Tag Archive | "cisplatin"

Are combination therapies effective for advanced SCCHN?

Tuesday, March 12, 2013

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Source: Author: DrBicuspid Staff In a recent study, researchers from the University of North Carolina (UNC) Lineberger Comprehensive Cancer Center examined whether the addition of multiple drugs to radiation therapy is superior to the current standard of care therapy with one drug and radiation for locally advanced squamous cell carcinoma of the head and neck […]

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Targeted Drugs No Help in Head and Neck Cancer

Thursday, March 7, 2013

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Source: medpagetoday.com Author: Charles Bankhead, Staff Writer, MedPage Today Date: March 05, 2013     The addition of targeted agents to standard chemotherapy failed to improve efficacy in two different trials of advanced head and neck cancer. In one trial, patients given gefitinib (Iressa) in addition to docetaxel lived about a month longer than those […]

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Erbitux add-on falls short in esophageal cancer

Monday, January 28, 2013

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Source: www.medpagetoday.com Author: Charles Bankhead, Staff Writer, MedPage Today The addition of a targeted agent to definitive chemoradiation failed to improve survival in an unselected population with esophageal cancer, a randomized trial showed. In fact, patients who received cetuximab (Erbitux) with chemoradiation had significantly worse overall survival (OS) reflected in a 50% increase in the […]

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Ten year results of landmark neck cancer trial published

Friday, November 30, 2012

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Source: www.modernmedicine.com Author: Gabriel Miller The latest data from a trial that opened in 1992 confirm that for locally advanced laryngeal cancer, sequential and concomitant chemoradiotherapy each produce similar survival rates, but the concomitant approach more often allows the larynx to be preserved. When the results of RTOG 91-11 were first published in 2003. “they […]

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Neoadjuvant chemo does not improve oral cancer survival rates

Sunday, November 11, 2012

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Source: www.drbicuspid.com Author: DrBicuspid Staff Patients with advanced resectable oral squamous cell carcinoma (OSCC) who undergo surgery do not benefit from improved survival after induction with docetaxel, cisplatin, and fluorouracil (TPF), according to a new study (Journal of Clinical Oncology, November 5, 2012). Study author Zhi-yuan Zhang, MD, PhD, from Shanghai Jiao Tong University School […]

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Study will evaluate Panitumumab regimen in advanced SCCHN

Tuesday, September 11, 2012

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Source: http://www.onclive.com/ Author: staff Canadian researchers are investigating standard fractionation radiotherapy with concurrent high-dose cisplatin versus accelerated fractionation radiotherapy with panitumumab in patients with locally advanced stage III and IV squamous cell carcinoma of the head and neck (SCCHN). The NCIC Clinical Trials Group has completed accrual for the randomized phase III study, which has […]

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Facing the facts: HPV-associated head and neck cancers get a second look

Tuesday, July 3, 2012

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Source: www.curetoday.com Author: Charlotte Huff Kevin Pruyne knew he didn’t fit the stereotype of a hard drinker or heavy smoker who one day develops an oral cancer. The 52-year-old mechanic had been working a three-week stint in a remote section of northern Alaska, repairing trucks on an oil field, when he noticed a hard lump beneath […]

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CD4 counts predict chemo response in laryngeal cancer

Sunday, February 26, 2012

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Source: www.oncologyreport.com/ Author: Miriam E. Tucker Pretreatment CD4 levels predicted response to induction chemotherapy among 97 patients with advanced laryngeal cancer, but not for 66 patients with advanced oropharyngeal cancer, according to a retrospective analysis of data from two clinical trials. The two groups of head and neck cancer patients were enrolled in two identical […]

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Cisplatin Aids Survival of High-Risk Head and Neck Cancer

Wednesday, February 8, 2012

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Source: Oncology Report Adding chemotherapy to radiotherapy improved 10-year survival of resectable head and neck carcinomas among high-risk patients who had microscopically involved resection margins and/or extracapsular spread of disease – but not in high-risk patients who only had tumor in multiple lymph nodes. The findings come from a long-term update and unplanned subset analysis […]

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Cisplatin aids survival of high-risk head and neck cancer

Friday, February 3, 2012

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Source: www.oncologyreport.com Author: Miriam E. Tucker Adding chemotherapy to radiotherapy improved 10-year survival of resectable head and neck carcinomas among high-risk patients who had microscopically involved resection margins and/or extracapsular spread of disease – but not in high-risk patients who only had tumor in multiple lymph nodes. The findings come from a long-term update and […]

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