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So far Charlotte Parker has created 2907 blog entries.

How Norwich woman put the “fun” in fundraising

Source: Norwich evening news Author: Rowan Mantell She’s enlisted elephants and garden gnomes to her cause, met royalty, staged an impromptu strip show and helped make millions for charity. Theresa Cossey, who has just stepped down as a trustee of the Big C charity, talks about putting the fun into fundraising. She spoke to ROWAN MANTELL. All her life Theresa Cossey has fizzed with money-making ideas. Elephants and garden gnomes were early stars of her fund-raising fervour, and over the past 30 years she has helped raise millions for Norfolk charity Big C – with everything from huge society events to tiny table-top tombolas. She has encouraged people who have run marathons, rafted across the Channel, embarked on sponsored tandem rides in pantomime costume, raced hospital trollies and auctioned anything from bedspreads to baby donkeys. Theresa is, quite simply, a phenomenal fundraiser. Since 1980 she has raised big, big money for Big C, and despite the decades of hard graft, she still believes fund-raising is all about having fun. “Fundraising should be without the final ‘d’; it should be fun, and if it stops being fun you should stop doing it,” she said. That fun has funded hospital wards and equipment, paid for practical and emotional support for cancer patients and their families, and set up teams of scientists researching treatments and cures. This summer Theresa is handing over some of her Big C responsibilities, but not because she has lost her passion for the charity. “When you get past 70 [...]

2011-08-08T12:11:43-07:00August, 2011|Oral Cancer News|

World’s second youngest oral cancer patient

Source: Focus Taiwan News Channel, (By Tsai Pei-chi and Christie Chen) Taipei, Aug. 5  -  A seven-year-old boy in Taiwan has been diagnosed as Asia's youngest and the world's second youngest oral cancer patient, said Dr. Hsia Yi-jan from Taipei's Buddhist Tzu Chi General Hospital Friday. The boy, surnamed Liao, was diagnosed with oral cancer after pustules were found on his tooth extraction wound, which failed to heal after he pulled out a tooth at the beginning of the year, said Hsia, who directs the hospital's oral and maxillofacial surgery center. It is rare for children to contract oral cancer, as oral cancer patients in Taiwan are usually between 30 and 45 years old, the doctor said. The exact cause of Liao's cancer has not yet been determined.  Liao was discharged from the hospital Friday after successfully recovering from the surgery. Hsia, who performed the surgery for Liao, said many oral cancer patients mistake oral cancer for periodontal disease or ordinary mouth ulcers, and as a result, miss the best time for treatment.  He said patients should seek medical treatment if their oral wounds have failed to heal after more than two to three weeks.

2011-08-08T12:12:05-07:00August, 2011|Oral Cancer News|

Ischemic Stroke, Transient Ischemic Attack after Head & Neck Radiotherapy

Source: AHA Journals Author: Chris Plummer, PhD; Robert D. Henderson, PhD; John D. O'Sullivan, MD; Stephen J. Read, PhD Abstract Background and Purpose—Cerebrovascular disease can complicate head and neck radiotherapy and result in transient ischemic attack and ischemic stroke. Although the incidence of radiation vasculopathy is predicted to rise with improvements in median cancer survival, the pathogenesis, natural history, and management of the disease are ill defined. Methods—We examined studies on the epidemiology, imaging, pathogenesis, and management of medium- and large-artery intra- and extra-cranial disease after head and neck radiotherapy. Controlled prospective trials and larger retrospective trials from the last 30 years were prioritized. Results—The relative risk of transient ischemic attack or ischemic stroke is at least doubled by head and neck radiotherapy. Chronic radiation vasculopathy affecting medium and large intra- and extra-cranial arteries is characterized by increasing rates of hemodynamically significant stenosis with time from radiotherapy. Disease expression is the likely consequence of the combined radiation insult to the intima-media (accelerating atherosclerosis) and to the adventitia (injuring the vasa vasorum). Optimal medical treatment is not established. Carotid endarterectomy is confounded by the need to operate across scarred tissue planes, whereas carotid stenting procedures have resulted in high restenosis rates. Conclusions—Head and neck radiotherapy significantly increases the risk of transient ischemic attack and ischemic stroke. Evidence-based guidelines for the management of asymptomatic and symptomatic (medium- and large-artery) radiation vasculopathy are lacking. Long-term prospective studies remain a priority, as the incidence of the problem is anticipated to rise with improvements in [...]

2011-08-08T12:12:22-07:00August, 2011|Oral Cancer News|

Sentinel Node Biopsy Safe & Effective in Head/Neck Melanomas

Source: MD News Author: Staff *see below University of Michigan study refutes controversy about technique in delicate head, neck region. ANN ARBOR, MI — A common technique for determining whether melanoma has spread can be used safely and effectively even in tumors from the head and neck area, according to a new study from the University of Michigan Comprehensive Cancer Center. Sentinel lymph node biopsy involves injecting a special dye to identify the first node where cancer would likely spread. If that node is clean, patients can avoid further debilitating surgery to remove multiple lymph nodes. If that node shows cancer, patients know they need the more extensive surgery or further treatment with radiation, chemotherapy or a clinical trial. Patients with larger melanomas are routinely offered this procedure. But many surgeons believed that the complex anatomy combined with the critical nerves and blood vessels in the head and neck area made sentinel lymph node biopsy unsafe and inaccurate for melanomas in that region. In the current study, which appears online in Cancer, researchers looked at 353 head and neck melanoma patients who had received sentinel lymph node biopsy at U-M over a 10-year period. After reviewing patients’ records, the researchers found that the sentinel lymph node could be identified in all but one patient, and no patients sustained permanent nerve injuries during the procedure. About 20 percent of the patients had at least one sentinel node positive for cancer and were referred for a complete dissection to remove additional lymph [...]

2011-08-08T12:12:51-07:00August, 2011|Oral Cancer News|

Glowing Cornell Dots Target Cancer

SOURCE: Journal of Clinical Investigation, June 13, 2011 (Ivanhoe Newswire)-- New medical technology is showing that Cornell dots may be a potential cancer diagnostic tool. The U.S Food and Drug Administration (FDA) has recently approved the first clinical trial in humans using Cornell Dots- brightly glowing nanoparticles that can light up cancer cells in PET-optical imaging. Cornell Dots are silica spheres less than eight nanometers in diameter that enclose several dye molecules. To make the dots stick to tumor cells, organic molecules that bind to tumor surfaces, or even specific locations within the tumors, can be attached to a polyethylene glycol shell. This shell, also referred to as PEG, prevents the body from recognizing the dots as foreign substances. When exposed to near-infrared light, the dots fluoresce much brighter than dye to serve as a beacon identifying the target cells. Researchers say this technology enables visualization during surgical treatment. Cornell Dots were first developed in 2005 by Hooisweng Ow, a coauthor of the paper on this study and once a graduate student working with Ulrich Wiesner, Cornell Professor of Materials Science and Engineering. Ow and other researchers of this technology are currently in the process of forming a new commercial entity in New York City that will help transition this research into commercial products that will benefit cancer patients. Michelle S. Bradbury, M.D, of the Memorial Sloan-Kettering Cancer Center and an assistant professor of radiology at Weill Cornell Medical College, was quoted as saying, "This is the first FDA IND approved [...]

2011-06-15T11:14:48-07:00June, 2011|Oral Cancer News|

How do you conquer the main difficulties to accomplish a proper oral cancer screening?

Source: DentistryIQ.com From coast to coast the same answer complete As I tour this country presenting programs on early oral cancer detection, I ask the same question of all my attendees: What do you think is the main reason that dentists give for not doing a complete oral cancer examination? The unanimous response in more than 25 states and close to 50 locations is, “Time!” … Yes, time! My next question is always the same: How much time does it take to do a complete extraoral and intraoral cancer examination? The answer is always the same: “One to one-and-a-half minutes.” Something changed somewhere along the way Within this past year, I was made aware of a statewide study evaluating outcomes of dental school education at one particular state-supported dental school. Among the topic areas evaluated was the percent of graduates who are doing a complete extra-/intraoral cancer screening examination in their current practice setting. About 30% of respondents replied in the affirmative. Only one-third! And that was within the first five years out of dental school. Nationwide, the percent of dental offices doing a complete screening examination is only about 20%! My question is what happened that stopped dental professionals from doing a complete extra-/intraoral cancer screening? What are the barriers stopping us from doing what we all know we should be doing? Brief overview of Parts 1 and 2 In Part 1, I discussed that, in my opinion, there is a four-part “system of early oral cancer detection” for any [...]

2017-03-29T19:08:01-07:00April, 2011|Oral Cancer News|

Oral tongue squamous cell carcinoma is on the rise in young caucasian females, age 18 to 44 years

Source: Journal of Clinical Oncology   Abstract Purpose To evaluate the incidence of oral cavity squamous cell carcinoma (OCSCC) and oral tongue squamous cell carcinoma (OTSCC) in young white women, age 18 to 44 years. Patients and Methods We analyzed incidence and survival data from the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute from 1975 to 2007 for OCSCC and OTSCC. Three cohorts were examined: all ages, age 18 to 44 years (ie, “young”), and age > 44 years. Individuals were stratified by sex and/or race. Percentage change (PC) and annual percentage change (APC) were calculated. Joinpoint regression analyses were performed to examine trend differences. Results Overall, incidence of OCSCC was decreasing for all ages. However, incidence was increasing for young white women (PC, 34.8; APC, 2.2; P < .05). Incidence of OTSCC was decreasing for all ages except in the age 18 to 44 years group (PC, 28.8; APC, 1.8; P < .05). Young white individuals had increasing incidence trends of OTSCC (white women: PC, 111.3; APC, 4; P < .05; young white men: PC, 43.7; APC, 1.6; P < .05). The APC of OTSCC was significantly greater in young white women compared with that in young white men (P = .007). Furthermore, incidence of SCC in all other subsites of the oral cavity was decreasing. Nonwhites had a decreasing incidence of OCSCC and OTSCC. Cause-specific survival was similar among whites age 18 to 44 and individuals older than age 44 years. Conclusion OTSCC [...]

2011-04-10T17:26:36-07:00April, 2011|Oral Cancer News|

Dental professionals join The Oral Cancer Foundation to raise awareness as HPV is now the primary cause of Oral Cancers in America

NEWPORT BEACH, Calif., April 4, 2011 /PRNewswire/ -- A serious change in the cause of oral cancer is taking place nationally, and its implications are impacting the American public in a manner that a decade ago no one would have predicted. For decades, oral cancer (also known as mouth cancer, tongue cancer, tonsil cancer, and throat cancer) has been a disease which most often occurred in older individuals, who during their lifetimes had been tobacco users.  Most cases were ultimately the result of lifestyle choices. Today that paradigm has changed. A common, sexually transferred virus has replaced tobacco as the number one cause of oral cancers, Human Papilloma Virus number 16 (HPV16). This is one of the same viruses that are responsible for the majority of cervical cancers in women. This year alone, approximately 37,000 Americans will be newly diagnosed with oral cancer, and one person will die every hour of every day from this disease. HPV16, one of about 130 versions of the virus, is now the leading cause of oral cancer, and is found in about 60% of newly diagnosed patients. Dr. Maura Gillison from the James Cancer Center, a long time researcher of the relationship between HPV and oral cancers, recently reported these new findings at the American Academy for the Advancement of Science meeting. This change in etiology, which has accelerated its influence over the last two decades as tobacco use in the US simultaneously was declining, has also changed the demographics of who is getting [...]

2011-04-07T10:39:32-07:00April, 2011|OCF In The News, Oral Cancer News|

Patient who loses jaw to oral cancer from smoking tells her story

Source: Los Angeles Times By: Milton D. Carrero, The Morning Call   Look at Christine Brader's deep, amber eyes and you will see her beauty. Look beyond her contorted lips, and the jaw she lost as a three-time oral cancer survivor. Radiation took away her teeth, but she smiles. "I still feel like I've lost a great deal, she says, "but I'm still alive. And as long as I am alive, I am going to do what I can to help other people." Brader, 48, is sharing her face, her story and her time to tell the world about the dangers of smoking. The South Whitehall woman, who smoked about half-a-pack a day for 28 years, is featured in the national Truth campaign. Sponsored by the American Legacy Foundation, the series of ads present the unsweetened reality of those living with a serious illness caused by smoking. Brader's life is testament of resilience against oral cancer — a disease that, in five years, kills more than half of the 37,000 Americans diagnosed with it yearly, according to the Oral Cancer Foundation. "I still may not make it," she says, "and I don't have another chance in me. If I get it again, I'm done." Brader's life seemed idyllic until she discovered she had cancer. She had a stable job, a beautiful house in the woods and two teenage children who inspired her. But in 2007, she went to her family doctor, believing that she had a sinus infection. Her situation [...]

2017-03-29T19:08:10-07:00April, 2011|OCF In The News, Oral Cancer News|

Longitudinal study of human papillomavirus persistence and cervical intraepithelial neoplasia grade 2/3: critical role of duration of infection

Journal of the National Cancer Institute, April 5, 2011. Authors: Ana Cecilia Rodríguez, Mark Schiffman, Rolando Herrero, Allan Hildesheim, Concepción Bratti, Mark E. Sherman, Diane Solomon, Diego Guillén, Mario Alfaro, Jorge Morales, Martha Hutchinson, Hormuzd Katki, Li Cheung, Sholom Wacholder, Robert D. Burk Background The natural history of human papillomavirus (HPV) infections in older women is critical for preventive strategies, including vaccination and screening intervals, but is poorly understood. In a 7-year population-based cohort study in Guanacaste, Costa Rica, we examined whether women’s age and the duration of carcinogenic HPV infections influenced subsequent persistence of infection and risk of cervical intraepithelial neoplasia grade 2 (CIN 2) or worse disease. Methods At enrollment, of the 9466 participants eligible for pelvic examination, 9175 were screened for cervical neoplasia using multiple methods; those with CIN 2 or worse disease were censored and treated. Participants at low risk of CIN 2 or worse (n = 6029) were rescreened at 5–7 years (passively followed), whereas higher-risk participants (n = 2115) and subsets of low-risk women (n = 540) and initially sexually inactive women (n = 410) were rescreened annually or semiannually (actively followed) for up to 7 years. HPV testing was done using a polymerase chain reaction–based method. We determined, by four age groups (18–25, 26–33, 34–41, and ≥42 years), the proportion of prevalent infections (found at baseline) and newly detected infections (first found during follow-up) that persisted at successive 1-year time points and calculated absolute risks of CIN 2 and CIN grade 3 (CIN [...]

2011-04-10T17:25:47-07:00April, 2011|Oral Cancer News|
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