Researchers find overactive protein among mouth cancer patients

Source: http://www.ibtimes.co.uk/ Author: B.S. Akshaya An overactive protein in mouth cancer encourages tumours to grow fast and scientists claim that the protein will help them to find an effective treatment for the disease. Cancer Research UK scientists have discovered FRMD4A, a protein that is overactive among mouth cancer patients. They claim that just deactivating the protein will help save many lives. A study conducted on mice revealed that when FRMD4A protein is turned on, it helps the cancer cells to group and stick together, but when the protein is deactivated the stickiness of the cell is lost and ultimately it causes cancer cells to die. Scientists have already found some potential drugs that could help them deactivate the protein. “What’s really exciting about this research is that we already have potential drugs that can be used to target this protein or compensate for the effects that it is having,” said Dr Stephen Goldie, researcher at Cancer Research UK, in a statement. “These drugs could offer new options to patients where surgery and chemotherapy have not worked or could be used alongside them. We now need to start trials with these treatments, but we hope this could make a real difference to people with mouth cancer in the future,” he added. Mouth cancer starts anywhere in the oral cavity area like in the cheek lining area, the floor of the mouth, gums or the roof of the mouth (palate). Symptoms of this cancer are chewing problems, mouth sores, speech difficulty, swallowing [...]

2013-07-19T07:41:38-07:00July, 2013|Oral Cancer News|

Protein could provide target for new mouth cancer drugs

Source: www.netdoctor.co.uk Author: staff A protein that is overactive in mouth cancer could provide a new target for the development of drugs against the disease, researchers say. Scientists at Cancer Research UK's Cambridge Research Institute have discovered that a protein called FRMD4A is permanently switched on in cancer. Furthermore, the higher the levels of this protein, the more likely the disease is to spread and come back following treatment. Tests carried out in mice have revealed that by blocking FRMD4A, it may be possible to prevent mouth cancer from growing and spreading. Dr Stephen Goldie, whose findings are published in the journal Cancer Research, said: 'What's really exciting about this research is that we already have potential drugs that can be used to target this protein or compensate for the effects that it is having. 'These drugs could offer new options to patients where surgery and chemotherapy hasn't worked or could be used alongside them.' The research team now plan to carry out clinical trials involving these drugs to see if they work in patients with head and neck squamous cell carcinoma - a particularly aggressive form of mouth cancer. There are various types of mouth cancer which affect more than 5,300 people in the UK each year.

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