floor of mouth

Floor of the mouth cancer requires more aggressive treatment to prevent metastases

Source: www.docguide.com Author: Louise Gagnon More aggressive management of squamous cell carcinoma (SCC) of the floor of the mouth has decreased the number of failures in local, regional, and distant metastases, according to a retrospective chart review presented here at the 2nd World Congress of the International Academy of Oral Oncology (IAOO). In the study, a total of 142 treatment-naïve patients with newly diagnosed floor of mouth cancer received treatment with curative intent from 1994 through 2004 at the Princess Margaret Hospital in Toronto, Ontario. About a third of patients received postoperative radiation, explained lead author Jane Lea, MD, Department of Otolaryngology-Head and Neck Surgery at the University of Toronto/Princess Margaret Hospital. The researches wanted to review outcomes and assess any predictive information of survival in patients, noted Dr. Lea. "We wanted to determine clinical and pathological prognosticators of survival," Dr. Lea told attendees at an oral abstract session on July 9. The primary mode of treatment was surgery, with the majority (91%) of those undergoing surgery undergoing neck dissections, noted Dr. Lea. Overall 5-year survival was 68%, and 5-year cause-specific survival was 80%. Mortality due to floor of mouth disease was 14%, and failures were reported in 24 patients. Researchers compared the outcome of this chart review to previously published reviews on the management of SCC of the floor of mouth and found more aggressive management, characterised by increased rates of neck dissections, in their practice compared with management of the condition in the 1970s and 1980s. The more [...]

Oral Cancer Foundation News Team - A2009-07-21T20:05:37-07:00July, 2009|OCF In The News|

The prognostic significance of histological features in oral squamous cell carcinoma

Source: J Oral Pathol Med, June 25, 2009 Authors: S R Larsen et al. Background: Different factors predict nodal metastasis, recurrence and survival in oral cancer. The aim was to assess the prognostic value of histological features related to the primary tumour. Methods: A total of 144 patients surgically treated at Odense University Hospital for oral cancer between 1999 and 2004 were included in the study. Postoperative radiation therapy was given in case of close and involved margins or high TNM stages (UICC 1997). Median follow-up time was 38 months. All surgical resections were reviewed and 22 histological characteristics were assessed. Results: The predominant sites were floor of mouth (FOM, 39%) and lateral tongue (35%). Fifty-nine per cent had UICC97 stage I-II disease. Five-year cause-specific survival was observed in 65%. Nodal involvement at diagnosis was observed in 36% which was significantly related to grade, neural and vascular invasion; surgical margins and increasing tumour depth. A cut-off value of 2 mm (4 mm for FOM) separated patients without and with nodal metastasis at the time of diagnosis. However, on multivariate analysis, neck disease was only associated with tumour depth and grade. Cox analysis of local recurrence in the oral cavity over time showed that tumour diameter and surgical margins were significant predictors while cause-specific survival was related to diameter, depth of invasion, surgical margins and extracapsular spread (ECS). Conclusions: Tumour depth and grade were strong prognostic factors for nodal metastasis, independently of other histological features. Tumour diameter and margins independently predict [...]

Oral Cancer Foundation News Team - A2009-07-03T17:40:45-07:00July, 2009|Oral Cancer News|