ethanol – Oral Cancer News

Going sober beyond Dry January will help you avoid cancer: study

Source: themessenger.com Author: Mansur Shaheen More than half of 18- to 34-year-olds believe drinking in moderation is bad for your health. Getty Images Having a Dry January may feel great, but going sober forever could significantly drop your risk of developing multiple types of cancer, according to a new World Health Organization (WHO) study. In a massive meta-analysis of 91 studies, published this week in the New England Journal of Medicine, researchers found long term sobriety could significantly reduce risk of oral or esophageal cancer. They also found relatively small and inconclusive drops in larynx, colorectal or breast cancer risk. The WHO considers alcohol a carcinogen, saying that “when it comes to alcohol consumption, there is no safe amount that does not affect health.” It says that even light use of alcohol is linked to an increased risk of a host of diseases, including cancer, liver issues, Alzheimer’s and more. On the flip side, quitting alcohol can help a person reduce their risk of developing disease. In the new study, the WHO researchers found that people who stopped drinking for five to nine years were 34% less likely to develop oral cancer. If they kept it up for 10 to 19 years, the risk would drop 55%. For esophageal cancer, the risk drops 15% after going sober for five to nine years, and 65% for 10 to 19 years. The researchers blame the cancers linked to alcohol consumption on ethanol, a type of alcohol. When the body consumes [...]

Oral Cancer Foundation News Team - A2023-12-30T11:26:11-07:00December, 2023|Oral Cancer News|

Ethanol Promotes Chemically Induced Oral Cancer in Mice through Activation of the 5-Lipoxygenase Pathway of Arachidonic Acid Metabolism

Source: Cancer Prevention Research Abstract Alcohol drinking is a known risk factor for oral cancer in humans. However, previous animal studies on the promoting effect of ethanol on oral carcinogenesis were inconclusive. It is necessary to develop an animal model with which the molecular mechanism of ethanol-related oral carcinogenesis may be elucidated to develop effective prevention strategies. In this study, mice were first treated with 4-nitroquinoline-1-oxide (4NQO, 100 μg/mL in drinking water) for 8 weeks and then given water or ethanol (8%) as the sole drink for another 16 weeks. During the experiment, 8% ethanol was well tolerated by mice. The incidence of squamous cell carcinoma (SCC) increased from 20% (8/41) to 43% (17/40; P < 0.05). Expression of 5-lipoxygenase (5-Lox) and cyclooxygenase 2 (Cox-2) was increased in dysplasia and SCC of 4NQO-treated tongues and further enhanced by ethanol. Using this mouse model, we further showed that fewer cancers were induced in Alox5−/− mice, as were cell proliferation, inflammation, and angiogenesis in the tongue, as compared with Alox5+/+ mice. Interestingly, Cox-2 expression was induced by ethanol in knockout mice, whereas 5-Lox and leukotriene A4 hydrolase (LTA4H) expression and leukotriene B4 (LTB4) biosynthesis were dramatically reduced. Moreover, ethanol enhanced expression and nuclear localization of 5-Lox and stimulated LTB4 biosynthesis in human tongue SCC cells (SCC-15 and SCC-4) in vitro. In conclusion, this study clearly showed that ethanol promoted 4NQO-induced oral carcinogenesis, at least in part, through further activation of the 5-Lox pathway of arachidonic acid metabolism. This news story was resourced [...]

Oral Cancer Foundation News Team - A2011-10-19T15:36:04-07:00October, 2011|Oral Cancer News|

Mouthwash multiplies risk of cancer up to nine times

Source: www.theaustralian.com.au Author: Adam Creswell Mouthwashes containing alcohol should be used only for short periods because they may increase the risk of oral cancer by up to nine times. Dental researchers warned yesterday that among people using such mouthwashes, the risk of oral cancer was increased nine times if they smoked, and five times if they drank alcohol. For non-drinkers using alcohol-based mouthwashes, the risk of oral cancer is just under five times higher, the experts warn in the latest edition of the National Prescribing Service journal Australian Prescriber. Brands of mouthwash with more than 20 per cent alcohol could have other harmful effects, including the gum disease gingivitis, flat red spots called petechiae and detachment of the cells lining the mouth, they said. "Although many popular mouthwashes may help to control dental plaque and gingivitis, they should only be used for a short time and only as an adjunct to other oral hygiene measures such as brushing and flossing," they wrote. "Long-term use of ethanol-containing mouthwashes should be discouraged, given recent evidence of a possible link with oral cancer." The paper expands on concerns aired by university researchers early this year.

Oral Cancer Foundation News Team - A2009-12-01T15:27:54-07:00December, 2009|Oral Cancer News|