11/12/2007 Denver, CO Regina Sass AssociatedContent (www.associatedcontent.com) Researchers at Imperial College, London, United Kingdom, have shown that by using a combination of light activated cancer drugs with antibodies targeted to find cancerous tumors, the antibodies might be able to be a much more effective treatment for many different types of cancers. In the study, the researchers show how they have been able to attach 10 light activated molecules of a potent cancer drug to an antibody that is known to seek out the cancerous cells. They have been able to prove that this method makes it possible to deliver the powerful drug molecules to the cancer targets more efficiently than when they are not attached to an antibody. The process is called photodynamic therapy (PDT). It focuses on getting the drugs to the cancerous tissues and then lighting the area with a cold laser. The cold laser starts off a chain reaction by converting oxygen to a very toxic type of oxygen-like bleach. The bleach then destroys any cells in its vicinity. If it has been targeted right to the tumor, then the tumor is destroyed, if it misses the tumor, like in other methods of delivery, healthy tissue can be destroyed. This has been shown to be a successful method for treating cancers of the head and neck, prostate and skin. But there is a limitation to the current PDT. And that is the fact that the light activated drugs are not the efficient in hitting the tumors. Basically [...]

11/12/2007 Boston, MA Scott Allen Boston Globe Scientists are only beginning to discover the hidden role of some viruses and bacteria The almond-shaped lump on Brian Hill's throat didn't make sense to him. The doctor said it was a symptom of advanced oral cancer, but Hill had never smoked a cigarette or chewed a plug of tobacco, considered the main causes of the disease when he was diagnosed in 1997. So why was it there? Not until four years later did Hill get an explanation for his brush with death: a microbe called human papilloma virus-16 had apparently moved into his tonsils, gradually turning normal cells into cancer. Hill, now 59, had become part of a wave of relatively young nonsmokers who contracted oral cancer from the sexually transmitted virus, fueling an overall increase in new cases. Viruses such as human papilloma may be the most overlooked bad guys in the war on cancer, silent invaders that contribute to more than a dozen malignancies and may cause 15 percent of the cancer cases worldwide each year. "What we know about HPV-16 as a cancer causer is just the tip of the iceberg," said Hill, founder of the Oral Cancer Foundation, which funds research for a disease that strikes 34,000 Americans annually and is caused by the same virus that can lead to cancers of the cervix, vulva, anus, and penis. The cancer toll from germs - both viruses and bacteria - may turn out to be higher as researchers discover [...]

11/11/2007 Bolton, England Jane Lavender Bolton News (www.theboltonnews.co.uk) Cancer patients are to be given "on the spot" test results following the introduction of a speedier diagnosis system at the Royal Bolton Hospital. People with suspected head and neck cancer can be in and out of hospital in less than four hours. In that time they will have been tested and diagnosed - a vast improvement on previous times which saw many patients wait weeks for results. People who find a lump see their GP and may be referred to hospital for further checks. If they arrive at 9am on the day of their hospital appointment, they could be told by a consultant whether or not they have cancer by 11.30am the same day. It is the first scheme of its kind at the hospital. Karenza Graves, head and neck specialist nurse at the Royal Bolton Hospital, said: "This certainly speeds things up. There is a good prognosis with head and neck cancer if there is an early diagnosis." "Finding a lump is an extremely worrying time for a patient, so making this process faster eases their concern, especially if the tests show there is nothing to worry about." Around three patients are referred to the head and neck cancer clinic every week with an average of 75 people diagnosed with the disease every year. The fast scheme was piloted in January and ran until the summer, but the scheme was not introduced full-time until a few weeks ago. Among those [...]

11/11/2007 web-based article staff Huliq.com According to the report, represented in the U.S. on the part of CDC - national Center for Disease Control and Prevention in November 9, 2007, the decline in smoking rates during the recent years has stalled, thus turning the problem into a real concern for the federal health officials. It happened so that the positive results of smoking rate decline have ceased to please authorities involved in anti-smoking campaigns and programs since 2004. Among serious reasons of this process Jia-Rui Chong from Los Angeles Times named reduced spendings on anti-tobacco campaigns and bigger marketing budgets from cigarette companies. As the director of the CDC's Office on Smoking and Health Dr. Matt McKenna said, "What is happening doesn't have to happen. With appropriate support and efforts and counter-marketing, tens of thousands of people don't have to die." In McKenna's estimates a 0.1% decline in 2006 doesn't play a significant role in the solution of this vital problem, which takes lives of 480000 people each year and results in tobacco-related diseases. "Among smokers who already have a smoking-related chronic disease, those who quit have a lower risk for death from the disease than those who continue smoking," states the CDC. Marc Kaufman from The Washington Post reported that statistic data collected during the last 40 years of researches have shown unexpected and discouraging results. It is the first time since the researches have been carried out, that smoking rates have stalled for three years and have levelled [...]

11/8/2007 United Kingdom Emily Walker SwintonAdvertiser (www.thisisswindon.co.uk) Most men would be delighted to hear that their wife will never speak again, but it does not stop Bob Taylor's wife nagging him. Lorry driver Bob, 54, fell in love with Rita, 49, across a busy nightclub dance floor a year after the care worker was diagnosed with cancer and had to have her tongue removed. Bob was in the Cardiff bar after driving to the Welsh city in December 2004 from his home in Swindon and said Rita silently captured his heart. "I think it was the physical attraction to start with," said Bob. "We smiled at each other across the room. "Then I went over and tried to chat her up but she didn't say anything so I said You don't say much, do you?' "Then her friend told me she couldn't talk because she had tongue cancer. "The fact that she couldn't talk didn't stop us getting to know each other, because we did most of the talking on her notepad. "After that night, we started texting each other. Then when I got home from work in the evenings we would email. "By Christmas she came to stay with me in Swindon." Bob gave up his job and moved to Cardiff to look after Rita and set up his graffiti and chewing gum cleaning company called Grime Blasters. Then last August Rita made her silent "I do" to Bob when they got married. "I lip-read Rita saying she would [...]

11/7/2007 web-based article staff Health24.com In a study of sexually active young male, heterosexual college students, almost two thirds developed genital human papillomavirus (HPV) infection over two years of follow-up, according to Seattle-based researchers. Certain strains of HPV, which can be transmitted from male to female partners, are responsible for most cases of cervical cancer. In The Journal of Infectious Diseases, Dr Laura A. Koutsky and colleagues at the University of Washington note that, although much is known about HPV infection in women, this is not the case in men. To investigate further, the researchers collected samples of genital cells at four-month intervals from 240 heterosexually active male university students between 18 and 20 years old. Higher rates in males After 24 months, the incidence of new genital HPV infections was 62.4 percent. This is considerably greater than the 38- to 43 percent rate seen in comparable studies of young women, the investigators note. Acquisition rates did not differ by site of initial detection. Overall, 33 different HPV types were recorded, but the most commonly detected types were HPV-16 and HPV-84. HPV-16 is a subtype known to be associated with cervical cancer - previous studies have found that about 50 percent of cervical cancers are caused by this virus. Among the factors associated with increased risk of HPV infection were having a new sex partner within four months of evaluation and having a history of cigarette smoking. "The high rates of HPV infection in men," the investigators conclude, "should be [...]

11/7/2007 Memphis, TN staff CancerConsultants.com Researchers affiliated with RTOG 99-03 study have reported that the administration of radiotherapy with or without recombinant erythropoietin alfa did not affect survival or relapse of anemic patients with head and neck cancer. The details of this study were published in the November 15, 2007 issue of the International Journal of Radiation Oncology * Biology * Physics.1 Epoetin alfa (Procrit®, Epogen®) and darbepoetin alfa (Aranesp®) have been evaluated in anemic patients with head and neck cancer receiving radiation therapy or chemoradiotherapy. The administration of erythropoietins improves hemoglobin levels and decreases transfusion requirements without having an impact on survival. However, there has been concern that erythropoietins could stimulate tumor growth and result in a higher relapse rate. In one study from Denmark in patients with head and neck cancer receiving radiotherapy, the goal was to maintain high hemoglobin levels. In this study, patients receiving prophylactic epoetin alfa to maintain high hemoglobin levels had a lower disease-free survival than patients receiving placebo. In the current study, 141 patients with head and neck cancer receiving radiation therapy were randomly allocated to receive epoetin alfa or no epoetin alfa. Hemoglobin levels were 9.0-13.5 g/dL at baseline. Hemoglobin levels rose by 1.66 g/dL in the treatment group and decreased by 0.24 g/dL in the control group. Local failure rate was 36% for the control group and 44% for the Epo group. The 3 year local and distant PFS was 53% for the control group and 47% for the Epo group. [...]

11/7/2007 London, England Lia Mills Daily Mail (www.dailymail.co.uk) Novelist Lia Mills put off seeing a dentist about a sore tooth for months. Even then, the true nature of her condition was missed and it took a year before she was diagnosed with oral cancer. Here, Lia - who is 50 and lives in Dublin with her husband, Simon - tells her harrowing story... The receptionist at the Dental Hospital looks about 12. She is completely indifferent to me and to the painful open sore in my mouth. She takes my referral letter and says it could be seven months before I get an appointment. But my GP says this is too long and gets me an appointment with a maxillofacial surgeon ten days later. When I see him, I explain this is all a mistake. The swelling in my cheek has gone down, and I'm sorry for wasting the consultant's time. He says it's better to get these things checked out. He begins to poke around and at first says what other people have said. It looks like a trauma, I've probably been chewing my cheek. He pokes around a bit more and says: 'Mmm, maybe not.' He does a biopsy; he says he's sorry, he knows it hurts. The biopsy request is marked as 'urgent'. The pain in my cheek throbs and swells. I've been on the internet again, and now I'm sleepless with pain and sudden anxieties. I return to the hospital a week later. The doctor studies [...]

11/6/2007 web-based article Liz Savage, Andrea Widener JNCI Journal of the National Cancer Institute 2007 99(21):1561 No relationship was found between vitamin D levels and the overall risk of dying from cancer, according to a study published online October 30 in the Journal of the National Cancer Institute. However, higher vitamin D levels were associated with a decreased risk of colorectal cancer death. Several epidemiological studies have supported the hypothesis that that vitamin D can reduce cancer mortality by decreasing cancer incidence or improving survival. Animal and cell studies suggest that vitamin D may reduce tumor growth and induce cancer cell death. Diet and exposure to sunlight are the major sources of vitamin D. D. Michal Freedman, Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues analyzed data from the third national Health and Nutrition Examination Survey to examine the relationship between levels of circulating vitamin D in the blood and cancer mortality in a group of 16,818 participants aged 17 and older. After about a decade of follow-up, 536 participants had died of cancer. Cancer mortality was not related to the level of circulating vitamin D for the overall group, nor was it related when the researchers looked at the data by sex, race, or age. But higher levels of vitamin D (80 nmol/L or more) were associated with a 72 percent reduced risk of colorectal cancer mortality, compared with lower levels (less than 50 nmol/L). "To our knowledge, this study is the first to examine the [...]