Cancer Cell Map Initiative reveals protein interactions that drive cancer
Source: www.scienceboard.net Author: Leah Sherwood, The Science Advisory Board assistant editor A research group has mapped previously unknown interactions between proteins that drive cancer, thereby revealing potential new biomarkers and drug targets. The findings were published in a trio of papers in Science on October 1. The research is the work of the Cancer Cell Map Initiative (CCMI), a multi-institution research program founded in 2015 at the University of California, San Diego (UCSD) and San Francisco (UCSF) campuses. From the gene level to the protein level The CCMI approach seeks to gain a more expansive view of the activity underlying cancer by zooming in from the gene level to the protein level, which is far more detailed. "This is an entirely new way to do cancer research," Nevan Krogan, PhD, director of UCSF's Quantitative Biosciences Institute and co-senior author of the papers, said in a statement. "We realized we need another way to look at cancer that takes it a step beyond DNA." Genes contain instructions for building proteins, which then interact with other proteins. When gene mutations cause disruptions, they are reflected in the interactions among protein complexes that regulate activities in the body or turn individual functions on or off. For example, if a gene mutation results in misshapen protein, it may not interact correctly with other proteins, causing a loss of function that, in some cases, can lead to cancer. "We're elevating the conversation about cancer from individual genes to proteins, allowing us to look at how [...]