Hall of Fame Slugger, Killebrew Enters Hospice Care

Source: Yahoo News MINNEAPOLIS – Harmon Killebrew announced Friday that he no longer plans to fight his esophageal cancer and has settled in for the final days of his life, saddening friends and fans of the 74-year-old Hall of Fame slugger. In a statement released jointly by the Minnesota Twins and the National Baseball Hall of Fame, Killebrew said "it is with profound sadness" that he will no longer receive treatment for the "awful disease." He said the cancer has been deemed incurable by his doctors and he will enter hospice care. "With the continued love and support of my wife, Nita, I have exhausted all options," Killebrew said. He added: "I have spent the past decade of my life promoting hospice care and educating people on its benefits. I am very comfortable taking this next step and experiencing the compassionate care that hospice provides." Killebrew, who's 11th on baseball's all-time home run list with 573, thanked his well-wishers for their support. "I look forward to spending my final days in comfort and peace with Nita by my side," he said. Killebrew lives in the Phoenix area and was receiving treatment at a branch of the Mayo Clinic nearby after his diagnosis in December. He expressed optimism at the time, saying he expected to make a full recovery while acknowledging he was in "perhaps the most difficult battle" of his life. Killebrew was able to travel to Fort Myers, Fla., in March for his annual stint as a guest instructor [...]

New Smokeless Tobacco from Sweden is Gaining Popularity in the US

Source: DrugFree.org A type of smokeless tobacco popular in Sweden called snus is growing in popularity in the United States. While most recognize that it is a safer alternative to cigarettes or older forms of smokeless tobacco, others are concerned that it will attract young people, becoming a steppingstone to cigarettes, says a researcher who spoke this week at the Smokeless Tobacco Summit in Austin, TX. There is also concern that smokers may use snus in places where they can’t smoke, which will encourage them to keep smoking instead of quitting, says Lois Biener, PhD, Adjunct Professor, Department of Psychology at the University Of Massachusetts – Boston and Senior Research Fellow at the Center for Survey Research, University Of Massachusetts – Boston. Snus (pronounced snoos) was first introduced in several U.S. test markets in 2006, and has been available nationwide since 2009. It is sold under several brands including Marlboro Snus and Camel Snus. The product is different from other types of smokeless tobacco in several important ways, Dr. Biener says. Snus is manufactured using a process that makes it lower in carcinogens called tobacco-specific nitrosamines. Snus also doesn’t stimulate saliva the way that snuff does and thus doesn’t require spitting. A person using snus puts a small pouch filled with the product between the lip and the gum. Dr. Biener’s research has shown that the primary group of snus users in the United States is male smokers. “There is very little trial of the product among females and virtually [...]

Alcohol may lower oral cancer risk in older women

Source: www.drbicuspid.com Author: staff Contrary to previous research, postmenopausal women are not more vulnerable than men to alcohol-induced carcinogenesis in the oral cavity, according to a new study in Oral Oncology (May 5, 2011). While it has been well documented that alcohol consumption is a strong risk factor for oral cancer, "an ambiguous biphasic impact of moderate and excessive alcohol intake on the risk of upper aerodigestive tract cancers" also has been published, according to researchers from Semmelweis University in Budapest. To clarify the dose-related risk of alcohol consumption for oral cancer in men and women, they studied 608 nonsmoker patients (466 males and 142 females) with squamous cell oral carcinomas and 406 nonsmoker tumor-free controls (264 males and 142 females). The researchers recorded the drinking habits of both groups, dividing them into abstinent, moderate, and excessive consumers of alcohol. Blood glucose levels in male and female cases and the menopausal state of the women also were registered. The researchers found that while excessive alcohol consumption was a strong risk factor for both sexes, moderate alcohol intake proved to be an oral cancer risk for men but it decreased the risk for women. However, elevated blood glucose levels proved to be a risk factor for the predominantly postmenopausal women but did not affect the oral cancer risk among the men. These findings suggest that increased insulin sensitivity and higher estrogen levels are advantageous systemic effects of moderate alcohol intake and might reduce the risk for oral carcinoma in postmenopausal women, [...]

Ultrasound as effective as CT scans for most diagnoses, reducing the dangers of radiation

Source: www.medicalnewstoday.com Author: staff For diagnosing head and neck ailments, tests that use radiation are always less desirable than those that don't. Otolaryngologists have a wide range of techniques available to them, including CT or "CAT" scans, MRI and ultrasound. CT uses significant radiation and MRI a lower amount, but ultrasound is a non-invasive, non-radiating technique. It does not require injection of radioactive contrast material and has no side effects. Now, a new study by Tel Aviv University exploring the efficacy of expensive and invasive CT scans has found that, in some cases, they don't offer a clinical advantage over a simple, inexpensive ultrasound procedure. In his study, Dr. Michael Vaiman of Tel Aviv University's Sackler Faculty of Medicine compared the efficacy of CT versus ultrasound scans for locating vertebral arteries in the throat, an important assessment that must be completed before a surgeon operates in the neck area of the body. After comparing the outcomes of 250 CT scans with 500 ultrasound images, he concluded that there is no advantage to using CT scans for most of these procedures, especially those that are used to locate anomalies in the neck to map major arteries before surgery can take place. Dr. Vaiman's results were published in the March issue of the European Archives of Oto-Rhino-Laryngology. When scans are sound CT scans combine X-rays with highly sophisticated computers to produce a number of pictures of the interior of the body. Traditionally, doctors have relied on these scans to find neck arteries [...]

Tobacco is Estimated to Kill a Billion People in this Century

Source: San Francisco Chronicle For all the debate and pain and money expended on our ongoing "drug war' - which is too much a failing, endless one - the worst drug of all is too often unmentioned, but kills and maims more than the rest of them put together. And it's legal. Tobacco abuse is projected to cause a billion premature deaths in this century; To put it another way, until and unless we have a nuclear war, the tobacco industry will continue killing more people than any other man-made cause. This true in just about any region, but here in California, there are nearly four million smokers, and as the American Lung Association reminds us, "Tobacco-related illness remains the number one preventable cause of death in the state, responsible for more than 36,000 deaths each year - that's more people lost to tobacco than alcohol, HIV/AIDS, car crashes, illegal drugs, murders, and suicides combined." The national toll is about 438,000 deaths per year. One of them was my dad, but I hated tobacco long before it claimed him. In any event, the annual UCSF Center for Tobacco Control Research and Education symposium again keyed off on the "billion lives" estimate and showcased ongoing efforts to apply research to decreasing that daunting figure. This year, American Cancer Society CEO John Seffrin. PhD said that the 12 million cigarettes smoked each minute meant an ever-increasing morbidity and mortality, despite whatever progress, with a tripling of disease and death in the developing [...]

HPV and EGFR are hottest topics in head and neck cancer

Source: www.medscape.com Author: Zosia Chustecka The hottest topic in head and neck cancers is the role of human papillomavirus (HPV) in the disease, although there is also a lot interest in treatment with EGRF inhibitors, especially the second-generation products, according to an expert here at the European Society for Therapeutic Radiology and Oncology 11th Biennial Conference. HPV has only been associated with head and neck cancer in the last few years, but it is now clear that patients who are positive for the virus have a better prognosis, said Cai Grau, MD, DMSC, professor of oncology at Aarhus University Hospital, Denmark. He chaired a session during which both hot topics were discussed. "These patients have a better prognosis, irrespective of treatment, and their risk of a second cancer is virtually zero," added session participant Lisa Licitra, MD, medical oncologist at the Istituto Nazionale per lo Studio e la Cura dei Tumori in Milan, Italy. However, there is a difference between patients in the United States and those in Europe with regard to risk, she told meeting attendees. For American patterns, Dr. Licitra cited the analysis published last year in the New England Journal of Medicine (2010;363:24-35), which reported a risk model for death from oropharyngeal squamous cell carcinoma on the basis of HPV status, pack-years of tobacco smoking, and tumor and nodal stage. In this 266-patient cohort, 43% were low risk, 30% were intermediate risk, and 27% were high risk. Dr. Licitra reported that when she performed the same analysis [...]

High Interest in HPV and EGRF When Referring to Head and Neck Cancer

Source: MedScape Today May 12, 2011 (London, United Kingdom) — The hottest topic in head and neck cancers is the role of human papillomavirus (HPV) in the disease, although there is also a lot interest in treatment with EGRF inhibitors, especially the second-generation products, according to an expert here at the European Society for Therapeutic Radiology and Oncology 11th Biennial Conference. HPV has only been associated with head and neck cancer in the last few years, but it is now clear that patients who are positive for the virus have a better prognosis, said Cai Grau, MD, DMSC, professor of oncology at Aarhus University Hospital, Denmark. He chaired a session during which both hot topics were discussed. "These patients have a better prognosis, irrespective of treatment, and their risk of a second cancer is virtually zero," added session participant Lisa Licitra, MD, medical oncologist at the Istituto Nazionale per lo Studio e la Cura dei Tumori in Milan, Italy. However, there is a difference between patients in the United States and those in Europe with regard to risk, she told meeting attendees. For American patterns, Dr. Licitra cited the analysis published last year in the New England Journal of Medicine (2010;363:24-35), which reported a risk model for death from oropharyngeal squamous cell carcinoma on the basis of HPV status, pack-years of tobacco smoking, and tumor and nodal stage. In this 266-patient cohort, 43% were low risk, 30% were intermediate risk, and 27% were high risk. Dr. Licitra reported that when [...]

New Breath Test to Identify Head and Neck Cancer

Source: British Journal of Cancer M Hakim, S Billan, U Tisch, G Peng, I Dvrokind, O Marom, R Abdah-Bortnyak, A Kuten and H Haick Abstract Background: Head-and-neck cancer (HNC) is the eighth most common malignancy worldwide. It is often diagnosed late due to a lack of screening methods and overall cure is achieved in <50% of patients. Head-and-neck cancer sufferers often develop a second primary tumour that can affect the entire aero-digestive tract, mostly HNC or lung cancer (LC), making lifelong follow-up necessary. Methods: Alveolar breath was collected from 87 volunteers (HNC and LC patients and healthy controls) in a cross-sectional clinical trial. The discriminative power of a tailor-made Nanoscale Artificial Nose (NA-NOSE) based on an array of five gold nanoparticle sensors was tested, using 62 breath samples. The NA-NOSE signals were analysed to detect statistically significant differences between the sub-populations using (i) principal component analysis with ANOVA and Student's t-test and (ii) support vector machines and cross-validation. The identification of NA-NOSE patterns was supported by comparative analysis of the chemical composition of the breath through gas chromatography in conjunction with mass spectrometry (GC–MS), using 40 breath samples. Results: The NA-NOSE could clearly distinguish between (i) HNC patients and healthy controls, (ii) LC patients and healthy controls, and (iii) HNC and LC patients. The GC–MS analysis showed statistically significant differences in the chemical composition of the breath of the three groups. Conclusion: The presented results could lead to the development of a cost-effective, fast, and reliable method for the differential [...]

HPV Becomes a Major Topic for Researchers as a Source of Oral Cancers

By Andy Blatchford, The Canadian Press MONTREAL — Amid Michael Douglas's personal and philanthropic battle with throat cancer, the Oscar-winning actor is shedding light on a viral form of the disease lurking in a growing number of mouths. Oral cancer has long been linked to tobacco and alcohol use, but an expanding body of research suggests human papillomavirus, or HPV, is an increasing cause of the deadly disease. The culprit behind the sexually transmitted virus' emergence in mouth and throat cancers? Experts say a major factor is the prevalence of oral sex. More and more researchers have cast their microscopes on the mysteries of HPV-caused oral cancers, including McGill University, which received a big fundraising boost last week with the help of Douglas. The grateful actor, diagnosed with throat cancer last year in a Montreal hospital, volunteered to headline a charity event for the McGill Head and Neck Cancer Fund. The 66-year-old, who calls himself a "poster boy" for head-and-neck cancer, has blamed alcohol as a likely source of his illness, not HPV. Still, a portion of the $2 million amassed at the event will support HPV-caused oral cancer research. The doctor who first detected the walnut-sized tumour in Douglas's throat said the fund has supported HPV projects in the past and more are in the works. "This is an area of increasing incidence," Dr. Saul Frenkiel said of HPV-caused oral cancer at the university-affiliated hospital where he treated Douglas. Although relatively rare, the Canadian Cancer Society estimates oral cancers, [...]

New Research Shows Chemo Brain Could Last More Than 5 Years

Source: New York Times “Chemo brain,” the foggy thinking and forgetfulness that cancer patients often complain about after treatment, may last for five years or more for a sizable percentage of patients, new research shows. The findings, based on a study of 92 cancer patients at Fred Hutchinson Cancer Research Center in Seattle, suggest that the cognitive losses that seem to follow many cancer treatments are far more pronounced and longer-lasting than commonly believed. The study, published in The Journal of Clinical Oncology, is a vindication of sorts for many cancer patients, whose complaints about thinking and memory problems are often dismissed by doctors who lay blame for the symptoms on normal aging or the fatigue of illness. “It’s clearly established now that chemo brain does exist and can continue long-term,” said Karen L. Syrjala, co-director of the Survivorship Program at Fred Hutchinson and the study’s lead author. “The real issue here is that recovery from cancer treatment is not a one-year process but a two- to five-year process. People need to understand the extent to which the cells in their bodies have really been compromised by not only the cancer, but also the treatment.” The 92 patients in the study had all undergone chemotherapy as part of bone marrow or stem cell transplants to treat blood cancers. Although the range of effects of different cancers and treatments probably varies, researchers said the finding that cognitive recovery can take five years or more is likely to apply to breast cancer [...]

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