Charlotte Parker, Author at Oral Cancer News

Facing the Facts: HPV-Associated Head and Neck Cancers Get a Second Look

Source: CureToday.com HPV causes surge in oral cancer rates. Kevin Pruyne knew he didn’t fit the stereotype of a hard drinker or heavy smoker who one day develops an oral cancer. The 52-year-old mechanic had been working a three-week stint in a remote section of northern Alaska, repairing trucks on an oil field, when he noticed a hard lump beneath his jaw while shaving. For nearly three months, as Pruyne was prescribed antibiotics for a possible infection and then later shuttled between physician specialists, he kept hearing the same thing: the lump could not be cancer. Pruyne only occasionally consumed alcohol and had never smoked. His wife, Kathy, began researching her husband’s symptoms, which included repetitive throat clearing, a nagging sensation that something was lodged in his throat and ringing in his ears. And the lump, which looked like the top half of an egg, felt solid to the touch. This wasn’t some inflamed lymph node from a lingering head cold, Kathy Pruyne says. “He had every symptom [of cancer], but nobody would listen to me.” Kevin Pruyne, with his wife, Kathy, is hopeful his HPV-positive oral cancer will be cured. Photo by Rick Bacmanski. Pruyne received a diagnosis of stage 4 oral cancer, which started with a tumor at the base of his tongue. He had already begun chemotherapy when he learned that researchers had discovered an association between the human papillomavirus (HPV) and increasing rates of oropharyngeal cancers. He asked that his tissue be tested; the results came [...]

Charlotte Parker2012-06-20T12:05:38-07:00June, 2012|Oral Cancer News|

Allentown woman who lost jaw to cancer shares anti-smoking message

Source: LehighVallyLive.com People often stare at Christine Brader. Sometimes strangers ask the Allentown woman what happened to her. She tells them, "I used to smoke." Tobacco users flinch when they hear her response, Brader says. Smoking led to oral cancer, which eventually cost the 49-year-old all of her teeth and part of her lower jaw.Brader has had three bouts with the disease since her first diagnosis five years ago, but is now cancer free. "I have to go through life disfigured, all because I made a bad decision and smoked," she says. Brader doesn't want others to follow in her footsteps, so she is working with Tobacco Free Northeast Pennsylvania to spread the word about the dangers of smoking. The organization serves a 10-county area, including Lehigh and Northampton, spokeswoman Alice Dalla Palu said. Brader recently shared her story in a radio advertisement broadcast during the week of World No Tobacco Day, which was May 31. In the ad -- part of the Centers for Disease Control "Tips from Former Smokers" campaign -- she describes preparing liquid meals and consuming them through a feeding tube. Last year, Brader appeared in a TV commercial for Truth, a national smoking prevention campaign that targets youth. BREAK THE HABIT: Call 1-800-784-8669 or visit tobaccofreene.com to get help quitting smoking. She started smoking at 16 to fit in with her peers and continued for 28 years. Brader quit cold turkey at 44 after learning in June 2007 that the growth inside her cheek was cancer. [...]

Charlotte Parker2012-06-18T10:03:27-07:00June, 2012|OCF In The News, Oral Cancer News|

Cross-sectional study on the prevalence of HPV antibodies in the general population of the Czech Republic

Source: BMJ Correspondence to Dr Eva Hamsikova, Department of Experimental Virology, Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Praha 2, Czech Republic; [email protected] Contributors EH participated in the design and coordination of the study, evaluated results, performed statistical analysis and drafted the manuscript. VL prepared antigens for assessment of antibody presence. JS performed the immunoassays. RT participated in the design of the study and helped to draft the manuscript. All authors read and approved the final manuscript. Abstract Objectives The assessment of the prevalence of antibodies to human papillomaviruses (HPV) in the healthy population is essential for effective planning of HPV vaccine implementation into the preventive programmes for HPV-associated diseases and for the prospective monitoring of the impact of HPV vaccines in the Czech population. Methods The seropositivity for HPV-6, 11, 16, 18, 31 and 33 virus-like particles was determined in sera from 3150 healthy individuals (age range 6–76 years) by means of enzyme-linked immunoassay. Results The seroprevalences for HPV-6, 11, 16, 18, 31 and 33 were 23.8%, 15.2%, 14.5%, 9.9%, 16.4% and 9.6% in women and 18.4%, 13.7%, 6.5%, 5.4%, 6.1% and 4.3% in men. For both genders, except for HPV11, these rates were age dependent. The prevalence of antibodies to HPV-16 and/or 18 reached the maximum of 27.0% in women 30–39 years of age and of 14.4% in men 50–59 years of age. The highest proportion of individuals' seropositive for any of the vaccine types HPV-6/11/16/18 was in 30- to 39-year-old women (50.0%) and in ≥60-year-old men [...]

Charlotte Parker2012-06-11T11:09:53-07:00June, 2012|Oral Cancer News|

Part of jaw removed after mix-up

Source: 3news.co.nz A lab mix-up is being blamed for an operation on the wrong patient at an Otago dental hospital An Otago dental hospital has apologized to a woman who had part of her jaw removed after being wrongly diagnosed with mouth cancer. The misdiagnosis happened after a laboratory worker at Medlab Dental, part of the University of Otago Dental Hospital, dropped two samples on the floor and mixed them up, the Otago Daily Times reports. As a result the 63-year-old patient was wrongly diagnosed with cancer and had the right side of her upper jaw removed. An area on the woman's lower leg where bone and blood vessels were taken to reconstruct her jaw later became infected and she had trouble walking. "I can't for the life of me understand how you can get tissue samples mixed up," Nelson oral surgeon Iain Wilson, the woman's dentist, told the newspaper. "I am astonished and horrified by these lab mix-ups." University faculty of medicine dean, Professor Peter Crawford, says the university has apologized to the patient. "We have taken this incident very seriously, and have already taken all appropriate measures to minimise the likelihood of any such incidents occurring again," he said. "The patient was contacted very soon after the incident was discovered, and we offered a full apology at that time." The case is being investigated by the Health and Disability Commissioner and the patient has consulted a lawyer about compensation. The patient was one of six who had [...]

Charlotte Parker2012-06-11T10:07:33-07:00June, 2012|Oral Cancer News|

Tobacco Smoking and Increased Risk of Death and Progression for Patients With p16-Positive and p16-Negative Oropharyngeal Cancer

Source: Journal of Clinical Oncology Purpose Tobacco smoking is associated with oropharynx cancer survival, but to what extent cancer progression or death increases with increasing tobacco exposure is unknown. Patients and Methods Patients with oropharynx cancer enrolled onto a phase III trial of radiotherapy from 1991 to 1997 (Radiation Therapy Oncology Group [RTOG] 9003) or of chemoradiotherapy from 2002 to 2005 (RTOG 0129) were evaluated for tumor human papillomavirus status by a surrogate, p16 immunohistochemistry, and for tobacco exposure by a standardized questionnaire. Associations between tobacco exposure and overall survival (OS) and progression-free survival (PFS) were estimated by Cox proportional hazards models. Results Prevalence of p16-positive cancer was 39.5% among patients in RTOG 9003 and 68.0% in RTOG 0129. Median pack-years of tobacco smoking were lower among p16-positive than p16-negative patients in both trials (RTOG 9003: 29 v 45.9 pack-years; P = .02; RTOG 0129: 10 v 40 pack-years; P < .001). After adjustment for p16 and other factors, risk of progression (PFS) or death (OS) increased by 1% per pack-year (for both, hazard ratio [HR], 1.01; 95% CI, 1.00 to 1.01; P = .002) or 2% per year of smoking (for both, HR, 1.02; 95% CI, 1.01 to 1.03; P < .001) in both trials. In RTOG 9003, risk of death doubled (HR, 2.19; 95% CI, 1.46 to 3.28) among those who smoked during radiotherapy after accounting for pack-years and other factors, and risk of second primary tumors increased by 1.5% per pack-year (HR, 1.015; 95% CI, 1.005 to [...]

Charlotte Parker2012-06-11T10:02:05-07:00June, 2012|Oral Cancer News|

Dental oncology: Meeting a growing need

Source: Dr.Biscuspid.com The good news is more cancer patients are surviving than ever before. The bad news is it creates new challenges for the medical community to provide adequate and appropriate aftercare and treat the many short- and long-term side effects of cancer treatment. For example, chemotherapy and radiation often cause oral problems such as mucositis, xerostomia, oral and systemic infections, and accelerated caries development. But many dentists refuse to treat cancer patients with these conditions due to the increased risk of osteonecrosis from radiation treatment or bisphosphonate use. Enter Ryan Lee, DDS, MPH, MHA, who is finishing a postgraduate clinical fellowship in dental oncology at Memorial Sloan-Kettering Cancer Center in New York City. He hopes to help solve the shortage of dentists with the training to treat the growing number of cancer patients who need specialized oral care. Ryan Lee, DDS, is one of a handful of dentists specializing in dental oncology. Dr. Lee is one of two fellows in Sloan-Kettering's dental oncology fellowship program, which has been offering the specialty training for at least a decade. "All along I've liked working on medically complex cases with dental needs, so cancer fit into that niche very well," he told DrBicuspid.com. "I've come to realize how much of a growing need it is and how little is available to meet that need," he explained. Currently, only two cancer hospitals offer fellowship training programs for dental oncology: the Memorial Sloan-Kettering Cancer Center and the University of Texas MD Anderson Cancer Center. [...]

Charlotte Parker2012-06-07T10:09:20-07:00June, 2012|Oral Cancer News|

If You Fail to Look

Source: The American Academy of Oral Systemic Health Newsletter Author: Cris Duval Detecting oral cancer in its earliest stages saves lives, eases suffering, reduces morbidity, and ameliorates post-surgery recovery. Remember when you took driver’s education in high school? I do! When I grew up, driver’s education students in Washington State were required to watch “shock” highway-safety films. These videos, depicting the aftermath of drivers’ actions, showed actual accident scenes, complete with audio recordings of victims’ screams and color close-ups of mangled bodies. My bet is that, if you have ever watched one of these videos, you have never forgotten it. For me, when I saw these videos, I thought about my family and my friends. I know that I have a family that loves and cares about me, and thus, I owe it to them to avoid doing something stupid behind-the-wheel. I never want one of my loved ones to have to go through the pain of seeing me hurt. This means to me that my driver’s license is more than just a “key” to get behind the wheel. Rather, as a website for traffic safety in Texas states, a driver’s license signifies that the driver possesses the “essential knowledge, skills, and experience to perform reduced risk practices in [a] total traffic environment.” In other words, the driver is accountable to himself and other drivers. My response to these driver’s education videos is akin to my reaction to videos that I watched at the Pacific Northwest Head, Neck & Thyroid Cancer [...]

Charlotte Parker2012-06-01T09:35:08-07:00June, 2012|Oral Cancer News|

Penn study finds delayed side effects of head and neck cancer treatments go unreported

Source: Eurekalert.org Results reinforce need for improved 'survivorship care' to encourage patients to seek help for their symptoms CHICAGO – New data from an Internet-based study show that patients with head and neck cancers (HNC) may be at risk for significant late effects after their treatment, but they're unlikely to discuss these and other survivorship care issues with their doctors. The findings, from researchers at the Perelman School of Medicine at the University of Pennsylvania, will be presented Monday, June 4, at the 2012 American Society of Clinical Oncology (ASCO) meeting in Chicago. The research team says the study reinforces the need to improve survivorship care for patients as they complete their active treatment, better educate patients about late effects they may experience, and encourage them to report these problems to their healthcare providers so they can be addressed. Data from nearly 4,000 cancer survivors were gathered between April 2010 and October 2011 via patients who completed LIVESTRONG Care Plans via OncoLink, Penn Medicine's online cancer resource. Approximately four percent of those patients had been treated for a primary head or neck cancer. Of those, nearly 88 percent reported having undergone radiation, 73 percent surgery, and 67 percent chemotherapy. Many patients reported late effects such as difficulty swallowing/speaking (83 percent), decreased saliva production (88 percent), thyroid problems (33 percent), decreased neck mobility (60 percent), concerns regarding cognitive function (53 percent), or vision deficits. However, since results show that patients only discuss the survivorship care plans they created on the site [...]

Charlotte Parker2012-05-31T12:09:42-07:00May, 2012|Oral Cancer News|

Suicide Rates Among Oral Cancer Patients on the Rise

Source: Dr.Bicuspid.com May 23, 2012 -- Suicide rates among patients with oral cavity and oropharyngeal (OC/OP) cancer have increased significantly over the past three decades, particularly among male patients during the first year after diagnosis. As many as half of patients with head and neck cancer suffer from depression, among the highest of all oncology patients (Clinical Advances in Hematology & Oncology, June 2009 Vol. 7:6, pp. 397-403). However, despite documented high rates of depression and suicide among patients with head and neck cancer, studies examining suicide and other noncancer-related deaths in patients with OC/OP have not been published. Brian Hill, executive director of the Oral Cancer Foundation, survived stage 4 bilateral cervical lymph node metastases from oropharyngeal cancer. This gap prompted researchers from the New York Eye and Ear Infirmary, New York Medical College, and Peking University to analyze 32,487 patients with OC/OP cancer using the Surveillance, Epidemiology, and End Results cancer registry data for 1980-1984, 1990-1994, 2000-2003, and 2004-2007 (Archives of Otolaryngology-Head & Neck Surgery, January 2012, Vol. 138:1, pp. 25-32). They found that from 1980-1984 to 2004-2007, deaths from suicide increased by 406.2% (p = .01), while cardiovascular disease-related and pneumonia-related deaths decreased by 45.9% (p < .001) and 42.9% (p = .009), respectively. Risk factors for mortality included age (55-64), marital status, advanced tumor stage, and tumor location. The researchers also calculated standardized mortality ratios (SMRs) for suicide, cardiovascular disease, and pneumonia and compared them with patient demographic and clinical characteristics. The risk of death from [...]

Charlotte Parker2012-05-24T10:21:11-07:00May, 2012|OCF In The News, Oral Cancer News|

The Dangers of Self Diagnosis via the Internet

Source: ABC News (Australian Broadcasting Corporation) Do you have a rash and a sore throat? A high fever? A splitting headache? Forget spending time and money on seeing a doctor - there is a plethora of internet sites that will help you diagnose your own illness for free. Simply answer a series of questions about your age, body measurements and symptoms and the internet will do the rest. The Australian Medical Association says it's seriously concerned with the increasing number of WA residents who are doing just that. Last year, a study found nearly 80 per cent of Australians get health information off the net, with almost half of those doing so to diagnose a medical condition. The AMA's Doctor Richard Chong says those statistics seem to reflect local trends in WA. "Every single day I see patients that have come to me after checking their symptoms on the internet," he said. "I accept that it's a part of life now due to the sheer number of people who're more familiar with the internet. "To be honest, most people who do it aren't harmed." "They rush in thinking they have something that's going to kill them when they're actually fine." Dr Chong is, however, concerned about people who don't go to their GP because their research has reassured them that nothing's wrong. "At least with the first group of people, we get to discuss their symptoms because they always come in," he said. "The people that don't are the ones [...]

Charlotte Parker2012-05-23T09:27:03-07:00May, 2012|Oral Cancer News|

Oral Cancer News
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