Does chocolate hold the key to cure HPV?

Source: Yahoo News Indulgent chocolate treats may be the best-known and most widely appreciated product of the cacao tree, but new scientific research from New York Based Cacao Biotechnologies is uncovering potential new applications for the antioxidant-rich beans which could spur an innovative approach to treating human papillomavirus (HPV), a precursor to cervical cancer. The human papillomavirus is the most common sexually transmitted infection (STI) in the United States, with an estimated 24 million active cases and 5.5 million new cases each year, according to the National Cancer Institute. HPV is the leading cause of cervical cancer in woman with more than 12,000 cases reported in the U.S. each year. HPV vaccines approved by the Food and Drug Administration are available, but they are not a cure and they can’t effectively prevent all strains of HPV infection in those who are sexually active. Existing vaccines are only proven effective against a small number of high-risk, cancer-causing HPV strains and are not free of serious side effects including convulsions and paralysis. While condoms can reduce the risk of HPV infection, the virus can still be transmitted simply through skin contact of areas not covered by the condom. Vaccination will not cure someone who is already infected with the virus, so even with massive public health education campaigns, HPV will not soon be eradicated because it is so widely spread in the adult population. According to Penny Hitchcock, Chief of the Sexually Transmitted Diseases Branch of the U.S. government’s National Division of [...]

2011-02-04T12:16:39-07:00February, 2011|Oral Cancer News|

Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial

Source: www.thelancet.com Authors: Dr Christopher M Nutting FRCR et al. Background: Xerostomia is the most common late side-effect of radiotherapy to the head and neck. Compared with conventional radiotherapy, intensity-modulated radiotherapy (IMRT) can reduce irradiation of the parotid glands. We assessed the hypothesis that parotid-sparing IMRT reduces the incidence of severe xerostomia. Methods: We undertook a randomised controlled trial between Jan 21, 2003, and Dec 7, 2007, that compared conventional radiotherapy (control) with parotid-sparing IMRT. We randomly assigned patients with histologically confirmed pharyngeal squamous-cell carcinoma (T1—4, N0—3, M0) at six UK radiotherapy centres between the two radiotherapy techniques (1:1 ratio). A dose of 60 or 65 Gy was prescribed in 30 daily fractions given Monday to Friday. Treatment was not masked. Randomisation was by computer-generated permuted blocks and was stratified by centre and tumour site. Our primary endpoint was the proportion of patients with grade 2 or worse xerostomia at 12 months, as assessed by the Late Effects of Normal Tissue (LENT SOMA) scale. Analyses were done on an intention-to-treat basis, with all patients who had assessments included. Long-term follow-up of patients is ongoing. This study is registered with the International Standard Randomised Controlled Trial register, number ISRCTN48243537. Findings: 47 patients were assigned to each treatment arm. Median follow-up was 44·0 months (IQR 30·0—59·7). Six patients from each group died before 12 months and seven patients from the conventional radiotherapy and two from the IMRT group were not assessed at 12 months. At 12 months xerostomia side-effects were reported in [...]

2011-02-04T12:18:59-07:00February, 2011|Oral Cancer News|

Wrong way to go smoke-free

Source: Newsobserver.com By: Joseph G.L. Lee CHAPEL HILL -- So, now R.J. Reynolds Tobacco Company wants to help smokers "break free" from tobacco? That statement should make parents, health care providers and smokers nervous. Last month, Reynolds promoted its Camel Snus (a "spit-free" tobacco pouch) with advertisements in national magazines that read "If you've decided to quit tobacco use, we support you," under a large "2011 Smoke-free Resolution" banner. Reynolds then offered its smoke-free snus as the solution. For smokers, the majority of whom try to quit every year, the message should be to quit tobacco use, not to substitute one form of cancer for another. No safe form of tobacco use exists. Smokers who try tobacco snus products are at high risk of becoming addicted to both cigarettes and snus, thus continuing or even adding to their risk for lung, bladder, breast, cervical, oral and pancreatic cancer. In addition to running these misleading ads in People, Time and Rolling Stone, R.J. Reynolds is continuing a long-standing practice of targeting vulnerable populations such as young people, African-Americans and gays and lesbians. Last year, research in the medical journal Pediatrics implicated Reynolds' "Camel No. 9" campaign in an increase in smoking among young teenage girls. The tobacco industry has long targeted African-Americans by focusing on marketing and so-called "corporate social responsibility" strategies to buy favor with civil rights organizations. Researchers at the University of California, San Francisco estimated that the approximately $25 million in tobacco industry corporate philanthropy that funded African-American [...]

2011-02-03T12:09:00-07:00February, 2011|Oral Cancer News|

Jimmy Bradley is being treated for oral cancer

Source: NY Times Author: Sam Sifton Jimmy Bradley, the chef and an owner of the Red Cat and the Harrison, two restaurants in Manhattan, said he is recovering from oral cancer, and will not be moving forward with plans to open J & S Food Hall in the Nolitan Hotel. “It’s a bad break,” he said in a telephone interview on Tuesday morning, his voice only slightly thicker than its usual laconic drawl. “But long-term the prognosis is pretty good. I just think at this point the best thing for me is to concentrate on my health and on the livelihood of the 100 people I already have working for me, not on hiring 50 people for a new business.” Mr. Bradley, 43, said that in late October his dentist spotted a tumor in the center of his tongue. He sought four subsequent opinions from oncologists, and underwent surgery to remove the growth at Mount Sinai Medical Center in Manhattan on Nov. 17. Three days later, he said, he returned to the kitchen of the Harrison, where he had recently started cooking again. Radiation treatments for the cancer are ongoing. “I was super bummed for the first month or so,” Mr. Bradley said. He struggled to regain his ability to speak, and was terrified that he would lose his ability to taste. Some of his palate has already returned, he said. “Every day is a little better,” he said. “It’s like being a little kid and learning again what coffee tastes like, or [...]

2011-02-04T06:18:19-07:00February, 2011|Oral Cancer News|

Tobacco industry adapts to world of fewer smokers

Source: The Tennessean Author: Anita Wadhwani By any name or variety you choose — call it snuff, dip, chew or plug — smokeless tobacco is making a comeback, and Tennessee farmers, factory workers and consumers are playing a major role in the renewed buzz. Farmers here and in Kentucky who once made a good living off raising burley tobacco for cigarettes have had to eliminate 40 percent of acreage devoted to that crop as demand has declined, while farmers who cultivate the dark tobacco used for chewing have been able to expand their fields by 22 percent in three years. Now, the massive marketing muscle of the nation's biggest tobacco companies — Altria Group and its subsidiary Philip Morris USA, which owns the 100-year-old U.S. Smokeless Tobacco Co. factory within view of the state Capitol, and R.J. Reynolds, which runs its smokeless operations out of a Memphis factory — are battling for market dominance. Together, the two manufacturers already control 90 percent of the American smokeless tobacco sector with brands such as U.S. Smokeless' Skoal and R.J. Reynolds' Kodiak. They're competing with new fruit- and mint-flavored products (some packaged to look like miniature cigarette packs) to attract a new generation of consumers and entice ex-smokers looking for nicotine- infused alternatives. Former cigarette smokers like Dave Kenner, 31, a construction worker making a pit stop at a West Nashville convenience store last week, said he switched to Red Seal Wintergreen smokeless because heavily taxed cigarettes cost too much — nearly $300 [...]

2011-02-04T12:24:02-07:00February, 2011|Oral Cancer News|
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