genetic – Oral Cancer News

Certain genetic alterations may explain head and neck cancer survival disparities

Source: www.sciencecodex.com Author: staff Certain genetic alterations to the PAX gene family may be responsible for survival disparities seen between African-American and non-Latino white men with head and neck cancer, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9. "During the last 30 years, the overall five-year relative survival rates for head and neck squamous cell carcinoma (HNSCC) have increased, but despite that, the gap in overall survival rates between non-Latino white patients and African-American patients has remained unchanged," said Rafael Guerrero-Preston, Dr.P.H., assistant professor at Johns Hopkins University in Baltimore, Md. "This disparity may be due to differences in genetic and epigenetic alterations among African-American patients." To test this theory, Guerrero-Preston and colleagues performed a two-stage epigenomic study. In the stage-one discovery phase, the researchers used next-generation sequencing and array-based technologies to evaluate 107 HNSCC samples. In the stage-two validation phase, they validated the findings of the discovery phase and evaluated their effect on survival rates in 279 patient samples from The Cancer Genome Atlas project. "Our results highlight the differential genomic and epigenomic alterations in PAX, NOTCH, and TP53 pathways between African-American and non-Latino white HNSCC patients, which underlie the complex biology of morphologically similar tumors and explain HNSCC survival disparities," Guerrero-Preston said. "If further validated in larger cohorts, these discoveries could be used to develop genomic and epigenomic panels that will enable more treatment options, a reduction in treatment [...]

Oral Cancer Foundation News Team - A2013-12-09T14:38:31-07:00December, 2013|Oral Cancer News|

If teeth could talk…

Source: wsj.com Author: Melinda Beck The eyes may be the window to the soul, but the mouth provides an even better view of the body as a whole. Some of the earliest signs of diabetes, cancer, pregnancy, immune disorders, hormone imbalances and drug issues show up in the gums, teeth and tongue -- sometimes long before a patient knows anything is wrong. There is also growing evidence that oral health problems, particularly gum disease, can harm a patient's general health as well, raising the risk of diabetes, heart disease, stroke, pneumonia and pregnancy complications. "We have lots of data showing a direct correlation between inflammation in the mouth and inflammation in the body," said Anthony Iacopino, director of the International Centre for Oral-Systemic Health, which opened at the University of Manitoba Faculty of Dentistry in Canada in 2008. Recent studies also show that treating gum disease improves circulation, reduces inflammation and can even reduce the need for insulin in people with diabetes. Such findings are fueling a push for dentists to play a greater role in patients' overall health. Some 20 million Americans -- including six percent of children and nine percent of adults -- saw a dentist but not a doctor in 2008, according to a study in the American Journal of Public Health this month. "It's an opportunity to tell a patient, 'You know, I'm concerned. I think you really need to see a primary care provider,' so you are moving in the direction of better health," said [...]

Oral Cancer Foundation News Team - A2012-01-02T06:53:06-07:00January, 2012|Oral Cancer News|

Poor oral health can be passed through generations

Source: www.dentistryiq.com Author: staff A new 27-year research project suggests that mothers with poor oral health are likely to have children who also have poor oral health when they reach adulthood. The long-term study of more than a thousand children born in New Zealand in 1972 and 19731 provides strong evidence that the children of mothers with poor oral health are more likely to grow up with above average levels of tooth loss, tooth decay, and fillings. The findings strengthen the notion from previous research that adult oral health is affected by a combination of genetic and environmental factors.2 The research compared the oral health of the children at the age of 5 in 1978, and again at the age of 32. The findings were compared with the mother’s own self-rated oral health measured in 1978. Analysis 27 years later indicated that approaching half of children (45.1%) whose mothers rated their oral health as "very poor" had severe tooth decay. Around four in every 10 children (39.6%) experienced tooth loss in adulthood. The research commented on the influence of environmental risk factors on oral health including socioeconomic status (SES), attitudes, beliefs, and oral health-related knowledge persisting across generations, providing further evidence of how a mother’s view of her own oral health can affect that of her child’s. Chief Executive of the British Dental Health Foundation Dr. Nigel Carter said: "These findings represent important confirmation of a trend that has long been recognised. Work by Per Axelsson in Sweden in the [...]

Oral Cancer Foundation News Team - A2011-07-11T14:22:45-07:00July, 2011|Oral Cancer News|