2/2/2005 New York, NY Journal of Clinical Oncology January 2005 as reported by Medscape (www.medscape.com) Chemotherapy combined with chemoradiotherapy allows organ preservation in patients with advanced resectable cancer of the tongue or hypopharynx, according to a report in the January 1st issue of the Journal of Clinical Oncology. The base of the tongue and hypopharynx are good candidates for organ preservation because of the potential compromise of speech and swallowing resulting from surgery, the authors explain. Dr. Susan G. Urba from University of Michigan Medical Center, Ann Arbor, and colleagues investigated the benefits of two cycles of induction chemotherapy followed by chemoradiotherapy for responders in a phase II trial of 59 patients with advanced resectable cancer of the tongue base (n=37) or hypopharynx (n=22). Fifty-eight percent had stage IV and 42% had stage III disease. Seventy-eight percent of the patients had a 50% or greater response to induction chemotherapy at their primary tumor site, the authors report. Of the 43 patients that went on to receive concurrent chemoradiotherapy, 32 (54%) achieved a documented histologic complete response, the results indicate, and 9 additional patients achieved a complete clinical response, but did not undergo the recommended biopsies. Overall, the researchers note, 44 patients (75%) were deemed organ preservation successes; they did not require salvage surgery of the primary tumor immediately following completion of the treatment because of their excellent responses to therapy. Apart from one death attributed to the induction chemotherapy, the report indicates, the treatment was well tolerated, the researchers report. [...]

2/2/2005 Richard C. Semelka, MD Medscape Radiology Medscape Radiology Editor's Note: Richard Semelka, MD, is one of the preeminent practitioners of abdominal MRI in the United States and is a frequent contributor to Medscape Radiology. The hot-button issues raised in this opinion piece call into question some of the current practices surrounding the use of CT scanning. It's the opinion of this editor that a topic of importance, such as the safety and health of patients referred for diagnostic imaging evaluation, merits a broad dialogue in an open, spontaneous, and timely forum. --------------------------- Hippocrates is credited with the expression "First, do no harm" (ca 460-ca 377 B.C.), which has become the oath of all physicians in their doctoral graduation. The radiology community adheres to the fundamental precept of ALARA (as low as reasonably achievable) in order to limit patients' exposure to harmful radiation. "First, Do No Harm": The Present-Day Fallacy In recent years, there has been an increased awareness of the rights of patients and their need for information and protection. The regulations of the recently implemented Health Insurance Portability and Accountability Act (HIPAA) is one example of efforts to protect patients. The obligation of physicians to provide information on diseases and treatment options has always been important, but has come under greater emphasis in the modern medical environment. Despite this, one egregious example in which patients are not provided sufficient information to make informed decisions on their healthcare involves the limited information provided to them on diagnostic imaging tools, [...]

2/1/2005 JB Thomsen, JA Sorensen, and A Krogdahl J Oral Pathol Med, February 1, 2005; 34(2): 65-9 Background: Sentinel lymph node biopsy, step sectioning and immunohistochemistry have changed detection of tumor deposits. Isolated tumor cells (ITC) are detected more frequently than earlier because of a changed level of detection. Methods: A total of 108 sentinel lymph nodes from 30 patients with T1/T2 cN0 oral cancer were re-classified histologically to find possible ITC and to describe technical pitfalls. Results: Primarily we found metastatic spread in 12 of 108 sentinel lymph nodes: five macrometastasis and seven micrometastasis. After re-classification, we found seven lymph nodes with macrometastasis, five with micrometastasis and two with ITC. Conclusion: The ITC are probably precursors of micrometastasis waiting to grow and should be treated as such. Benign inclusions and dendritic cells did not cause problems, but can mimic ITC.

1/30/2005 Bruce Ames and Lois Swirsky Gold "Cancer Prevention and the Environmental Chemical Distraction" This is an edited version of a chapter titled 'Cancer Prevention and the Environmental Chemical Distraction', by Bruce Ames and Lois Swirsky Gold, in Politicizing Science: the Alchemy of Policymaking, Michael Gough ed., Hoover Institute Press, Stanford, California (2003). Blaming synthetic chemicals for a 'cancer epidemic' is flawed science that makes for dubious policy. Entering a new millennium seems a good time to challenge some old ideas about cancer cause and prevention, which in our view are implausible, have little supportive evidence, and might best be left behind. In this essay, we summarise data and conclusions from 15 years of work, raising five issues that involve toxicology, nutrition, public health, and US government regulatory policy: 1. There is no cancer epidemic other than that due to smoking. 2. The dose makes the poison. Half of all chemicals tested, whether natural or synthetic, cause cancer in high-dose rodent cancer tests. Evidence suggests that this high rate is due primarily to effects that are unique to high doses. The results of these high-dose tests have been used to regulate low-dose human exposures, but are not likely to be relevant. 3. Even Rachel Carson was made of chemicals: natural v synthetic chemicals. Human exposure to naturally occurring rodent carcinogens is ubiquitous and dwarfs the exposure of the general public to synthetic rodent carcinogens. 4. Errors of omission. The major causes of cancer (other than smoking) do not involve exposures [...]

1/30/2005 www.advocate.com Diane Harper, a researcher at Norris Cotton Cancer Center in Lebanon, N.H., has studied the link between human papillomavirus infection and cervical cancer for 20 years. Harper now believes she may have found a vaccine that protects against the two strains of HPV that are linked to 70% of cervical cancers. The vaccine, made by GlaxoSmithKline, was tested from 2000 to 2003 on 1,113 women ages 15 to 25 from the United States, Canada, and Brazil. In women who received three injections and follow-up testing, the vaccine was 100% effective. In those who received only one or two injections, the vaccine proved to be 91% effective. The vaccine offers protection for three to five years. No side effects, except for pain or redness at the injection site, were reported, said Harper, who added that she is an independent researcher and is not paid by GlaxoSmithKline. "It offers such an advantage for women and such a change in health care, one that we will actually see in the next five years," Harper said of the vaccine. If approved by the Food and Drug Administration, it could be available early next year. "I'm extremely excited about the possibilities." According to preliminary findings, said Harper, the vaccine may protect against HPV-associated diseases such as anal cancer, vaginal cancer, vulvular cancer, esophageal cancer, abnormal Pap smears, and mouth or oral cancer. "It's going to take us 20 to 30 years to get the data, but we're really hopeful this has long-term protective [...]

1/30/2005 U.S. Dept. of Health & Human Services: Report on Carcinogens, 9th edition For the first time alcoholic beverages have been listed as a known human carcinogen by the U.S. Department of Health and Human Services in its "Report on Carcinogens" 9th edition. The report states that consumption of alcoholic beverages is causally related to cancers of the mouth pharynx larynx and esophagus and that studies indicate that the risk is most pronounced among smokers and at the highest levels of consumption. The effect of a given level of alcoholic beverage intake on cancers of the head and neck is influenced by other factors, especially smoking, but that smoking does not explain the increased cancer hazard associated with alcoholic beverage consumption according to the report. There is evidence that suggests a link between alcoholic beverage consumption and cancer of the liver and breast. Potential Hazard The report was first ordered by Congress in 1978 to educate both the public and health professionals in the recognition that many cancers are apparently induced by chemicals in the home workplace general environment and from the use of certain drugs. It identifies "potential" cancer hazards. A listing in the report does not by itself establish that a substance presents a cancer risk to an individual in daily life, according to press releases. However the "known" category is reserved for those substances for which there is sufficient evidence of carcinogenicity from studies in humans that indicates a cause and effect relationship between the exposure and [...]

1/27/2005 CL Hashimoto et al. Am J Gastroenterol, February 1, 2005; 100(2): 275-82 Objective: Patients with primary head and neck cancer show a predisposition to develop esophageal cancer. The aim of this study was to investigate in these patients: the prevalence of esophageal cancer comparing the value of chromoendoscopy using Lugol's solution examination to standard endoscopy, in the early diagnosis of esophageal cancer. Methods: Prospective observational study at a state general university hospital in Sao Paulo, Brazil. 326 consecutive adult patients with primary head and neck cancer were evaluated. A standard endoscopy was performed, followed by a 2% lugol's dye spray chromoendoscopy and histopathologic study. The prevalence of esophageal cancer was defined. The results of the two endoscopic methods were compared. Results: Twenty-four patients with esophageal cancer and high-grade intraepithelial neoplasia were detected and had a prevalence of 7.36%. Chromoendoscopy and standard endoscopy were equivalent to the diagnosis of advanced and invasive esophageal cancer. However, standard endoscopy diagnosed 55% of high-grade intraepithelial neoplasia, in comparison to chromoendoscopy that detected 100%. Conclusions: Patients with primary head and neck cancer should be considered as high risks for the presence of esophageal cancer. Lugol's dye chromoendoscopy diagnosed high-grade intraepithelial neoplasia, which went unnoticed with standard endoscopy. It permits a more exact detection of lesion boundaries and facilitates a more precise targeting of biopsy fragments. Authors: CL Hashimoto, K Iriya, ER Baba, T Navarro-Rodriguez, MC Zerbini, JN Eisig, R Barbuti, D Chinzon, and JP Moraes-Filho Authors' affiliation: Department of Gastroenterology, Faculty of Medicine, University [...]

1/27/2005 TJ Belbin et al. Arch Otolaryngol Head Neck Surg, January 1, 2005; 131(1): 10-8 Objective: To assess gene expression changes associated with tumor progression in patients with squamous cell carcinoma of the oral cavity. Design: A microarray containing 17 840 complementary DNA clones was used to measure gene expression changes associated with tumor progression in 9 patients with squamous cell carcinoma of the oral cavity. Samples were taken for analysis from the primary tumor, nodal metastasis, and "normal" mucosa from the patients' oral cavity. Setting: Tertiary care facility.Patients Nine patients with stage III or stage IV untreated oral cavity squamous cell carcinoma. RESULTS: Our analysis to categorize genes based on their expression patterns has identified 140 genes that consistently increased in expression during progression from normal tissue to invasive tumor and subsequently to metastatic node (in at least 4 of the 9 cases studied). A similar list of 94 genes has been identified that decreased in expression during tumor progression and metastasis. We validated this gene discovery approach by selecting moesin (a member of the ezrin/radixin/moesin [ERM] family of cytoskeletal proteins) and one of the genes that consistently increased in expression during tumor progression for subsequent immunohistochemical analysis using a head and neck squamous cell carcinoma tissue array. Conclusion: A distinct pattern of gene expression, with progressive up- or down-regulation of expression, is found during the progression from histologically normal tissue to primary carcinoma and to nodal metastasis. Authors: TJ Belbin, B Singh, RV Smith, ND Socci, VB Wreesmann, [...]

1/27/2005 Richard L Holloway et al. Head Neck, January 24, 2005 Background: To identify and rate the importance of several psychosocial and physiologic influences on quality of life (QOL) among a cohort of 5-year head and neck cancer survivors, we conducted a cross-sectional study of a convenience sample that used both questionnaires and physiologic evaluations. Methods: QOL was assessed by the Functional Assessment of Cancer Therapy (FACT) and the FACT Head and Neck additional concerns (FACT-H&N) questionnaires. Psychosocial characteristics (or risk factors) potentially influencing QOL were measured by the Millon Behavioral Health Inventory (MBHI) and the Social Support Questionnaire (SSQSR). Physiologic risk factors were measured in examinations that included shoulder and neck range of motion, whole and stimulated saliva measurements, and oropharyngeal swallowing efficiency. We evaluated the association of selected QOL measures with three groups of potential risk factors: psychosocial factors, consisting of selected MBHI and SSQSR scales; physiologic factors, consisting of selected physical ability measures; and a combination of psychosocial/physiologic factors. Results: The entire study population of 105 subjects completed the FACT and FACT-H&N questionnaires; 86 of these completed the physiologic tests as well. Combined psychosocial/physiologic models best predicted all QOL measures considered. Psychosocial models alone, compared with physiologic models alone, better predicted FACT physical and social/family well-being measures. Physiologic models alone, compared with psychosocial models alone, better predicted FACT-H&N additional concerns measures. Premorbid pessimism (MBHI) was consistently the best predictor of QOL measures. Conclusions: Both psychosocial and physiologic factors influence QOL in patients with head and neck cancer, [...]

1/27/2005 Larry K. Kvols, MD Society of Nuclear Medicine Jan 2005 as reported by RedNova.com The ideal radiation sensitizer would reach the tumor in adequate concentrations and act selectively in the tumor compared with normal tissue. It would have predictable pharmacokinetics for timing with radiation treatment and could be administered with every radiation treatment. The ideal radiation sensitizer would have minimal toxicity itself and minimal or manageable enhancement of radiation toxicity. The ideal radiation sensitizer does not exist today. This review outlines the concept of combining 2 modalities of cancer treatment, radiation and drug therapy, to provide enhanced tumor cell kill in the treatment of human malignancies and discusses molecules that target DNA and non-DNA targets. Combining drugs that have unique mechanisms of action and absence of overlapping toxicities with systemically administered radiotherapy should be exploited in future clinical trials. This is an exciting time in clinical oncology research, because we have a plethora of new molecules to evaluate. Surgery, radiation, and chemotherapy have been the mainstays of treatment for human malignancies for more than 40 years. The use of a combination of radiation and chemotherapy is often called chemoradiation in the medical literature. For most of the last 4 decades, this has involved the use of cytotoxic agents with external beam radiation. Recently, however, with newer molecules that target very specific pathophysiology or molecular pathways and the use of radiation delivered systemically by antibodies or hormones labeled with radionuclides, the concept of radiation sensitizers has been expanded. Heidlberger's preclinical [...]