Charlotte Parker, Author at Oral Cancer News

Oral Cancer Foundation to donate screening devices to free clinics

Phoenix’s Native American Community Health Center Is First Recipient of adjunctive screening system Newport Beach, CA - October 5, 2009 The Oral Cancer Foundation recently initiated a program of donating VELscope Oral Cancer Screening Systems to free clinics and others located in, and helping communities with, underserved populations. The first recipient of this program is the Native American Community Health Center, commonly known as Native Heath, in Phoenix, Arizona, a 501(c)3 non-profit organization. According to Oral Cancer Foundation executive director Brian Hill, “Our intent is to identify free clinics and health service providers in areas that have a high concentration of people who are both at risk for oral cancer and without the financial means to pay for comprehensive oral exams.” The Foundation is also careful to ensure that any clinic receiving aid in the form of equipment and materials has at least one dentist on staff that is regularly present to see patients. Native Health’s Dental Director, Dr. Mahasin Hangalay, believes it would be hard to find an area with a greater need for regular oral cancer screenings. “The Native American community that we serve has the highest rate of tobacco usage of any major demographic group in the country,” she said, “as well as an extremely high poverty rate and very poor access to health care.” The doctor also noted that because of the reported link between oral cancer and the sexually transmitted human papilloma virus, screenings at the clinic are not just provided to tobacco users, but [...]

Charlotte Parker2009-10-05T15:08:42-07:00October, 2009|OCF In The News, Oral Cancer News|

Initial COIN study results presented at European Oncology Congress

Source: Drugs.com Author: Staff • Results inconsistent with data from all Erbitux pivotal studies • Further analyses planned by the Medical Research Council that conducted the independent COIN study Berlin/Darmstadt, Germany, September 23, 2009 – The Medical Research Council (MRC), a UK-based, publicly-funded organization dedicated to improving human health, today presented the initial results of the independent Phase III COINa study, which did not meet its primary endpoint of overall survival (OS).1 These findings were presented today at the joint 15th Congress of the European Cancer Organisation (ECCO) and 34th Congress of the European Society for Medical Oncology (ESMO) in Berlin, Germany. The COIN study was designed to evaluate whether the addition of Erbitux® (cetuximab) to one of two oxaliplatin-based chemotherapy regimens significantly improved outcomes in previously untreated metastatic colorectal cancer (mCRC) patients with KRAS wild-type tumors. The median OS was not statistically significant at 17.0 months in the Erbitux treatment arm compared to 17.9 months for the chemotherapy-alone group (hazard ratio [HR] 1.038; p=0.68).1 “Imbalances in the chemotherapy administered between the different study arms were reported previously in the interim safety analysis,” explained Dr. Wolfgang Wein, Executive Vice President, Oncology, Merck Serono, a division of Merck KGaA, Darmstadt, Germany. “Further analysis of the dose intensity and 2nd-line treatment, and other factors, such as the advanced disease of patients in the study, are ongoing to determine why the COIN results are not aligned with existing evidence from the other randomized, 1st-line studies, including the significant increase in overall survival achieved with the CRYSTAL study.” Results [...]

Charlotte Parker2009-09-24T16:48:29-07:00September, 2009|Oral Cancer News|

Flavored cigarette ban takes effect 9/22

Source: MSN.com Author: Karen Pallarito New federal law may help deter young smokers, health advocates say TUESDAY, Sept. 22 (HealthDay News) -- Young people who enjoy a hint of vanilla, berry or chocolate when they light up are about to have their favorite smokes snuffed out. A new federal law banning fruit- and candy-flavored cigarettes takes effect Sept. 22. The prohibition is part of the Family Smoking Prevention and Tobacco Control Act, legislation that grants the U.S. Food and Drug Administration the authority to regulate tobacco products. President Barack Obama signed the measure into law June 22. Studies show that flavored cigarettes, which have been around for about a decade, disproportionately appeal to America's youth. Thus, banning the manufacture and sale of kid-friendly flavored cigarettes is a critical step toward deterring young smokers, health advocates said. "Almost 90 percent of adult smokers start smoking as teenagers. These flavored cigarettes are a gateway for many children and young adults to become regular smokers," FDA Commissioner Dr. Margaret A. Hamburg said in a news release. "The FDA will utilize regulatory authority to reduce the burden of illness and death caused by tobacco products to enhance our nation's public health." Gregg Haifley, associate director of federal relations for the American Cancer Society Cancer Action Network in Washington, D.C., said, "Banning candy and fruit flavorings in cigarettes can have a significant effect on the reduction of initiation of smoking among youth, as well as reducing the number of youth who go on to regular, [...]

Charlotte Parker2009-09-22T16:48:58-07:00September, 2009|Oral Cancer News|

BioVex Agrees SPA With the FDA for a Pivotal Phase III Study With OncoVEX (GM-CSF) in Head and Neck Cancer

Source: PR Newswire Author: Staff WOBURN, Mass., Sept. 15 /PRNewswire/ -- BioVex Inc, a biotechnology company developing clinical stage treatments for cancer and the prevention of infectious disease, announced today that the U.S. Food and Drug Administration (FDA) has approved the design of a single, pivotal, Phase III clinical trial evaluating its lead product, OncoVEX (GM-CSF), for the first-line treatment of patients with squamous cell cancer of the head and neck. The study is the second the Company has agreed with the FDA under the Special Protocol Assessment (SPA) procedure and highlights the broad potential utility of BioVex's first-in-class cancer destroying virus technology. The first SPA was in melanoma under which BioVex is currently conducting a pivotal Phase III trial. Patients with head and neck cancer often present with locally advanced, bulky disease that is too large, or too close, to vital organs to remove surgically. These patients typically undergo combination radiation and chemotherapy treatment, in some cases with additional surgery. Patients who present with tumor-containing lymph nodes are particularly difficult to treat and approximately half of these patients relapse within two years. Philip Astley-Sparke, President & CEO, for BioVex said: "The announcement of our second SPA governing a Phase III study demonstrates the breadth of the commercial opportunity with OncoVEX (GM-CSF). In addition to treating metastatic disease as is the intention in our ongoing Phase 3 study in melanoma, following multiple systemic responses in Phase II, OncoVEX (GM-CSF) also has considerable potential utility in treating discrete solid tumor masses [...]

Charlotte Parker2009-09-16T16:29:05-07:00September, 2009|Oral Cancer News|

UCLA awarded Government grant to extended oral cancer research

Source: Privatemdlabs.com Author: Brendan Missett Funding made available from the Obama Administration's stimulus plan will assist the UCLA School of Dentistry in cancer research. The National Institutes of Health awarded more than $5 million to UCLA which will be used toward the construction of a state-of-the-art complex designed to expand the School of Dentistry's research on the detection and treatment of oral cancer. The building will be called the Yip Center for Oral/Head & Neck Oncology Research. In the past three years, the school was awarded close to $30 million in grants for oral cancer research. Construction plans for the complex, which is named after philanthropists Felix and Mildred Yip, have already begun. The construction is expected to conclude in 2013. No-Hee Park, dean of the UCLA School of Dentistry, commented, "This visionary funding will enable the dental school to become a nexus of multidisciplinary, collaborative research." She added that she hopes the school will become the "premier" oral cancer research program in the country. According to the Oral Cancer Foundation, oral cancer kills about one person every hour, and only half of oral cancer patients survive for more than 5 years after their diagnosis. The National Cancer Institute recommends oral cancer testing to detect the disease at an early, treatable stage.

Charlotte Parker2009-09-15T15:44:10-07:00September, 2009|OCF In The News, Oral Cancer News|

Some question benefit of costly treatments

Source: Indystar.com Author: John Russell Cancer doctors say thousands of dollars may buy little time When a cancer patient is facing a steep, painful decline, the high cost of drugs may seem worth every penny. But some cancer specialists are starting to wonder about the cost-effectiveness of some treatments and are raising pointed questions about Eli Lilly and Co.'s newest cancer drug, Erbitux. Treating a lung-cancer patient with Erbitux costs $80,000 for an 11-week regimen, according to a study published in the June issue of the Journal of the National Cancer Institute. Yet such treatment prolongs survival by 1.2 months, the study found. "Many Americans would not regard a 1.2-month survival advantage as significant progress," wrote the authors, Tito Fojo, an oncologist with the National Cancer Institute, and Christine Grady, a bioethicist at theNational Institutes of Health. The study's findings raise the question: How can the U.S. control ever-growing health costs, particularly at the end of life? When Lilly announced its acquisition of Erbitux last year, the drug maker said it planned to become "an oncology powerhouse." The Indianapolis-based company has two other cancer drugs, Gemzar and Alimta, each with sales of more than $1 billion last year. Some cancer specialists say the widespread use of expensive treatments is questionable. "Erbitux, which costs $10,000 a month for treatment, can lead to what might be described as a marginal benefit," said Dr. Paul Helft, an oncologist at theIndiana University Simon Cancer Center. Some oncologists use various lengths of treatment depending on the [...]

Charlotte Parker2009-09-14T09:56:42-07:00September, 2009|Oral Cancer News|

FDA Panel OKs HPV Vaccine Gardasil for Boys

Source: WebMD Author: Miranda Hitti Sept. 9, 2009 -- An FDA advisory committee voted to recommend approval of the vaccine Gardasil for males ages 9 to 26 to prevent genital warts. Gardasil targets four strains of human papillomavirus, commonly called HPV. Males can carry HPV and transmit it sexually to their partners. HPV can cause genital warts and penile and anal cancer in men. Each year, about 200 out of 100,000 males are newly diagnosed with genital warts, according to background information cited by the FDA. Penile cancer and anal cancer are much rarer. Gardasil already has FDA approval for use in females ages 9 to 26. In females, HPV can cause cervical cancer. The FDA advisory committee ruled 7 to 0, with one abstaining vote, that Gardasil's clinical trial data support the vaccine's effectiveness at preventing genital warts in males ages 9 to 26. And in a 7 to 1 vote, the advisory committee ruled that the data show Gardasil to be safe for males in that age range. The FDA advisory committeereviewed three studies of Gardasil that together included more than 5,000 males ages 9 to 26 in various countries including the U.S. Participants got a total of three shots of Gardasil or a placebo spread over six months. They also got checkups and tests to check for HPV infection. Gardasil was 89% effective in preventing genital warts. The vaccine was less effective in participants who had already been exposed to HPV. No serious side effects were seen, [...]

Charlotte Parker2009-09-11T10:42:14-07:00September, 2009|Oral Cancer News|

Widespread, growing use of snus

Source: WebMD Author: Marlene Busko Lyon, France - Smokeless tobacco—such as snuff and chewing tobacco—is not harmless when it comes to heart health, according to a new meta-analysis [1]. A review of 11 studies from Sweden and the US, almost entirely in men, showed that smokeless-tobacco users had an increased risk of death from MI or stroke. The study, by researchers at the International Agency for Research on Cancer(IARC), is published online August 18, 2009 in BMJ. Contrary to common belief that smokeless tobacco has very little effect on health, these products have been shown to increase cancer risk, coauthor and IARC researcher Dr Kurt Straif (Lyon, France) told heartwire. "There is sufficient evidence for a causal association between smokeless tobacco and oral and pancreatic cancer [2] and probably also esophageal cancer [3]," he said. "Now, this study adds evidence that smokeless tobacco causes death from cardiovascular diseases," Straif summarized. Widespread, growing use of snus Types of smokeless tobacco used in North America and Europe include dry snuff that is inhaled, as well as moist snuff (called snus in Sweden) and chewing tobacco (or spit tobacco), which are sucked inside the cheek. These products have been around for centuries, and after a decline in consumption for most of the 20th century, use has rebounded in the past few decades, the authors write. In 2000, 23.9% of men and 4.1% of women in Sweden reported using snus daily or occasionally. In the same year, in the US, 4.4% of men and 0.3% of women were [...]

Charlotte Parker2009-08-25T20:10:54-07:00August, 2009|Oral Cancer News|

First ever list of top-rated cancer fighting nonprofits

Source: Hotindienews.com Author: Staff Menlo Park, Calif. — For donors and volunteers looking to support a cancer charity, GreatNonprofits releases the first ever list of top-rated cancer fighting nonprofits. A huge variety of cancer support, education, and advocacy organizations were reviewed during the 2009 GreatNonprofits Cancer Fighters Awards in July. The large diversity of organizations that received reviews combined with the large number of reviews posted, shows the incredible passion and commitment these organizations inspire. “We’re really proud of this,” says Brian Hill, Founder and Executive Director of The Oral Cancer Foundation, which won for top-rated cancer organization with an annual budget below $250,000. “It’s an honest appraisal of metrics of what we’ve accomplished that’s actually human.” Nancy Frank is the Executive Director of the Pediatric Cancer Research Foundation, the winner among organizations with budgets over $1,000,000. She says, “We were thrilled with the response. We work our little nose to the grindstone every day and this kind of renewed our spirits in this hard year.” The contest, held throughout July, asked people to submit reviews and ratings about nonprofits serving the cancer community. The contest was sponsored by GreatNonprofits, GuideStar and Planet Cancer. The results provide surprising and inspiring insights into the diversity of organizations that are considered effective and important by volunteers, donors and stakeholders of the cancer community. This is the first ever list providing reviews of cancer fighting nonprofits by those who have actually experienced their work. These unique results will be helpful to donors and [...]

Charlotte Parker2009-08-24T22:36:54-07:00August, 2009|OCF In The News, Oral Cancer News|

Worldwide study shows MI risk increases with all forms of tobacco use

Source: HeartWire Author: Steve Stiles London, UK - Tobacco use significantly ups the risk of nonfatal MI independently of its varied methods around the world and whether exposure is direct or through second-hand smoke, according to INTERHEART, a large, broadly international case-control study [1]. The findings sharpen and add a global perspective to the massive epidemiologic evidence implicating smoking and other tobacco uses as causes of heart disease. The analysis, which appears in the August 19, 2006 issue of the Lancet, suggests that current cigarette smoking confers nearly triple the adjusted MI risk faced by persons who have never smoked and that the hazards can't be escaped by resorting to other forms of tobacco use. The study looked at the effects of not only smokeless tobacco but also less common modes of smoking, including some that are primarily limited to specific geographic regions such as South and Central Asia. "Our findings show that tobacco in any form is harmful," write the authors, Dr Koon K Teo (McMaster University-Hamilton Health Sciences, Hamilton, ON) and associates. Other noteworthy observations include a significant dose-response relationship between the number of cigarettes consumed daily and the likelihood of MI, even at only a few cigarettes per day. Commenting on the study for heartwire, Dr Ira S Ockene (University of Massachusetts Medical School, Worcester) said that it replicates much earlier work but "adds so much more," including a global perspective not only geographically but in terms of spanning virtually all forms of tobacco exposure. Its data on the risks of chewing [...]

Charlotte Parker2009-08-20T14:47:56-07:00August, 2009|Oral Cancer News|

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