solid tumor

Aspirin a day helps to keep cancer at bay, say scientists

Source: www.guardian.co.uk Author: Sarah Boseley Taking a low-dose aspirin every day will reduce your chances of dying from cancer, scientists say today, confirming the over-the-counter pill as the most extraordinary drug yet discovered. Daily aspirin has already been shown to cut the chances of heart attacks and stroke in people who are at risk. The study published today in the Lancet medical journal reveals that it also has a powerful preventive action against a range of cancers – and possibly more of them than there is currently enough evidence to prove. While the doctors who carried out the study say it is not for them to make recommendations, the lead author, 46-year-old Prof Peter Rothwell from Oxford University, says he has been taking aspirin for the last two years. The beneficial dose is 75mg – a quarter of a standard tablet, which is 300mg. Some pharmacies sell low-dose tablets, but at a higher price. Rothwell and his colleagues have already shown that daily aspirin cuts death rates from colorectal cancer by more than a third. For the study published today, they examined all the data they could find from well-conducted trials that had assessed the use of aspirin against a control drug and had recorded deaths from cancer. In eight trials involving more than 25,000 patients, they found there were 21% fewer deaths after five years among those who took a daily aspirin tablet, compared with those who did not. The effect was most noticeable in gastrointestinal cancers, where deaths [...]

Oral Cancer Foundation News Team - A2010-12-10T08:21:25-07:00December, 2010|Oral Cancer News|

Biovex agrees to Special Protocol Assessment (SPA) with the FDA for a pivotal phase III study with Oncovexin head and neck cancer

Source: www.pressreleasepoint.com Author: press release BioVex Inc, a biotechnology company developing clinical stage treatments for cancer and the prevention of infectious disease, announced today that the U.S. Food and Drug Administration (FDA) has approved the design of a single, pivotal, Phase III clinical trial evaluating its lead product, OncoVEXGM-CSF for the first line treatment of patients with squamous cell cancer of the head and neck. The study is the second the Company has agreed with the FDA under the Special Protocol Assessment (SPA) procedure and highlights the broad potential utility of BioVex’s first-in-class cancer destroying virus technology. The first SPA was in melanoma under which BioVex is currently conducting a pivotal Phase III trial. Patients with head and neck cancer often present with locally advanced, bulky disease that is too large, or too close to vital organs, to remove surgically. These patients typically undergo combination radiation and chemotherapy treatment, with in some cases additional surgery. Patients who present with tumor containing lymph nodes are particularly difficult to treat and approximately half of these patients relapse within two years. Philip Astley-Sparke, President & CEO, for BioVex said: "The announcement of our second SPA governing a Phase III study demonstrates the breadth of the commercial opportunity with OncoVEXGM-CSF. In addition to treating metastatic disease as is the intention in our ongoing Phase 3 study in melanoma, following multiple systemic responses in Phase II, OncoVEXGM-CSFalso has considerable potential utility in treating discrete solid tumor masses across multiple indications including those that are poorly [...]

Oral Cancer Foundation News Team - A2009-11-04T12:54:36-07:00November, 2009|Oral Cancer News|

Saliva test for microRNA could detect oral cancer

Source: www.medpagetoday.com Author: Chris Emery, Contributing Writer, MedPage Today Researchers say they have identified dozens of microRNAs in saliva, raising hopes that saliva tests could assist in early detection of oral cancers. Analyzing patient saliva with a polymerase chain reaction (PCR) technique, the researchers identified about 50 microRNAs -- molecules that halt mRNA translation and/or lead to mRNA degradation, according to a report in the Sept. 1 edition of Clinical Cancer Research. Of the miRNAs they found, a few were present at significantly lower levels in the saliva of patients with oral squamous cell carcinoma (OSCC) than in control subjects (P<0.05). "Two of these miRNAs, miR-125a and miR-200a, are differentially expressed in the saliva of the OSCC patients compared with that of healthy controls," David T. Wong, DMD, DMSc, of the Los Angeles School of Dentistry, and colleagues wrote. "These findings suggest that the detection of miRNAs in saliva can be used as a noninvasive and rapid diagnostic tool for the diagnosis of oral cancer." The authors noted that OSCC is the sixth most common cancer in the U.S., accounting for 90% of oral cancers and leading to 8,000 deaths per year. "The average five-year survival rate for OSCC is [about] 50%," they wrote. "Shockingly, this number has not changed in last three decades. Therefore, an early detection method for OSCC is needed to increase long-term patient survival." Other recent studies have discovered hundreds of miRNAs in various organisms that play roles in cell growth, differentiation, apoptosis, stress response, immune [...]

Oral Cancer Foundation News Team - A2009-08-25T20:10:52-07:00August, 2009|Oral Cancer News|