A wealth of options in oncology
9/14/2005 Newton, PA Neal Bellucci PharmaLive (www.pharmalive.com) With a continued investment in innovative therapies in oncology, Merck KGaA has ongoing active development programs with additional novel therapies that may offer new hope to people with cancer. The company is best known for the first-in-class EGFR-targeted monoclonal antibody, Erbitux, comprising cetuximab, that works by blocking the epidermal growth factor receptor to inhibit tumor growth and spread. Merck KGaA focuses on four therapeutic technology platforms in oncology: EGFR-targeting monoclonal antibodies that may block tumor growth; immunocytokines that may provide local stimulation of the immune system; angiogenesis inhibitors that may starve tumors of the blood supply they need to grow and spread; and cancer vaccines that may stimulate a specific immune response against tumors. "These are exciting times in oncology," says Dr. Bernhard Ehmer, VP, oncology, Merck KGaA (merck.de). "With a better understanding of the growth and spread of tumors, we are able to develop treatments that target the cancer cells and give physicians and their patients additional options with which to fight cancer. "We are particularly excited by Erbitux not only in the treatment of colorectal cancer but also in its potential in head and neck cancer, and by BLP25 Liposome Vaccine, which is showing impressive results in the treatment of nonsmall cell lung cancer. Furthermore, our humanized EGFR-targeting monoclonal antibody matuzumab is showing potential in several types of cancer." Erbitux is a first-in-class and highly active IgG1 monoclonal antibody targeting the epidermal growth factor receptor. As a monoclonal antibody, the mode [...]