U.S. Warns of Dangers From Patch Used for Pain
7/16/2005 Washington, DC Denise Grady New York Times The government warned yesterday that painkilling skin patches could cause drug overdoses and said it was investigating reports of serious side effects and 120 deaths that might have resulted. The patches, containing the narcotic fentanyl, are marketed under the name Duragesic by Janssen, a company owned by Johnson & Johnson. A generic version was put on the market in February by Mylan Laboratories. Duragesic had sales of more than $2 billion in 2004. The patches are intended for people with moderate to severe chronic pain that requires treatment around the clock for an extended period of time and that cannot be controlled by other narcotics alone, the F.D.A. and the manufacturer say. Only those already tolerant of narcotics, as some cancer patients are, should use the patches. People recovering from surgery, or suffering from short-term pain for other reasons, should not. A spokeswoman for the Food and Drug Administration said the 120 deaths had occurred since Duragesic was first approved in 1990 and added that the investigation was still going on and that it was not known whether the product actually caused the deaths and other problems reported in users. Describing fentanyl as a "very strong narcotic," the F.D.A. issued a public health advisory stating that some patients and doctors might not be fully aware of its dangers. An overdose can cause a person to stop breathing; taking off the patch will not reverse the effects because the drug has already built [...]