New therapy shortens treatment for HPV-related cancers of the tonsils, tongue

Source: medicalxpress.com Author: From Mayo Clinic News Network, Mayo Clinic News Network Patients with HPV-related oropharyngeal cancer who undergo surgery and are treated with chemotherapy, may be able to forgo significant radiation therapy without increasing the risk of their cancer spreading, according to the results of a clinical trial led by researchers at Mayo Clinic. "We found that decreasing the amount of radiation therapy after a minimally invasive robotic surgery improved the quality of life of patients with HPV-related oropharyngeal cancer while delivering excellent cure rates," says Dr. Eric Moore, a Mayo Clinic otolaryngologist. "In essence, we found exactly the right amount of treatment to deliver without over-treating these patients." Dr. Moore and his colleagues compared 79 patients treated at Mayo Clinic for HPV-related tonsil and tongue cancer with surgery and two weeks of radiation therapy to a group of 115 patients with the same cancer who were treated with surgery, and the standard six weeks of radiation therapy and chemotherapy. Dr. Moore and his colleagues found no decrease in survival or cancer recurrence in the group that received two weeks of radiation therapy, compared to the group that received six weeks of radiation therapy. He says that by decreasing the amount of radiation therapy after minimally invasive robotic surgery, physicians were able to improve the quality of life of patients and achieve excellent cure rates. "In essence, we found exactly the right amount of treatment to deliver without overtreating," says Dr. Moore. Dr. Moore says Mayo Clinic now offers [...]

Robotics surgery may improve outcomes in mouth and throat cancer

Source: eandt.theiet.org Author: E&T editorial staff Robotic surgery may improve the health outcomes in mouth and throat cancer patients, including better long-term survival, new research suggests. The method used for the study focused on oropharyngeal cancer that occurs in the back of the throat and includes the base of the tongue and tonsils. In transoral robotic surgery, a surgeon uses a computer-enhanced system to guide an endoscope – a flexible tube with a light and camera attached to it – to provide high-resolution, 3D images of the back of the mouth and throat. Naturally, this is an area that is difficult to reach with conventional tools; therefore, robots can be used during this procedure. Here, two robotically guided instruments, acting as a surgeon’s arms, work around corners to safely remove tumours from surrounding tissue. The observational study, conducted by non-profit Los Angeles hospital Cedars-Sinai, used data from the US National Cancer Database and included 9,745 surgical patients – 2,694 of whom underwent transoral robotic surgery between 2010 and 2015. “At a minimum, robotic surgery for oropharyngeal cancer patients seems safe and effective compared to what’s been the standard of care for many years,” said Zachary S Zumsteg, assistant professor of Radiation Oncology at Cedars-Sinai, referring to standard surgery, radiation therapy, and chemotherapy. The researchers found that the five-year overall survival rate for patients with early-stage disease who underwent robotic surgery was 84.5 per cent, compared with 80.3 per cent for patients who had non-robotic surgery. They adjusted for differences in [...]

Less intense treatment safe for HPV+ throat cancer

Source: www.miragenews.com Author: public release, University of Pittsburgh School of Medicine A less intense treatment for human papillomavirus positive (HPV+) throat cancer—using robotic surgery followed by low-dose radiation—could provide as much benefit as standard higher-dose radiation and chemotherapy while preserving a patient’s throat function, and with potentially less toxicities, according to researchers at UPMC Hillman Cancer Center and Yale Cancer Center. The results of their randomized phase two clinical trial will be presented virtually this week at the American Society of Clinical Oncology (ASCO) annual meeting during the Head and Neck Oral Abstract Session (Abstract 6500). “These results present a promising deintensification approach that has proven to be safe in patients with intermediate risk, locally advanced oropharynx cancer,” said Robert Ferris, M.D., Ph.D., director, UPMC Hillman Cancer Center and a surgical oncologist specializing in head and neck cancer, who was lead investigator of the trial. The results are not yet published in a peer-reviewed journal. About 60% of oropharynx cancer, in which cancer cells form in the back of the throat, base of the tongue and tonsils, is associated with HPV infection. The incidence has been increasing in recent years, especially in individuals under the age of 45. Following robotic surgery, patients with HPV-associated throat cancer would typically undergo high dose radiation and chemotherapy. While robotic surgery allows for more precise and optimal preservation of the organs and surrounding tissue, there is still concern with the toxicities from the chemotherapy and consequences of tissue damage from radiation therapy, particularly in [...]

Head and neck cancer: Novel treatment approaches

Source: www.curetoday.com Author: staff Meryl Kaufman, M.Ed., CCC-SLP, BRS-S, and Itzhak Brook, M.D., M.Sc., board members of the Head and Neck Cancer Alliance, share insight into the role of novel treatment approaches like immunotherapy, robotic surgery and de-escalation in the management of cancers of the head and neck. Transcript: Meryl Kaufman, M.Ed., CCC-SLP, BRS-S: Dr. Brook, traditionally the treatment for head and neck cancer has been surgery, radiation, chemotherapy or some combination of those three. But there are some new and emerging treatment approaches to head and neck cancer along with many other cancers. Can you tell us a little bit about immunology? What is immunotherapy in the care of the head and neck cancer patient? Itzhak Brook, M.D., M.Sc.: Most days, we don’t get cancer because our immune system is like the police department of our body. They detect cancer early and eliminate it. Unfortunately, in the case of cancer, the cancer cells can fool the immune system, and they go undetected and cause the disease. The main advantage of immunotherapy is that we are using the body’s defenses, the immune system, to kill the cancer in a much better way than the chemotherapy. Chemotherapy destroys the cancer cells, but it also affects the body cells. Immunotherapy is more precise. It is directed only to the cancer cells, so the rest of the body stays unscathed. That’s the beauty of immunotherapy. So, immunotherapy is an evolving field in cancer. They have many, many new drugs in the pipeline, and [...]

2018-09-04T12:56:32-07:00September, 2018|Oral Cancer News|

The rise of HPV-related cancers in men

Source: www.tmc.edu Author: Alexandra Becker Scott Courville admired his full beard and round belly in the mirror: He was ready for the upcoming holiday season. It was November 2015 and Courville, who plays Santa Claus in Lafayette, Louisiana, was too excited about his favorite time of year to worry much about the pain developing in his jaw. By February, though, the ache had worsened and was accompanied by new symptoms: white spots on his right tonsil, difficulty swallowing and lumps in his throat. He finally made his way to a walk-in clinic where he was diagnosed with tonsillitis and prescribed antibiotics. “They sent me home and said, ‘In two weeks everything should clear up,’” Courville recalled. But his symptoms only worsened. Courville made an appointment with a local ear, nose and throat (ENT) specialist who also diagnosed Courville with tonsillitis. The doctor prescribed more antibiotics and steroids, but two weeks later there were no improvements. Courville was referred to a dentist—“In case they see something we don’t”—but that, too, was a dead end. Courville’s dentist insisted he return to his ENT, where he ultimately had a CT scan that revealed a mass in his throat. That was June 6, 2016. Two days later, Courville underwent a biopsy. When he awoke from the surgery, his doctor was standing over him. Courville always gets choked up retelling this part of his story. “The hardest part for me is always remembering when the doctor said, ‘I’m sorry, but you’ve got cancer.’” Courville was [...]

Flexible robotic surgery opens new paths in cancer treatment

Source: newsok.com Author: staff Robotic surgery is continuing to expand and provide patients with a variety of less invasive treatment options – especially when it comes to cancer treatment. Dr. Brad Mons, a head and neck surgeon at Cancer Treatment Centers of America®in Tulsa, said the Flex Robotic® System, which the hospital added last year, is an especially significant breakthrough for people diagnosed with head and neck cancer. “With this system, we can get to the small areas of the mouth and pharynx more easily to remove tumors in the region,” Mons said. “This affords us the ability to be much less invasive in head and neck cancer surgeries.” Robotic surgery is continuing to expand and provide patients with a variety of less invasive treatment options. Photo provided by CTCA. Currently only available at a small number of hospitals in the United States and designed to overcome line-of-sight limitations, the Flex Robotic System utilizes a uniquely flexible robotic endoscope to give surgeons the ability to navigate a path through challenging areas of the mouth, throat, rectum and colon. For patients, this means potentially faster recovery time and lower risk of complications or side effects. Because the Flex Robotic System operates through natural openings rather than requiring large incisions in the body, potential benefits include shorter hospital stays, reduced post-surgical pain, lower risk of infection and complications, less blood loss (and fewer transfusions) and scarring and faster return to normal activities. For throat cancer patients, the technology also means [...]

Dr. Califano discusses the role of surgery in head and neck cancer

Source: www.onclive.com Author: Joseph A. Califano, MD Joseph A. Califano, MD, professor of surgery, University of California, San Diego, discusses the role of surgery in head and neck cancer. The surgeon has evolved to have a more integrative role in patient care for those with head and neck cancer. Current surgical techniques used in the treatment of head and neck cancers have greatly evolved in the last two decades. Surgery is more precise, and leaves patients with excellent function and cosmetic results by incision through natural orifices, Califano says. Robotic surgery is the cornerstone of head and neck cancer surgery, says Califano. It is effective in terms of resecting tumors of the throat, tonsils, back of the tongue, and the nasopharynx—which are hard to reach without robotic instrumentation. Califano says that the benefits of robotic surgery in this setting are that it leaves patients with excellent function, swallowing, voice, and allows for a rapid recovery.

Evolving role of surgery in multidisciplinary care for head and neck cancer

Source: www.onclive.com Author: Danielle Bucco Even with the advent of systemic therapeutic advancements to the armamentarium of head and neck cancer, surgery and novel techniques continue to rapidly evolve to effectively treat patients and leave less opportunity for adverse events (AEs). Additionally, the role of the surgeon has changed to be a more integrative role in patient care. “We are more precise and more integrated with other therapeutic modalities,” said Joseph A. Califano, MD. “Together, we work as a team and that is the best way that patients can receive their optimal outcomes. We do not just want to cure their cancer but to get back to function and wellness.” In an interview during the 2017 OncLive State of the Science SummitTM on Head and Neck Squamous Cell Carcinoma, Califano, a professor of surgery at the University of California, San Diego, discussed how surgery factors into modern multidisciplinary care for patients with head and neck cancer. OncLive: Please provide an overview of your presentation on surgery for patients with head and neck cancer. Califano: I discussed the fact that the surgery that we do now for head and neck cancers is very different from what used to be done 15 to 20 years ago. Our ability to do effective surgery is good, but now we can do it in a way that leaves patients with excellent function and cosmetic results. When you see someone walking down the street who has had major head and neck surgery, you wouldn't know it [...]

2017-12-19T09:27:11-07:00December, 2017|Oral Cancer News|

Trans oral robotic surgery saves public Australian hospital patients from disfiguring procedure

Source: www.smh.com.au Author: Kate Aubusson The cancerous tumour growing at the back of Brian Hodge's tongue was about as hard-to-reach as cancers get. The 73-year-old was told he'd need radical, invasive surgery to remove the 50¢-sized tumour. His surgeon would make an incision almost from ear-to-ear and split his jaw in two for the 10-12 hour surgery. After five days in intensive care, another three weeks in hospital and four to six months recovery, re-learning how to eat and talk Mr Hodge would have been left with disfiguring scars, and a voice that he may not recognise as his own. "My kids didn't want me to have it," Mr Hodge said. "But I'm not one to throw in the towel ... Then the unbelievable happened," he said. Mr Hodge became one of the first public patients to undergo robotic surgery for head, neck and throat cancer at Nepean Hospital, the state's only hospital offering the service to patients who can't afford private healthcare. Mr Hodge's surgeon, Associate Professor Ronald Chin, performed the trans oral robotic surgery (TORS) by guiding the robot's arm into his patient's open mouth to remove the cancerous tumour. "I went in on Monday morning for the surgery and I was discharged Tuesday night," Mr Hodge said of his surgery performed on June 19. "It's just amazing. Two days compared to six months recovering. "What's got me is that before it was only available to people who could pay the big money. I've worked all my life, [...]

Mayo Clinic Q and A: Throat cancer symptoms

Source: newsnetwork.mayoclinic.org Author: Dr. Eric Moore, Otorhinolaryngology, Mayo Clinic DEAR MAYO CLINIC: Are there early signs of throat cancer, or is it typically not found until its late stages? How is it treated? ANSWER: The throat includes several important structures that are relied on every minute of the day and night to breathe, swallow and speak. Unfortunately, cancer can involve any, and sometimes all, of these structures. The symptoms of cancer, how early these symptoms are recognized and how the cancer is treated depend on which structures are involved. All of the passageway between your tongue and your esophagus can be considered the throat. It includes three main areas. The first is the base of your tongue and tonsils. These, along with the soft palate and upper side walls of the pharynx, are called the oropharynx. Second is the voice box, or larynx. It consists of the epiglottis — a cartilage flap that helps to close your windpipe, or trachea, when you swallow — and the vocal cords. Third is the hypopharynx. That includes the bottom sidewalls and the back of the throat before the opening of the esophagus. Tumors that occur in these three areas have different symptoms, behave differently and often are treated differently. That’s why the areas of the throat are subdivided into separate sections by the head and neck surgeons who diagnose and treat them. For example, in the oropharynx, most tumors are squamous cell carcinoma. Most are caused by HPV, although smoking and alcohol can [...]

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