Researchers Discover Inhibitor Of Infection By HPV
7/19/2006 San Francisco, CA staff Biocompare.com Researchers have discovered a potent inhibitor of the human papilloma viruses (HPV), particularly those types that cause cervical cancer and genital warts, according to a study published in PLoS Pathogens. The inhibitor is found in commercially available products, including sexual lubricants and baby food. In laboratory tests, carrageenan, a compound derived from red algae, prevented HPV infection by both genital wart and cancer-causing types. "We were floored by how much better it worked than anything else we have tested. It's effective at 100-fold lower concentration than the next best inhibitor we've found," said Dr. John Schiller, senior investigator at the National Cancer Institute. Normally, HPV attacks cells by attaching to proteins on their surface and then chemically manipulating access to the cells. Carrageenan thwarts this process by attaching to HPV and preventing its entry into cells. Christopher Buck, lead author of the study and post-doctoral fellow at the National Cancer Institute, searched for candidate inhibitory compounds by looking for substances that were structurally similar to a key cell surface component involved in HPV infection. "When carrageenan came up to be the clear winner, Chris started to search for products that might contain it," said Schiller. "It quickly became clear that it is widely used as a thickening agent in many foods and topically applied products. So he decided to search for sexual lubricants that might contain it as the gelling agent and came up with several. Although carrageenan was identified in a systematic screen, [...]