Oral Cancer Foundation breaks records in April’s Awareness and Screening Month

Source: MSNBC News Author: staff Oral cancer is an insidious disease that too often is not discovered until very late in its development, as it might not produce symptoms the average person may notice. By then treatments are less effective, and because of late discovery in far too many patients, it has a five year survival rate of only about 57%, much lower than cancers we commonly hear about. Oral cancer has existed outside the awareness of much of the public, yet it will take one life, every hour of every day in the U.S. This year the combination of unprecedented efforts by the relatively small, non-profit Oral Cancer Foundation, a coalition of strategic partners they formed, and a dose of celebrity power, created what might be called a perfect storm; and one that potentially will change public awareness of one of the few cancers that is actually increasing in incidence in the U.S. For thirteen years in a row, April has been oral cancer awareness month nationally. More than 85% of all head and neck cancers are oral and oropharyngeal disease. Historically, a loose coalition of stakeholders in the disease has mustered about 200 screening events in April in facilities ranging from large institutions to individual dental offices around the country. Those participants opened their doors for at least a half-day to opportunistically screen members of the public in their communities for free, to find early stage disease, and to raise public awareness. This year the Oral Cancer Foundation, [...]

VEGF expression tied to poor psychological function

Source: www.doctorslounge.com Author: press release Patients with newly diagnosed head and neck squamous cell carcinoma who have increased levels of perceived stress and depressive symptoms may have higher levels of vascular endothelial growth factor expression, which is associated with shorter disease-free survival, according to a study presented at the 32nd Annual Meeting & Scientific Sessions of the Society of Behavioral Medicine, held April 27 to 30 in Washington, D.C. Carolyn Y. Fang, Ph.D., from the Fox Chase Cancer Center in Philadelphia, and colleagues analyzed the association between psychosocial functioning and biological pathways related to tumor growth (VEGF expression) in 37 newly diagnosed, predominantly male HNSCC patients with an average age of 56.7 years. The primary tumor sites were oral cavity, larynx, and oropharynx, and more than 40 percent of patients were categorized as having early-stage disease. Prior to treatment, patients completed psychosocial questionnaires, and VEGF expression was evaluated by immunohistochemical analysis of the tumor tissue obtained during surgery. The investigators found that, after controlling for disease stage, higher levels of perceived stress and depressive symptoms were significantly correlated with greater expression of VEGF in tumor tissue. After controlling for disease stage and other variables, increased VEGF expression was correlated with shorter disease-free survival (hazard ratio, 3.97). "Poorer psychosocial functioning was associated with greater expression of VEGF in tumor tissue. Greater VEGF expression was, in turn, associated with shorter disease-free survival in HNSCC patients," the authors write.

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