Public urged to help cancer researchers by playing online game

Source: news.sky.com Author: staff Scientists have turned to the public to help with their latest cancer research in the form of an online citizen science game. The game is designed to train a computer algorithm to recognise oral cancers in medical images. AcCELLerate tasks users with tracing the outline of a series of fluorescent dye-stained tongue images which become increasingly complex, using their computer mouse or finger on a smartphone. It is designed to train a computer algorithm to recognise oral cancers in medical images, improving its ability to differentiate between healthy and cancerous cells. "I'm really excited that the public will be contributing to my work on oral cancer," said Dr Priyanka Bhosale, from King's College London's Centre for Stem Cells and Regenerative Medicine. "The outcomes of the public training the AI will help me assess tumour tissue samples in a faster and more reliable way." It is hoped the tool can be used to advance research into other cancers. The game forms part of the Royal Society Summer Science 2021 event and can be found at citizen.cellari.io.

RowanSOM researcher begins human trials for cancer treatment drug

Source: today.rowan.edu Author: news release Could a targeted therapy derived from a plant used medicinally in China for centuries offer the next breakthrough in cancer treatment? Dr. Gary Goldberg, associate professor in the Department of Molecular Biology at Rowan University School of Osteopathic Medicine (RowanSOM), is undertaking a human clinical trial to find out. Goldberg and his team are collaborating with a group at the Rutgers New Jersey Medical School headed by Dr. Mahnaz Fatazadeh, professor at Rutgers School of Dental Medicine, to test a new drug candidate called MASL. This novel compound has been trademarked and licensed from Rowan University by Sentrimed, a company founded by Goldberg. MASL is derived from Maackia amurensis, a legume tree native to the Amur River valley, which flows through parts of Russia and China. The MASL human trial marks a milestone for RowanSOM, Goldberg noted. “Coming up with a new drug and taking it to a clinical trial is an excellent example of investigator-initiated research from bench to bedside,” said Goldberg. “It has taken a lot of collaboration and work to get to this point.” The FDA considers MASL an investigational new drug. “This is a unique Phase I trial,” Goldberg said. “This study integrates investigation of patient safety, along with potential efficacy and proof of concept mechanistic studies.” Goldberg and his team began the ongoing human trial, involving 20 cancer patients, in fall 2020. While MASL has the potential to treat many kinds of cancer, this trial will test MASL’s effects on [...]

World’s first research centre for recurrent head and neck cancer

Source: www.nationalhealthexecutive.com Author: Jasmine Jackson The Royal Marsden NHS FT have launched the world’s first research centre for recurrent head and neck cancer, as a result of funding from the Royal Marsden Cancer Charity. It hopes to accelerate research into the disease, which will be carried out by a world-class team of clinicians and researchers. The International Centre for Recurrent Head & Neck Cancer (IReC) also aims to improve patient outcomes in the UK and beyond, in the curative treatment, palliation, and supportive care of recurrent head and neck cancer. The IReC announced a series of initiatives to help achieve these goals, including: A national registry to improve understanding around recurrent head and neck cancer, whist capturing the different ways it is treated across the UK. A tissue biobank to support laboratory and translational research. An International Referral Centre to offer rapid second opinions for patients being treated in the UK and internationally. This will also include the funding of three PhD research fellows, trial managers, a clinical trial nurse and a data manager, to increase research capacity. Head and neck cancer is the 8th most common cancer in the UK, with more than 12,000 diagnoses each year. After treatment, it is estimated that between 20% and 40% of head and neck cancers will return, and in England, between 28% and 67% survive for five years or more. IReC Director Professor Vinidh Paleri, Consultant Head and Neck Surgeon at The Royal Marsden, said: “Treating recurrent head and neck cancer is [...]

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