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Research shows ‘substantial’ cardiovascular risk among patients with head and neck cancer

Source: www.healio.com Author: Drew Amorosi Key takeaways: Individuals with newly diagnosed HNSCC showed evidence of suboptimally controlled cardiovascular risk factors. Black race appeared associated with increased risk for uncontrolled cardiovascular risk factors. Individuals with newly diagnosed head and neck squamous cell carcinoma are at high risk for adverse cardiovascular events, results of a retrospective study of U.S. veterans showed. Findings from the analysis, published in JAMA Otolaryngology – Head & Neck Surgery, indicate suboptimal control of multiple cardiovascular risk factors among these patients, leading to increased risk for incident stroke, myocardial infarction (MI) and all-cause mortality. “We hope that these findings bring awareness to the fact that patients with head and neck cancers have a substantial burden of modifiable cardiovascular risk factors and encourage providers, including oncologists and primary care physicians, to screen for and manage these risk factors to mitigate risk for cardiovascular events,” Lova Sun, MD, MSCE, assistant professor of hematology-oncology at Perelman School of Medicine at University of Pennsylvania, told Healio. “Overall, these findings highlight the cardiovascular risk in patients with HNSCC and underscore the critical need for targeted interventions to improve stratification and mitigation of cardiac risk in the growing population of HNSCC survivors.” Background The researchers hypothesized that patients with head and neck cancer may experience increased risk for cardiovascular events due to a number of shared risk factors and the use of cardiotoxic therapies to treat the disease. “Cardiovascular disease is a significant cause of morbidity and mortality in patients with cancer, but our [...]

Oral Cancer Foundation News Team - A2023-06-23T04:37:49-07:00June, 2023|Oral Cancer News|

A Disorder That’s Hard to Swallow

Source: www.usnews.comAuthor: Anna Medaris Miller Ed Steger’s last meal was a bowl of soup in Las Vegas. “I remember it all too clearly, as if it were yesterday,” he says. But it wasn’t yesterday – it was 2006. “Life is very different” now, says Steger, a 63-year-old former program manager in Houston. Steger was diagnosed with head and neck cancer in 2005. In addition to 36 rounds of radiation and eight regimens of chemotherapy, he underwent six surgeries, including one that replaced a portion of his pharynx and removed parts of his left jawbone, tongue, epiglottis and soft palate. “The part that makes it odd is that I’m alive after having four recurrences,” Steger says. The part that makes it distressing is that he can’t eat solid foods. “There are many case studies I’ve seen where patients have said [their] swallowing disorder is the worst part of their disease – and I believe this to be true,” says Steger, who’s president of the National Foundation of Swallowing Disorders. His daily diet consists of four 8-ounce cans of the nutritional drink Boost Plus, along with two to four bottled Starbucks Frappuccinos, which he buys at his local supermarket. “It’s a very boring diet that allows me to maintain my weight,” says Steger, who’s 5 feet 10 inches tall and 155 pounds. It’s unknown how many people have dysphagia, or difficulty swallowing, but the condition can be caused by any one of 30 diverse health events, Steger says. While his dysphagia is a result of surgery, other people [...]

Oral Cancer Foundation News Team - A2015-06-02T16:23:17-07:00June, 2015|Oral Cancer News|

Possible Link Between HPV and Heart Disease

Source: CVTNews.ca We already know HPV, or human papillomavirus, can cause cervical cancer. It's also known to cause some kinds of oral cancer. But could HPV also cause heart disease? An intriguing new study is drawing a link. The study found that women who are known to be infected with cancer-causing strains of the virus may be at increased risk for cardiovascular disease and stroke -- even when they have none of the usual heart disease risk factors. The study authors say their research is one of the first to investigate a potential link between heart disease and HPV, which is one of the most common sexually transmitted infections. The Public Health Agency of Canada estimates that more than 70 per cent of sexually-active Canadian men and women will have a sexually transmitted HPV infection at some point in their lives. They say they began the study because they wanted to know why some people have heart attacks even though they have none of the usual risk factors, like high cholesterol or high blood pressure. About 20 per cent of patients with heart disease lack risk factors, which has left open the possibility that underlying "nontraditional" causes might be involved in the disease. If there is indeed a link between the virus and heart disease, it could have a number of implications. It would mean that doctors would have to monitor patients with HPV to help prevent heart attack and stroke. As well, there is the possibility that the HPV vaccine [...]

Oral Cancer Foundation News Team - A2011-10-26T10:59:28-07:00October, 2011|Oral Cancer News|

Researchers Find New Hope for Oral Cancer

Source: Newswise.com NIH Director: rescuing and repurposing abandoned therapies for new uses could save time and money Newswise — COLUMBUS, Ohio. September 6, 2011. Scientists on the cutting edge of biomedical research know that research is a process – a combination of successes and failures that inform the next step forward. However, for some researchers at The Ohio State University progress means taking a step back. Supported by the Ohio State University Center for Clinical and Translational Science (CCTS), these scientists are using failed and forgotten research to uncover future treatments for major health conditions as diverse as oral cancer and stroke. In a recent editorial that detailed the goals of the soon-to-be launched National Center for Advancing Translational Science (NCATS), NIH Director Francis Collins, M.D. noted that the current research process for discovering new therapies is often slow, expensive and unsuccessful. He went on to describe several ways that translational medicine could revolutionize the system, including the idea of “repurposing and rescuing” drugs that could potentially have other uses - an idea being put into action at Ohio State. “The translational science approach puts cross-functional teams and new technologies to work in more efficient ways, ” says Rebecca Jackson, M.D., Associate Dean for Clinical Research in the College of Medicine and Principal Investigator of the Ohio State CCTS. “It allows our researchers to do innovative work – like resurrecting old data – that maintains a focus on answering questions that will make timely, positive impacts on the major health [...]

Oral Cancer Foundation News Team - A2011-09-07T16:00:59-07:00September, 2011|Oral Cancer News|

Smokeless tobacco won’t help smokers quit

Source: www.webmd.com Author: Bill Hendrick Smokeless tobacco products -- whether chewed or used as dry or moist snuff -- may increase the risk of heart attack, fatal stroke and certain cancers, says a new policy statement published online in Circulation: Journal of the American Heart Association. "No tobacco product is safe to consume," Mariann Piano, PhD, lead writer of the policy statement and a professor in the department of behavioral health science at the University of Illinois at Chicago, says in a news release. The notion that smokeless tobacco may help reduce the rate of cigarette smoking is based in part on Swedish research, which showed a significant decline in smoking by Swedish men between 1976 and 2002 that corresponded with an increase in the use of smokeless tobacco. But in similar research in the U.S., the opposite was found to be true, the article says. There was no reduction in smoking rates among people who used smokeless tobacco products. Nicotine-Replacement Therapy Piano says that smokers trying to kick the habit might want to try nicotine-replacement therapy, by chewing nicotine gum or using a nicotine patch that can be attached to the skin, rather than using smokeless tobacco products. Piano tells WebMD that most people who use nicotine-replacement therapy do so for short periods of time, and it doesn't appear to be as addictive as smokeless tobacco "because of slower absorption, lower doses of nicotine, greater cost, lack of flavoring, sociocultural influences" or a combination of such factors. She says [...]

Oral Cancer Foundation News Team - A2010-09-14T09:06:26-07:00September, 2010|Oral Cancer News|

Radiation exposure may increase risk of stroke and heart disease

Source: www.onmedica.com Author: OnMedica Staff Exposure to moderate levels of radiation may increase the rates of heart disease and stroke, according to new research. Several studies have shown that high doses of radiation to the heart or head and neck from radiotherapy cause an excess of deaths from heart disease or stroke in later years. But it is uncertain whether radiation exposures at relatively low dose levels (under 1 Gy) also increase the risk. To investigate this further, Dr Yukiko Shimizu and colleagues from the Radiation Effects Research Foundation in Japan examined the risk of heart disease and stroke in 86,611 atomic bomb survivors from Hiroshima and Nagasaki who have been followed up for 53 years, from 1950 to 2003, as part of the Japanese atomic bomb survivor Life Span Study. Each member of the group had received an estimated radiation dose from 0-4 Gy (86% received less than 0.2 Gy) at the time of the bomb. Other risk factors for circulatory disease that could have affected the results, such as smoking, alcohol intake, education, occupation, obesity and diabetes were also taken into account. The researchers found an elevated risk of both stroke and heart disease at doses above 0.5 Gy, but the degree of risk at lower doses was unclear. Together, this represents about 210 excess deaths from circulatory disease associated with radiation exposure – about a third as many as the total excess number of cancer deaths (about 625) among atomic bomb survivors in the Life Span Study. [...]

Oral Cancer Foundation News Team - A2010-01-15T19:58:54-07:00January, 2010|Oral Cancer News|

Snuff and chewing tobacco linked to increased risk of fatal MI or stroke

Source: WebMD Author: Marlene Busko Lyon, France - Smokeless tobacco—such as snuff and chewing tobacco—is not harmless when it comes to heart health, according to a new meta-analysis [1]. A review of 11 studies from Sweden and the US, almost entirely in men, showed that smokeless-tobacco users had an increased risk of death from MI or stroke. The study, by researchers at the International Agency for Research on Cancer(IARC), is published online August 18, 2009 in BMJ. Contrary to common belief that smokeless tobacco has very little effect on health, these products have been shown to increase cancer risk, coauthor and IARC researcher Dr Kurt Straif (Lyon, France) told heartwire. "There is sufficient evidence for a causal association between smokeless tobacco and oral and pancreatic cancer [2] and probably also esophageal cancer [3]," he said. "Now, this study adds evidence that smokeless tobacco causes death from cardiovascular diseases," Straif summarized. Widespread, growing use of snus Types of smokeless tobacco used in North America and Europe include dry snuff that is inhaled, as well as moist snuff (called snus in Sweden) and chewing tobacco (or spit tobacco), which are sucked inside the cheek. These products have been around for centuries, and after a decline in consumption for most of the 20th century, use has rebounded in the past few decades, the authors write. In 2000, 23.9% of men and 4.1% of women in Sweden reported using snus daily or occasionally. In the same year, in the US, 4.4% of men and 0.3% of women were [...]

Charlotte Parker2009-08-19T12:14:50-07:00August, 2009|Oral Cancer News|

Up in smoke: health insurers hold billions in tobacco stocks

Source: Southernstudies.org Author: Desiree Evans A recent study published in the New England Journal of Medicine found that major U.S., Canadian and British life and health insurance companies are investing billions of dollars in tobacco company stock. Researchers first revealed that health and life insurance companies had major investments in tobacco companies in 1995 in an article in the British medical journal Lancet. More than 10 years later, insurance companies are still deeply invested in "big" tobacco, despite the national calls upon them to divest. "Despite calls upon the insurance industry to get out of the tobacco business by physicians and others, insurers continue to put their profits above people's health," said Wesley Boyd, the new report's lead author and a faculty member of Harvard Medical School. "It's clear their top priority is making money, not safe-guarding people's well-being." The report found that seven health and life-insurance companies in both the United States and overseas have nearly $4.5 billion invested in companies whose affiliates produce cigarettes, cigars and chewing tobacco. "Although investing in tobacco while selling life or health insurance may seem self-defeating, insurance firms have figured out ways to profit from both," Boyd said. "Insurers exclude smokers from coverage or, more commonly, charge them higher premiums. Insurers profit -- and smokers lose -- twice over." The study highlights New Jersey-based Prudential Financial Inc., which sells life insurance and long-term disability coverage. With total tobacco holdings of $264.3 million, Prudential Financial is a major investor in three tobacco firms, including America's biggest cigarette [...]

Charlotte Parker2009-06-19T07:41:28-07:00June, 2009|Oral Cancer News|

Chewing tobacco use surges among boys

Source: Msnbc.msn.com Author: Staff WASHINGTON - Use of snuff and chewing tobacco by U.S. adolescent boys, particularly in rural areas, has surged this decade, a federal agency said in a report on Thursday that raised concern among tobacco control advocates. The use of such smokeless tobacco products increases the risk of oral cancer as well as heart disease and stroke. It leads to nicotine addiction just like cigarette smoking. The report by the U.S. Substance Abuse and Mental Health Services Administration showed a 30 percent increase in the rate of smokeless tobacco use among boys aged 12 to 17 from 2002 to 2007. Use by adults remained stable. In 2007, the report estimated that 566,000 boys in that age group had used chewing tobacco or snuff. "This trend toward more smokeless tobacco use by kids is of great concern," Danny McGoldrick, vice president for research at the Campaign for Tobacco-Free Kids advocacy group, said in a telephone interview. "This is an industry that has a history of targeting kids because they know that's when everybody starts," he added. Among adolescent boys, the rate of use of smokeless tobacco rose from 3.4 percent in 2002 to 4.4 percent in 2007, according to the report. McGoldrick said the increase occurred as smokeless tobacco companies greatly increased their spending on marketing and introduced a new range of products. The findings reiterated the need for the U.S. Food and Drug Administration to have the power to regulate tobacco products, as legislation being considered by [...]

Charlotte Parker2009-05-19T15:05:12-07:00May, 2009|Oral Cancer News|

Risk of cerebrovascular events after neck and supraclavicular radiotherapy: a systematic review

Source: Radiother Oncol, January 24, 2009 Author: Apryl S Scott, Luke A Parr, and Peter A S Johnstone Objective: Although low dose radiation therapy (RT) has been used to prevent re-occlusion of coronary arteries, it may also precipitate vascular damage. Specifically, irradiation to the neck is related to subsequent vascular wall thickening and atherosclerotic plaque formation. Several investigators, reporting patients with varied disease processes and using different methods, have described an increased risk of cerebrovascular events (CVEs) after RT to the neck for head and neck cancer, breast cancer, or lymphoma. Our purpose is to determine the rate and risk of CVEs in patients after receiving radiation therapy to the neck. Methods: We performed a pooled analysis of the published data to document the cumulative risk of subsequent stroke after RT to the neck. An extensive MEDLINE and PUBMED search yielded five articles involving 6908 patients describing institutional series or cohort analyses comparing the frequency of CVE in irradiated versus non-irradiated patients. Results: Sixty-six CVEs were reported in 2567 patients after neck RT, whereas only 12 CVEs were documented in 4119 non-irradiated patients. Crude risk of CVEs after neck RT was 2.6%, and was 0.29% in non-irradiated patients. This odds ratio of 9.0 was statistically significant (95% CI 4.9, 16.7; p<0.0001). Data for supraclavicular RT were more difficult to analyze given differences in populations and reporting between the three studies, but it appears a significant risk is unlikely. Conclusions: Neck RT increases the likelihood of CVEs, but this risk must [...]

Oral Cancer Foundation News Team - A2009-02-11T12:38:25-07:00February, 2009|Oral Cancer News|