2009 – Page 38 – Oral Cancer News

Pharmaceuticals, patents, publicity…and philanthropy?

Source: The Lancet, Volume 373, Issue 9665, Page 693, 28 February 2009 Author: staff Tensions between provision of and payment for health care are familiar. Though doctors assume principal responsibility for patients' health, those who work for pharmaceutical companies view the patented medicines they design as key components of health care. Creative ways are continually found to make such drugs available to as many patients in high-income countries as possible, the profits contributing to future investment in development and leaving national drug budgets affordable, just. Yet, a few hours' flying away, patients in developing countries usually have no access to these very same patented drugs. GlaxoSmithKline (GSK) has grown in size and influence by successful drug development, timely takeovers, and shrewd management. Andrew Witty, who ascended to the vertiginous position of chief executive at GSK in the past year, has attracted attention by a surprising presentation at Harvard Medical School on Feb 13. He promises that GSK will now not only make its medicines available much more cheaply to patients in low-income countries, but also make a bolder commitment to research into neglected diseases. As one blogger puts it, “arise Sir Andrew Witty (or is it Saint Andrew?)”. Does this announcement mark a sea change in pharma's attitude to the provision of drugs in poor countries, or could it be more reminiscent of the zany hybrid vehicles that distract attention from car manufacturers' shamelessly polluting stock in trade? Witty's words were carefully weighed to cast a rosy glow around GSK's [...]

Oral Cancer Foundation News Team - A2009-05-08T18:54:41-07:00May, 2009|Oral Cancer News|

Snus news & other tobacco products

Source: snus-news.blogspot.com Author: blog post Twenty-six of the United States' leading tobacco control researchers and policy experts have called for regulatory control of all tobacco products. They also called for policies that encourage current tobacco users to reduce their health risks by switching from the most to the least harmful nicotine-containing products. This group met in a two-year process they called The Strategic Dialogue on Tobacco Harm Reduction - members met four times between December 2005 and August 2007. Their vision: a world in which virtually no one uses cigarettes. But the group acknowledged that smokeless-tobacco products are an option for reducing health risks for tobacco users. They also called for policies that encourage current tobacco users to reduce their health risks by switching from the most to the least harmful nicotine-containing products. Paper: Mitch Zeller et al., The strategic dialogue on tobacco harm reduction: A vision and blueprint for action in the United States, Tob Control 2009 0: 200802731, ABSTRACT... Murray Kessler, former Chief Executive Officer of UST, Inc - the world's leading producer of moist smokeless tobacco products - tells us that 9 out of 10 smokers that try smokeless reject the product. Smokers faced with the increased in the federal tax on cigarettes (effective April 1, 2009) have been telling clerks at c-stores they're thinking of quitting but hardly anyone has indicated they are thinking of switching to smokeless tobacco. We’re all for this safer alternative if distribution could be limited to inveterate tobacco smokers (smokers who [...]

Oral Cancer Foundation News Team - A2009-05-08T18:49:23-07:00May, 2009|Oral Cancer News|

Glaxo’s cervical cancer vaccine faces US battle

Source: Forbes.com Author: Linda A. Johnson New studies show GlaxoSmithKline PLC's vaccine Cervarix blocks the virus that causes cervical cancer, but if it wins approval for U.S. sales, it will face an uphill battle against Gardasil, which has owned the market here for three years. Cervarix, Glaxo's vaccine against human papilloma virus or HPV, already is approved in more than 90 other countries, but has been held up by delays in the United States. Several years ago, the British drugmaker was in a neck-and-neck race with rival Merck & Co., Gardasil's maker, to be first on the U.S. market, but it lost when Gardasil got approved in June 2006. Late in 2007, the Food and Drug Administration declined to approve approve Cervarix. GlaxoSmithKline submitted a new application on March 30 that included final data from an 18,000-woman study recently completed. Final results from that study and two others are being presented this weekend at a conference in Sweden on papillomavirus. FDA is expected to decide whether to approve Cervarix within several months. If it does, analyst Erik Gordon, a professor at the University of Michigan's Ross School of Business, said doctors who have prescribed Gardasil for a few years may see no reason to switch - unless GlaxoSmithKline convinces them its product is much more effective or has fewer side effects. Both vaccines target the two types of HPV that cause about 70 percent of cervical cancers, types 16 and 18, and data indicate both are about 98 percent effective. But Merck also [...]

Charlotte Parker2009-05-08T18:53:28-07:00May, 2009|Oral Cancer News|

New diagnostic advance seen for head, throat cancer

Source: www.biocompare.com Author: press release Pharmacy researchers at Oregon State University today announced the discovery of a genetic regulator that is expressed at higher levels in the most aggressive types of head and neck cancers, in work that may help to identify them earlier or even offer a new therapy at some point in the future. This "transcriptional regulator" is called CTIP2, and in recent research has been demonstrated to be a master regulator that has important roles in many biological functions, ranging from the proper development of enamel on teeth to skin formation and the possible treatment of eczema or psoriasis. In the newest study, published today in PLoS ONE, a professional journal, scientists found for the first time that levels of CTIP2 were more than five times higher in the "poorly differentiated" tumor cells that caused the most deadly types of squamous cell carcinomas in the larynx, throat, tongue and other parts of the head. There was a high correlation between greater CTIP2 expression and the aggressive nature of the cancer. Head and neck squamous cell cancers are the sixth most common cancers in the world, the researchers said in their study, and a significant cause of mortality. In 2008, cancers of the oral cavity and pharynx alone accounted for 35,310 new cases in the United States and 7,590 deaths. They have been linked to such things as tobacco use and alcohol consumption. "Serious head and throat cancer is pretty common, and mortality rates from it haven't improved [...]

Oral Cancer Foundation News Team - A2009-05-06T13:44:22-07:00May, 2009|Oral Cancer News|

From cars to cancer: UH professor employs auto industry tools for tumor therapy

Source: www.genengnews.com Author: staff An effort is under way at the University of Houston to use technologies with origins in the automobile industry to develop new tools that will help doctors and technicians better plan radiation therapy for patients with head and neck cancer. Dr. Ali Kamrani, founding director of the Design and Free Form Fabrication Laboratory at UH and a former auto industry researcher, is teaming up with Dr. Lei Dong, associate professor and deputy research director of radiation physics at the University of Texas M.D. Anderson Cancer Center, to develop predictive models of tumors that hopefully will increase the accuracy of radiation therapy. "We aim to better understand tumor deformations using geometric and statistical models rather than repetitive CT scans," said Kamrani, an associate professor of industrial engineering at the Cullen College of Engineering. "In this case, patients will undergo a minimum number of CT scans, and the radiation plans will be developed using the predictive models." Traditional computed tomography sessions, also known as CT scans, require a large series of two-dimensional X-ray images that, when combined, provide detailed three-dimensional images of many types of tissue. "A CT scan is used to collect information with respect to tumor size, location and volume," he said. "But the CT scan itself is a source of harmful radiation to body tissues and other organs. During the treatment, patients undergo a series of CT scans, which are costly and tedious." Reducing the number of CT scans is a primary objective for Kamrani, [...]

Oral Cancer Foundation News Team - A2009-05-06T13:31:06-07:00May, 2009|Oral Cancer News|

Acupuncture relieves radiation-induced xerostomia in head and neck cancer

Source: www.medscape.com Author: Roxanne Nelson Acupuncture can improve subjective symptoms of dry mouth in patients with radiation-induced xerostomia, according to the results of a pilot trial. When treated twice a week for 4 weeks with acupuncture, oncology patients who received radiation treatments to the head and neck area reported significant improvements in physical well being and quality of life. The results of the trial, published online April 17 in Head & Neck, showed that acupuncture relieved symptoms as early as 2 weeks after starting therapy, with the benefits lasting for at least 1 month after treatment ended. Although this was a pilot study, the results appear quite encouraging; little or no recovery is generally seen in these patients after they reach the damaging threshold of radiation. But all patients in this study had reached the damaging threshold, explained senior author William Chambers, DMD, MS, chief of the Section of Oncologic Dentistry and Prosthodontics at the University of Texas MD Anderson Cancer Center in Houston. "They all received over 50 Gy of definitive external-beam radiation therapy," he said. However, the data did not find a change in measured stimulated or unstimulated salivary flow, even though the patients reported symptom relief. "There was no statistically significant increase in saliva flow from baseline, but there was a positive trend, with a spike for unstimulated saliva [P = .08]," Dr. Chambers told Medscape Oncology. The researchers also note that basal and salivary flow rates vary significantly among individuals, and therefore, subjective perceptions and objective [...]

Oral Cancer Foundation News Team - A2009-05-02T05:42:13-07:00May, 2009|Oral Cancer News|

Robot-assisted surgery feasible for head and neck cancer

Source: www.medscape.com Author: Roxanne Nelson Robot-assisted surgery appears feasible for resection of select upper aerodigestive tract tumors, according to a study published in the April issue of Archives of Otolaryngology — Head & Neck Surgery. Researchers found that the surgical robot had several advantages over traditional endoscopic and open approaches, such as 3-dimensional visualization, tremor filtration, and greater freedom of instrument movement. "Robotic surgery in head and neck patients is still considered investigational," said senior author William Carroll, MD, associate professor of surgery and otolaryngology at the University of Alabama in Birmingham. "The procedure is under consideration by the [US Food and Drug Administration] for an approved indication." The key message from this study is that this technology could prove useful for the surgical management of select patients with head and neck cancers. "We hope to see similar or improved cure rates with fewer side effects and quicker return to function," he told Medscape Oncology. Since they were introduced a decade ago, robot-assisted surgeries have become widely accepted in the United States, especially for cardiac, gynecologic, and urologic procedures. The authors note that in 2007, about 60% of all radical prostatectomies were performed with robot assistance, and that robot-assisted cardiac and urological procedures can result in less blood loss and fewer complications than standard open approaches. In addition, the use of robots in cardiac surgery has had a favorable effect on operative time, length of stay in intensive care units, and length of overall inpatient care days, compared with open [...]

Oral Cancer Foundation News Team - A2009-04-30T13:08:30-07:00April, 2009|Oral Cancer News|

AACR show report: Dentists balk at cancer screenings

Source: DrBicuspid.com Author: Barbara Boughton SAN DIEGO -- Dentists don't want to spend time screening patients for oral cancer because they're not sure how to do it properly -- or how to make money from it, researchers said at the American Association for Cancer Research annual meeting here. The researchers, from Simon Fraser University and the British Columbia Oral Cancer Prevention Program in Canada, collected four months of data from pilot cancer screening projects at 10 dental offices in Vancouver, then queried dental staff in focus groups. "The idea was to raise public awareness, and remind dentists and their staff about how easy an oral cancer exam can be," said study author Denise Laronde, a dental hygienist and doctoral candidate at Simon Fraser University. Earlier research has suggested that dentists could save lives with oral cancer screenings. In a British Columbia study, 70 percent of oral cancer patients who had regular dental office visits were diagnosed at an early stage (stage I or II), while only 40 percent of those who did not have regular dental visits were diagnosed at an early stage, the researchers said. Oral cancer screening is a quick and painless procedure, yet fewer than 30 percent of people surveyed report being screened, the researchers added. In the current study, dental personnel were taught to use a novel screening device that uses loss of autofluorescence to identify potential areas of concern in the oral mucosa. Dentists, dental hygienists, and dental assistants participated in a one-day workshop on [...]

Charlotte Parker2009-05-08T18:40:34-07:00April, 2009|Oral Cancer News|

New diagnostic advance seen for head, throat cancer

Source: www.sciencedaily.com Author: staff Pharmacy researchers at Oregon State University today announced the discovery of a genetic regulator that is expressed at higher levels in the most aggressive types of head and neck cancers, in work that may help to identify them earlier or even offer a new therapy at some point in the future. This "transcriptional regulator" is called CTIP2, and in recent research has been demonstrated to be a master regulator that has important roles in many biological functions, ranging from the proper development of enamel on teeth to skin formation and the possible treatment of eczema or psoriasis. In the newest study, published April 28 in PLoS One, scientists found for the first time that levels of CTIP2 were more than five times higher in the "poorly differentiated" tumor cells that caused the most deadly types of squamous cell carcinomas in the larynx, throat, tongue and other parts of the head. There was a high correlation between greater CTIP2 expression and the aggressive nature of the cancer. Head and neck squamous cell cancers are the sixth most common cancers in the world, the researchers said in their study, and a significant cause of mortality. In 2008, cancers of the oral cavity and pharynx alone accounted for 35,310 new cases in the United States and 7,590 deaths. They have been linked to such things as tobacco use and alcohol consumption. "Serious head and throat cancer is pretty common, and mortality rates from it haven't improved much in 20 [...]

Oral Cancer Foundation News Team - A2009-04-30T08:53:36-07:00April, 2009|Oral Cancer News|

Experimental drug shows promise against head and neck cancer

Source: www.eurekalert.org Author: press release A laboratory study by researchers at Albert Einstein College of Medicine of Yeshiva University suggests that an anti-cancer compound studied for treating blood cancers may also help in treating cancers of the head and neck. The work is reported in the April 28th online edition of the Journal of Pathology. Head and neck cancer refers to tumors in the mouth, throat, or larynx (voice box). Each year about 40,000 men and women develop head and neck cancer in the U.S., making it the country's sixth-most common type. Surgery, chemotherapy and/or radiation are the main treatment options but can cause serious side effects. Better treatments are needed, since only about half of patients with head and neck cancer survive for five or more years after diagnosis. The Einstein study involved a new class of chemotherapy agents known as histone deacetylase (HDAC) inhibitors, which affect the availability of genes that are transcribed and translated into proteins. In many types of cancer, out-of-control cell growth results from certain genes that are either too active or not active enough in producing proteins. HDAC inhibitors appear to combat cancer by restoring the normal expression of key regulatory genes that control cell growth and survival. The Einstein researchers focused on a particular HDAC inhibitor known as LBH589 that has already shown some success in clinical trials involving people with cancers of the blood. The researchers found that LBH589 succeeded in killing tumor cells that had been removed from head and neck [...]

Oral Cancer Foundation News Team - A2009-04-29T19:29:39-07:00April, 2009|Oral Cancer News|