Teams of microbes are at work in our bodies. Researchers have figured out what they’re up to

Source: phys.org Author: staff, Drexel University In the last decade, scientists have made tremendous progress in understanding that groups of bacteria and viruses that naturally coexist throughout the human body play an important role in some vital functions like digestion, metabolism and even fighting off diseases. But understanding just how they do it remains a question. Researchers from Drexel University are hoping to help answer that question through a clever combination of high-throughput genetic sequencing and natural language processing computer algorithms. Their research, which was recently published in the journal PLOS ONE, reports a new method of analyzing the codes found in RNA that can delineate human microbial communities and reveal how they operate. Much of the research on the human microbial environment—or microbiome—has focused on identifying all of the different microbe species. And the nascent development of treatments for microbiota-linked maladies operates under the idea that imbalances or deviations in the microbiome are the source of health problems, such as indigestion or Crohn's disease. But to properly correct these imbalances it's important for scientists to have a broader understanding of microbial communities as they exist—both in the afflicted areas and throughout the entire body. "We are really just beginning to scrape the surface of understanding the health effects of microbiota," said Gail Rosen, Ph.D., an associate professor in Drexel's College of Engineering, who was an author of the paper. "In many ways scientists have jumped into this work without having a full picture of what these microbial communities look [...]

2019-12-12T07:16:08-07:00December, 2019|Oral Cancer News|

Scientists untangle the evolutionary history of the world’s most common STI

Source: www.iflscience.com Author: Rosie McCall Scientists have analyzed the genomes of viruses to reveal the surprisingly complex evolutionary past of the human papillomavirus (HPV), exposing the salacious details of our ancestors' sexual history in the process. HPV comes in several flavors but HPV16 is the most common subtype worldwide – and it is the one most frequently identified in cervical cancer. Together HPV16 and HPV18 are responsible for 70 percent of all cases, accord to stats from the World Health Organization (WHO). The problem is, it isn't exactly clear how HPV strains contribute to cervical cancer (and other types, including cancer of the anus, the throat, the base of the tongue, and the tonsils). Or why the virus naturally clears in some people but not others. Researchers hope that studying the evolution of the virus will expose biological insights and point at mechanisms that might explain how cervical cancer develops. To try to untangle HPV16's thorny evolutionary past, scientists led by the Chinese University of Hong Kong isolated and examined oral, perianal, and genital samples in 10 adult female squirrel monkeys (Saimiri sciureus) and eight adult rhesus monkeys (Macaca mulatta), half of whom were male and half of whom were female. They found that the virus strains with most in common came from the same part of the body – meaning the oral samples from the squirrel monkeys and rhesus monkeys had more in common than oral and genital samples from the same species, for example. This, the authors say, [...]

2018-11-05T12:52:42-07:00November, 2018|Oral Cancer News|

Viruses recruited as killers of tumors

Source: nytimes.com Author: Rachel Nuwer In 1951, a 4-year-old boy with leukemia contracted chickenpox. His liver and spleen, swollen by the cancer, soon returned to normal, and his elevated blood cell count fell to that of a healthy child. His doctors at the Laboratory of Experimental Oncology in San Francisco were thrilled by his sudden remission, but the blessing was short-lived. After one month, his leukemia returned and progressed rapidly until the child’s death. In the early 1900s, not much could be done for cancer patients. Unless surgeons could excise a tumor, the disease typically spelled a swift and inevitable end. But in dozens of published cases over the years, doctors noticed a peculiar trend: Struggling cancer patients sometimes enjoyed a brief reprieve from their malignancies when they caught a viral infection. It was not a coincidence. Common viruses sometimes attack tumor cells, researchers discovered. For decades, they tried to harness this phenomenon, to transform it into a cancer treatment. Now, after a long string of failures, they are nearing success with viruses engineered to kill cancer. “It’s a very exciting time,” said Dr. Robert Martuza, chief neurosurgeon at the Massachusetts General Hospital and professor of neuroscience at Harvard Medical School. “I think it will work out in some tumor, with some virus.” Candidates are already in advanced trials, he noted. Cancer cells are able to replicate wildly, but there’s a trade-off: They cannot ward off infection as effectively as healthy cells. So scientists have been looking for ways to [...]

Lab at Hershey Medical Center identifies a virus that could kill cancer

Source: www.pennlive.com Author: Nick Malawskey, The Patriot-News This is not the kind of lab we picture when we think of world-changing science. It’s not the clean, spotless modern laboratories of television or movies. It’s a cluttered, workaday environment, where plastic test tubes rub shoulders with petri dishes and tubs of chemicals on busy shelves. The white board isn’t covered with the scrawl of complex mathematical formulas, but reminders of whose turn it is to buy the doughnuts. But it is here, on the fifth floor of the Penn State Milton S. Hershey Medical Center, where Dr. Craig Meyers and his team might have conducted a miracle. What he and his lab claim discovery of is breathtaking in its simplicity. A common virus, omnipresent in the world. When it infects humans, it does no harm. But introduce it into certain kinds of tumors and the virus appears to go wild, liquefying every cancer cell it comes into contact with. It’s the type of discovery that could change the world. And like all great stories of scientific discovery, it begins with a moment of sublime serendipity, not unlike Isaac Newton nodding off beneath an apple tree. A Tiny Virus It’s one of the smallest, simplest viruses and yet adeno-associated virus type 2, or AAV2, could be among the most important agents in modern medicine. That’s because it’s almost perfectly imperfect. For whatever reason, through its evolution, AAV2 developed what would, in most cases, be a dead end — it cannot easily reproduce. [...]

2011-11-27T14:38:16-07:00November, 2011|Oral Cancer News|

Fighting cancer with scorpions?

Source: www.foxnews.com Author: Chris Kilham In the fight against cancer, scientists and medical researchers around the world are developing new medicines from seemingly unlikely natural substances. Recent reported developments involve the use of a bacteria found in soil, a poison from a highly toxic scorpion, and the virus that causes herpes. All three demonstrate novel properties that may save lives in cases of otherwise hard to treat killer cancers. The use of bacteria for health and therapeutic purposes is in fact quite common. Various beneficial bacteria within the human digestive tract support digestion and elimination, help to detoxify the body, reduce the risk of some types of disease, and help to maintain overall health. These bacteria are widely available in supplements, and in various “live, active” yogurts. But ever since Edward Jenner developed the first vaccine (for cow pox) in 1796, bacteria have also played central roles in the development of vaccines against several diseases, including against tuberculosis, and even for plague, as in the case of Yersinia pestis. A team from North Carolina State University is developing an oral vaccine against deadly Anthrax poisoning, using Lactobacillus acidophilus, a common beneficial bacteria used to culture yogurt. Recent findings from Britain’s University of Nottingham show another ingenious use for bacteria, in the treatment of cancers. A team of scientists led by Professor Nigel Minton has reported that the bacteria Clostridium sporogenes a species widespread in nature, can be used as a vehicle to deliver anovel enzyme that activates a cancer drug [...]

2011-09-09T05:49:57-07:00September, 2011|Oral Cancer News|

Government Certified: What’s Causing Cancer — Research Summary

CANCER-INSIDE AND OUT: Cancer is one of the most prominent diseases in the world. According to the National Cancer Institute, "cancer is a renegade system of growth inside the human body. The changes that must occur inside for cancer to flourish are genetic changes, but factors outside the body also play a role."  Outside factors, such as: diet, smoking, alcohol use, hormone levels, and even exposure to certain chemicals and viruses over time, can all work together to create defects and maturation in cells. Furthermore, they go on to explain that environmental, in science, means, everything outside the body, in the environment, that enters and interacts with it. This type of exposure can also include things such as: sunshine, rain, water, food intake, and workplace environment. Researchers have concluded approximately 67 percent of all cancers are due in some part to the environment. Feeling like you can't go anywhere now without being faced with cancer? The good news is these risks can decrease significantly if lifestyle changes are made. The National Cancer Institute suggests about one third of all cancer deaths could have been prevented if lifestyle changes were made, such as avoiding or completely eliminating tobacco and alcohol use. NOT JUST ON THE OUTSIDE: Environmental factors are not the only culprit when it comes to cancer. A lot of cancer is gene related and based on our composition from within. Random gene changes occurring now, as well as gene changes that occur from cell growth and division, accumulate and [...]

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