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The UK’s first robotic mouth cancer operation

Source: www.privatehealth.co.uk Author: staff Pioneering surgery which allows doctors to remove cancer in the mouth using a minimally invasive technique is now available at the Wellington Hospital. Traditionally, the only way to remove Squamous Cell Carcinoma – cancer of the oropharynx which encompasses the tonsils and base of the tongue – has been to split the jaw, take out the cancer and repair the neck with tissue from the forearm. This 10-hour procedure requires two surgical teams and often has complications. Patients are in hospital for at least three weeks and need months of rehabilitation to help them swallow and speak again. Because the treatment is so invasive, many doctors try to avoid it using chemotherapy and radiotherapy instead. However, surgery is often the best chance of a cure. The new one-hour technique called Transoral Robotic Surgery allows the cancer to be removed without splitting the jaw or taking tissue from other parts of the body. Instead, the tonsils are accessed through the mouth using a specially designed robotic machine. Developed in the US in 2009 and now approved by the American Food and Drug Administration and licensed for use in the UK, it uses the Da Vinci robot to access this difficult to reach area. It gives the surgeon greater precision, dexterity and accuracy while carrying out the procedure and the patient has no stitches. Infection rates are reduced which speeds up recovery rates, patients are in hospital for just a week and are able to swallow normally soon afterwards [...]

2012-05-30T13:56:28-07:00May, 2012|Oral Cancer News|
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Advaxis recruiting for HPV+ head and neck cancer trial

Source: www.cancertreatment.net Author: Ross Bonander Advaxis is announcing the enrollment of patients into the REALISTIC Phase I/II trial sponsored by Cancer Research UK to evaluate ADXS-HPV for the treatment of HPV-positive head and neck cancer. HPV has been linked to as many as seventy percent of all head and neck cancers. ADXS-HPV is a next-generation immunotherapy that acts as a therapeutic vaccine and is being tested in trials against HPV-associated diseases, including cervical cancers. Cancer Research UK assumes all patient costs. Advaxis seeks to recruit 45 patients. The REALISTIC trial is being carried out at the Aintree Hospital at the University of Liverpool, the Royal Marsden Hospital at the University of London, and the Cardiff Hospital at the University of Wales. Qualified patients will have already received treatment for head and neck cancer, either surgery, radiotherapy, chemotherapy, or a combination of treatments. Head and neck cancers account for roughly three percent of all cancers in the US, according to the American Cancer Society. They are more commonly diagnosed in men than women, and while they are traditionally linked to smoking and to alcohol consumption, HPV-related oropharyngeal cancers are on the rise among white males under 50 years of age. "We are pleased to be working with an internationally-renowned oncology group to further expand the ADXS-HPV clinical development program to another HPV-associated tumor type," said Advaxis Chairman & CEO Thomas A. Moore. "Through this collaboration, we hope that our proprietary technology will be able to offer a new treatment option to [...]

2012-05-24T14:21:07-07:00May, 2012|Oral Cancer News|
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Vitamin B veggies cut risk of mouth cancer

Source: www.dentistry.co.uk Author: staff Women who consume high volumes of folic acid found in vitamin B from vegetables and some fruits are less likely to suffer from mouth cancer. A sample of 87,000 nurses were followed for 30 years from 1976 by researchers from the Columbia University Medical Centre and Harvard School of Public Health. Women who drank a high volume of alcohol and had low folic acid intake were three times more likely to develop mouth cancer than those who drank high volumes of alcohol but had high volumes of folic acid in their diet. Alcohol is one of the major risk factors for mouth cancer and those who drink to excess are four times more likely to be diagnosed. This is the first time that folic acid intake has been shown to affect the risk of the disease. Alcohol leads to a reduction in folic acid metabolism by creating acetaldehyde which leads to a reduction of folic acid in the body. Chief executive of the British Dental Health Foundation, Dr Nigel Carter, said: 'Rates of mouth cancer in women have been increasing for many years as a result of changed social habits with more women smoking and drinking. 'This new research could offer a method to reduce this by looking at the folic acid intake and increasing fruit and vegetables containing folic acid in the diet. “In the past studies have tended to focus on males, as they are twice as likely to suffer from the disease. While [...]

2012-05-20T17:52:11-07:00May, 2012|Oral Cancer News|
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Oral sex may cause more oral cancer than smoking in men, researchers say

Source: www.bloomberg.com Author: Robert Langreth A virus spread by oral sex may cause more cases of throat cancer in men than smoking, a finding that spurred calls for a new large-scale test of a drug used against the infection. Researchers examined 271 throat-tumor samples collected over 20 years ending in 2004 and found that the percentage of oral cancer linked to the human papillomavirus, or HPV, surged to 72 percent from about 16 percent, according to a report released yesterday in the Journal of Clinical Oncology. By 2020, the virus-linked throat tumors -- which mostly affected men -- will become more common than HPV-caused cervical cancer, the report found. HPV is known for infecting genitals. The finding that it can spread to the throat and cause cancer may increase pressure on Merck & Co., the second-largest U.S. drugmaker, to conduct large-scale trials to see if its vaccine Gardasil, which wards off cervical cancer in women, also prevents HPV throat infections. “The burden of cancer caused by HPV is going to shift from women to men in this decade,” Maura Gillison, an oncologist at Ohio State University and study senior author, said in a telephone interview. “What we believe is happening is that the number of sexual partners and exposure to HPV has risen over that same time period.” Gillison said she worked with researchers at Whitehouse Station, New Jersey-based Merck several years ago to design a study in men. After Merck acquired Schering-Plough Corp. in 2009, though, the trial “was canceled,” [...]

2012-05-20T20:54:05-07:00May, 2012|Oral Cancer News|
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Photographer inspires others with throat cancer survival

Source: www.getsurrey.co.uk Author: Rebecca Younger When Thames Ditton photographer, Keith Hern, was diagnosed with throat cancer five years ago, he dealt with it the only way he knew how – by taking pictures. Through an incredibly honest and stark photographic portrayal of his treatment, Keith captured everything from the first bout of chemotherapy at the Royal Marsden Hospital in London to the making of his radiotherapy mask and the eight-inch scar left on his neck after an operation to remove dead cancer cells. The candid imagery appears in Keith’s book, Bangers & Mash, which he started writing shortly after he was first diagnosed in 2007. “I’d started writing a couple of days after diagnosis as the only way I could maintain some semblance of mental control, it would later become therapeutic,” he recounted. “My treatment consisted of five days of 24x7 chemotherapy, 11 days off, five days of chemotherapy again, 11 days off, then radiotherapy for six weeks daily with two top-up chemo sessions in weeks one and five. “Radiotherapy side effects kicked in at the end of week one – I could no longer eat, then lost my taste, then I couldn’t sleep (my mouth was so dry I was sipping water 24x7), I lost two-and-a-half stone in the six weeks.” Keith worked with a Neurolinguistic Programming (NLP) coach to stay positive and it was while talking to her about writing a book of his experiences that the idea for a photo diary came about. “She laughed at the [...]

2012-05-07T08:23:05-07:00May, 2012|Oral Cancer News|
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New method of predicting the spread of throat cancer to other body parts found

Source: starglobaltribune.com Author: staff Independent of other factors, such as smoking history and HPV status, matted lymph nodes appear to signal increased chance of oropharyngeal cancer spreading to other parts of the body. Researchers at the University of Michigan Health System have found a new indicator that may predict which patients with a common type of throat cancer are most likely have the cancer spread to other parts of their bodies. Patients with oropharyngeal squamous cell carcinoma who had “matted” lymph nodes – nodes that are connected together – had a 69 percent survival rate over three years, compared to 94 percent for patients without matted nodes, according to a study published online ahead of print publication in Head & Neck. The oropharynx is an area that includes the back of the tongue, soft palate, throat and tonsils. “The spread of cancer throughout the body accounts for about 45 percent of the deaths from oropharyngeal carcinoma,” says the study’s senior author, Douglas B. Chepeha, M.D., M.S.P.H., an associate professor of otolaryngology head and neck surgery at the U-M Medical School. “Our findings may help doctors identify patients who are at higher risk for having their cancer metastasize and who would benefit from additional systemic therapy. Conversely, some patients without matted nodes may benefit from a reduction of the current standard treatment, which would cut down on uncomfortable side effects.” Notably, the findings indicate an increased risk independent of other established prognostic factors, such as the patient’s history of smoking or [...]

2012-05-07T08:16:13-07:00May, 2012|Oral Cancer News|
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200 Years of surgery: cutting to cure has come a long way

Source: abcnews.go.com Author: Katie Moisse The three-and-a-half-inch tumor in Cynthia Miller's throat threatened to choke her, leaving her no choice but to have it removed. "I had no idea I was even sick," said Miller, 55, who lives in Maitland, Fla. "I woke up in the middle of the night coughing. … The next thing I knew they were booking emergency surgery." Instead of radical surgery -- which would involved cutting her face, pulling teeth and breaking her jaw -- Miller had her tumor removed through her mouth by a miniature robotic arm guided by the surgeon. "With the robot, there are no cuts anywhere. No breathing tube, no broken bones," said Dr. Bert O'Malley, who pioneered the procedure at the University of Pennsylvania's Head and Neck Cancer Center in Philadelphia. "We go in through the mouth with a high-magnification 3-D camera and very small instruments, like a surgeon's fingers but very tiny, and we're able to remove the tumor without the side effects of traditional surgery." Side effects like spasms, difficulty with swallowing and speech, not to mention chronic pain. "The more you disrupt and injure tissue, the greater the risk of dysfunction and chronic problems," said O'Malley. Today's minimally invasive surgery is far different from the procedures of 200 years ago, when surgeons hacked through skin, muscle and bone briskly and brutally without anesthesia or antisepsis. "Pain and the always-looming problem of infection restricted the extent of a surgeon's reach," Dr. Atul Gawande, a surgeon at Brigham and [...]

2012-05-06T12:11:05-07:00May, 2012|Oral Cancer News|
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Ireland: mouth cancer awareness day yields results

Source: http://www.dentistryiq.com/ Author: staff Dentists are emphasizing the importance of early detection with mouth cancer, after 12 cases of the potentially deadly cancer were discovered on Mouth Cancer Awareness Day and one of these was discovered in Waterford. The Irish Dental Association estimates that 10,000 people availed of free mouth cancer examinations carried out by participating dentists countrywide on September 21 of last year. As well as the confirmed cases, 286 people were advised to attend their GP for other related problems. Mouth Cancer Awareness Day was set up by a group of mouth, head and neck cancer survivors in September 2010. It is now a joint initiative by the Irish Dental Association, Irish Cancer Society, Dublin Dental University Hospital, Cork Dental University Hospital, the Dental Health Foundation and Mouth, Head and Neck Cancer Awareness Ireland. The President of the IDA, Conor McAlister said the fact twelve cancers were discovered in one day showed the importance of early detection and the need for everyone to have a regular examination. He said, "Three hundred cases of mouth cancer are detected here each year with 100 deaths and this type of cancer actually kills more Irish people than cervical cancer or skin melanoma. "According to the National Cancer Register in Ireland, roughly 50% of all mouth cancers are diagnosed at an advanced stage. Hopefully the fact these 12 cases have been caught at an earlier stage means the impact on quality of life will be reduced." He added, "This year we saw [...]

2012-05-06T11:25:21-07:00May, 2012|Oral Cancer News|
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Exercise helps cancer patients

Source: www.dailyrx.com Author: staff A small trial shows that rehabilitation therapy for head and neck cancer patients clearly improves their ability to swallow faster, something that's often damaged with the cancer treatment. Intense treatment for cancers of the head and neck often involves both chemotherapy and radiation. With many important muscles involved in the region, preventing the areas targeted by radiation from weakening can be avoided with swallowing exercises. The study compared a control group given no swallowing exercises to another group given the series of targeted rehabilitation therapy. It took nine months for the two groups to have equivalent ability, highlighting the importance of preserving muscle function prior to cancer treatment. Importantly, rehabilitation after cancer treatment can prevent some of the worst side effects, and allows patients to get back to their normal day to day life. The initial damage from cancer treatment was extensive, as both groups had equal ability immediately after cancer therapy. Yet the muscle function rebounded quickly in the rehabilitation group, as results at 3 and 6 months after treatment were improved as a result of the swallowing exercises. The group given exercises also rated themselves as more comfortable eating in public, an important qualifier in showing how well the exercises worked. "With improvements in swallowing function from post-treatment exercises, interest in the use of prophylactic swallowing exercises to prevent or minimize post-CRT swallowing dysfunction has grown" the authors write as background in the study. "Indeed, some cancer treatment centers recommend prophylactic swallowing exercises for [...]

2012-04-30T12:28:50-07:00April, 2012|Oral Cancer News|
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