Viventia presents Proxinium(TM) posters at ASCO
5/17/2005 Toronto, Ontario, Canada press release Newswire Canada (www.newsire.ca) Viventia Biotech Inc. today announced that it disclosed updated clinical data for its anti-cancer therapeutic, Proxinium(TM) (VB4-845), in two poster presentations on Saturday, May 14th given at the 2005 American Society of Clinical Oncology's (ASCO) annual meeting in Orlando, Florida being held from May 13-17, 2005. Dr. Nick Glover, President and CEO of Viventia Biotech, commented: "In these poster presentations, we provided an update on previously disclosed clinical data demonstrating that Proxinium(TM) has a good safety profile and beyond this, that the drug can produce very encouraging efficacy results including a demonstrable survival benefit in patients with refractory head & neck cancer." The first poster presented by the Company (Abstract No. 5569) entitled "A Phase I study of VB4-845 in patients with advanced, recurrent head & neck cancer on a weekly dosing scheme," disclosed updated results from an exploratory Phase I efficacy trial using direct intratumoral injection of Proxinium(TM) as a monotherapy. A total of 20 patients were enrolled in the study and 18 were considered evaluable at the end of the trial. VB4-845 administered on a weekly basis for 4 weeks was safe and well tolerated. The maximum tolerated dose (MTD) on this schedule was determined to be 930 (micro) g/day. Preliminary results from this study were previously described in a press release dated March 29th, 2005. Although this study was primarily designed to evaluate safety and tolerability, clinical observations indicated that VB4-845 demonstrated promising anti-tumor responses against Ep-CAM-positive SCCHN [...]