July 2010 – Page 4 – Oral Cancer News

New study shows that testing for HPV genotypes 16 and 18 detects cervical pre-cancer missed by pap test

Source: Roche Molecular Systems, In Author: April Falcone 1 in 10 women in the ATHENA trial, age 30-years and older, who tested positive for HPV genotypes 16 and/or 18 by the cobas® 4800 HPV Test had cervical pre-cancer, although their Pap test was normal Involving more than 47,000 women, the ATHENA trial is the largest registration study ever conducted for cervical cancer screening Roche today announced that data from the ATHENA (Addressing THE Need for Advanced HPV Diagnostics) U.S. registration trial of over 47,000 women demonstrate that two human papillomavirus genotypes, HPV 16 and HPV 18, can identify those women with cervical pre-cancer missed by cytologic examination with a Papanicolau (Pap) test. In the trial, 1 in 10 women age 30-years and older, who tested positive for HPV genotypes 16 and/or 18 by the cobas® 4800 HPV Test had cervical pre-cancer, although their Pap test was normal. The data demonstrate the importance of HPV genotyping to increase the accuracy of assessing cervical cancer risk, especially by screening for the two highest risk HPV genotypes (16 and 18), and underscore the limitations of relying upon cytology (Pap) testing alone in identifying women with cervical pre-cancer. The data were presented today by Thomas C. Wright Jr., M.D. of Columbia University at the 26th International Papillomavirus Conference in Montreal, Canada. "The ATHENA data show that women who are positive for HPV 16 and/or 18 should be directly referred for closer examination of the cervix by colposcopy," said Dr. Wright. "Screening for high-risk HPV genotypes provides important additive information to [...]

Charlotte Parker2010-07-20T14:22:17-07:00July, 2010|Oral Cancer News|

Could HPV be transmitted orally?

Source: Bright Hub Author: Kira Jaines Can a kiss transmit HPV? Or oral sex? Studies conducted by researchers at Johns Hopkins University found that not only can human papilloma virus be transmitted orally, it can also increase the risk of oropharyngeal cancer. Can HPV Be Transmitted Orally? In a word, yes. Once thought to be uncommon, the oral transmission of human papilloma virus (HPV) through oral sex and even French kissing has been documented and linked to an increasing rate of oropharyngeal cancer. The oropharynx consists of the base the tongue, the tonsils, the back of the mouth and the walls of the throat. Results of a study by Johns Hopkins researchers published in the New England Journal of Medicine in 2007 linked HPV exposure and infection to an increased risk of cancer of the mouth and throat. HPV infection has rapidly caught up with tobacco and alcohol as a risk factor for oral cancer, and has, in fact, become one of the leading causes of oral cancer in men, independently of smoking and drinking. About HPV Over 120 different HPV viruses have been identified, according to the Oral Cancer Foundation. Different types of HPV infect different parts of the body. Some cause warts on the skin. Some cause warts on the genitals. Some are harmless. Some cause cancer. The HPV virus is easily passed via skin-to-skin contact or sexual contact. HPV viruses cause no early identifiable symptoms and most are fought off by the body’s immune system. In fact, sexually-active adults have a [...]

Charlotte Parker2010-07-11T16:10:45-07:00July, 2010|OCF In The News, Oral Cancer News|

Disadvantages of using chewing tobacco to quit smoking

Source: www.helium.com Author: Dawn Hawkins If you are a smoker who is trying to quit smoking, there are several ways in which you might attempt to attain the goal. Chewing tobacco might seem like one of the best answers to your problem. The goal is to stop the smoke from going into your lungs, right? That is partially true. There are many advantages of using chewing tobacco to quit smoking, but there are great disadvantages to it also. Disadvantages of using chewing tobacco to quit smoking: Teeth- Your teeth become discolored much faster when you chew tobacco in order to try to quit smoking. Your teeth will suffer discoloring when you smoke cigarettes, but chewing tobacco comes into direct contact with the tooth's surface making them more susceptible to staining. Spitting- When you chew tobacco, you also have to spit it somewhere. This can be a problem if someone takes away the container that you are spitting in. It is also not a very attractive thing to do. You have to carry something around with you at all times that contains your already chewed tobacco and your spit. That is another thing that is definitely not attractive. Accidents- When you have a bottle that you are using to spit the tobacco into, there is a good chance your or someone else will accidentally drink the mixture thinking it is something else. chewing tobacco has a very foul taste when combined with spit. It is also very unhealthy to swallow. That [...]

Oral Cancer Foundation News Team - A2010-07-05T17:34:30-07:00July, 2010|Oral Cancer News|

Betel nut, oral cancer pilot study for Saipan, Guam now underway

Source: www.saipantribune.com Author: Moneth Deposa A betel nut and oral cancer pilot study will be conducted on Saipan and Guam beginning this year. The study hopes to gather baseline date to develop protocols for studying oral precancerous lesions and other health risks among betel nut users in Micronesia. University of Guam epidemiologist Dr. Yvette Paulino, co-leader in the pilot study, will work with Dr. Suzanne Murphy from the Cancer Research Center of Hawaii in the pilot study. In a presentation to members of the Commonwealth Cancer Association last week, Dr. Paulino disclosed that oral cancer is the sixth leading cancer worldwide, but ranks in the Top 3 cancers in countries where there are betel nut/areca nut chewers. Betel nut, she said, is apparently a misnomer. The nut itself is more accurately called “areca nut” and “betel” refers to the leaf that is sometimes used with the nut. “Betel quid” refers to the mixture of nut and leaf. The three-year pilot study aims to collect information on betel nut/areca nut use among 300 study participants in Guam and on Saipan and members of their families. In the course of the study, oral examinations and biopsies will be performed as needed, health risks will be measured, and associations of duration, frequency, and type of betel nut/areca nut use with oral pre-cancers and health risks will be studied. Dr. Paulino said that betel nut/areca nut is considered a human carcinogen. She revealed that betel nut chewing has been shown to be associated with [...]

Oral Cancer Foundation News Team - A2010-07-05T17:25:11-07:00July, 2010|Oral Cancer News|

Oral cancer treatment and reconstruction

Source: www.cancernewstoday.com Author: staff Trace the steps of Carolyn Coogan, a patient who discovered she had oral cancer and her subsequent treatment options as Dr. Neal Futran, director of otolaryngology head and neck surgery at the University of Washington Medical Center, leads a discussion of the processes. Discover how Coogans treatment crossed medical disciplines as it involved surgeries to remove cancer, reconstruct the jaw and install the dental prosthesis.

Oral Cancer Foundation News Team - A2010-07-04T14:53:01-07:00July, 2010|Oral Cancer News|

AACR recognizes one-year anniversary of tobacco law and the additional provisions taking effect today; calls for more research to combat tobacco epidemic

Source: AACR Author: Staff WASHINGTON, D.C. — The American Association for Cancer Research recognizes the first anniversary of the Family Smoking Prevention and Tobacco Control Act, which was signed into law by President Obama on June 22, 2009. The law empowered the Food and Drug Administration (FDA) to regulate the marketing, advertising and manufacturing of tobacco products. Provisions that go into effect today include restrictions on youth access to tobacco products, enhanced warning labels on smokeless tobacco products, and a ban on the use of deceptive terms such as “light” or “mild.” “While most people know that cigarette smoking causes cancer, we need to do a far better job of educating the public about the risks of all tobacco products,” said Margaret Foti, Ph.D., M.D. (h.c.), chief executive officer of the AACR. “In fact, there is sufficient scientific evidence to causally link tobacco use to cancers at 18 different organ sites. For example, smokeless tobacco alone can cause cancer of the mouth, esophagus and pancreas, and new smokeless tobacco labels will help to deliver that message.” Starting today, smokeless tobacco product labels must be larger, and incorporate messages including that smokeless tobacco is addictive and can cause mouth cancer. “With nearly a third of all cancer deaths caused by tobacco use, it is imperative that the research community come together to support the FDA in its efforts to establish a science-based framework for evaluating the harms caused by tobacco products,” said Chairperson of the AACR Task Force on Tobacco and [...]

Charlotte Parker2010-07-04T14:48:08-07:00July, 2010|Oral Cancer News|

Researchers develop high-precision cancer tests using patients’ saliva

Source: mdn.mainichi.jp Author: staff Researchers develop high-precision cancer tests using patients' saliva Researchers have developed a high-precision method to diagnose three types of cancer from saliva, enabling patients to undergo tests without physical discomfort. The method, announced at the current meeting of the international Metabolomics Society in the Netherlands, was developed by a team including researchers from Keio University's Institute for Advanced Biosciences. "We want to proceed with analysis of other types of cancer and other illnesses, and put this to practical use," university research lecturer Masahiro Sugimoto said. Sugimoto said the University of California, Los Angeles, which is participating in the research, collected saliva from 215 people aged 11 to 87. Eighty-seven of the patients were healthy, 18 had cancer of the pancreas, 30 had breast cancer, 69 had oral cancer, and 11 had gum disease. Researchers analyzed the 500 or so types of substances found in their saliva, and identified 54 substances whose concentrations differed markedly between healthy people and people with three specific types of cancer. Since concentrations of a single substance varied among the subjects, the researchers combined several substances and then examined the concentrations. As a result, the team found that they could identify patients with cancer of the pancreas with 99 percent accuracy by examining five substances in their saliva including the amino acid phenylalanine. Using similar tests, the researchers were able to identify breast cancer with 95 percent accuracy and oral cancer with 80 percent accuracy. Sugimoto said that research to diagnose cancer [...]

Oral Cancer Foundation News Team - A2010-07-01T14:59:39-07:00July, 2010|Oral Cancer News|

The global market for snus and snuff is estimated to be in excess of 1.4 billion cans, and growing. Scandinavia and the US are by far the world’s largest markets for snus and snuff. Scandinavia is a pasteurized snus market, while the US market is dominated by the fermented moist snuff.

Source: The Swedish Match Author: Staff The Scandinavian snus market is comprised of a broad range of brands and product varieties, with pouch products being the most popular and continuing to grow in importance. The largest market in Scandinavia is Sweden, the largest snus market in the world measured in per capita consumption. Norway was the fastest growing market but Travel Retail and the Swedish market also experienced volume growth in 2009. Snus, traditionally a Swedish product, is increasingly being recognized globally as an exciting new market category. This is evidenced by the big tobacco players testing Swedish style snus in chosen markets. During 2009, one of Swedish Match competitors rolled-out snus nationally in the US. Still a very small category in the US, Swedish style snus is considered to have a long term growth potential. Swedish Match is continuing its efforts to assess and develop the market for Swedish style snus in the US market through the marketing of brands such as General. Moreover, through the 2009 joint venture with Philip Morris International, Swedish Match will pursue growth opportunities outside Scandinavia and the US. While still undeveloped, these marketsprovide future growth opportunities. Within the European Union, sales of snus have been banned since 1992. Sweden was exempted from the sales ban for the Swedish market when it became an EU member in 1995. The traditional US moist snuff market has achieved sustained volume growth over the past decade. The US snuff market is comprised primarily of loose varieties in a [...]

Charlotte Parker2010-07-01T10:54:36-07:00July, 2010|Oral Cancer News|

Simulation of scattering dffects of irradiation on surroundings using the example of titanium dental implants: a Monte Carlo approach

Source: International Journal of Cancer Research and Treatment Authors: REINHARD E. FRIEDRICH1, MANUEL TODROVIC2 and ANDREAS KRÜLL2 Correspondence to: Professor R.E. Friedrich, Oral and Maxillofacial Surgery, Eppendorf Medical Center, University of Hamburg, Martinist. 52, D-20246 Hamburg, Germany. Tel: +49 40428033259, Fax: +49 428038120, email:[email protected] Abstract Occasionally, head and neck cancer patients treated with high-energy X-rays and gamma rays have titanium dental implants. The aim of this study was to calculate alterations in the irradiated bone caused by a foreign body, representing a titanium implant in size and physical qualities, using a stochastic (Monte Carlo) simulation. A clinical linear accelerator was simulated using BEAM/EGS4. The calculations showed that the presence of an implant results in differences of the dose distribution all around the implant. Titanium dental implants in the field of irradiation were capable of causing significant radiation scattering. The risk for dose enhancement was notably important for the bone in direct contact with the foreign body. Therapists involved in radiation planning should consider the impact of dental implants on the radiation beam as a putative cause of osteoradionecrosis.

Charlotte Parker2010-07-01T14:56:38-07:00July, 2010|Oral Cancer News|