89% reported a history of tobacco use and 79% alcohol use; 14% of all tumors and 53% of oropharyngeal tumors were found to be positive for human papillomavirus. Tumor sites also were selected so as to be roughly representative of the general HNSCC patient population; thus, most were oral cavity cancers, followed by a substantial proportion of oropharynx cancer samples, and a few from patients with hypopharyngeal or laryngeal tumors, Tward explained. Investigators used hybrid capture sequencing to compare tumor tissue with nontumor tissue from the same individual. They also compared the total number of mutations in the HNSCC samples [...]

Oral Cancer Foundation News Team - A2012-12-23T08:22:47-07:00December, 2012|Oral Cancer News|

Do fruits and veggies offset tobacco/alcohol cancer risks?

Source: www.drbicuspid.com Author: DrBicuspid Staff Consuming fresh fruits and vegetables has been shown to reduce the risk of oral cancer, and now a new study suggests that these "protective effects" may impede the negative effects of tobacco and alcohol consumption with regard to cancer risk (Nutrition and Cancer, November 2012, Vol. 64:8, pp. 1182-1189). For the study, researchers from the University of São Paulo assessed the association between frequent consumption of fruits and vegetables and the risk of oral cancer, comparing results between nonsmokers and smokers and nondrinkers and drinkers. Their case-control study involved 296 patients with oral squamous cell carcinoma attended in three major hospitals in São Paulo, paired with 296 controls recruited from outpatient units of the same hospitals. The researchers found that eating both fruit and vegetables was associated with prevention of the disease in light (odds ratio [OR] = 0.46; 95% confidence interval [CI] = 0.27-0.78) and heavy (OR = 0.30; 95% CI = 0.14-0.65) smokers. For nonsmokers, no fruit (OR = 50; 95% CI = 0.22-1.12) or vegetable (for tomato, OR = 0.53; 95% CI = 0.31-0.93) was associated with reduced risk of oral and oropharyngeal cancer. Similar results were found with regard to drinking status, with OR = 0.51 (95% CI = 0.30-0.87) and 0.18 for fruits (95% CI = 0.07-0.45), respectively, for light and heavy drinkers. "This observation suggests that the protective effect of fruit and salad intake may modulate the deleterious effects from tobacco and alcohol," the researchers concluded.

Oral Cancer Foundation News Team - A2012-11-28T10:18:37-07:00November, 2012|Oral Cancer News|

Periodontitis increases risk of oral leukoplakia

Source: www.drbicuspid.com Author: Donna Domino, Features Editor Periodontitis increases the risk of developing oral leukoplakia and mucosal lesions that are predisposed to become oral cancer, according to a study in Oral Oncology (September 2012, Vol. 48:9, pp. 859-863). The findings provide clues into the complex relationship between systemic and local disease, noted the study authors from the University of Greifswald in Germany. The development of oral cancer proceeds through discrete molecular changes that are acquired from loss of genomic integrity after continued exposure to environmental risk factors. It is preceded in the majority of cases by clinically evident, potentially malignant oral disorders, the most common of which is leukoplakia, the researchers noted. Leukoplakia is an asymptomatic lesion in the oral mucosa. Oral cancer -- especially oral squamous cell carcinoma -- often develops out of these lesions, they added. Studies have shown that as many as 18% of oral premalignant lesions will develop into oral cancer. In addition, periodontal sites are often involved in proliferative types of leukoplakia. The oral cancer rate attributed to leukoplakia is between six and 29 per 100,000, according to the authors. Smoking and drinking alcohol are the main risk factors for this disease, but acute infections in the oral cavity may contribute to the risk. Inflammatory markers The study evaluated 4,310 German residents ages 20 to79 from 1997 to 2001. After five years, 3,300 participants were available for follow-up. The periodontal assessment included probing depth, clinical attachment loss, plaque, bleeding on probing, and the number of [...]

Oral Cancer Foundation News Team - A2012-10-04T14:06:25-07:00October, 2012|Oral Cancer News|

New gene test detects early mouth cancer risk

Source: www.health.am Researchers from Queen Mary, University of London have developed a new gene test that can detect pre-cancerous cells in patients with benign-looking mouth lesions. The test could potentially allow at-risk patients to receive earlier treatment, significantly improving their chance of survival. The study, published online in the International Journal of Cancer, showed that the quantitative Malignancy Index Diagnostic System (qMIDS) test had a cancer detection rate of 91-94 per cent when used on more than 350 head and neck tissue specimens from 299 patients in the UK and Norway. Mouth cancer affects more than 6,200 people in the UK each year and more than half a million people worldwide, with global figures estimated to rise above one million a year by 2030*. The majority of cases are caused by either smoking or chewing tobacco and drinking alcohol. Mouth lesions are very common and only five to 30 per cent may turn into cancers. If detected in the early stages treatment can be curative, but until now no test has been able to accurately detect which lesions will become cancerous. The current diagnostic gold standard is histopathology – where biopsy tissue taken during an operation is examined under a microscope by a pathologist . This is a relatively invasive procedure and many mouth cancers are being diagnosed at later stages when the chances of survival are significantly reduced. For patients presenting with advanced disease, survival rates are poor (10-30 per cent at five years). Lead investigator and inventor of [...]

Oral Cancer Foundation News Team - A2012-10-04T13:58:21-07:00October, 2012|Oral Cancer News|

Researchers explain link between alcohol, cancer risk

Source: Dr.Bicuspid.com September 4, 2012 -- Almost 30 years after discovery of a link between alcohol consumption and certain forms of cancer, scientists are reporting the first evidence from research on people explaining how the popular beverage may be carcinogenic. The findings were reported August 22 during the American Chemical Society annual meeting in Philadelphia. The human body metabolizes the alcohol in beer, wine, and hard liquor into several substances, including acetaldehyde, a substance with a chemical backbone that resembles formaldehyde -- a known human carcinogen, according to lead author Silvia Balbo, PhD, a research associate at the University of Minnesota. "We now have the first evidence from living human volunteers that acetaldehyde formed after alcohol consumption damages DNA dramatically," Balbo stated in a press release. "Acetaldehyde attaches to DNA in humans in a way that results in the formation of a 'DNA adduct.' It's acetaldehyde that latches onto DNA and interferes with DNA activity in a way linked to an increased risk of cancer." To test the hypothesis that acetaldehyde causes DNA adducts to form in humans, Balbo and colleagues gave 10 volunteers increasing doses of vodka (comparable to one, two, and three drinks) once a week for three weeks. They found that levels of a key DNA adduct increased up to 100-fold in the subjects' oral cells within hours after each dose, then declined about 24 hours later. Adduct levels in blood cells also rose. "These findings tell us that alcohol, a lifestyle carcinogen, is metabolized into acetaldehyde [...]

Charlotte Parker2012-09-05T09:14:48-07:00September, 2012|Oral Cancer News|

Even one drink can raise cancer risk – research

Source: www.nzherald.co.nz Just one alcoholic drink a day may increase the risk of cancer, according to a new study, which estimates that light drinking is responsible for 34,000 deaths a year worldwide. New research based on more than 150,000 men and women shows that light drinking increases the likelihood of cancer of the mouth, pharynx, oesophagus and breast. One drink a day increased the risk of cancer of the oesophagus by almost a third, according to the study being reported in the Annals of Oncology, which analysed data from more than 200 research projects. Low alcohol intake increased the risk of oral cavity and pharynx cancer by 17 per cent, and breast cancer in women by 5 per cent. "Alcohol increases the risk of cancer even at low doses," say the researchers. "Given the high proportion of light drinkers in the population, and the high prevalence of these tumours, especially of breast cancer, even small increases in cancer risk are of great public health relevance." When it comes to enjoying your favourite drink and looking after your health, advice has often been complicated. Evidence suggests that drinking in moderation may decrease the risk of heart disease, type-2 diabetes and dementia, leading many to believe a glass of wine a day is good for you. But the damaging effects of drinking are well known. An estimated 2.2 million deaths a year worldwide are linked to alcohol, according to the report, and 3.6 per cent of all cancers are attributable to drinking [...]

Oral Cancer Foundation News Team - A2012-08-28T09:36:35-07:00August, 2012|Oral Cancer News|