periodontal disease

New oral cancer saliva test could reduce false-positive results

Source: www.drbicuspid.com Author: staff Researchers at Texas A&M University Baylor College of Dentistry have discovered a new saliva test for oral cancer that could reduce false-positive results. As new oral cancer diagnoses rose to more than 41,000 in 2013, the demand for early detection continues to increase. Yi-Shing Lisa Cheng, DDS, PhD, an associate professor in diagnostic sciences at Baylor College, has been working to develop a saliva test as an oral cancer screening tool, according to an A&M announcement. In 2009, she received a $381,000 R21 grant from the National Institutes of Health's National Institute of Dental and Craniofacial Research to find reliable oral cancer salivary biomarkers, which can be used as indicators of disease or other health conditions. Dr. Cheng recently received a $50,000 faculty bridge grant from Texas A&M Health Science Center and A&M Baylor College of Dentistry's diagnostic sciences department to continue this research. The goal is to determine whether patients with oral lichen planus and periodontal disease exhibit false positives for the future oral cancer saliva tests. Dr. Cheng noted that early detection of cancer is always good and using a saliva test is a noninvasive and relatively easy procedure. Her research differs from models that compare salivary biomarkers of oral cancer patients with those of completely healthy individuals. Instead, Dr. Cheng looked at the biomarkers of patients with noncancerous oral conditions. It's an effort that could save patients thousands of dollars, not to mention the stress and health complications associated with false-positive results. Dr. [...]

Oral Cancer Foundation News Team - A2014-01-31T08:39:38-07:00January, 2014|Oral Cancer News|

Dentists key to quitting ‘smokeless tobacco’

Source: http://www.dentistry.co.uk/ The National Institute for Health and Clinical Excellence (NICE) is recommending a key role for dental professionals in their public health intervention proposals to help stop the use of smokeless tobacco by people of South Asian Origin. Dentists, dental nurses and dental hygienists may be asked to play a leading role as part of new proposals to stop the use of smokeless tobacco in the UK. NICE has published a consultation on their proposals, which recommends a key intervention and education role for dental professionals. It is also recommending more training for dental professionals to help them gain a greater understanding of smokeless tobacco including terminology, symptoms and approaches to successful intervention. Smokeless tobacco is associated with a number of health problems including nicotine addiction, mouth and oral cancer, periodontal disease, heart attacks and strokes, problems in pregnancy and following childbirth and late diagnosis of dental problems as smokeless tobacco products can often mask pain. Smokeless tobacco is mainly used by 'people of South Asian origin', which includes people with ancestral links to Bangladesh, India, Nepal, Pakistan or Sri Lanka. The draft guidance recommends that dental professionals take specific actions including: • Asking patients about their smokeless tobacco use and record the outcome in their patient notes • Making users aware of the potential health risks and advise them to stop, using a brief intervention • Referring users who want to quit the habit to tobacco cessation services that use counsellors trained in behavioural support • Recording the [...]

Oral Cancer Foundation News Team - A2012-03-07T15:45:16-07:00March, 2012|Oral Cancer News|

Berry Nutrition

Source: www.foodproductdesign.com Author: Marie Spano, M.S., R.D., Contributing Editor Nutritionally speaking, good things come in sweet—and tart—little packages. Research is discovering berries pack a nutritional punch due to their vitamin, fiber and antioxidant content. Botanically speaking, berries are indehiscent fruits (they don’t need to be opened to release their seeds) that ripen through the ovary wall. However, any small, edible fruit with multiple seeds is typically considered a berry. In addition to lending flavor and brilliant colors to a wide variety of dishes, all berries are packed with an array of antioxidants, nutrients and potential health benefits. Berries that are especially antioxidant-rich include fresh crowberries, bilberries, black currants, wild strawberries, blackberries, blueberries, goji berries, sea buckthorn, blueberries and cranberries. However, the antioxidant content of berries varies based on the geographical growing condition. And, while fresh berries are an excellent source of antioxidants, total phenol content drops during processing. In fact, processed berry jams and syrup contain approximately half the antioxidant capacity of fresh berries, and juices show the greatest loss of anthocyanins and tannins due to the removal of seeds and skin (Nutrition Journal, 2010; 9:3; Journal of Agricultural and Food Chemistry, Jan 13, 2012). Botanical berries Shiny, scarlet-colored cranberries are rich in vitamin C, loaded with antioxidants, including flavonoids, and score higher in their ORAC score than many other fruits ("Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods—2007", USDA ARS). Cranberries are perhaps best known for the role their juice plays in the prevention of urinary tract infections (UTI) [...]

Oral Cancer Foundation News Team - A2012-02-19T10:53:06-07:00February, 2012|Oral Cancer News|

Caring for the oral health of patients battling cancer: oral care before cancer treatment

Source: www.dentistryiq.com/ Author: Dennis M. Abbott, D.D.S. Cancer. The New Oxford American Dictionary defines it as “the disease caused by an uncontrolled division of abnormal cells in a part of the body;” but for the millions of people it has touched, cancer is so much more. Cancer is a constant unwanted companion that opens the door to an unchosen journey and demands to be followed. It affects individuals, families and friends. Cancer changes lives. Beyond the emotional toll it imposes, cancer alters the well-being of those it afflicts. Modern treatment regimens given to combat this disease come with a host of deleterious side effects, many of which occur in the mouth. Dentists, dental hygienists and dental auxiliaries are in a unique and necessary position to make a positive impact in the lives of patients battling cancer Making a difference begins with a desire to help and a willingness to take a risk. It is followed by a commitment to learn about the unique oral health care needs of patients engaged in the fight of their lives and put into practice skills that can literally provide comfort and hope. We, as dental professionals, can and should be a part of a comprehensive cancer care team for an ever-growing number of people facing cancer. Dental Oncology Dental oncology is a focus of dentistry dedicated to meeting the unique dental and oral health care needs that arise as a result of cancer therapy. It is an area of oral medicine devoted to improving [...]

Oral Cancer Foundation News Team - A2012-02-12T08:48:16-07:00February, 2012|Oral Cancer News|

High risk of developing ONJ for cancer patients on bisphosphonates

Source: Dr.Bicuspid.com Research has shown that cancer patients on bisphosphonates are at risk of developing osteonecrosis of the jaw (ONJ) and that those on the intravenous form of the drug are at a higher risk compared with those on the oral drugs. However, a new study that looked at cancer patients on zoledronic acid (ZOL) and chemotherapy combined with the antiangiogenic agent bevacizumab (BEV) who underwent a dental exam before starting treatment found that none of them developed ONJ (JADA, May 2011, Vol. 142:5, pp. 506-513). Researchers from the University of Siena in Italy investigated the incidence of and risk factors for ONJ in patients with metastases to the bone from solid tumors who received ZOL and BEV. Their study included 59 patients (34 with breast cancer and 25 with non-small cell lung cancer [NSCL]) who received 4 mg of ZOL intravenously every four weeks and 15 mg per kg of BEV every three weeks. The median time the participants received ZOL therapy was 18 months, while the median time participants received BEV therapy was 16 months. The researchers took several measures to reduce the study participants' risk of developing ONJ, including the following: Dental caries and periodontal disease were treated before starting study treatment. Mouth rinses with chlorhexidine and local antibiotic agents were administered before baseline oral hygiene. Recommendations were made for maintaining good oral hygiene. Teeth were extracted at least four weeks before starting ZOL and BEV therapy. Invasive dental procedures were avoided during treatment. If invasive dental [...]

Oral Cancer Foundation News Team - A2011-05-24T10:21:55-07:00May, 2011|Oral Cancer News|

Researchers study relationship of oral cancers and periodontal disease

Source: www.medicalnewstoday.com Author: staff During the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, author J. Meyle, Justus Liebig University, Giessen, Germany, presented an abstract titled "P. gingivalis Infection and Immune Evasion of Oral Carcinomas." Meyle and his team are investigating the relationship of oral cancers and periodontal disease. They achieved results by infecting cell carcinoma cells SCC-25 with Porphyromonas gingivalis (P.g.) W83. After 48h the cells were stained with antibodies against human B7-H1, B7-DC and TLR4 and analysed by flow cytometry. RNA was extracted after 24h and gene expression of B7-H1, B7DC, TLR4, IFN-γ and IL-10 was quantified by real time PCR and analysed by the (2 triangles)CT method. Up-regulation of B7-H1 in host cells may contribute to the chronicity of inflammatory disorders which frequently precede the development of human cancers. B7-H1 expression was detected in the majority of human cancers and leads to anergy and apoptosis of activated T cells, which might enable tumors to evade the immune response. TLR4 signalling has been shown to induce B7-H1 in bladder cancer cells. P.g., a putative periodontal pathogen, is an etiologic agent of periodontitis and expresses a variety of virulence factors. In this study the expression of B7-H1 and B7-DC receptors and TLR4 on squamous cell carcinoma cells SCC-25 was analysed after infection with P.g. in vitro. The research concludes that P.g. is able to induce the expression of the immune regulating receptors B7-H1 and B7-DC in squamous cell carcinoma which may facilitate [...]

Oral Cancer Foundation News Team - A2010-07-16T13:09:40-07:00July, 2010|Oral Cancer News|

Dental Calamities That Can Truly Hurt

Source: New York Times Writer: Nicholas Bakalar DENTAL cavities are not good news, but when it comes to preventive oral health, they may be among the smaller problems. The advice is familiar: brush and floss regularly, use fluoride mouthwash, limit snacks and sweet drinks, visit the dentist twice a year. Good suggestions, even if not everyone follows them: by age 12, 50 percent of children have cavities. But there are two much more serious problems, common dental diseases that can lead not only to loss of teeth but also to loss of life: periodontal disease and oral cancer. Periodontal disease — a chronic bacterial infection of the gums that destroys the bone and tissues that hold the teeth — is the leading cause of tooth loss in adults. Some people are genetically susceptible, and the problem can be aggravated by smoking, taking certain medications, stress and other factors. Several studies have found that gum disease is associated with an increased risk for heart attack. “It isn’t nailed down yet,” said Dr. Martin J. Davis, professor of clinical dentistryat the College of Dental Medicine at Columbia, “but there seems to be a link between the inflammation of gums and the inflammatory markers of heart disease.” It may be that oral bacteria enter the bloodstream, attach to fatty plaques in the coronary arteries and cause clots to form. Or maybe inflammation itself increases plaque buildup. A 2007 study showed that periodontal disease increased the risk of heart disease in men by one third and doubled it in women, even [...]

Webmaster2009-02-17T09:56:09-07:00February, 2009|Oral Cancer News|