black raspberries – Oral Cancer News

Black raspberries reduce DNA damage in oral cancer survivors

Source: www.prweb.com Author: press release New research presented Wednesday, April 10, at the American Association for Cancer Research Annual Meeting 2013 in Washington, DC, suggests that a food-based cancer prevention study aimed at oral cancer survivors was effective at attenuating highly reactive oxygen molecules that can damage DNA and trigger cancer. In the study, a phase 1b clinical trial conducted at The Ohio State University, participants consumed 4 - 8 grams of black raspberries daily for six months. The berries were well tolerated by the participants and adherence to the regimen was good. This study provides compelling data that indicate biochemical markers of cancer-causing DNA damage were reduced in participants who adhered to the food-based regimen and supports other evidence from a phase 2 human trial linking application of black raspberry gel to precancerous lesions to a reduced risk of developing oral cancer. Black raspberries, not to be confused with blackberries, are almost exclusively grown in Oregon, on the west coast of the United States. They have been studied extensively because of their high concentration of certain phytonutrients and antioxidants. BerriProducts, an Oregon-based company, has been supplying black raspberry products to research universities across the country for the last four years.

Oral Cancer Foundation News Team - A2013-04-11T08:20:55-07:00April, 2013|Oral Cancer News|

Oral gel contains cancer-preventing compounds derived from black raspberries

Source: www.dentistryiq.com Author: Maria Perno Goldie, RDH, MS, with the assistance of Allison Walker Maria Perno Goldie (MPG): I had the opportunity to interview Dr. Susan Mallery, who is a humble as she is intelligent. I had the assistance of Allison Walker, a freelance journalist who has been involved in dental publishing for more than 20 years. Dr. Susan Mallery (SM) is a Professor in the Division of Oral Surgery, Oral Pathology, and Anesthesiology at The Ohio State University, College of Dentistry, in Columbus, Ohio. Her research interests include oral cancer initiation, AIDS-related oral cancer and chemoprevention. Dr. Mallery has published articles in journals such as Cancer Research, Cancer Prevention Research, Molecular Pharmaceutics, Carcinogenesis and Clinical Cancer Research, to name a few. She graduated from The Ohio State University with her DDS and later returned to receive her oral pathology specialty training and a PhD in Pathology. Dr. Mallery is licensed by the Ohio State Dental Board and board certified by the American Board of Oral Pathology and American Academy of Oral Pathology. She belongs to the American Academy of Oral Pathology, American Board of Oral Pathology, American Association for Cancer Research, and is a Fellow of the American Association for the Advancement of Science. She is a consultant at The Ohio State University and James Cancer hospitals. MPG: Oral squamous cell carcinoma (OSCC) will be diagnosed in more than 36,000 Americans this year and has a particularly high mortality rate—as it will kill approximately 8,000 patients this year. As [...]

Oral Cancer Foundation News Team - A2012-03-15T11:56:00-07:00March, 2012|Oral Cancer News|

Adapting the science of supplements and cancer prevention

Source: www.cancer.gov Author: Carmen Phillips Numerous studies suggest that avoiding excess weight, exercising regularly, and eating a diet heavy on fruits and vegetables decreases the risk of many diseases, including cancer. But as the expanding obesity epidemic has shown, there are major obstacles to getting broad swaths of people to adopt such a healthful lifestyle. So, for many years, cancer researchers have investigated whether specific nutrients—those that epidemiologic and animal model studies have suggested could sway cancer’s course—could decrease cancer risk. Much has been learned from this work, researchers in the field say, but, as is the case with treatment, each new discovery points to new areas of focus and other potential avenues of progress. With promising bioactive compounds in the pipeline, many prevention researchers are focused on figuring out not just whether something like sulforaphane, a natural compound found in broccoli and broccoli sprouts, can kill cancer cells in a test tube or animal model—which it does, quite well—but how, at the molecular level, it accomplishes this task, whether there are some cancer cells that are more likely to respond to it, and whether there are ways of discerning early on that the intervention is having its intended effect. Prevention: A Complex Matter A number of supplements have been tested in large prevention trials, including vitamins A, C, and E; selenium; beta-carotene; and folic acid. At least one trial has demonstrated a reduction in cancer deaths with a combination of supplements, while several others found no reduction or even [...]

Oral Cancer Foundation News Team - A2009-12-17T19:42:35-07:00December, 2009|Oral Cancer News|

Chemopreventive agents in black raspberries identified

Source: news.biocompare.com Author: staff A study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, identifies components of black raspberries with chemopreventive potential. Researchers at the Ohio State Comprehensive Cancer Center found that anthocyanins, a class of flavonoids in black raspberries, inhibited growth and stimulated apoptosis in the esophagus of rats treated with an esophageal carcinogen. "Our data provide strong evidence that anthocyanins are important for cancer prevention," said the study's lead author, Gary D. Stoner, Ph.D., a professor in the department of internal medicine at Ohio State University. Stoner and his team of researchers fed rats an anthocyanin-rich extract of black raspberries and found that the extract was nearly as effective in preventing esophageal cancer in rats as whole black raspberries containing the same concentration of anthocyanins. This study demonstrates the importance of anthocyanins as preventive agents in black raspberries and validated similar in vitro findings. It is among the first to look at the correlation between anthocyanins and cancer prevention in vivo. Stoner and his colleagues have conducted clinical trials using whole berry powder, which has yielded some promising results, but required patients to take up to 60 grams of powder a day. "Now that we know the anthocyanins in berries are almost as active as whole berries themselves, we hope to be able to prevent cancer in humans using a standardized mixture of anthocyanins," said Stoner. "The goal is to potentially replace whole berry powder with its active components and then figure [...]

Oral Cancer Foundation News Team - A2009-01-15T08:29:19-07:00January, 2009|Oral Cancer News|

New findings show cancer prevention effects of black raspberries, blueberries, olive leaves and green tea

Source: www.naturalnews.com Author: David Gutierrez Three studies presented at the American Association for Cancer Research's Sixth Annual International Conference on Frontiers in Cancer Prevention Research in Philadelphia have demonstrated the powerful cancer-fighting benefits of dark berries, green tea and olive leaves, and suggest that gels and beverages may some day be used to prevent against cancer and tumor growth. In the first study, researchers from Ohio State University discovered that a gel based on freeze-dried black raspberries helps prevent precancerous mouth tumors (lesions) from becoming malignant. "This gel appears to be a valid means of delivering anthocyanins and other cancer-preventing compounds directly to precancerous cells, since it slowed or reduced lesion progression in about two-thirds of study participants," said researcher Susan Mallery. According to the American Cancer Society, oral squamous cell carcinoma is one of the deadliest forms of cancer, causing 7,500 deaths each year in the United States. Because no chemopreventive agent or treatment method other than radical mouth surgery exists, even those who survive the cancer often emerge significantly disfigured. And even in many cases where tumors are fully removed, they still recur. "Oral cancer is a debilitating disease and there is a desperate need for early detection and management of precancerous lesions," said Mallery. Most mouth cancer begins as small, noncancerous lesions in the mouth that are difficult to detect. It was these lesions that were treated in the Ohio State University study. Researchers carried out the study on 20 participants who had identifiable precancerous mouth lesions [...]

Oral Cancer Foundation News Team - A2008-09-29T18:53:12-07:00September, 2008|Oral Cancer News|