Oral Cancer News – Page 208 – The Oral Cancer Foundation News Archive

Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial

Source: annonc.oxfordjournals.org Authors: M. R. Posner et al. Background: The association between human papillomavirus (HPV) and overall survival (OS) in oropharynx cancer (OPC) was retrospectively examined in TAX 324, a phase III trial of sequential therapy for locally advanced head and neck cancer. Methods: Accrual for TAX 324 was completed in 2003 and data updated through 2008. Pretherapy tumor biopsies were studied by PCR for human papillomavirus type 16 and linked to OS, progression-free survival (PFS) and demographics. Results: Of 264 patients with OPC, 111 (42%) had evaluable biopsies; 56 (50%) were HPV+ and 55 (50%) were HPV−. HPV+ patients were significantly younger (54 versus 58 years, P = 0.02), had T1/T2 primary cancers (49% versus 20%, P = 0.001), and had a performance status of zero (77% versus 49%, P = 0.003). OS and PFS were better for HPV+ patients (OS, hazard ratio = 0.20, P

Oral Cancer Foundation News Team - A2011-02-12T15:06:18-07:00February, 2011|Oral Cancer News|

Nanoparticles may enhance circulating tumor cell detection

Source: insciences.org/ Author: Quinn Eastman Tiny gold particles can help doctors detect tumor cells circulating in the blood of patients with head and neck cancer, researchers at Emory and Georgia Tech have found. The detection of circulating tumor cells (CTCs) is an emerging technique that can allow oncologists to monitor patients with cancer for metastasis or to evaluate the progress of their treatment. The gold particles, which are embedded with dyes allowing their detection by laser spectroscopy, could enhance this technique’s specificity by reducing the number of false positives. The results are published online in the journal Cancer Research. One challenge with detecting CTCs is separating out signals from white blood cells, which are similarly sized as tumor cells and can stick to the same antibodies normally used to identify tumor cells. Commercially available devices trap CTCs using antibody-coated magnetic beads, and technicians must stain the trapped cells with several antibodies to avoid falsely identifying white blood cells as tumor cells. Emory and Georgia Tech researchers show that polymer-coated and dye-studded gold particles, directly linked to a growth factor peptide rather than an antibody, can detect circulating tumor cells in the blood of patients with head and neck cancer. “The key technological advance here is our finding that polymer-coated gold nanoparticles that are conjugated with low molecular weight peptides such as EGF are much less sticky than particles conjugated to whole antibodies,” says Shuming Nie, PhD, a professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech [...]

Oral Cancer Foundation News Team - A2011-02-11T14:42:46-07:00February, 2011|Oral Cancer News|

DoD asks troops to kiss the spit goodbye

Source: www.tradingmarkets.com Author: staff When the U.S. Department of Defense (DoD) weighs in on kissing and spitting, it's with good reason--two good reasons, in fact: love and health. Using smokeless tobacco--spit, dip, chew, snus, etc.--can pose a stinky, unsavory obstacle to sharing a kiss with a loved one, parent, child or sweetheart. It also may cause a slew of serious health problems. That's why DoD/TRICARE(R) wants military personnel to participate in the Great American Spit Out (GASpO) on February 24, 2011, and kiss the spit goodbye for a day. Some 19 percent of 18- to 24-year-old men in the armed forces use smokeless tobacco, more than double the national rate. To help cut that number down, the DoD Quit Tobacco--Make Everyone Proud campaign at http://www.ucanquit2.org is focusing this month on helping those who spit and chew tobacco to develop a personalized quit plan and to take action that may get them more kisses and help them gain more years of a healthy life. "Many of our servicemen started using smokeless tobacco at a young age due to peer pressure and became addicted before realizing the negative effects it could have on their personal relationships and health," said Cmdr. Aileen Buckler, M.D., M.P.H., U.S. Public Health Service officer and chairman of the DoD Alcohol and Tobacco Advisory Committee. Throughout the month, the DoD website will host a special GASpO page, http://www.ucanquit2.org/facts/gaspo/, where service members can publicly post their pledge to quit. Capt. Larry N. Williams, U.S. Navy tobacco clinical cessation champion, [...]

Oral Cancer Foundation News Team - A2011-02-11T14:22:13-07:00February, 2011|Oral Cancer News|

Tobacco companies expand their epidemic of death

Tobacco companies expand their epidemic of death on Feb 10, Philip Morris International will report their 2010 full-year results. We guess that they will make much of their claim to sell their products in 160 countries worldwide. Tobacco is a good global business to be in. Last week saw Imperial Tobacco report increases in sales of cigarettes to Africa, the Middle East, and Asia Pacific. The company’s share price rose steeply. One newspaper reported that “Imperial declared it was increasing the [share] dividend on the back of its strengthening position”. Analysts said forecasts that smoking was on the decline had been “overdone”. Go to Imperial Tobacco’s website and you will find boasts that sales are up 10% in Saudi Arabia, Ukraine, and Russia. New markets are opening up—in South Korea, for example. Sales are on the rise in Laos and Vietnam. And across Africa, the Middle East, eastern Europe, and Asia Pacific, revenues increased to £2·34 billion last year. For companies like Philip Morris and Imperial Tobacco—selling, addicting, and killing, surely the most cruel and corrupt business model human beings could have invented—it is not surprising that they see “many opportunities for us to develop our business” in vulnerable low-income and middle-income countries. Without a trace of irony or shame, Imperial’s management team reported to investors last week that the company won a Gold Award rating in a 2009 corporate responsibility index. Yet tobacco executives know they are peddling death. If one tries to view Imperial’s investor presentation, several slides are now blank. Why? Imperial says “because we do not feature tobacco product imagery on our website”. While tobacco companies such as Philip Morris and Imperial Tobacco spread [...]

Oral Cancer Foundation News Team - A2011-02-11T12:15:06-07:00February, 2011|Oral Cancer News|

Probe into ‘late cancer diagnoses’

Source: Google News An urgent independent inquiry is to investigate how 15 cancer patients examined at Belfast's Royal School of Dentistry may have received late diagnoses. Health Minister Michael McGimpsey apologised for the failings which emerged after the review of a consultant's work. Professor Philip Lamey has now been removed from his post and is due to face a hearing at the General Dental Council later this year. The Belfast Health and Social Care Trust has already identified concerns over 22 patients, 15 of whom had cancer, and last week recalled an additional 117 people to have their cases reviewed as a precautionary measure. "I want to take this opportunity to apologise to all patients who may have had delays in their diagnosis," the minister told the Assembly. "The public must have confidence that their treatment will be responsive, rapid and of the highest quality." "For the vast majority of people their experiences will reflect high quality care. However, when this care falls short, every possible step must be taken to ensure that patients are informed and any failings are addressed quickly to avoid any unnecessary pain and distress." He added: "I have to say that I share the shock and concern that the public will rightly feel about this matter. I am very unhappy about the distress caused to patients and the handling of this matter." Concerns were first raised about the consultant's work in late 2009 when it emerged that six patients with oral cancer had potentially received [...]

Oral Cancer Foundation News Team - A2011-02-11T09:52:48-07:00February, 2011|Oral Cancer News|

Cancer vaccinations for boys by 2012?

Source: Star Observer The Pharmaceutical Benefits Advisory Committee (PBAC) will determine if the human papillomavirus (HPV) vaccine, Gardasil, should be included in the National Immunisation Program for boys. Gardasil is currently administered to girls when they begin high school to prevent cervical cancer. HPV, however, also causes throat cancer, genital and anal warts, and cancer of the penis. Gardasil is approved in Australia for use in boys and men aged nine to 26. Without subsidy, it costs $450 a treatment, and most parents are unaware of the protection it offers boys. Professor Andrew Grulich, of the National Centre in HIV Epidemiology and Clinical Research, told the Star Observer that few boys outside those from medical families were being immunised. “The boys who are getting it more than any others are the sons of doctors because doctors are aware of the enormous benefits of this vaccine for boys,” Grulich said. “There is absolutely no doubt it will prevent most anal cancer, that it will prevent quite a bit of penile cancer, and that it will prevent almost all anal and genital warts.” Grulich said HPV was now responsible for the lion’s share of cancers in the back of the throat in Australia due to lower rates of smoking, and oral sex growing in acceptability. “Those cancers have been increasing over the last 20 or 30 years. Previously we thought perhaps 20 or 30 percent of those cancers were caused by HPV and now it’s more like 70 percent. “It’s really important [...]

Oral Cancer Foundation News Team - A2011-02-10T11:06:22-07:00February, 2011|Oral Cancer News|

Reirradiation with intensity-modulated radiotherapy in recurrent head and neck cancer.

Source: HighWire- Stanford University In this retrospective investigation we analyzed outcome and toxicity after intensity-modulated reirradiation of recurrent head and neck cancer. METHODS: Thirty-eight patients with local recurrent head and neck cancer were evaluated. The median dose of initial radiotherapy was 61 Gy. Reirradiation was carried out with step-and-shoot intensity-modulated radiotherapy (median dose: 49 Gy). RESULTS: Median overall survival was 17 months, and the 1- and 2-year overall survival rates were 63% and 34%. The 1- and 2-year local control rates were 57% and 53%. Distant spread occurred in 34%, and reirradiation induced considerable late toxicity in 21% of the patients. Thirty-two percent showed increased xerostomia after reirradiation. The risk for xerostomia was significantly higher for cumulative mean doses of ?45 Gy to parotid glands. Considering median cumulative maximum doses of 53 Gy to the spinal cord and 63 Gy to the brainstem, no late toxicities were observed. CONCLUSIONS: Reirradiation with intensity-modulated radiotherapy in recurrent head and neck cancer is feasible with acceptable toxicity and yields encouraging rates of local control and overall survival. � 2011 Wiley Periodicals, Inc. Head Neck, 2011.

Oral Cancer Foundation News Team - A2011-02-09T11:45:36-07:00February, 2011|Oral Cancer News|

Cancer incidence, deaths expected to double by 2030 without preventive measures

Source: HemOnc Today In a report released for World Cancer Day, the American Cancer Society said worldwide cancer incidence will increase to 21.4 million diagnoses per year, with 13.2 million cancer deaths, by 2030 unless preventive measures are adopted worldwide. ACS attributes the predicted increase in diagnoses and death to an aging world population and a rise in lifestyle- and behavior-related cancers such as lung, breast and colorectal disease caused by improved economic development. The findings come from the second edition of “Global Cancer Facts & Figures” and its academic publication, “Global Cancer Statistics,” published in CA: A Cancer Journal for Clinicians. Both publications were released Feb. 4, World Cancer Day. The International Agency for Research on Cancer estimates that there were approximately 12.7 million new cancer diagnoses and 7.6 million cancer deaths worldwide in 2008. OCF More than half of those diagnoses, 7.1 million, occurred in developing countries, and those countries accounted for 4.8 million cancer deaths. The agency took a specific look at cancer in Africa. The continent accounted for approximately 681,000 new cancers and 512,400 deaths in 2008. In keeping with worldwide trends, those numbers are projected to double by 2030 because of population growth and the aging of the population. Writing in an accompanying editorial, Otis W. Brawley, MD, ACS chief medical officer, said roughly one-third of cancer deaths in 2008 could be attributed to known risk factors, including tobacco use, physical inactivity, diet, infection and alcohol use. “The worldwide application of existing cancer control knowledge [...]

Oral Cancer Foundation News Team - A2011-02-09T11:41:43-07:00February, 2011|Oral Cancer News|

Physicians Say Good Riddance to ‘Worst Drug in History’

Source: Medscape Today By: Allison Gandey An estimated 10 million patients have used the pain reliever propoxyphene and were sent scrambling to doctors' offices when it was recently pulled from the market. Many physicians are still dealing with the aftermath of the product, first approved by the US Food and Drug Administration (FDA) in 1957. "Propoxyphene is the worst drug in history," Ulf Jonasson, doctor of public health, from the Nordic School in Gothenburg, Sweden, told Medscape Medical News. The researcher played a role in the decision to stop the pain reliever in the United Kingdom, Sweden, and later in the entire European Union. "No single drug has ever caused so many deaths," Dr. Jonasson said. Clinicians are now prescribing analgesic alternatives to propoxyphene. Propoxyphene was banned in the United Kingdom 5 years ago because of its risk for suicide. It was taken off the market in Europe in 2009 over concerns about fatal overdoses and now in the United States for arrhythmias. "I agree that propoxyphene is among the worst drugs in history," Eduardo Fraifeld, MD, president of the American Academy of Pain Medicine, said in an interview. "I'm surprised it stayed on the market so long. It's addictive, in my experience not very effective, and toxic." "I'd probably add Demerol to the list too," Dr. Fraifeld said. "It's toxic and sedating, and my personal opinion is it should not be used at all." Also known as pethidine, Demerol was the first synthetic opioid synthesized in 1932 as a [...]

Oral Cancer Foundation News Team - A2011-02-07T12:51:33-07:00February, 2011|Oral Cancer News|

Dog Sniffing Out Cancer May Lead to Early Detection Test

Source: Medscape Today By: Zosia Chustecka The latest study demonstrating that dogs can sniff out cancer has confirmed the notion that a specific cancer smell does exist, and has added fuel to the idea of developing a test based on odor. Previous studies have reported on dogs that can detect lung and breast cancer from breath samples, and there has been anecdotal evidence suggesting that dogs can detect melanoma, bladder, and ovarian cancers. In this latest study, published online January 31 in Gut, a Labrador retriever was trained over several months to sniff out colorectal cancer in breath and watery stool samples. Hideto Sonoda, MD, and colleagues from Kyushu University in Fukuoka, Japan, report that this dog was then tested with samples obtained from colorectal cancer patients and from volunteers, some of whom had gastrointestinal problems such as ulcers and inflammatory bowel disease. The dog correctly identified cancer in 33 of 36 breath tests and in 37 of 38 stool tests. This equates to 95% accuracy overall for the breath test and 98% accuracy overall for the stool test, the researchers report. The highest detection rates were among samples taken from patients with early-stage cancer, they add. Samples taken from smokers and from people with other gastrointestinal diseases, which might be expected to mask or interfere with cancer odors, did not appear to confuse the dog. "This study shows that a specific cancer scent does indeed exist," the researchers conclude. They are not suggesting using dogs in clinical practice, however. They [...]

Oral Cancer Foundation News Team - A2011-02-07T12:28:00-07:00February, 2011|Oral Cancer News|